The network for 'cell cycle arrest' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell cycle arrest

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

NameDescriptionProbabilityFunc Analog Organism
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.999
RB1retinoblastoma 10.997
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.997
AKT1v-akt murine thymoma viral oncogene homolog 10.996
SMAD7SMAD family member 70.994
SMAD1SMAD family member 10.992
CCND1cyclin D10.992
FGFR2fibroblast growth factor receptor 20.991
MDM2Mdm2 p53 binding protein homolog (mouse)0.982
MAPK1mitogen-activated protein kinase 10.978
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.971
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.965
SMAD3SMAD family member 30.965
CASP3caspase 3, apoptosis-related cysteine peptidase0.958
BRCA1breast cancer 1, early onset0.948
SMURF1SMAD specific E3 ubiquitin protein ligase 10.931
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.919
CCND3cyclin D30.918
SMAD2SMAD family member 20.914
CDK6cyclin-dependent kinase 60.908
STK3serine/threonine kinase 30.872
RASSF5Ras association (RalGDS/AF-6) domain family member 50.854
IRF1interferon regulatory factor 10.834
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.828
CASP8caspase 8, apoptosis-related cysteine peptidase0.813
CASP2caspase 2, apoptosis-related cysteine peptidase0.806
H2AFXH2A histone family, member X0.787
ARandrogen receptor0.769
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.756
EP300E1A binding protein p3000.734
FGF1fibroblast growth factor 1 (acidic)0.713
SIRT1sirtuin 10.710
APAF1apoptotic peptidase activating factor 10.705
XIAPX-linked inhibitor of apoptosis0.703
UHRF2ubiquitin-like with PHD and ring finger domains 20.700
CXCL2chemokine (C-X-C motif) ligand 20.694
SYVN1synovial apoptosis inhibitor 1, synoviolin0.690
CXCL3chemokine (C-X-C motif) ligand 30.671
STK4serine/threonine kinase 40.668
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.659
CCNE1cyclin E10.658
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.650
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.650
SMAD5SMAD family member 50.637
CDK2cyclin-dependent kinase 20.578
RBL1retinoblastoma-like 1 (p107)0.572
CREBBPCREB binding protein0.565
PMLpromyelocytic leukemia0.527
MAP3K5mitogen-activated protein kinase kinase kinase 50.520
RIN3Ras and Rab interactor 30.514
STAT1signal transducer and activator of transcription 1, 91kDa0.490
RASSF1Ras association (RalGDS/AF-6) domain family member 10.486
APPamyloid beta (A4) precursor protein0.484
ADRB1adrenergic, beta-1-, receptor0.475
IER3immediate early response 30.464
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.444
CFLARCASP8 and FADD-like apoptosis regulator0.432
CKS2CDC28 protein kinase regulatory subunit 20.408
FASFas (TNF receptor superfamily, member 6)0.391
CDK4cyclin-dependent kinase 40.379
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.377
PSEN1presenilin 10.376
CASP10caspase 10, apoptosis-related cysteine peptidase0.368
SNX9sorting nexin 90.367
IL8interleukin 80.366
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.339
POU3F2POU class 3 homeobox 20.314
POU5F1POU class 5 homeobox 10.300
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.288
SCHIP1schwannomin interacting protein 10.287
CXCL10chemokine (C-X-C motif) ligand 100.284
TADA3transcriptional adaptor 30.283
RXRAretinoid X receptor, alpha0.282
CDC25Bcell division cycle 25 homolog B (S. pombe)0.280
CALM1calmodulin 1 (phosphorylase kinase, delta)0.278
FGFR1fibroblast growth factor receptor 10.273
PKD1polycystic kidney disease 1 (autosomal dominant)0.273
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.271
PKM2pyruvate kinase, muscle0.268
CDC6cell division cycle 6 homolog (S. cerevisiae)0.259
KAT2BK(lysine) acetyltransferase 2B0.258
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.251
LRDDleucine-rich repeats and death domain containing0.240
STAT2signal transducer and activator of transcription 2, 113kDa0.240
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.238
FGF10fibroblast growth factor 100.232
RARAretinoic acid receptor, alpha0.215
PKD2polycystic kidney disease 2 (autosomal dominant)0.214
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.207
LRP1low density lipoprotein receptor-related protein 10.202
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.201
SENP3SUMO1/sentrin/SMT3 specific peptidase 30.201
RASSF2Ras association (RalGDS/AF-6) domain family member 20.198
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.196
SMAD4SMAD family member 40.195
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.194
PIAS4protein inhibitor of activated STAT, 40.189
PPFIA1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 10.189
DAXXdeath-domain associated protein0.188
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
mpk-1Protein MPK-10.026
cam-1Protein CAM-10.015
pha-4Protein PHA-40.015
zfp-3Protein ZFP-30.012
elt-6Protein ELT-60.011
ttm-4Protein TTM-40.010
spdl-1Protein SPDL-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mycamyelocytomatosis oncogene a0.154
sox11aSRY-box containing gene 11a0.127
ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.119
inhbaainhibin, beta Aa0.117
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.100
mapk1mitogen-activated protein kinase 10.095
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.095
sox11bSRY-box containing gene 11b0.089
igf1rbinsulin-like growth factor 1b receptor0.088
mef2camyocyte enhancer factor 2ca0.086
lppLIM domain containing preferred translocation partner in lipoma0.084
bmp4bone morphogenetic protein 40.082
dtngdystrobrevin, gamma and dystrobrevin, gamma-like0.082
ascl1aachaete-scute complex-like 1a (Drosophila)0.080
tgfb1atransforming growth factor, beta 1a0.078
rxrgaretinoid x receptor, gamma a0.077
rtkn2rhotekin 20.073
frzbfrizzled-related protein0.066
ldlrap1alow density lipoprotein receptor adaptor protein 1a0.063
btg1B-cell translocation gene 10.060
ntrk1neurotrophic tyrosine kinase, receptor, type 10.060
jhdm1dajumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)0.059
lamc1laminin, gamma 10.059
rradRas-related associated with diabetes0.058
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.058
alcamaactivated leukocyte cell adhesion molecule a0.058
acvr1bactivin A receptor, type IB0.057
rac3aras-related C3 botulinum toxin substrate 3a (rho family, small GTP binding protein Rac3)0.054
wnt10awingless-type MMTV integration site family, member 10a0.050
inhainhibin, alpha0.050
sox3SRY-box containing gene 30.048
wnt11rwingless-type MMTV integration site family, member 11, related0.048
myf6myogenic factor 60.047
bonbonnie and clyde0.045
akt2v-akt murine thymoma viral oncogene homolog 20.045
sulf2lsulfatase 2, like0.045
lrrn1leucine rich repeat neuronal 10.045
bbc3BCL2 binding component 30.045
nr2f1bnuclear receptor subfamily 2, group F, member 1b0.044
lhcgrluteinizing hormone/choriogonadotropin receptor0.044
tfap2btranscription factor AP-2 beta0.043
islr2immunoglobulin superfamily containing leucine-rich repeat 20.043
hoxd4ahomeo box D4a0.043
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.043
hsp90a.1heat shock protein 90-alpha 10.043
stac3SH3 and cysteine rich domain 30.042
brd2abromodomain-containing 2a0.042
aldh18a1aldehyde dehydrogenase 18 family, member A10.042
fbxl14aF-box and leucine-rich repeat protein 14a0.042
tbx1T-box 10.041
zc4h2zinc finger, C4H2 domain containing0.041
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.041
marcksamyristoylated alanine rich protein kinase C substrate a0.041
enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.040
paqr7bprogestin and adipoQ receptor family member VII, b0.040
stap2asignal transducing adaptor family member 2a0.040
vsx1visual system homeobox 1 homolog, chx10-like0.040
tpm4tropomyosin 40.040
mef2dmyocyte enhancer factor 2d0.040
plagl2pleiomorphic adenoma gene-like 20.039
tgfbitransforming growth factor, beta-induced0.039
junjun proto-oncogene0.039
irf2bp2ainterferon regulatory factor 2 binding protein 2a0.038
slc7a6ossolute carrier family 7, member 6 opposite strand0.038
det1de-etiolated homolog 1 (Arabidopsis)0.038
polepolymerase (DNA directed), epsilon0.038
mychmyelocytomatosis oncogene homolog0.037
neurodneurogenic differentiation0.037
acss2acyl-CoA synthetase short-chain family member 20.037
tcf12transcription factor 120.036
sdprbserum deprivation response b0.036
mybl2myeloblastosis oncogene-like 20.036
fcho2FCH domain only 20.036
rrp1ribosomal RNA processing 1 homolog (S. cerevisiae)0.036
junbljun B proto-oncogene, like0.036
g2e3G2/M-phase specific E3 ubiquitin ligase0.035
stmn4lstathmin-like 4, like0.035
tppp3tubulin polymerization-promoting protein family member 30.034
igf2rinsulin-like growth factor 2 receptor0.034
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.034
polr1apolymerase (RNA) I polypeptide A0.034
runx1runt-related transcription factor 10.033
celsr1bcadherin EGF LAG seven-pass G-type receptor 1b0.033
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.033
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.033
chrndcholinergic receptor, nicotinic, delta polypeptide0.033
igf1insulin-like growth factor 10.033
mettl3methyltransferase like 30.033
gapdhglyceraldehyde-3-phosphate dehydrogenase0.033
LOC100151531zinc finger protein Gfi-1b-like0.032
ccng1cyclin G10.032
tmsbthymosin, beta0.032
acvr2aactivin receptor IIa0.032
esco2establishment of cohesion 1 homolog 20.032
fgf20afibroblast growth factor 20a0.032
spc24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.031
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
p53CG33336 gene product from transcript CG33336-RB0.368
debcldeath executioner Bcl-2 homologue0.108
SAKSak kinase0.105
Dcp-1Death caspase-10.093
Actnalpha actinin0.086
howheld out wings0.085
bratbrain tumor0.078
Dsor1Downstream of raf10.072
Ras85DRas oncogene at 85D0.061
Akt1CG4006 gene product from transcript CG4006-RA0.058
CycDCyclin D0.057
AblAbl tyrosine kinase0.055
AP-1sigmaCG5864 gene product from transcript CG5864-RA0.054
EndoGIEndonuclease G inhibitor0.053
stcksteamer duck0.048
coroCG9446 gene product from transcript CG9446-RC0.046
aopanterior open0.043
SsdpSequence-specific single-stranded DNA-binding protein0.043
imdimmune deficiency0.041
rolsrolling pebbles0.040
Vap-33-1CG5014 gene product from transcript CG5014-RB0.039
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.039
Cg25CCollagen type IV0.038
eyaeyes absent0.038
ttm50tiny tim 500.036
piepineapple eye0.036
EgfrEpidermal growth factor receptor0.035
Rac1CG2248 gene product from transcript CG2248-RA0.035
IceCG7788 gene product from transcript CG7788-RA0.035
OliOlig family0.034
nbsCG6754 gene product from transcript CG6754-RC0.034
CspCysteine string protein0.034
Msp-300Muscle-specific protein 3000.033
CG10267CG10267 gene product from transcript CG10267-RB0.033
betaTub60Dbeta-Tubulin at 60D0.033
CycECyclin E0.033
JraJun-related antigen0.033
Rab11Rab-protein 110.032
htshu li tai shao0.031
Su(H)Suppressor of Hairless0.031
CG5933CG5933 gene product from transcript CG5933-RA0.030
dallydivision abnormally delayed0.030
RagACG11968 gene product from transcript CG11968-RA0.030
gbbglass bottom boat0.030
alpha-Catalpha Catenin0.029
Vrp1Verprolin 10.029
phlpole hole0.029
LaspCG3849 gene product from transcript CG3849-RB0.029
spn-Aspindle A0.029
G-oalpha47AG protein oalpha 47A0.029
MaxCG9648 gene product from transcript CG9648-RA0.028
MadMothers against dpp0.028
rheaCG6831 gene product from transcript CG6831-RA0.027
DokDownstream of kinase0.027
CycJCyclin J0.027
E(z)Enhancer of zeste0.026
PpcsPhosphopantothenoylcysteine synthetase0.025
cln3CG5582 gene product from transcript CG5582-RA0.025
CkIalphaCasein kinase Ialpha0.025
sosine oculis0.025
Dip3Dorsal interacting protein 30.025
bibbig brain0.025
CycACyclin A0.025
pAbppolyA-binding protein0.025
PPP4R2rProtein phosphatase 4 regulatory subunit 2-related protein0.025
S6kRPS6-p70-protein kinase0.024
CtBPC-terminal Binding Protein0.024
gcmglial cells missing0.024
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Rb1retinoblastoma 10.999
Mdm2transformed mouse 3T3 cell double minute 20.999
Apcadenomatosis polyposis coli0.995
Neurod1neurogenic differentiation 10.983
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.973
Brca1breast cancer 10.927
Ptenphosphatase and tensin homolog0.888
Cdkn2acyclin-dependent kinase inhibitor 2A0.882
Cdkn1bcyclin-dependent kinase inhibitor 1B0.870
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.843
Ctnnb1catenin (cadherin associated protein), beta 10.734
Gata4GATA binding protein 40.730
Rxraretinoid X receptor alpha0.691
Msh2mutS homolog 2 (E. coli)0.655
Id3inhibitor of DNA binding 30.621
Id1inhibitor of DNA binding 10.594
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.552
Rararetinoic acid receptor, alpha0.543
Mdm4transformed mouse 3T3 cell double minute 40.494
BrafBraf transforming gene0.490
DaxxFas death domain-associated protein0.455
Trp63transformation related protein 630.420
Dkk1dickkopf homolog 1 (Xenopus laevis)0.404
Gata5GATA binding protein 50.402
Pitx2paired-like homeodomain transcription factor 20.396
Vhlvon Hippel-Lindau tumor suppressor0.385
Stk11serine/threonine kinase 110.384
Hdac1histone deacetylase 10.382
Ptf1apancreas specific transcription factor, 1a0.381
Tcf3transcription factor 30.362
Meox2mesenchyme homeobox 20.359
Pax3paired box gene 30.359
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.347
Trp73transformation related protein 730.339
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.330
Thbs1thrombospondin 10.328
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.321
Neurog2neurogenin 20.317
Gli2GLI-Kruppel family member GLI20.316
E2f1E2F transcription factor 10.314
Tcf4transcription factor 40.314
Nf1neurofibromatosis 10.312
Neurod4neurogenic differentiation 40.287
Cdk2cyclin-dependent kinase 20.285
Amhr2anti-Mullerian hormone type 2 receptor0.279
Ccnd1cyclin D10.273
Ascl1achaete-scute complex homolog 1 (Drosophila)0.264
Isl1ISL1 transcription factor, LIM/homeodomain0.253
Foxo3forkhead box O30.251
Onecut1one cut domain, family member 10.243
Itgb1integrin beta 1 (fibronectin receptor beta)0.241
Cdk4cyclin-dependent kinase 40.240
Sox9SRY-box containing gene 90.237
Appamyloid beta (A4) precursor protein0.222
Bmpr1abone morphogenetic protein receptor, type 1A0.219
Pthlhparathyroid hormone-like peptide0.217
Pax8paired box gene 80.199
Hif1ahypoxia inducible factor 1, alpha subunit0.198
Hprthypoxanthine guanine phosphoribosyl transferase0.197
Sox11SRY-box containing gene 110.197
MecomMDS1 and EVI1 complex locus0.195
Gdnfglial cell line derived neurotrophic factor0.188
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.185
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.183
Pdx1pancreatic and duodenal homeobox 10.172
Esr1estrogen receptor 1 (alpha)0.171
Wnt3awingless-related MMTV integration site 3A0.165
Twist1twist homolog 1 (Drosophila)0.165
Gja1gap junction protein, alpha 10.164
En1engrailed 10.162
Mycmyelocytomatosis oncogene0.158
Brca2breast cancer 20.152
Pax6paired box gene 60.151
Cdx2caudal type homeobox 20.150
Pax7paired box gene 70.147
Psen1presenilin 10.143
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.139
Rbl1retinoblastoma-like 1 (p107)0.135
Hoxa13homeobox A130.132
Shhsonic hedgehog0.130
Wnt10bwingless related MMTV integration site 10b0.129
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.127
Nf2neurofibromatosis 20.124
Xpaxeroderma pigmentosum, complementation group A0.122
Hes1hairy and enhancer of split 1 (Drosophila)0.121
Gli3GLI-Kruppel family member GLI30.121
Neurog3neurogenin 30.119
Arandrogen receptor0.117
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.117
Cdx1caudal type homeobox 10.115
Axin1axin 10.113
Map3k7mitogen-activated protein kinase kinase kinase 70.112
Insm1insulinoma-associated 10.111
Ptch1patched homolog 10.109
Rarbretinoic acid receptor, beta0.108
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism