The network for 'positive regulation of cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cell fate specification

Any process that activates or enables a cell to adopt a specific fate.

NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
FGFR1fibroblast growth factor receptor 11.000
FGF10fibroblast growth factor 101.000
FGF1fibroblast growth factor 1 (acidic)1.000
JAG1jagged 11.000
RBPJrecombination signal binding protein for immunoglobulin kappa J region1.000
FGF7fibroblast growth factor 71.000
NOTCH3notch 31.000
MAML1mastermind-like 1 (Drosophila)0.990
FGFR3fibroblast growth factor receptor 30.975
NEDD4neural precursor cell expressed, developmentally down-regulated 40.956
FZD1frizzled homolog 1 (Drosophila)0.921
FRS2fibroblast growth factor receptor substrate 20.849
PLCG1phospholipase C, gamma 10.829
XIAPX-linked inhibitor of apoptosis0.821
JAG2jagged 20.565
NOTCH2notch 20.504
CTGFconnective tissue growth factor0.455
DLL1delta-like 1 (Drosophila)0.437
LRP6low density lipoprotein receptor-related protein 60.369
FGF2fibroblast growth factor 2 (basic)0.321
IPO13importin 130.267
NOSTRINnitric oxide synthase trafficker0.205
FGF8fibroblast growth factor 8 (androgen-induced)0.112
ATXN1Lataxin 1-like0.062
GFI1Bgrowth factor independent 1B transcription repressor0.056
SIX3SIX homeobox 30.051
LHX2LIM homeobox 20.050
MAGED1melanoma antigen family D, 10.043
SOX2SRY (sex determining region Y)-box 20.043
FGF3fibroblast growth factor 30.042
HSPG2heparan sulfate proteoglycan 20.039
WNT3wingless-type MMTV integration site family, member 30.034
FGFBP1fibroblast growth factor binding protein 10.032
FZD2frizzled homolog 2 (Drosophila)0.029
KAL1Kallmann syndrome 1 sequence0.028
RPS19ribosomal protein S190.024
HOXB7homeobox B70.024
OGNosteoglycin0.023
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.022
SHBSrc homology 2 domain containing adaptor protein B0.021
FBLN1fibulin 10.021
EGFL7EGF-like-domain, multiple 70.020
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.020
MAP3K8mitogen-activated protein kinase kinase kinase 80.019
FGF4fibroblast growth factor 40.018
HIPK2homeodomain interacting protein kinase 20.018
RAXretina and anterior neural fold homeobox0.018
CIR1corepressor interacting with RBPJ, 10.017
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.017
EFNB2ephrin-B20.016
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.016
NTRK2neurotrophic tyrosine kinase, receptor, type 20.015
HEY1hairy/enhancer-of-split related with YRPW motif 10.013
TGFB2transforming growth factor, beta 20.013
CTNNBL1catenin, beta like 10.013
THBS1thrombospondin 10.013
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.013
FGF6fibroblast growth factor 60.012
WNT5Awingless-type MMTV integration site family, member 5A0.012
NKD2naked cuticle homolog 2 (Drosophila)0.011
SDC2syndecan 20.011
NKX2-2NK2 homeobox 20.011
CASP3caspase 3, apoptosis-related cysteine peptidase0.011
CRYABcrystallin, alpha B0.010
PTHLHparathyroid hormone-like hormone0.010
PDK1pyruvate dehydrogenase kinase, isozyme 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dladeltaA0.560
pax6apaired box gene 6a0.552
gli1GLI-Kruppel family member 10.333
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.327
tbx5aT-box 5a0.295
otx2orthodenticle homolog 20.284
pax6bpaired box gene 6b0.278
pax2apaired box gene 2a0.250
ascl1aachaete-scute complex-like 1a (Drosophila)0.247
dlcdeltaC0.242
her6hairy-related 60.218
notch3notch homolog 30.168
irx7iroquois homeobox protein 70.156
sox2SRY-box containing gene 20.149
crb2acrumbs homolog 2a0.146
foxn4forkhead box N40.132
pitx3paired-like homeodomain transcription factor 30.128
dlddeltaD0.113
nkx2.2aNK2 transcription factor related 2a0.112
efnb2aephrin B2a0.099
hoxb3ahomeo box B3a0.089
dmbx1adiencephalon/mesencephalon homeobox 1a0.086
rx3retinal homeobox gene 30.081
tbx2bT-box 2b0.080
neurod4neurogenic differentiation 40.080
isl1islet10.076
neurodneurogenic differentiation0.062
barhl2BarH-like 20.059
bocbrother of CDO0.058
shhasonic hedgehog a0.054
gli2aGLI-Kruppel family member GLI2a0.054
eya1eyes absent homolog 10.050
scube2signal peptide, CUB domain, EGF-like 20.049
jag2jagged 20.046
sfrp5secreted frizzled-related protein 50.045
lmx1b.1LIM homeobox transcription factor 1, beta 10.041
six3bsine oculis homeobox homolog 3b0.038
traf4atnf receptor-associated factor 4a0.038
meis2.2myeloid ecotropic viral integration site 2.20.038
fgfr2fibroblast growth factor receptor 20.033
hoxc8ahomeo box C8a0.033
bdnfbrain-derived neurotrophic factor0.033
crabp2acellular retinoic acid binding protein 2, a0.033
alcamaactivated leukocyte cell adhesion molecule a0.033
raraaretinoic acid receptor, alpha a0.032
rx2retinal homeobox gene 20.030
fgf3fibroblast growth factor 30.030
emx1empty spiracles homeobox 10.028
rx1retinal homeobox gene 10.027
ephb3aeph receptor B3a0.027
tjp1tight junction protein 1 (zona occludens 1)0.027
prox1prospero-related homeobox gene 10.026
dlx3bdistal-less homeobox gene 3b0.026
hoxc6ahomeo box C6a0.026
hoxb1ahomeo box B1a0.025
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.024
six4bsine oculis homeobox homolog 4b0.022
bmp4bone morphogenetic protein 40.022
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.021
jag1bjagged 1b0.021
ptch1patched 10.021
neurog1neurogenin 10.021
wif1wnt inhibitory factor 10.020
mdkbmidkine-related growth factor b0.019
hoxd4ahomeo box D4a0.019
dlbdeltaB0.018
cxcr4bchemokine (C-X-C motif), receptor 4b0.018
robo2roundabout homolog 20.018
sox9aSRY-box containing gene 9a0.018
thtyrosine hydroxylase0.018
spry4sprouty (Drosophila) homolog 40.017
her12hairy-related 120.017
foxb1.2forkhead box B1.20.017
hs6st1aheparan sulfate 6-O-sulfotransferase 1a0.016
ptgs1prostaglandin-endoperoxide synthase 10.016
restRE1-silencing transcription factor0.016
gyltl1bglycosyltransferase-like 1b0.016
fezf2FEZ family zinc finger 20.016
hoxa9ahomeo box A9a0.016
her8ahairy-related 8a0.016
notch1bnotch homolog 1b0.015
nova2neuro-oncological ventral antigen 20.015
fzd8afrizzled homolog 8a0.015
mab21l2mab-21-like 20.015
rad21RAD21 homolog (S. pombe)0.014
fstafollistatin a0.014
crabp2bcellular retinoic acid binding protein 2, b0.014
cadm3cell adhesion molecule 30.014
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.014
hoxb4ahomeo box B4a0.014
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.013
cdoncell adhesion molecule-related/down-regulated by oncogenes0.013
meis1myeloid ecotropic viral integration 10.013
irx1biroquois homeobox protein 1, b0.013
vsx2visual system homeobox 20.013
mnx1motor neuron and pancreas homeobox 10.013
hey1hairy/enhancer-of-split related with YRPW motif 10.013
rxrgaretinoid x receptor, gamma a0.013
irx5airoquois homeobox protein 5a0.013
foxj1aforkhead box J1a0.013
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Otx2orthodenticle homolog 2 (Drosophila)0.192
Shhsonic hedgehog0.142
Foxc1forkhead box C10.114
Pax3paired box gene 30.107
Foxg1forkhead box G10.098
Chd7chromodomain helicase DNA binding protein 70.095
Emx1empty spiracles homolog 1 (Drosophila)0.094
Dll1delta-like 1 (Drosophila)0.080
Psen1presenilin 10.076
Tgfb2transforming growth factor, beta 20.062
Rb1retinoblastoma 10.056
Efnb2ephrin B20.055
Ctnnb1catenin (cadherin associated protein), beta 10.049
Notch2Notch gene homolog 2 (Drosophila)0.042
Pitx2paired-like homeodomain transcription factor 20.041
Jag1jagged 10.040
Fgfr2fibroblast growth factor receptor 20.038
Sox2SRY-box containing gene 20.038
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.038
Gli3GLI-Kruppel family member GLI30.034
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.030
Isl1ISL1 transcription factor, LIM/homeodomain0.025
Eya1eyes absent 1 homolog (Drosophila)0.025
Pax2paired box gene 20.023
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.022
Fgfr1fibroblast growth factor receptor 10.019
Ptenphosphatase and tensin homolog0.017
Trp53transformation related protein 530.016
Hes1hairy and enhancer of split 1 (Drosophila)0.015
Neurod1neurogenic differentiation 10.015
Bmp4bone morphogenetic protein 40.015
Fgf10fibroblast growth factor 100.015
Gbx2gastrulation brain homeobox 20.014
Emx2empty spiracles homolog 2 (Drosophila)0.013
Tcfap2atranscription factor AP-2, alpha0.013
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.013
Otx1orthodenticle homolog 1 (Drosophila)0.012
Zeb1zinc finger E-box binding homeobox 10.012
Vegfavascular endothelial growth factor A0.011
S1pr3sphingosine-1-phosphate receptor 30.011
Fgf8fibroblast growth factor 80.011
Gata3GATA binding protein 30.011
Foxc2forkhead box C20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism