The network for 'positive regulation of nitric oxide synthase biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of nitric oxide synthase biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.

NameDescriptionProbabilityFunc Analog Organism
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.996
VEGFAvascular endothelial growth factor A0.944
MAP2K4mitogen-activated protein kinase kinase 40.847
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.782
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.741
LATlinker for activation of T cells0.716
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.670
MAPK8mitogen-activated protein kinase 80.662
MAPK14mitogen-activated protein kinase 140.582
CAV1caveolin 1, caveolae protein, 22kDa0.568
BCAR1breast cancer anti-estrogen resistance 10.462
EGFRepidermal growth factor receptor0.453
PDGFAplatelet-derived growth factor alpha polypeptide0.443
SOS1son of sevenless homolog 1 (Drosophila)0.433
MAPK9mitogen-activated protein kinase 90.371
ND1NADH dehydrogenase, subunit 1 (complex I)0.362
PLCG1phospholipase C, gamma 10.353
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.316
MAP3K1mitogen-activated protein kinase kinase kinase 10.295
XPO7exportin 70.283
INSRinsulin receptor0.277
CDH5cadherin 5, type 2 (vascular endothelium)0.251
IFNGR1interferon gamma receptor 10.213
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.190
NRP1neuropilin 10.181
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.169
LRRK2leucine-rich repeat kinase 20.151
PDGFCplatelet derived growth factor C0.146
PGFplacental growth factor0.135
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.134
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.132
PTPRBprotein tyrosine phosphatase, receptor type, B0.129
LY96lymphocyte antigen 960.108
GAB1GRB2-associated binding protein 10.096
PTPRJprotein tyrosine phosphatase, receptor type, J0.090
GHRgrowth hormone receptor0.089
SOCS1suppressor of cytokine signaling 10.089
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.088
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.080
MAPK1mitogen-activated protein kinase 10.073
ARRB1arrestin, beta 10.063
KITLGKIT ligand0.062
STAT5Asignal transducer and activator of transcription 5A0.058
TICAM2toll-like receptor adaptor molecule 20.057
GAB2GRB2-associated binding protein 20.053
EHD1EH-domain containing 10.051
NTRK1neurotrophic tyrosine kinase, receptor, type 10.050
TAOK2TAO kinase 20.050
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.050
MAP3K5mitogen-activated protein kinase kinase kinase 50.047
SOS2son of sevenless homolog 2 (Drosophila)0.045
FYNFYN oncogene related to SRC, FGR, YES0.042
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.041
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.040
IGF1Rinsulin-like growth factor 1 receptor0.039
FGFR1fibroblast growth factor receptor 10.038
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.033
ATF2activating transcription factor 20.032
CLEC4EC-type lectin domain family 4, member E0.032
LDLRlow density lipoprotein receptor0.031
CLEC4DC-type lectin domain family 4, member D0.031
XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble0.031
FTLferritin, light polypeptide0.031
KIAA1712KIAA17120.030
ZFP36L1zinc finger protein 36, C3H type-like 10.029
ITGAMintegrin, alpha M (complement component 3 receptor 3 subunit)0.029
MAP3K4mitogen-activated protein kinase kinase kinase 40.027
PTK2BPTK2B protein tyrosine kinase 2 beta0.026
MAP2K6mitogen-activated protein kinase kinase 60.026
SLASrc-like-adaptor0.025
GOLGA7golgin A70.025
ARRB2arrestin, beta 20.025
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.023
FYBFYN binding protein0.023
PRKCQprotein kinase C, theta0.023
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.023
FLT4fms-related tyrosine kinase 40.022
CMIPc-Maf-inducing protein0.022
JAK2Janus kinase 20.022
CAB39calcium binding protein 390.020
SOD2superoxide dismutase 2, mitochondrial0.020
ZBTB25zinc finger and BTB domain containing 250.020
MAP2microtubule-associated protein 20.019
IRS1insulin receptor substrate 10.019
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.018
FTH1ferritin, heavy polypeptide 10.018
CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)0.018
IL1R1interleukin 1 receptor, type I0.018
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.018
MKNK1MAP kinase interacting serine/threonine kinase 10.017
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.017
MAP2K7mitogen-activated protein kinase kinase 70.017
ARHGAP32Rho GTPase activating protein 320.017
ASGR1asialoglycoprotein receptor 10.017
SYKspleen tyrosine kinase0.017
TGFB3transforming growth factor, beta 30.017
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.016
AXLAXL receptor tyrosine kinase0.016
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.016
CCR2chemokine (C-C motif) receptor 20.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tlr4toll-like receptor 40.773
Tnftumor necrosis factor0.695
Ccr2chemokine (C-C motif) receptor 20.637
Casp4caspase 4, apoptosis-related cysteine peptidase0.446
Ticam1toll-like receptor adaptor molecule 10.443
Casp1caspase 10.329
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.274
Il1r1interleukin 1 receptor, type I0.175
PycardPYD and CARD domain containing0.167
Myd88myeloid differentiation primary response gene 880.162
Cd44CD44 antigen0.149
Il10interleukin 100.125
Leprleptin receptor0.117
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.106
Nos2nitric oxide synthase 2, inducible0.099
Mtmr1myotubularin related protein 10.075
Spp1secreted phosphoprotein 10.067
Lyz2lysozyme 20.066
Ifnginterferon gamma0.065
Mapk14mitogen-activated protein kinase 140.063
Ccl7chemokine (C-C motif) ligand 70.047
Flt4FMS-like tyrosine kinase 40.039
Cd33CD33 antigen0.033
Ccl2chemokine (C-C motif) ligand 20.032
Lcklymphocyte protein tyrosine kinase0.032
Aim2absent in melanoma 20.031
Tlr2toll-like receptor 20.029
Ooepoocyte expressed protein homolog (dog)0.028
Stat3signal transducer and activator of transcription 30.028
Cav1caveolin 1, caveolae protein0.028
Vegfavascular endothelial growth factor A0.027
MefvMediterranean fever0.025
Cd300ldCD300 molecule-like family member d0.021
Tgfb1transforming growth factor, beta 10.021
Il6interleukin 60.021
Siglecesialic acid binding Ig-like lectin E0.021
Ate1arginyltransferase 10.017
Ptprcprotein tyrosine phosphatase, receptor type, C0.017
Ccr6chemokine (C-C motif) receptor 60.017
Gm12185predicted gene 121850.017
Sh2b1SH2B adaptor protein 10.016
Ccl3chemokine (C-C motif) ligand 30.016
FasFas (TNF receptor superfamily member 6)0.015
Ppargperoxisome proliferator activated receptor gamma0.014
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.014
Ccl4chemokine (C-C motif) ligand 40.014
Mapk8mitogen-activated protein kinase 80.013
Gbp5guanylate binding protein 50.013
Ldlrlow density lipoprotein receptor0.012
BlkB lymphoid kinase0.012
Il1binterleukin 1 beta0.011
Col1a1collagen, type I, alpha 10.011
Mmp9matrix metallopeptidase 90.011
Ccr5chemokine (C-C motif) receptor 50.011
Ncoa3nuclear receptor coactivator 30.011
Il6stinterleukin 6 signal transducer0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il1binterleukin 1 beta0.310
Il6interleukin 60.182
Klrd1killer cell lectin-like receptor, subfamily D, member 10.131
Ccl4chemokine (C-C motif) ligand 40.127
Cxcl2chemokine (C-X-C motif) ligand 20.125
Cd14CD14 molecule0.103
Ccl2chemokine (C-C motif) ligand 20.097
Cxcl10chemokine (C-X-C motif) ligand 100.095
Il2rbinterleukin 2 receptor, beta0.066
Mmp12matrix metallopeptidase 120.052
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.050
Hckhemopoietic cell kinase0.047
Rgs1regulator of G-protein signaling 10.042
Il1ainterleukin 1 alpha0.034
Prf1perforin 1 (pore forming protein)0.031
Ccl3chemokine (C-C motif) ligand 30.030
Syt4synaptotagmin IV0.029
Jak1Janus kinase 10.028
Map3k8mitogen-activated protein kinase kinase kinase 80.028
Igsf6immunoglobulin superfamily, member 60.026
Reg3bregenerating islet-derived 3 beta0.026
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.025
NsfN-ethylmaleimide-sensitive factor0.023
Xcl1chemokine (C motif) ligand 10.023
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.023
Cd247Cd247 molecule0.017
Mmp3matrix metallopeptidase 30.016
Nkg7natural killer cell group 7 sequence0.016
Fcn1ficolin (collagen/fibrinogen domain containing) 10.015
Lancl2LanC lantibiotic synthetase component C-like 2 (bacterial)0.015
TcrbT-cell receptor beta chain0.015
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.015
Tlr2toll-like receptor 20.014
Neurl3neuralized homolog 3 (Drosophila)0.013
Vegfavascular endothelial growth factor A0.013
Cd86CD86 molecule0.013
Plrg1pleiotropic regulator 1, PRL1 homolog (Arabidopsis)0.012
Phaxphosphorylated adaptor for RNA export0.012
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.011
Map2k4mitogen activated protein kinase kinase 40.011
Ccl20chemokine (C-C motif) ligand 200.011
Cst7cystatin F (leukocystatin)0.010
Hpgdshematopoietic prostaglandin D synthase0.010
Clec2dC-type lectin domain family 2, member d0.010
Cd2Cd2 molecule0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism