The network for 'regulation of systemic arterial blood pressure by circulatory renin angiotensin' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of systemic arterial blood pressure by circulatory renin angiotensin

The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.

NameDescriptionProbabilityFunc Analog Organism
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.878
PSAPprosaposin0.527
CTSAcathepsin A0.498
CAV1caveolin 1, caveolae protein, 22kDa0.318
GRNgranulin0.295
ATP6AP1ATPase, H+ transporting, lysosomal accessory protein 10.182
GNSglucosamine (N-acetyl)-6-sulfatase0.120
ITM2Bintegral membrane protein 2B0.104
PLD3phospholipase D family, member 30.083
LAMP2lysosomal-associated membrane protein 20.082
LAMP1lysosomal-associated membrane protein 10.082
TPP1tripeptidyl peptidase I0.075
TIMP3TIMP metallopeptidase inhibitor 30.075
CTSBcathepsin B0.064
NUCB1nucleobindin 10.051
GLB1galactosidase, beta 10.044
MFSD1major facilitator superfamily domain containing 10.042
GAAglucosidase, alpha; acid0.040
ATP6V0D1ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d10.035
GRINAglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.033
SCARB2scavenger receptor class B, member 20.032
MTHFD1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase0.031
TIMP2TIMP metallopeptidase inhibitor 20.031
ARRB1arrestin, beta 10.029
KCTD15potassium channel tetramerisation domain containing 150.027
HEXBhexosaminidase B (beta polypeptide)0.027
APLP2amyloid beta (A4) precursor-like protein 20.026
NPC2Niemann-Pick disease, type C20.026
TUBB8tubulin, beta 80.025
CD164CD164 molecule, sialomucin0.022
MAN2B1mannosidase, alpha, class 2B, member 10.022
SDF4stromal cell derived factor 40.021
MARCH9membrane-associated ring finger (C3HC4) 90.021
AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.020
LAPTM4Alysosomal protein transmembrane 4 alpha0.019
MYL4myosin, light chain 4, alkali; atrial, embryonic0.019
CAV2caveolin 20.019
ATP6V0CATPase, H+ transporting, lysosomal 16kDa, V0 subunit c0.019
TMEM30Atransmembrane protein 30A0.018
TM9SF2transmembrane 9 superfamily member 20.018
C1orf85chromosome 1 open reading frame 850.018
CD46CD46 molecule, complement regulatory protein0.017
TMEM59transmembrane protein 590.017
IL13RA1interleukin 13 receptor, alpha 10.017
MRVI1murine retrovirus integration site 1 homolog0.017
ARL6IP5ADP-ribosylation-like factor 6 interacting protein 50.017
SH3BGRLSH3 domain binding glutamic acid-rich protein like0.017
TMEM9BTMEM9 domain family, member B0.017
FOLH1folate hydrolase (prostate-specific membrane antigen) 10.016
TMED2transmembrane emp24 domain trafficking protein 20.016
LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein0.016
CASP10caspase 10, apoptosis-related cysteine peptidase0.015
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A0.015
ATP6V0A1ATPase, H+ transporting, lysosomal V0 subunit a10.015
PLOD1procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 10.014
SCP2sterol carrier protein 20.014
GM2AGM2 ganglioside activator0.014
PROCRprotein C receptor, endothelial0.014
CD81CD81 molecule0.013
LEPROTleptin receptor overlapping transcript0.013
NPTNneuroplastin0.013
CREG1cellular repressor of E1A-stimulated genes 10.013
SCPEP1serine carboxypeptidase 10.013
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.013
RHAGRh-associated glycoprotein0.012
CLN3ceroid-lipofuscinosis, neuronal 30.012
EPHX1epoxide hydrolase 1, microsomal (xenobiotic)0.012
UTRNutrophin0.012
VAT1vesicle amine transport protein 1 homolog (T. californica)0.012
EDNRBendothelin receptor type B0.012
SGSHN-sulfoglucosamine sulfohydrolase0.012
DSTNdestrin (actin depolymerizing factor)0.012
MCOLN1mucolipin 10.011
GNPTGN-acetylglucosamine-1-phosphate transferase, gamma subunit0.011
ADAM9ADAM metallopeptidase domain 90.011
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.011
TOLLIPtoll interacting protein0.011
MVPmajor vault protein0.011
TRAM1translocation associated membrane protein 10.011
KIF1Akinesin family member 1A0.011
HMOX1heme oxygenase (decycling) 10.011
SKAP2src kinase associated phosphoprotein 20.011
APOBapolipoprotein B (including Ag(x) antigen)0.010
FBXO6F-box protein 60.010
PORP450 (cytochrome) oxidoreductase0.010
IGF2Rinsulin-like growth factor 2 receptor0.010
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.010
TMEM127transmembrane protein 1270.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ren1renin 1 structural1.000
Agtr1aangiotensin II receptor, type 1a0.998
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.994
Bdkrb2bradykinin receptor, beta 20.806
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.718
Leprleptin receptor0.649
Slc12a1solute carrier family 12, member 10.579
Umoduromodulin0.496
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.359
Egfrepidermal growth factor receptor0.313
Cyp11b2cytochrome P450, family 11, subfamily b, polypeptide 20.302
Cma1chymase 1, mast cell0.294
Ptgs2prostaglandin-endoperoxide synthase 20.270
Mcpt4mast cell protease 40.262
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.255
Nos3nitric oxide synthase 3, endothelial cell0.251
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.247
Aqp2aquaporin 20.227
Serpina12serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 120.212
Vegfavascular endothelial growth factor A0.183
Wt1Wilms tumor 1 homolog0.179
Nos2nitric oxide synthase 2, inducible0.168
Nr3c2nuclear receptor subfamily 3, group C, member 20.132
Ctsbcathepsin B0.130
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.117
Cpa3carboxypeptidase A3, mast cell0.115
F2coagulation factor II0.106
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.104
Ang2angiogenin, ribonuclease A family, member 20.101
Scn5asodium channel, voltage-gated, type V, alpha0.095
Col4a3collagen, type IV, alpha 30.085
Rhox6reproductive homeobox 60.084
Gpr182G protein-coupled receptor 1820.081
Tgfb1transforming growth factor, beta 10.081
Mup4major urinary protein 40.080
Adrb3adrenergic receptor, beta 30.075
KelKell blood group0.072
Agtrapangiotensin II, type I receptor-associated protein0.067
Serpina1bserine (or cysteine) preptidase inhibitor, clade A, member 1B0.062
Gzmbgranzyme B0.059
Pcdh12protocadherin 120.059
Atp6v0bATPase, H+ transporting, lysosomal V0 subunit B0.053
Hprthypoxanthine guanine phosphoribosyl transferase0.052
H2-M9histocompatibility 2, M region locus 90.050
Agtr2angiotensin II receptor, type 20.050
Ccl22chemokine (C-C motif) ligand 220.046
Serpina3cserine (or cysteine) peptidase inhibitor, clade A, member 3C0.044
Gzmcgranzyme C0.042
Fcer1aFc receptor, IgE, high affinity I, alpha polypeptide0.042
F12coagulation factor XII (Hageman factor)0.041
Cd3eCD3 antigen, epsilon polypeptide0.038
Itih3inter-alpha trypsin inhibitor, heavy chain 30.037
Mc2rmelanocortin 2 receptor0.036
Gjb2gap junction protein, beta 20.036
Ahsgalpha-2-HS-glycoprotein0.036
Sprr1bsmall proline-rich protein 1B0.035
Aqp7aquaporin 70.035
Gzmagranzyme A0.035
FaslFas ligand (TNF superfamily, member 6)0.034
Svaseminal vesicle antigen0.034
Klk6kallikrein related-peptidase 60.034
Klrg1killer cell lectin-like receptor subfamily G, member 10.034
Pitx2paired-like homeodomain transcription factor 20.033
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.033
Spry4sprouty homolog 4 (Drosophila)0.033
Lamp1lysosomal-associated membrane protein 10.033
Ccl11chemokine (C-C motif) ligand 110.032
Il9rinterleukin 9 receptor0.031
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.030
Tm4sf1transmembrane 4 superfamily member 10.030
Aprtadenine phosphoribosyl transferase0.029
Lipclipase, hepatic0.029
Vdrvitamin D receptor0.029
Ncr1natural cytotoxicity triggering receptor 10.028
Mcpt8mast cell protease 80.028
Apofapolipoprotein F0.027
Gzmdgranzyme D0.027
Ccbp2chemokine binding protein 20.027
Tpsb2tryptase beta 20.026
Adipoqadiponectin, C1Q and collagen domain containing0.026
Try5trypsin 50.026
Ccl8chemokine (C-C motif) ligand 80.025
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.025
Mas1MAS1 oncogene0.025
Slpisecretory leukocyte peptidase inhibitor0.025
Krt27keratin 270.024
Nkg7natural killer cell group 7 sequence0.023
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.022
Ubdubiquitin D0.022
Xcl1chemokine (C motif) ligand 10.022
Cxcl9chemokine (C-X-C motif) ligand 90.022
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.022
Enamenamelin0.022
Itih4inter alpha-trypsin inhibitor, heavy chain 40.022
Fut2fucosyltransferase 20.022
Dmgdhdimethylglycine dehydrogenase precursor0.021
Lamp2lysosomal-associated membrane protein 20.021
Retnresistin0.021
Ngfnerve growth factor0.020
Fgfr4fibroblast growth factor receptor 40.020
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cma1chymase 1, mast cell0.240
Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.100
Psapprosaposin0.062
Olr287olfactory receptor 2870.060
Nucb1nucleobindin 10.059
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.057
Crhbpcorticotropin releasing hormone binding protein0.055
Hoxa2homeo box A20.053
Pthparathyroid hormone0.045
Dnase1l3deoxyribonuclease 1-like 30.044
Ctsbcathepsin B0.043
Pmfbp1polyamine modulated factor 1 binding protein 10.042
Foxe3forkhead box E30.038
Mcpt1mast cell protease 10.037
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.036
Cgaglycoprotein hormones, alpha polypeptide0.036
Col10a1collagen, type X, alpha 10.035
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.035
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.034
Olr1500olfactory receptor 15000.033
Fgf2fibroblast growth factor 20.032
Plauplasminogen activator, urokinase0.031
Tpsab1tryptase alpha/beta 10.030
Ucp1uncoupling protein 1 (mitochondrial, proton carrier)0.030
Prp15proline-rich protein 150.029
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.029
Sstr1somatostatin receptor 10.029
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.029
Slc9a4solute carrier family 9 (sodium/hydrogen exchanger), member 40.029
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.028
Slc34a1solute carrier family 34 (sodium phosphate), member 10.028
Il1rninterleukin 1 receptor antagonist0.028
Hrh1histamine receptor H 10.028
Chrna6cholinergic receptor, nicotinic, alpha 60.027
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.027
Testintestin gene0.027
RGD1564327similar to integrin alpha 80.026
Ltb4r2leukotriene B4 receptor 20.026
Pdcphosducin0.026
KitlgKIT ligand0.026
Arandrogen receptor0.025
Grm6glutamate receptor, metabotropic 60.025
Ier5immediate early response 50.025
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.025
Akr1c18aldo-keto reductase family 1, member C180.025
Syt8synaptotagmin VIII0.024
Dusp4dual specificity phosphatase 40.024
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.024
Dock8dedicator of cytokinesis 80.023
Cntn5contactin 50.023
Il8rainterleukin 8 receptor, alpha0.023
C1qtnf6C1q and tumor necrosis factor related protein 60.023
Cckarcholecystokinin A receptor0.023
Sod3superoxide dismutase 3, extracellular0.022
LOC60591calcium-activated potassium channel beta subunit0.022
Igfbp3insulin-like growth factor binding protein 30.022
Cckbrcholecystokinin B receptor0.022
Edn2endothelin 20.022
Atp6v1hATPase, H+ transporting, lysosomal V1 subunit H0.022
Egr3early growth response 30.022
Acox2acyl-Coenzyme A oxidase 2, branched chain0.022
Lmbrd1LMBR1 domain containing 10.021
Hnmthistamine N-methyltransferase0.021
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.021
Gja3gap junction protein, alpha 30.021
Sycnsyncollin0.021
Chrna7cholinergic receptor, nicotinic, alpha 70.021
Tpsb2tryptase beta 20.020
Klk8kallikrein related-peptidase 80.020
Trhr2thyrotropin releasing hormone receptor 20.020
Insrrinsulin receptor-related receptor0.020
Cyp2b12cytochrome P450, family 2, subfamily b, polypeptide 120.020
Ghrhrgrowth hormone releasing hormone receptor0.020
Olr416olfactory receptor 4160.020
Sstr5somatostatin receptor 50.020
Epha8Eph receptor A80.020
Fgf14fibroblast growth factor 140.020
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.020
Aqp2aquaporin 2 (collecting duct)0.020
Kcna6potassium voltage gated channel, shaker related subfamily, member 60.019
Sult5a1sulfotransferase family 5A, member 10.019
Rph3arabphilin 3A0.019
Phkg1phosphorylase kinase, gamma 10.019
Cmklr1chemokine-like receptor 10.019
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.019
Tinagl1tubulointerstitial nephritis antigen-like 10.019
RGD1562234similar to S100 calcium-binding protein, ventral prostate0.018
Olr1078olfactory receptor 10780.018
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.018
P2ry14purinergic receptor P2Y, G-protein coupled, 140.018
LOC286992peptide HP (rs14)0.018
Cpa3carboxypeptidase A3, mast cell0.018
Akap4A kinase (PRKA) anchor protein 40.018
Srpxsushi-repeat-containing protein, X-linked0.018
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.018
Sgp158proline-rich glycoprotein (sgp158)0.018
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.018
Gfi1growth factor independent 1 transcription repressor0.018
Gckglucokinase0.017
Flnbfilamin, beta0.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism