The network for 'regulation of vasculature development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of vasculature development

Any process that modulates the frequency, rate or extent of vasculature development.

NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.970
TEKTEK tyrosine kinase, endothelial0.946
SKILSKI-like oncogene0.930
FGFR2fibroblast growth factor receptor 20.922
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.914
JAG1jagged 10.912
VEGFAvascular endothelial growth factor A0.906
NOTCH1notch 10.897
LATlinker for activation of T cells0.880
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.871
CCR5chemokine (C-C motif) receptor 50.859
YAP1Yes-associated protein 10.839
CAV2caveolin 20.810
IL8interleukin 80.774
CXCL2chemokine (C-X-C motif) ligand 20.728
CREBBPCREB binding protein0.714
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.686
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.685
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.684
TAL1T-cell acute lymphocytic leukemia 10.681
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.667
DUSP1dual specificity phosphatase 10.643
TGFB1transforming growth factor, beta 10.627
IL2RBinterleukin 2 receptor, beta0.614
FGFR1fibroblast growth factor receptor 10.586
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.559
CD34CD34 molecule0.554
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.524
NRP1neuropilin 10.521
HSPB8heat shock 22kDa protein 80.512
CYR61cysteine-rich, angiogenic inducer, 610.506
RUNX1runt-related transcription factor 10.497
CALM1calmodulin 1 (phosphorylase kinase, delta)0.492
PLAURplasminogen activator, urokinase receptor0.492
PLAUplasminogen activator, urokinase0.488
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.486
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.480
FGBfibrinogen beta chain0.478
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.470
PMLpromyelocytic leukemia0.464
CCL2chemokine (C-C motif) ligand 20.463
CAV1caveolin 1, caveolae protein, 22kDa0.463
COL4A2collagen, type IV, alpha 20.452
BCL6B-cell CLL/lymphoma 60.444
FGAfibrinogen alpha chain0.440
TIMP1TIMP metallopeptidase inhibitor 10.429
EPAS1endothelial PAS domain protein 10.421
FASFas (TNF receptor superfamily, member 6)0.406
CXCL3chemokine (C-X-C motif) ligand 30.398
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.384
PBX1pre-B-cell leukemia homeobox 10.381
NID1nidogen 10.375
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.367
PTPN1protein tyrosine phosphatase, non-receptor type 10.364
VEGFCvascular endothelial growth factor C0.360
CCR2chemokine (C-C motif) receptor 20.359
MEF2Cmyocyte enhancer factor 2C0.339
SMAD3SMAD family member 30.336
SMAD2SMAD family member 20.335
CDH5cadherin 5, type 2 (vascular endothelium)0.333
HOXB5homeobox B50.319
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.308
COL1A1collagen, type I, alpha 10.306
CCL5chemokine (C-C motif) ligand 50.306
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.299
IL1Binterleukin 1, beta0.298
CRYABcrystallin, alpha B0.293
NOTCH3notch 30.290
FOSFBJ murine osteosarcoma viral oncogene homolog0.290
MDM2Mdm2 p53 binding protein homolog (mouse)0.289
COL4A1collagen, type IV, alpha 10.289
TIMP3TIMP metallopeptidase inhibitor 30.289
IRF9interferon regulatory factor 90.284
CXCL5chemokine (C-X-C motif) ligand 50.282
FSTL1follistatin-like 10.272
EP300E1A binding protein p3000.268
IFNGinterferon, gamma0.258
PDGFCplatelet derived growth factor C0.256
CXCL10chemokine (C-X-C motif) ligand 100.251
VCAM1vascular cell adhesion molecule 10.250
CD44CD44 molecule (Indian blood group)0.245
BMPR1Bbone morphogenetic protein receptor, type IB0.244
BMPR1Abone morphogenetic protein receptor, type IA0.236
CTGFconnective tissue growth factor0.234
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.231
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.228
CXCL11chemokine (C-X-C motif) ligand 110.227
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.219
ANGPTL2angiopoietin-like 20.218
PSEN2presenilin 2 (Alzheimer disease 4)0.214
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.214
PRKCDprotein kinase C, delta0.213
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.210
IL4Rinterleukin 4 receptor0.210
EGFRepidermal growth factor receptor0.210
RAMP2receptor (G protein-coupled) activity modifying protein 20.204
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.737
notch3notch homolog 30.493
krit1KRIT1, ankyrin repeat containing0.337
ccm2cerebral cavernous malformation 20.336
plcg1phospholipase C, gamma 10.319
nrp1aneuropilin 1a0.304
fn1fibronectin 10.301
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.249
nrarpanotch-regulated ankyrin repeat protein a0.248
sox9aSRY-box containing gene 9a0.248
plxnd1plexin D10.219
fbn2bfibrillin 2b0.212
dll4delta-like 4 (Drosophila)0.188
etv2ets variant gene 20.179
tie1endothelium-specific receptor tyrosine kinase 10.154
col12a1collagen, type XII, alpha 10.148
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.142
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.139
tal1T-cell acute lymphocytic leukemia 10.135
vegfcvascular endothelial growth factor c0.129
thbs1thrombospondin 10.121
cnn2calponin 20.112
tpm4tropomyosin 40.108
agtr2angiotensin II receptor, type 20.102
acvrl1activin A receptor type II-like 10.100
vegfaavascular endothelial growth factor Aa0.092
notch1bnotch homolog 1b0.091
hs6st2heparan sulfate 6-O-sulfotransferase 20.087
tp63tumor protein p630.086
mrc1amannose receptor, C type 1a0.086
pcdh18bprotocadherin 18b0.084
col5a2lcollagen, type V, alpha 2-like0.082
lama5laminin, alpha 50.079
pax8paired box gene 80.077
bmp2bbone morphogenetic protein 2b0.076
efnb2aephrin B2a0.072
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.071
arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.071
sox2SRY-box containing gene 20.070
wt1awilms tumor 1a0.067
rxrbbretinoid x receptor, beta b0.065
cdh5cadherin 50.064
flt4fms-related tyrosine kinase 40.063
igf2binsulin-like growth factor 2b0.060
fras1Fraser syndrome 10.060
egr2bearly growth response 2b0.058
sulf2lsulfatase 2, like0.058
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.058
gli2aGLI-Kruppel family member GLI2a0.057
olig4oligodendrocyte transcription factor 40.057
tie2endothelium-specific receptor tyrosine kinase 20.057
mmp2matrix metalloproteinase 20.056
ednraendothelin receptor type A0.056
tbx20T-box 200.056
mcambmelanoma cell adhesion molecule b0.055
tagln2transgelin 20.055
selpselectin P0.055
otpborthopedia homolog b0.055
egr1early growth response 10.054
ephb4aeph receptor B4a0.054
jag1bjagged 1b0.052
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.051
sulf2sulfatase 20.051
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.051
hand2heart and neural crest derivatives expressed transcript 20.050
hey1hairy/enhancer-of-split related with YRPW motif 10.050
hspa12bheat shock protein 12B0.049
pdgfrlplatelet-derived growth factor receptor-like0.049
prdm16PR domain containing 160.048
nf1aneurofibromin 1a0.047
calcrlacalcitonin receptor-like a0.046
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.045
trpv6transient receptor potential cation channel, subfamily V, member 60.044
hlxb9lbhomeo box HB9 like b0.044
insm1binsulinoma-associated 1b0.043
postnperiostin, osteoblast specific factor0.043
ilkintegrin linked kinase0.043
cdoncell adhesion molecule-related/down-regulated by oncogenes0.043
nf1bneurofibromin 1b0.041
osr2odd-skipped related 2 (Drosophila)0.040
atoh8atonal homolog 80.040
itgb3bintegrin beta 3b0.040
hoxb2ahomeo box B2a0.039
ptgs1prostaglandin-endoperoxide synthase 10.039
unc5bunc-5 homolog B (C. elegans)0.039
junjun proto-oncogene0.038
cpb1carboxypeptidase B1 (tissue)0.038
antxr1anthrax toxin receptor 10.038
sulf1sulfatase 10.038
epas1bendothelial PAS domain protein 1b0.038
esamaendothelial cell adhesion molecule a0.038
ptprfprotein tyrosine phosphatase, receptor type, F0.037
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Efnb2ephrin B20.987
Wt1Wilms tumor 1 homolog0.952
Epha4Eph receptor A40.934
Kdrkinase insert domain protein receptor0.921
Nos2nitric oxide synthase 2, inducible0.904
Csf1colony stimulating factor 1 (macrophage)0.894
Smad6MAD homolog 6 (Drosophila)0.893
Cxcl12chemokine (C-X-C motif) ligand 120.877
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.862
Smad3MAD homolog 3 (Drosophila)0.845
Apcadenomatosis polyposis coli0.845
Ccr2chemokine (C-C motif) receptor 20.843
Jag1jagged 10.841
Gata6GATA binding protein 60.838
Cxcl13chemokine (C-X-C motif) ligand 130.826
Flt4FMS-like tyrosine kinase 40.816
Ptgs2prostaglandin-endoperoxide synthase 20.803
Flt1FMS-like tyrosine kinase 10.783
Gata4GATA binding protein 40.770
Gli3GLI-Kruppel family member GLI30.767
Acvrl1activin A receptor, type II-like 10.704
Npr3natriuretic peptide receptor 30.701
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.699
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.693
Bmp5bone morphogenetic protein 50.693
Ephb2Eph receptor B20.650
Loxlysyl oxidase0.621
Pax2paired box gene 20.612
Clockcircadian locomotor output cycles kaput0.610
Snai1snail homolog 1 (Drosophila)0.594
Sox7SRY-box containing gene 70.582
Ccl2chemokine (C-C motif) ligand 20.557
Tgfb2transforming growth factor, beta 20.555
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.552
Epha3Eph receptor A30.552
Col4a2collagen, type IV, alpha 20.546
Hey2hairy/enhancer-of-split related with YRPW motif 20.532
Ntf3neurotrophin 30.524
Foxf2forkhead box F20.522
Adra2badrenergic receptor, alpha 2b0.509
Ikzf1IKAROS family zinc finger 10.506
Vegfavascular endothelial growth factor A0.504
Fzd1frizzled homolog 1 (Drosophila)0.501
Tcf21transcription factor 210.492
Bmpr1abone morphogenetic protein receptor, type 1A0.491
Selpselectin, platelet0.491
Emx1empty spiracles homolog 1 (Drosophila)0.487
Id3inhibitor of DNA binding 30.469
Foxg1forkhead box G10.462
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.461
Fgf8fibroblast growth factor 80.461
Rag1recombination activating gene 10.460
Pcdh12protocadherin 120.444
Pgrprogesterone receptor0.441
Cfhcomplement component factor h0.436
Arntlaryl hydrocarbon receptor nuclear translocator-like0.435
Leprleptin receptor0.433
C3ar1complement component 3a receptor 10.432
Twist2twist homolog 2 (Drosophila)0.432
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.429
Nr5a1nuclear receptor subfamily 5, group A, member 10.423
Id1inhibitor of DNA binding 10.421
Tcf3transcription factor 30.418
Hoxd13homeobox D130.418
Ccbp2chemokine binding protein 20.409
Lhx1LIM homeobox protein 10.406
Mfap2microfibrillar-associated protein 20.405
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.400
Il1binterleukin 1 beta0.393
Tlr4toll-like receptor 40.392
Igkimmunoglobulin kappa chain complex0.391
Foxc1forkhead box C10.390
Hes1hairy and enhancer of split 1 (Drosophila)0.389
Tgfbr2transforming growth factor, beta receptor II0.384
Epas1endothelial PAS domain protein 10.380
Folr2folate receptor 2 (fetal)0.380
Fgfr2fibroblast growth factor receptor 20.377
Sox3SRY-box containing gene 30.370
Prl8a2prolactin family 8, subfamily a, member 20.366
Itgb1integrin beta 1 (fibronectin receptor beta)0.359
Emx2empty spiracles homolog 2 (Drosophila)0.350
Cdh5cadherin 50.344
Ncor2nuclear receptor co-repressor 20.343
Tgfb1transforming growth factor, beta 10.340
Ghrgrowth hormone receptor0.336
Gpc3glypican 30.333
Dab2disabled homolog 2 (Drosophila)0.330
Cd7CD7 antigen0.327
Mitfmicrophthalmia-associated transcription factor0.324
Smad4MAD homolog 4 (Drosophila)0.324
SrcRous sarcoma oncogene0.318
Ccr8chemokine (C-C motif) receptor 80.316
Myod1myogenic differentiation 10.314
Gdnfglial cell line derived neurotrophic factor0.312
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.308
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.303
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Egr2early growth response 20.661
Ccl2chemokine (C-C motif) ligand 20.563
MdficMyoD family inhibitor domain containing0.509
Mmp3matrix metallopeptidase 30.484
Csf1colony stimulating factor 1 (macrophage)0.375
Fgfr2fibroblast growth factor receptor 20.356
Ccr2chemokine (C-C motif) receptor 20.324
Adora2aadenosine A2a receptor0.302
Reg1aregenerating islet-derived 1 alpha0.240
Fosl1fos-like antigen 10.213
Tacr1tachykinin receptor 10.211
Smgbneonatal submandibular gland protein B0.209
Iappislet amyloid polypeptide0.199
Il1rninterleukin 1 receptor antagonist0.195
Il8rbinterleukin 8 receptor, beta0.190
Il6interleukin 60.180
Gucy2dguanylate cyclase 2d0.179
Stip1stress-induced phosphoprotein 10.174
Nos3nitric oxide synthase 3, endothelial cell0.171
Ccr5chemokine (C-C motif) receptor 50.169
A1i3alpha-1-inhibitor III0.166
Flt1FMS-related tyrosine kinase 10.164
Ccl3chemokine (C-C motif) ligand 30.163
Tpsab1tryptase alpha/beta 10.163
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.160
Cd151CD151 molecule (Raph blood group)0.158
Cd4Cd4 molecule0.157
Gzmkgranzyme K0.155
Map3k8mitogen-activated protein kinase kinase kinase 80.155
Cd200r1CD200 receptor 10.153
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.153
Il9rinterleukin 9 receptor0.151
Metmet proto-oncogene0.150
Id3inhibitor of DNA binding 30.146
Asgr2asialoglycoprotein receptor 20.131
Tas2r126taste receptor, type 2, member 1260.131
Ngfnerve growth factor (beta polypeptide)0.128
Anxa1annexin A10.126
Cxcl2chemokine (C-X-C motif) ligand 20.121
Trim47tripartite motif-containing 470.120
Dusp1dual specificity phosphatase 10.117
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.116
LOC100361571keratin associated protein 1-3-like0.109
Mmp10matrix metallopeptidase 100.107
GperG protein-coupled estrogen receptor 10.106
Ctsl1cathepsin L10.103
Ccl11chemokine (C-C motif) ligand 110.103
Il7interleukin 70.100
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.099
Cpa3carboxypeptidase A3, mast cell0.098
Mmp9matrix metallopeptidase 90.098
Prok2prokineticin 20.097
Il1binterleukin 1 beta0.096
Dusp6dual specificity phosphatase 60.094
LOC60591calcium-activated potassium channel beta subunit0.094
Prkchprotein kinase C, eta0.091
Hoxa2homeo box A20.091
Acvrl1activin A receptor type II-like 10.091
Itgamintegrin, alpha M0.090
Phyhd1phytanoyl-CoA dioxygenase domain containing 10.087
Ccl4chemokine (C-C motif) ligand 40.086
Adora3adenosine A3 receptor0.086
Tpc1808tropic 18080.086
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.085
Calcrlcalcitonin receptor-like0.082
Anxa4annexin A40.082
Hspa5heat shock protein 50.081
Sellselectin L0.079
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.078
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.077
FosFBJ osteosarcoma oncogene0.076
Adam7ADAM metallopeptidase domain 70.076
Crhr2corticotropin releasing hormone receptor 20.074
Cd80Cd80 molecule0.074
Nmbrneuromedin B receptor0.073
Ctla4cytotoxic T-lymphocyte-associated protein 40.073
Plauplasminogen activator, urokinase0.071
Pmfbp1polyamine modulated factor 1 binding protein 10.071
Ptpreprotein tyrosine phosphatase, receptor type, E0.070
Mmp2matrix metallopeptidase 20.069
Pou3f2POU class 3 homeobox 20.068
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.068
Akr1c18aldo-keto reductase family 1, member C180.067
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.067
Pemtphosphatidylethanolamine N-methyltransferase0.067
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.066
Bst1bone marrow stromal cell antigen 10.065
Cd8aCD8a molecule0.064
Fgf2fibroblast growth factor 20.063
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.063
Junbjun B proto-oncogene0.063
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.063
Crisp1cysteine-rich secretory protein 10.062
Il2rainterleukin 2 receptor, alpha0.062
Vipvasoactive intestinal peptide0.062
Egfl7EGF-like-domain, multiple 70.061
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism