The network for 'renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure

The physiological response of the kidneys to a decrease in blood flow.

NameDescriptionProbabilityFunc Analog Organism
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 21.000
CAV1caveolin 1, caveolae protein, 22kDa0.997
ARRB1arrestin, beta 10.590
PTENphosphatase and tensin homolog0.183
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.137
PROCRprotein C receptor, endothelial0.129
EDNRBendothelin receptor type B0.074
PTPRFprotein tyrosine phosphatase, receptor type, F0.046
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.045
GJA1gap junction protein, alpha 1, 43kDa0.044
SDPRserum deprivation response0.040
TXNRD1thioredoxin reductase 10.033
PRKCDBPprotein kinase C, delta binding protein0.031
GFERgrowth factor, augmenter of liver regeneration0.030
DLG4discs, large homolog 4 (Drosophila)0.025
AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.023
CHGBchromogranin B (secretogranin 1)0.022
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.022
SYT11synaptotagmin XI0.020
PTPN1protein tyrosine phosphatase, non-receptor type 10.019
TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)0.019
PLIN1perilipin 10.018
ZBTB16zinc finger and BTB domain containing 160.017
TIMP4TIMP metallopeptidase inhibitor 40.016
MPZL2myelin protein zero-like 20.016
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.015
APOBapolipoprotein B (including Ag(x) antigen)0.015
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)0.015
DLC1deleted in liver cancer 10.015
FASFas (TNF receptor superfamily, member 6)0.014
PPP1R1Aprotein phosphatase 1, regulatory (inhibitor) subunit 1A0.014
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.014
ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide0.013
NEUROD1neurogenic differentiation 10.013
HTR2B5-hydroxytryptamine (serotonin) receptor 2B0.013
GFRA1GDNF family receptor alpha 10.013
MUL1mitochondrial E3 ubiquitin protein ligase 10.013
SCG2secretogranin II0.013
AGTR1angiotensin II receptor, type 10.013
EID3EP300 interacting inhibitor of differentiation 30.013
CCNDBP1cyclin D-type binding-protein 10.013
CHGAchromogranin A (parathyroid secretory protein 1)0.013
CDO1cysteine dioxygenase, type I0.012
ACOX2acyl-CoA oxidase 2, branched chain0.012
SCGNsecretagogin, EF-hand calcium binding protein0.012
AOX1aldehyde oxidase 10.012
APPBP2amyloid beta precursor protein (cytoplasmic tail) binding protein 20.012
DLGAP1discs, large (Drosophila) homolog-associated protein 10.012
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.011
TAC1tachykinin, precursor 10.011
NPTX1neuronal pentraxin I0.011
INSM1insulinoma-associated 10.011
FAM92A1family with sequence similarity 92, member A10.011
KCNE4potassium voltage-gated channel, Isk-related family, member 40.011
ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 10.011
AMIGO2adhesion molecule with Ig-like domain 20.011
RYR3ryanodine receptor 30.010
KCND2potassium voltage-gated channel, Shal-related subfamily, member 20.010
NPY1Rneuropeptide Y receptor Y10.010
PLS3plastin 30.010
ADIPOQadiponectin, C1Q and collagen domain containing0.010
GYG2glycogenin 20.010
KCNJ3potassium inwardly-rectifying channel, subfamily J, member 30.010
LSAMPlimbic system-associated membrane protein0.010
NOL4nucleolar protein 40.010
CALCRLcalcitonin receptor-like0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ren1renin 1 structural0.975
Scn5asodium channel, voltage-gated, type V, alpha0.671
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.547
Slc12a1solute carrier family 12, member 10.453
Agtr1aangiotensin II receptor, type 1a0.398
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.327
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.219
Tbx5T-box 50.181
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.165
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.158
Wt1Wilms tumor 1 homolog0.093
Pcdh12protocadherin 120.068
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.067
Fggfibrinogen gamma chain0.054
Gjb2gap junction protein, beta 20.050
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.049
Serpina1bserine (or cysteine) preptidase inhibitor, clade A, member 1B0.047
Tjp1tight junction protein 10.044
Fgafibrinogen alpha chain0.044
F2coagulation factor II0.042
KelKell blood group0.039
Phldb2pleckstrin homology-like domain, family B, member 20.037
Itih3inter-alpha trypsin inhibitor, heavy chain 30.033
Tbx3T-box 30.033
Leprleptin receptor0.032
Agtrapangiotensin II, type I receptor-associated protein0.030
Gpr182G protein-coupled receptor 1820.028
Kcne1lpotassium voltage-gated channel, Isk-related family, member 1-like, pseudogene0.027
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.026
Itih4inter alpha-trypsin inhibitor, heavy chain 40.025
Ryr2ryanodine receptor 2, cardiac0.024
F12coagulation factor XII (Hageman factor)0.024
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.021
Gjb6gap junction protein, beta 60.021
Col13a1collagen, type XIII, alpha 10.021
Ptgs2prostaglandin-endoperoxide synthase 20.021
Krt36keratin 360.020
Serpina1aserine (or cysteine) peptidase inhibitor, clade A, member 1A0.019
Sox7SRY-box containing gene 70.019
Spry4sprouty homolog 4 (Drosophila)0.018
Apoa1apolipoprotein A-I0.018
Prss22protease, serine, 220.017
Pahphenylalanine hydroxylase0.015
Nr3c2nuclear receptor subfamily 3, group C, member 20.015
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.015
Gjb1gap junction protein, beta 10.015
Fut2fucosyltransferase 20.015
Apofapolipoprotein F0.014
Serpina3mserine (or cysteine) peptidase inhibitor, clade A, member 3M0.014
Wnt7awingless-related MMTV integration site 7A0.014
Aqp2aquaporin 20.014
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.013
Fbn1fibrillin 10.013
Klk6kallikrein related-peptidase 60.013
Gjb3gap junction protein, beta 30.012
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.012
Dsc3desmocollin 30.012
Apoc4apolipoprotein C-IV0.012
Vegfavascular endothelial growth factor A0.012
Gja1gap junction protein, alpha 10.012
Akr1c6aldo-keto reductase family 1, member C60.012
Bmp8bbone morphogenetic protein 8b0.011
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.011
Ighmbp2immunoglobulin mu binding protein 20.011
Nid1nidogen 10.011
Shesrc homology 2 domain-containing transforming protein E0.011
Tmprss11etransmembrane protease, serine 11e0.011
Gjb5gap junction protein, beta 50.010
Hnf4ahepatic nuclear factor 4, alpha0.010
Pzppregnancy zone protein0.010
Dsc1desmocollin 10.010
Ambpalpha 1 microglobulin/bikunin0.010
Tm4sf1transmembrane 4 superfamily member 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.150
Arandrogen receptor0.136
Cgaglycoprotein hormones, alpha polypeptide0.129
Insrrinsulin receptor-related receptor0.123
Olr1500olfactory receptor 15000.119
Phkg1phosphorylase kinase, gamma 10.117
Olr1278olfactory receptor 12780.117
Olr1654olfactory receptor 16540.115
Foxe3forkhead box E30.114
Hnmthistamine N-methyltransferase0.112
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.110
Cckbrcholecystokinin B receptor0.110
Tacr2tachykinin receptor 20.108
Gna15guanine nucleotide binding protein, alpha 150.103
Svs1seminal vesicle secretory protein 10.087
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.084
Mbl2mannose-binding lectin (protein C) 20.083
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.082
Chrna6cholinergic receptor, nicotinic, alpha 60.078
Fgf14fibroblast growth factor 140.078
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.076
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.075
Crhbpcorticotropin releasing hormone binding protein0.074
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.071
Olr287olfactory receptor 2870.070
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.068
Epha8Eph receptor A80.068
Pthparathyroid hormone0.066
Rasa2RAS p21 protein activator 20.064
Inhbeinhibin beta E0.062
Egr3early growth response 30.062
Dusp4dual specificity phosphatase 40.061
A3galt2alpha 1,3-galactosyltransferase 20.060
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.060
Olr416olfactory receptor 4160.060
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.059
Edn1endothelin 10.057
Fosl2fos-like antigen 20.056
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.056
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.055
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.055
Rup2urinary protein 20.053
Syt8synaptotagmin VIII0.053
RGD1564327similar to integrin alpha 80.050
Adora3adenosine A3 receptor0.050
C1qtnf6C1q and tumor necrosis factor related protein 60.050
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.049
Cpa3carboxypeptidase A3, mast cell0.048
Trpc4transient receptor potential cation channel, subfamily C, member 40.048
Svs3aseminal vesicle secretory protein 3A0.048
Gja3gap junction protein, alpha 30.047
Odf4outer dense fiber of sperm tails 40.047
Col10a1collagen, type X, alpha 10.046
Prp15proline-rich protein 150.046
Clcn5chloride channel 50.045
Akr1c18aldo-keto reductase family 1, member C180.045
Aqp5aquaporin 50.045
Ier5immediate early response 50.044
Map3k8mitogen-activated protein kinase kinase kinase 80.044
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.044
Olr442olfactory receptor 4420.044
Oprd1opioid receptor, delta 10.044
LOC60591calcium-activated potassium channel beta subunit0.043
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.043
Selpselectin P0.043
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.042
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.042
Cxcr5chemokine (C-X-C motif) receptor 50.042
Gria1glutamate receptor, ionotropic, AMPA 10.042
CartptCART prepropeptide0.040
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.040
Vcsa1variable coding sequence A10.039
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.039
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.039
RGD1564664similar to LOC387763 protein0.038
Grm6glutamate receptor, metabotropic 60.038
Agtr1aangiotensin II receptor, type 1a0.038
Cmklr1chemokine-like receptor 10.037
Cma1chymase 1, mast cell0.037
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.036
Plauplasminogen activator, urokinase0.036
Ghrgrowth hormone receptor0.036
Srd5a2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)0.035
Cyp4a8cytochrome P450, family 4, subfamily a, polypeptide 80.035
Sstr5somatostatin receptor 50.035
Twist2twist homolog 2 (Drosophila)0.035
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.034
Prm2protamine 20.034
Obp3alpha-2u globulin PGCL40.034
Adam7ADAM metallopeptidase domain 70.033
Ptafrplatelet-activating factor receptor0.033
Esr1estrogen receptor 10.032
Fut9fucosyltransferase 9 (alpha (1,3) fucosyltransferase)0.032
Hrh1histamine receptor H 10.032
Muskmuscle, skeletal, receptor tyrosine kinase0.032
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.032
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism