The network for 'protein import into mitochondrial matrix' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein import into mitochondrial matrix

The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CYCScytochrome c, somatic0.978
ETF1eukaryotic translation termination factor 10.956
GRPEL1GrpE-like 1, mitochondrial (E. coli)0.829
HSPH1heat shock 105kDa/110kDa protein 10.819
HSPA8heat shock 70kDa protein 80.683
DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 10.497
HSPE1heat shock 10kDa protein 1 (chaperonin 10)0.482
IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha0.479
EIF5eukaryotic translation initiation factor 50.470
HSPA9heat shock 70kDa protein 9 (mortalin)0.447
EIF4Eeukaryotic translation initiation factor 4E0.398
VDAC1voltage-dependent anion channel 10.354
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)0.236
HSPD1heat shock 60kDa protein 1 (chaperonin)0.235
HCCSholocytochrome c synthase0.235
PNO1partner of NOB1 homolog (S. cerevisiae)0.193
TIMM23translocase of inner mitochondrial membrane 23 homolog (yeast) and translocase of inner mitochondrial membrane 23 homolog (yeast)0.142
TIMM17Atranslocase of inner mitochondrial membrane 17 homolog A (yeast)0.132
GSPT1G1 to S phase transition 10.119
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.061
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.060
FASTKD5FAST kinase domains 50.053
SUPV3L1suppressor of var1, 3-like 1 (S. cerevisiae)0.049
POLR2Kpolymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa0.048
DNAJA3DnaJ (Hsp40) homolog, subfamily A, member 30.043
PPIFpeptidylprolyl isomerase F0.040
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.039
AMD1adenosylmethionine decarboxylase 10.039
TCP1t-complex 10.038
C2orf47chromosome 2 open reading frame 470.038
TRA2Btransformer 2 beta homolog (Drosophila)0.037
RG9MTD1RNA (guanine-9-) methyltransferase domain containing 10.031
BAG2BCL2-associated athanogene 20.027
TMEM70transmembrane protein 700.026
EIF1AXeukaryotic translation initiation factor 1A, X-linked0.023
MRPL35mitochondrial ribosomal protein L350.022
UCHL3ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)0.021
SPG20spastic paraplegia 20 (Troyer syndrome)0.021
EPRSglutamyl-prolyl-tRNA synthetase0.020
TSFMTs translation elongation factor, mitochondrial0.019
NDUFAF4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 40.018
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.018
GTPBP4GTP binding protein 40.016
DNAJB6DnaJ (Hsp40) homolog, subfamily B, member 60.016
SRSF3serine/arginine-rich splicing factor 30.016
DNAJC19DnaJ (Hsp40) homolog, subfamily C, member 190.015
PPIDpeptidylprolyl isomerase D0.014
C20orf7chromosome 20 open reading frame 70.014
PGRMC1progesterone receptor membrane component 10.014
COPS8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)0.013
TFRCtransferrin receptor (p90, CD71)0.013
VDAC2voltage-dependent anion channel 20.013
RABGGTBRab geranylgeranyltransferase, beta subunit0.012
BZW1basic leucine zipper and W2 domains 10.012
MRPL32mitochondrial ribosomal protein L320.012
COPS3COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)0.011
UBXN8UBX domain protein 80.011
MRFAP1Morf4 family associated protein 10.011
UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.011
PNPpurine nucleoside phosphorylase0.010
EIF4A3eukaryotic translation initiation factor 4A30.010
SAR1ASAR1 homolog A (S. cerevisiae)0.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
TIM23Tim23p1.000
TIM17Tim17p1.000
TIM44Tim44p1.000
TOM22Tom22p1.000
PAM18Pam18p1.000
TIM50Tim50p0.996
TOM40Tom40p0.993
TOM20Tom20p0.990
SSC1Ssc1p0.953
TOM7Tom7p0.877
TOM5Tom5p0.859
TOM70Tom70p0.828
PAM16Pam16p0.705
TOM6Tom6p0.488
SAM35Sam35p0.327
MGE1Mge1p0.156
TIM10Tim10p0.153
CUR1Cur1p0.105
BTN2Btn2p0.072
MIC17Mic17p0.069
LHS1Lhs1p0.065
SIS1Sis1p0.053
TIM21Tim21p0.050
MGR2Mgr2p0.050
TIM8Tim8p0.045
ALT2Alt2p0.043
GRX5Grx5p0.039
SRD1Srd1p0.038
UGO1Ugo1p0.038
YLR264C-Ahypothetical protein0.033
LEU2Leu2p0.032
KAR2Kar2p0.026
CLU1Clu1p0.026
JEM1Jem1p0.025
YOL038C-Ahypothetical protein0.025
TIM22Tim22p0.025
ARP10Arp10p0.025
YLR162Whypothetical protein0.025
TIM18Tim18p0.025
STI1Sti1p0.024
HOR2Hor2p0.023
MER1Mer1p0.021
UPS3Ups3p0.021
TOA2Toa2p0.021
YLR042Chypothetical protein0.020
HXT3Hxt3p0.020
MTG1Mtg1p0.019
ACP1Acp1p0.019
NTA1Nta1p0.019
ATP6Atp6p0.019
YAR068Whypothetical protein0.018
YBR013Chypothetical protein0.018
CUP1-1Cup1-1p0.018
YPR157Whypothetical protein0.018
ARG8Arg8p0.018
CHA1Cha1p0.018
AIM1Aim1p0.018
FMT1Fmt1p0.018
RDL2Rdl2p0.018
YKR075Chypothetical protein0.018
GTO1Gto1p0.017
ZPS1Zps1p0.017
YOL013W-Ahypothetical protein0.017
RTC6Rtc6p0.017
SPL2Spl2p0.017
TYE7Tye7p0.017
CPD1Cpd1p0.016
YML003Whypothetical protein0.016
SOV1Sov1p0.016
YJL181Whypothetical protein0.016
AUA1Aua1p0.016
HPF1Hpf1p0.016
SWC7Swc7p0.015
ADH2Adh2p0.015
RTT105Rtt105p0.015
AQY2Aqy2p0.015
REE1Ree1p0.014
OPT2Opt2p0.014
DIC1Dic1p0.014
YIR035Chypothetical protein0.014
DIF1Dif1p0.014
ARO10Aro10p0.014
LCB4Lcb4p0.014
BSC1Bsc1p0.014
YIL151Chypothetical protein0.014
LCL2Lcl2p0.014
HEM12Hem12p0.014
HOHop0.014
MF(ALPHA)2Mf(alpha)2p0.014
BNA4Bna4p0.013
MRPL50Mrpl50p0.013
YAH1Yah1p0.013
IZH4Izh4p0.013
TFC7Tfc7p0.013
YAR066Whypothetical protein0.013
RNP1Rnp1p0.013
YNL018Chypothetical protein0.013
MRPL20Mrpl20p0.013
YLL053Chypothetical protein0.013
DUR1,2Dur1,2p0.013