The network for 'response to gamma radiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to gamma radiation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.

NameDescriptionProbabilityFunc Analog Organism
CRYABcrystallin, alpha B0.927
BRCA1breast cancer 1, early onset0.893
RING1ring finger protein 10.856
IL8interleukin 80.837
HDAC1histone deacetylase 10.821
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.799
CXCL2chemokine (C-X-C motif) ligand 20.735
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.703
FANCD2Fanconi anemia, complementation group D20.696
BCL2L1BCL2-like 10.684
APLFaprataxin and PNKP like factor0.560
CASP3caspase 3, apoptosis-related cysteine peptidase0.537
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.525
HSPB8heat shock 22kDa protein 80.503
CRYBB2crystallin, beta B20.483
IL6interleukin 6 (interferon, beta 2)0.475
PARP1poly (ADP-ribose) polymerase 10.448
TP53tumor protein p530.442
USP11ubiquitin specific peptidase 110.429
CXCL3chemokine (C-X-C motif) ligand 30.389
HSPB1heat shock 27kDa protein 10.377
CASP9caspase 9, apoptosis-related cysteine peptidase0.366
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.357
MDM2Mdm2 p53 binding protein homolog (mouse)0.337
RNF2ring finger protein 20.324
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.313
IL1Binterleukin 1, beta0.289
PCGF3polycomb group ring finger 30.286
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.261
BMI1BMI1 polycomb ring finger oncogene0.247
HIPK2homeodomain interacting protein kinase 20.236
PCGF2polycomb group ring finger 20.226
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.170
SIRT1sirtuin 10.168
TRIM63tripartite motif containing 630.165
EP300E1A binding protein p3000.156
TP53BP2tumor protein p53 binding protein, 20.153
MDC1mediator of DNA-damage checkpoint 10.148
LIG4ligase IV, DNA, ATP-dependent0.140
CCL20chemokine (C-C motif) ligand 200.127
H2AFXH2A histone family, member X0.113
BCL2B-cell CLL/lymphoma 20.108
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.088
BAK1BCL2-antagonist/killer 10.085
GFM1G elongation factor, mitochondrial 10.079
WRNWerner syndrome, RecQ helicase-like0.074
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.072
MDM4Mdm4 p53 binding protein homolog (mouse)0.072
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.063
BAG3BCL2-associated athanogene 30.062
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.055
HDAC2histone deacetylase 20.053
WWOXWW domain containing oxidoreductase0.053
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.051
RAD50RAD50 homolog (S. cerevisiae)0.050
HSPB2heat shock 27kDa protein 20.050
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.047
ACACAacetyl-CoA carboxylase alpha0.046
BLMBloom syndrome, RecQ helicase-like0.046
SNAI1snail homolog 1 (Drosophila)0.036
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.036
BCL2L11BCL2-like 11 (apoptosis facilitator)0.036
PCGF1polycomb group ring finger 10.035
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.034
CBX6chromobox homolog 60.034
STK4serine/threonine kinase 40.031
BCL2A1BCL2-related protein A10.030
AMOTL1angiomotin like 10.029
XIAPX-linked inhibitor of apoptosis0.028
STK3serine/threonine kinase 30.028
TP53BP1tumor protein p53 binding protein 10.028
HUWE1HECT, UBA and WWE domain containing 10.027
IL1R1interleukin 1 receptor, type I0.027
CXCL5chemokine (C-X-C motif) ligand 50.026
RASSF5Ras association (RalGDS/AF-6) domain family member 50.024
ICAM1intercellular adhesion molecule 10.024
TNFAIP6tumor necrosis factor, alpha-induced protein 60.024
PCGF5polycomb group ring finger 50.023
BAZ1Abromodomain adjacent to zinc finger domain, 1A0.023
HSPB7heat shock 27kDa protein family, member 7 (cardiovascular)0.022
CXCL11chemokine (C-X-C motif) ligand 110.022
UBE3Aubiquitin protein ligase E3A0.020
FANCEFanconi anemia, complementation group E0.019
CCL2chemokine (C-C motif) ligand 20.019
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.017
BIDBH3 interacting domain death agonist0.017
ARIH2ariadne homolog 2 (Drosophila)0.016
KRT5keratin 50.016
EGR2early growth response 20.016
SOCS1suppressor of cytokine signaling 10.016
MRPL38mitochondrial ribosomal protein L380.016
NAMPTnicotinamide phosphoribosyltransferase0.016
HCFC1host cell factor C1 (VP16-accessory protein)0.016
RAD52RAD52 homolog (S. cerevisiae)0.016
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D0.016
MAP1Smicrotubule-associated protein 1S0.015
ATMataxia telangiectasia mutated0.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
p53CG33336 gene product from transcript CG33336-RB0.033
Ppat-DpckBifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase0.032
tefutelomere fusion0.028
dvedefective proventriculus0.025
mus101mutagen-sensitive 1010.025
Hsp27Heat shock protein 270.024
MED19Mediator complex subunit 190.024
NcNedd2-like caspase0.022
grimCG4345 gene product from transcript CG4345-RA0.020
rad50CG6339 gene product from transcript CG6339-RD0.020
RecQ5homolog of RecQ0.019
Hsp23Heat shock protein 230.019
Rpb4CG33520 gene product from transcript CG33520-RF0.018
cindrCIN85 and CD2AP orthologue0.017
nbsCG6754 gene product from transcript CG6754-RC0.016
CG9139CG9139 gene product from transcript CG9139-RA0.016
Uba1Ubiquitin activating enzyme 10.015
CG5524CG5524 gene product from transcript CG5524-RA0.015
ari-2ariadne 20.014
mus205mutagen-sensitive 2050.014
mus201mutagen-sensitive 2010.014
Hsp68Heat shock protein 680.013
Bre1CG10542 gene product from transcript CG10542-RA0.013
kibrakibra ortholog0.012
CG11327CG11327 gene product from transcript CG11327-RA0.012
CG15199CG15199 gene product from transcript CG15199-RA0.012
Hsp22Heat shock protein 220.012
bratbrain tumor0.012
su(f)suppressor of forked0.011
ThorCG8846 gene product from transcript CG8846-RA0.011
mei-9meiotic 90.011
pr-set7CG3307 gene product from transcript CG3307-RC0.011
Rpd3CG7471 gene product from transcript CG7471-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.939
Trp53transformation related protein 530.880
Atmataxia telangiectasia mutated homolog (human)0.612
Rnf2ring finger protein 20.544
Pnp2purine-nucleoside phosphorylase 20.435
Brca1breast cancer 10.431
Ptenphosphatase and tensin homolog0.233
Brca2breast cancer 20.214
Pcgf2polycomb group ring finger 20.200
Trp63transformation related protein 630.134
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.124
Mdm2transformed mouse 3T3 cell double minute 20.121
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.114
Ccl12chemokine (C-C motif) ligand 120.101
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.092
Cxcl1chemokine (C-X-C motif) ligand 10.083
Trp73transformation related protein 730.080
Runx1runt related transcription factor 10.062
Hdac1histone deacetylase 10.056
Ezh2enhancer of zeste homolog 2 (Drosophila)0.053
H2afxH2A histone family, member X0.049
Nab2Ngfi-A binding protein 20.040
Lig4ligase IV, DNA, ATP-dependent0.039
Huwe1HECT, UBA and WWE domain containing 10.036
Lhx9LIM homeobox protein 90.036
Apcadenomatosis polyposis coli0.035
Ptgs2prostaglandin-endoperoxide synthase 20.034
Emx2empty spiracles homolog 2 (Drosophila)0.034
DaxxFas death domain-associated protein0.034
Lrp2low density lipoprotein receptor-related protein 20.031
Rbl1retinoblastoma-like 1 (p107)0.031
Ptger4prostaglandin E receptor 4 (subtype EP4)0.031
Arandrogen receptor0.030
Sin3atranscriptional regulator, SIN3A (yeast)0.028
Kitkit oncogene0.027
FosFBJ osteosarcoma oncogene0.026
Hhathedgehog acyltransferase0.026
Ch25hcholesterol 25-hydroxylase0.026
Kiss1KiSS-1 metastasis-suppressor0.025
Vhlvon Hippel-Lindau tumor suppressor0.025
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.025
Atp11cATPase, class VI, type 11C0.023
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.022
Amhr2anti-Mullerian hormone type 2 receptor0.021
JunbJun-B oncogene0.020
Mis18bp1MIS18 binding protein 10.019
RybpRING1 and YY1 binding protein0.018
Wwtr1WW domain containing transcription regulator 10.018
Mybl2myeloblastosis oncogene-like 20.017
Cdx2caudal type homeobox 20.017
Terf1telomeric repeat binding factor 10.017
Mlh1mutL homolog 1 (E. coli)0.017
Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 10.017
Sox2SRY-box containing gene 20.017
Atf3activating transcription factor 30.017
Ccl2chemokine (C-C motif) ligand 20.017
Rararetinoic acid receptor, alpha0.017
Dok1docking protein 10.017
MaxMax protein0.016
Esr1estrogen receptor 1 (alpha)0.016
Sgol1shugoshin-like 1 (S. pombe)0.016
Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.016
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.016
Arid1aAT rich interactive domain 1A (SWI-like)0.015
Egr1early growth response 10.015
Irf8interferon regulatory factor 80.015
Stk4serine/threonine kinase 40.015
Mcm8minichromosome maintenance deficient 8 (S. cerevisiae)0.015
Egr2early growth response 20.015
Mfn2mitofusin 20.015
FanciFanconi anemia, complementation group I0.014
Hmga1high mobility group AT-hook 10.014
Gadd45agrowth arrest and DNA-damage-inducible 45 alpha0.014
Socs3suppressor of cytokine signaling 30.014
Smn1survival motor neuron 10.014
Dclre1cDNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)0.014
Slc10a6solute carrier family 10 (sodium/bile acid cotransporter family), member 60.013
Parp1poly (ADP-ribose) polymerase family, member 10.013
Socs1suppressor of cytokine signaling 10.013
Ikzf1IKAROS family zinc finger 10.013
Ccnd1cyclin D10.013
Mta2metastasis-associated gene family, member 20.013
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.013
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.013
Tead1TEA domain family member 10.013
Rad50RAD50 homolog (S. cerevisiae)0.013
Casp3caspase 30.013
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.013
Nod2nucleotide-binding oligomerization domain containing 20.012
BidBH3 interacting domain death agonist0.012
WwoxWW domain-containing oxidoreductase0.012
Aicdaactivation-induced cytidine deaminase0.012
Icam1intercellular adhesion molecule 10.012
Nr5a1nuclear receptor subfamily 5, group A, member 10.012
Pcgf6polycomb group ring finger 60.012
Ren1renin 1 structural0.012
Atad5ATPase family, AAA domain containing 50.012
Dclre1aDNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)0.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il1binterleukin 1 beta0.884
Ccl2chemokine (C-C motif) ligand 20.814
Cd14CD14 molecule0.746
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.744
Igsf6immunoglobulin superfamily, member 60.666
Il1ainterleukin 1 alpha0.664
Ptprcprotein tyrosine phosphatase, receptor type, C0.574
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.472
Cxcl10chemokine (C-X-C motif) ligand 100.457
Ccl3chemokine (C-C motif) ligand 30.344
Casp1caspase 10.344
FosFBJ osteosarcoma oncogene0.343
Socs3suppressor of cytokine signaling 30.340
Ccl4chemokine (C-C motif) ligand 40.320
Cxcl2chemokine (C-X-C motif) ligand 20.317
Egr2early growth response 20.305
LOC100362824caveolin 2-like0.286
Cd44Cd44 molecule0.274
Cav2caveolin 20.251
Nrasneuroblastoma ras oncogene0.239
Tpm4tropomyosin 40.236
Jak2Janus kinase 20.218
Il1r2interleukin 1 receptor, type II0.211
Junbjun B proto-oncogene0.207
Adam17ADAM metallopeptidase domain 170.201
Calcrlcalcitonin receptor-like0.194
Cav1caveolin 1, caveolae protein0.191
Dusp6dual specificity phosphatase 60.191
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.165
Cishcytokine inducible SH2-containing protein0.142
Map3k8mitogen-activated protein kinase kinase kinase 80.139
Ier2immediate early response 20.121
Tnftumor necrosis factor (TNF superfamily, member 2)0.117
Ccl7chemokine (C-C motif) ligand 70.111
Il6interleukin 60.103
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.103
Atf3activating transcription factor 30.101
Plaurplasminogen activator, urokinase receptor0.089
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.088
Ly6cLy6-C antigen0.081
Cd83CD83 molecule0.079
Klrd1killer cell lectin-like receptor, subfamily D, member 10.077
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.069
Ctsccathepsin C0.066
Ier3immediate early response 30.063
Hckhemopoietic cell kinase0.063
Lbrlamin B receptor0.058
Nr4a3nuclear receptor subfamily 4, group A, member 30.057
Btg2BTG family, member 20.056
Rgs1regulator of G-protein signaling 10.052
S1pr2sphingosine-1-phosphate receptor 20.052
Socs2suppressor of cytokine signaling 20.051
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.050
Myo1bmyosin Ib0.049
Reg3bregenerating islet-derived 3 beta0.048
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.046
Ccl11chemokine (C-C motif) ligand 110.046
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.046
Cd53Cd53 molecule0.045
Cxcl11chemokine (C-X-C motif) ligand 110.042
Selpselectin P0.040
Nat1N-acetyltransferase 10.040
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.040
Sellselectin L0.038
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.037
Nkg7natural killer cell group 7 sequence0.036
P2ry14purinergic receptor P2Y, G-protein coupled, 140.036
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.036
Il2rbinterleukin 2 receptor, beta0.035
Mmp12matrix metallopeptidase 120.035
Tlr4toll-like receptor 40.032
Gch1GTP cyclohydrolase 10.031
Wipf1WAS/WASL interacting protein family, member 10.031
Psme3proteasome (prosome, macropain) activator subunit 30.030
Gtpbp4GTP binding protein 40.030
Ccr2chemokine (C-C motif) receptor 20.029
Rab20RAB20, member RAS oncogene family0.029
Tgm1transglutaminase 1, K polypeptide0.028
Neurl3neuralized homolog 3 (Drosophila)0.028
Hes2hairy and enhancer of split 2 (Drosophila)0.027
Sp1Sp1 transcription factor0.027
Cfdcomplement factor D (adipsin)0.027
Tlr7toll-like receptor 70.026
Clec4a3C-type lectin domain family 4, member a30.025
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.025
Runx1runt-related transcription factor 10.025
Casp7caspase 70.025
Zfp36zinc finger protein 360.024
Itgamintegrin, alpha M0.024
RradRas-related associated with diabetes0.024
Rararetinoic acid receptor, alpha0.024
Slfn3schlafen 30.024
Cxcl3chemokine (C-X-C motif) ligand 30.023
Ccr5chemokine (C-C motif) receptor 50.023
Ripk3receptor-interacting serine-threonine kinase 30.023
Il1r1interleukin 1 receptor, type I0.022
Pim1pim-1 oncogene0.022
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.022
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism