The network for 'negative regulation of transporter activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of transporter activity

Any process that stops or reduces the activity of a transporter.

NameDescriptionProbabilityFunc Analog Organism
GSTM1glutathione S-transferase mu 10.995
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.806
GSTM2glutathione S-transferase mu 2 (muscle)0.758
SMURF2SMAD specific E3 ubiquitin protein ligase 20.686
CAB39calcium binding protein 390.674
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.672
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.340
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.332
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.331
SMURF1SMAD specific E3 ubiquitin protein ligase 10.275
TGFBR1transforming growth factor, beta receptor 10.242
CRHcorticotropin releasing hormone0.232
ACVR1Bactivin A receptor, type IB0.218
MYOZ1myozenin 10.200
GSTM4glutathione S-transferase mu 40.142
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.142
GRPEL1GrpE-like 1, mitochondrial (E. coli)0.116
PKD1polycystic kidney disease 1 (autosomal dominant)0.112
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.106
WWP1WW domain containing E3 ubiquitin protein ligase 10.103
TGFB1transforming growth factor, beta 10.094
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.091
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.086
ZFYVE9zinc finger, FYVE domain containing 90.086
SETD8SET domain containing (lysine methyltransferase) 80.083
GLRXglutaredoxin (thioltransferase)0.081
PDLIM1PDZ and LIM domain 10.079
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.078
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.075
CYLDcylindromatosis (turban tumor syndrome)0.070
ACTN4actinin, alpha 40.068
CALM1calmodulin 1 (phosphorylase kinase, delta)0.067
ZYXzyxin0.060
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.056
SMAD7SMAD family member 70.055
FBXL15F-box and leucine-rich repeat protein 150.053
GSTM3glutathione S-transferase mu 3 (brain)0.050
ADORA2Aadenosine A2a receptor0.049
TIMP2TIMP metallopeptidase inhibitor 20.048
SMAD4SMAD family member 40.044
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.044
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.043
CTTNBP2NLCTTNBP2 N-terminal like0.043
STK24serine/threonine kinase 240.042
CAPZBcapping protein (actin filament) muscle Z-line, beta0.042
SMAD2SMAD family member 20.042
EPORerythropoietin receptor0.040
RHOAras homolog gene family, member A0.040
WNK4WNK lysine deficient protein kinase 40.039
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast)0.038
PDCD6programmed cell death 60.038
ANKRD13Aankyrin repeat domain 13A0.035
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.035
GFAPglial fibrillary acidic protein0.035
NEDD4neural precursor cell expressed, developmentally down-regulated 40.035
DMDdystrophin0.033
EZRezrin0.033
CXXC5CXXC finger protein 50.032
CTTNBP2cortactin binding protein 20.031
ACTN1actinin, alpha 10.031
GNB2guanine nucleotide binding protein (G protein), beta polypeptide 20.029
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.029
WWP2WW domain containing E3 ubiquitin protein ligase 20.029
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.028
TBC1D10ATBC1 domain family, member 10A0.028
DTNAdystrobrevin, alpha0.028
CAPN2calpain 2, (m/II) large subunit0.028
CALCOCO2calcium binding and coiled-coil domain 20.026
THBS1thrombospondin 10.026
MTORmechanistic target of rapamycin (serine/threonine kinase)0.026
SGK3serum/glucocorticoid regulated kinase family, member 30.025
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.025
MAPTmicrotubule-associated protein tau0.025
GNG5guanine nucleotide binding protein (G protein), gamma 50.024
CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)0.024
FLNAfilamin A, alpha0.024
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.024
ENGendoglin0.024
ARPC1Aactin related protein 2/3 complex, subunit 1A, 41kDa0.024
SMAD1SMAD family member 10.023
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.023
PPP4Cprotein phosphatase 4, catalytic subunit0.023
MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)0.022
IRS1insulin receptor substrate 10.022
SNCAIPsynuclein, alpha interacting protein0.022
ILKintegrin-linked kinase0.022
LDB3LIM domain binding 30.022
MMP12matrix metallopeptidase 12 (macrophage elastase)0.021
FOXD3forkhead box D30.021
MMP10matrix metallopeptidase 10 (stromelysin 2)0.020
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.020
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.020
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.020
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.020
DOCK7dedicator of cytokinesis 70.019
GNG2guanine nucleotide binding protein (G protein), gamma 20.019
ARPC4actin related protein 2/3 complex, subunit 4, 20kDa0.019
UTRNutrophin0.019
A2Malpha-2-macroglobulin0.019
ARF3ADP-ribosylation factor 30.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-7Protein UNC-70.609
vab-3Protein VAB-30.444
inx-12Protein INX-120.282
unc-9Protein UNC-90.237
efn-2Protein EFN-20.215
ZC247.2Protein ZC247.20.210
K10D6.2Protein K10D6.20.195
inx-4Protein INX-40.183
inx-17Protein INX-170.134
unc-36Protein UNC-360.134
mec-2Protein MEC-20.129
egl-19Protein EGL-190.118
inx-5Protein INX-50.114
eat-4Protein EAT-40.109
che-3Protein CHE-30.100
nmgp-1Protein NMGP-10.086
R03H10.2Protein R03H10.20.085
daf-10Protein DAF-100.080
cng-4Protein CNG-40.080
aat-2Protein AAT-20.078
glr-5Protein GLR-50.076
unc-1Protein UNC-10.074
mec-1Protein MEC-10.069
syg-1Protein SYG-10.068
inx-8Protein INX-80.068
sdz-28Protein SDZ-280.060
tsp-7Protein TSP-70.055
CELE_C39H7.4Protein C39H7.40.055
T23G4.3Protein T23G4.30.054
che-2Protein CHE-20.052
glr-1Protein GLR-10.050
acl-14Protein ACL-140.049
T27A3.6Protein T27A3.60.049
F54E4.3Protein F54E4.30.045
sol-1Protein SOL-10.045
hrg-4Protein HRG-40.045
C48B4.8Protein C48B4.80.044
gly-6Protein GLY-60.044
ger-1Protein GER-10.043
zig-1Protein ZIG-10.041
R148.4Protein R148.40.040
clc-3Protein CLC-30.040
CELE_M176.5Protein M176.50.038
rad-51Protein RAD-510.036
CELE_C27A7.6Protein C27A7.60.036
ifd-1Protein IFD-10.036
unc-86Protein UNC-860.035
C06E4.2Protein C06E4.20.035
dyb-1Protein DYB-10.034
unc-47Protein UNC-470.033
K10D3.4Protein K10D3.40.033
aat-1Protein AAT-10.033
iglr-1Protein IGLR-10.033
F39G3.5Protein F39G3.50.032
T05G5.1Protein T05G5.10.031
CELE_F17C11.12Protein F17C11.120.031
hst-6Protein HST-60.031
pdfr-1Protein PDFR-10.031
che-1Protein CHE-10.031
pkg-1Protein PKG-10.031
Y47D3A.29Protein Y47D3A.290.030
ztf-30Protein ZTF-300.030
inx-13Protein INX-130.029
daf-6Protein DAF-60.029
C48B4.10Protein C48B4.100.028
T05F1.11Protein T05F1.110.027
unc-42Protein UNC-420.027
unc-29Protein UNC-290.027
mab-3Protein MAB-30.027
R11G1.6Protein R11G1.60.026
rab-3Protein RAB-30.026
C46A5.6Protein C46A5.60.026
T20D3.5Protein T20D3.50.026
cwp-1Protein CWP-10.025
K04G2.9Protein K04G2.90.025
madd-4Protein MADD-40.025
clhm-1Protein CLHM-10.024
F14B8.6Protein F14B8.60.023
K03B8.6Protein K03B8.60.023
CELE_F55D12.1Protein F55D12.10.023
ZK470.1Protein ZK470.10.023
C44B7.5Protein C44B7.50.023
T27A1.5Protein T27A1.50.022
tbb-4Protein TBB-40.022
ajm-1Protein AJM-10.022
F35G2.1Protein F35G2.10.022
R08D7.7Protein R08D7.70.022
CELE_F40F9.5Protein F40F9.50.021
ser-2Protein SER-20.021
C03A3.1Protein C03A3.10.021
C08G9.2Protein C08G9.20.021
hum-4Protein HUM-40.020
inx-11Protein INX-110.020
lev-8Protein LEV-80.020
hsp-12.1Protein HSP-12.10.020
cup-4Protein CUP-40.020
sng-1Protein SNG-10.019
upp-1Protein UPP-10.019
ceh-48Protein CEH-480.019
sul-2Protein SUL-20.019
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Neurod1neurogenic differentiation 10.540
Slc34a1solute carrier family 34 (sodium phosphate), member 10.351
Ascl1achaete-scute complex homolog 1 (Drosophila)0.303
Ptf1apancreas specific transcription factor, 1a0.245
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.233
Shhsonic hedgehog0.225
Ldb3LIM domain binding 30.167
Neurod4neurogenic differentiation 40.142
Onecut1one cut domain, family member 10.075
Pax6paired box gene 60.073
Nos1nitric oxide synthase 1, neuronal0.070
Dtnadystrobrevin alpha0.070
Ryr2ryanodine receptor 2, cardiac0.059
Nedd4neural precursor cell expressed, developmentally down-regulated 40.051
Lepleptin0.049
Kiss1KiSS-1 metastasis-suppressor0.048
Dmddystrophin, muscular dystrophy0.043
Neurog2neurogenin 20.041
Neurog3neurogenin 30.040
MecomMDS1 and EVI1 complex locus0.039
Nos3nitric oxide synthase 3, endothelial cell0.035
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.034
Isl1ISL1 transcription factor, LIM/homeodomain0.033
Gata1GATA binding protein 10.029
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.024
Prox1prospero-related homeobox 10.023
Lhx3LIM homeobox protein 30.022
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.022
Gnrh1gonadotropin releasing hormone 10.022
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.021
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.020
Pdx1pancreatic and duodenal homeobox 10.019
Tlr4toll-like receptor 40.018
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.018
Drd2dopamine receptor D20.017
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.017
Kcnk3potassium channel, subfamily K, member 30.016
Rab5aRAB5A, member RAS oncogene family0.015
Nkx3-2NK3 homeobox 20.014
Emx1empty spiracles homolog 1 (Drosophila)0.014
Ank1ankyrin 1, erythroid0.014
Pkd1polycystic kidney disease 1 homolog0.014
Cys1cystin 10.014
Pitx3paired-like homeodomain transcription factor 30.014
Casq2calsequestrin 20.013
Mab21l2mab-21-like 2 (C. elegans)0.013
Pitx2paired-like homeodomain transcription factor 20.013
Tnnt3troponin T3, skeletal, fast0.013
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.012
Otx2orthodenticle homolog 2 (Drosophila)0.012
Irs2insulin receptor substrate 20.012
Nr3c1nuclear receptor subfamily 3, group C, member 10.012
Runx2runt related transcription factor 20.012
Pgrmc1progesterone receptor membrane component 10.012
Pdzd3PDZ domain containing 30.011
Lhx5LIM homeobox protein 50.011
Plin4perilipin 40.011
Nr5a1nuclear receptor subfamily 5, group A, member 10.011
Grb10growth factor receptor bound protein 100.011
Slc4a1solute carrier family 4 (anion exchanger), member 10.011
Igbp1immunoglobulin (CD79A) binding protein 10.011
Stim2stromal interaction molecule 20.010
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.010
Insm1insulinoma-associated 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.227
Nckap1NCK-associated protein 10.196
Kykyphoscoliosis peptidase0.130
LOC100362824caveolin 2-like0.118
Strnstriatin, calmodulin binding protein0.103
Cav2caveolin 20.074
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.070
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.067
Efhd2EF-hand domain family, member D20.064
Opn1swopsin 1 (cone pigments), short-wave-sensitive0.060
Csrp3cysteine and glycine-rich protein 30.055
Nptnneuroplastin0.054
Tnni1troponin I type 1 (skeletal, slow)0.048
Gnb3guanine nucleotide binding protein (G protein), beta polypeptide 30.047
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.040
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.039
Pygmphosphorylase, glycogen, muscle0.038
Avpr1barginine vasopressin receptor 1B0.037
Eef1a2eukaryotic translation elongation factor 1 alpha 20.032
Esr2estrogen receptor 2 (ER beta)0.026
Lim2lens intrinsic membrane protein 20.026
Plb1phospholipase B10.026
Map2k1mitogen activated protein kinase kinase 10.025
Myl1myosin, light chain 10.024
Appamyloid beta (A4) precursor protein0.023
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.022
Trhr2thyrotropin releasing hormone receptor 20.022
MosMoloney sarcoma oncogene0.021
Sycnsyncollin0.021
Gdi1GDP dissociation inhibitor 10.020
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.020
Ednraendothelin receptor type A0.020
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.020
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.019
Fcer2Fc fragment of IgE, low affinity II, receptor for (CD23)0.019
Aldh6a1aldehyde dehydrogenase 6 family, member A10.019
Msmbmicroseminoprotein, beta0.019
Drd4dopamine receptor D40.019
Nrapnebulin-related anchoring protein0.019
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 20.019
Scarb1scavenger receptor class B, member 10.018
Pde4aphosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)0.018
Gstm1glutathione S-transferase mu 10.018
Neu2sialidase 2 (cytosolic sialidase)0.018
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.017
Sept2septin 20.017
Galr2galanin receptor 20.017
Sp1Sp1 transcription factor0.017
Pftk1PFTAIRE protein kinase 10.017
Clcnkbchloride channel Kb0.016
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.016
Nexnnexilin (F actin binding protein)0.016
Adrb1adrenergic, beta-1-, receptor0.016
VapaVAMP (vesicle-associated membrane protein)-associated protein A0.016
Cav3caveolin 30.016
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.016
Olr1361olfactory receptor 13610.016
Gucy2eguanylate cyclase 2E0.016
Pgam2phosphoglycerate mutase 2 (muscle)0.016
Olr1867olfactory receptor 18670.016
Dbhdopamine beta-hydroxylase (dopamine beta-monooxygenase)0.015
Fitm1fat storage-inducing transmembrane protein 10.015
Ifnginterferon gamma0.015
Scn5asodium channel, voltage-gated, type V, alpha subunit0.015
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.015
Olr857olfactory receptor 8570.015
Hs3st2heparan sulfate (glucosamine) 3-O-sulfotransferase 20.014
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.014
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.014
Sctsecretin0.014
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.014
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.014
Xirp1xin actin-binding repeat containing 10.014
LOC100359739F-box and leucine-rich repeat protein 13-like0.014
Clstn3calsyntenin 30.013
Lhx4LIM homeobox 40.013
Hspb3heat shock protein 30.013
Tmem101transmembrane protein 1010.013
Epha8Eph receptor A80.013
Actc1actin, alpha, cardiac muscle 10.013
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.013
Myoz2myozenin 20.013
Aqp2aquaporin 2 (collecting duct)0.013
Crybb3crystallin, beta B30.012
Nf1neurofibromin 10.012
Pipprolactin induced protein0.012
Chrna2cholinergic receptor, nicotinic, alpha 2 (neuronal)0.012
Shox2short stature homeobox 20.012
Lats2large tumor suppressor 20.012
Aipl1aryl hydrocarbon receptor-interacting protein-like 10.012
Pgm3phosphoglucomutase 30.012
Ccr3chemokine (C-C motif) receptor 30.012
Kcne1potassium voltage-gated channel, Isk-related family, member 10.012
KitlgKIT ligand0.012
Htr2a5-hydroxytryptamine (serotonin) receptor 2A0.012
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.012
LOC683077similar to praja1, RING-H2 motif containing0.011
Ckmcreatine kinase, muscle0.011
Gtf2a1general transcription factor IIA, 10.011
Gcm1glial cells missing homolog 1 (Drosophila)0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism