The network for 'canonical wnt signaling pathway involved in osteoblast differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

canonical wnt signaling pathway involved in osteoblast differentiation

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation.

NameDescriptionProbabilityFunc Analog Organism
BBS10Bardet-Biedl syndrome 100.999
WNT3Awingless-type MMTV integration site family, member 3A0.993
FGF18fibroblast growth factor 180.962
SFRP1secreted frizzled-related protein 10.957
WNT5Awingless-type MMTV integration site family, member 5A0.919
ELF5E74-like factor 5 (ets domain transcription factor)0.911
FOXF2forkhead box F20.893
MXRA5matrix-remodelling associated 50.881
NDPNorrie disease (pseudoglioma)0.846
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.826
WNT1wingless-type MMTV integration site family, member 10.813
IHHIndian hedgehog0.609
WIF1WNT inhibitory factor 10.590
WNT10Awingless-type MMTV integration site family, member 10A0.516
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.493
WNT3wingless-type MMTV integration site family, member 30.366
THBS2thrombospondin 20.341
SOX21SRY (sex determining region Y)-box 210.337
MMP11matrix metallopeptidase 11 (stromelysin 3)0.337
BMP4bone morphogenetic protein 40.324
FZD8frizzled homolog 8 (Drosophila)0.308
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.306
EHFets homologous factor0.301
FGF3fibroblast growth factor 30.282
AQP5aquaporin 50.249
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.239
FGF4fibroblast growth factor 40.236
NR4A1nuclear receptor subfamily 4, group A, member 10.235
WNT11wingless-type MMTV integration site family, member 110.219
CXCL14chemokine (C-X-C motif) ligand 140.216
LRP6low density lipoprotein receptor-related protein 60.191
RGS2regulator of G-protein signaling 2, 24kDa0.186
FGF8fibroblast growth factor 8 (androgen-induced)0.177
HES2hairy and enhancer of split 2 (Drosophila)0.170
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.165
SMAD1SMAD family member 10.164
COL10A1collagen, type X, alpha 10.159
GUCA2Aguanylate cyclase activator 2A (guanylin)0.155
PRRX1paired related homeobox 10.149
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.147
COL4A6collagen, type IV, alpha 60.133
BMP7bone morphogenetic protein 70.129
FOXF1forkhead box F10.120
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.119
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.108
POU3F1POU class 3 homeobox 10.105
PTGISprostaglandin I2 (prostacyclin) synthase0.105
COL14A1collagen, type XIV, alpha 10.104
GDF10growth differentiation factor 100.102
EPHB3EPH receptor B30.102
LBX1ladybird homeobox 10.101
SFRP2secreted frizzled-related protein 20.100
SIX2SIX homeobox 20.099
FOXD3forkhead box D30.098
GAS1growth arrest-specific 10.097
INHBBinhibin, beta B0.094
ITGBL1integrin, beta-like 1 (with EGF-like repeat domains)0.093
GPR124G protein-coupled receptor 1240.093
C1QL1complement component 1, q subcomponent-like 10.092
HOXD13homeobox D130.092
VEGFCvascular endothelial growth factor C0.092
OGNosteoglycin0.091
COL5A1collagen, type V, alpha 10.090
OMDosteomodulin0.089
FOXE1forkhead box E1 (thyroid transcription factor 2)0.087
BMP8Abone morphogenetic protein 8a0.086
WNT6wingless-type MMTV integration site family, member 60.085
NPAS1neuronal PAS domain protein 10.084
HMX1H6 family homeobox 10.082
EGFL6EGF-like-domain, multiple 60.082
P2RX2purinergic receptor P2X, ligand-gated ion channel, 20.082
TLX3T-cell leukemia homeobox 30.081
RAXretina and anterior neural fold homeobox0.080
TWIST1twist homolog 1 (Drosophila)0.080
PRRX2paired related homeobox 20.080
ENTPD2ectonucleoside triphosphate diphosphohydrolase 20.080
HS3ST6heparan sulfate (glucosamine) 3-O-sulfotransferase 60.079
FOXB1forkhead box B10.078
MNX1motor neuron and pancreas homeobox 10.078
NKX3-2NK3 homeobox 20.076
WNT7Awingless-type MMTV integration site family, member 7A0.073
HOXC8homeobox C80.073
NEUROG2neurogenin 20.073
COL2A1collagen, type II, alpha 10.073
WNT4wingless-type MMTV integration site family, member 40.070
SHHsonic hedgehog0.070
FBLN1fibulin 10.069
GDNFglial cell derived neurotrophic factor0.069
DLX4distal-less homeobox 40.068
SOX1SRY (sex determining region Y)-box 10.066
EPHB2EPH receptor B20.066
GLT8D2glycosyltransferase 8 domain containing 20.066
RAMP3receptor (G protein-coupled) activity modifying protein 30.066
LRRC17leucine rich repeat containing 170.065
ROR2receptor tyrosine kinase-like orphan receptor 20.064
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 20.064
HOXD10homeobox D100.064
OLFML1olfactomedin-like 10.062
HOXD11homeobox D110.062
NKD1naked cuticle homolog 1 (Drosophila)0.062
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism