The network for 'endochondral bone morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endochondral bone morphogenesis

The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone.

NameDescriptionProbabilityFunc Analog Organism
POU5F1POU class 5 homeobox 10.981
TGFB1transforming growth factor, beta 10.903
PAX3paired box 30.900
ANGPT2angiopoietin 20.718
PTPN12protein tyrosine phosphatase, non-receptor type 120.640
NOTCH1notch 10.635
SMAD7SMAD family member 70.634
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.624
FYNFYN oncogene related to SRC, FGR, YES0.540
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.481
NOTCH3notch 30.432
COL4A1collagen, type IV, alpha 10.392
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.368
COL6A1collagen, type VI, alpha 10.359
ENGendoglin0.346
BCAR1breast cancer anti-estrogen resistance 10.339
POU3F2POU class 3 homeobox 20.286
TGFB3transforming growth factor, beta 30.264
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 400.256
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.249
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.241
EPORerythropoietin receptor0.205
APPamyloid beta (A4) precursor protein0.204
FSTL1follistatin-like 10.192
NRP1neuropilin 10.189
JAG1jagged 10.185
MSX1msh homeobox 10.181
HDAC4histone deacetylase 40.172
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.171
ANGPT1angiopoietin 10.161
FN1fibronectin 10.155
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.153
MED25mediator complex subunit 250.152
IGFBP3insulin-like growth factor binding protein 30.149
SORBS3sorbin and SH3 domain containing 30.143
ARID1AAT rich interactive domain 1A (SWI-like)0.141
COL5A1collagen, type V, alpha 10.136
INSRinsulin receptor0.134
BMP1bone morphogenetic protein 10.133
TIMP2TIMP metallopeptidase inhibitor 20.131
COL1A1collagen, type I, alpha 10.127
COL11A2collagen, type XI, alpha 20.126
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.125
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.120
FURINfurin (paired basic amino acid cleaving enzyme)0.110
NID2nidogen 2 (osteonidogen)0.110
IL4Rinterleukin 4 receptor0.107
RXRAretinoid X receptor, alpha0.105
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.101
NOTCH2notch 20.100
COL1A2collagen, type I, alpha 20.098
PDGFAplatelet-derived growth factor alpha polypeptide0.094
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.092
NRP2neuropilin 20.091
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.091
PTPN1protein tyrosine phosphatase, non-receptor type 10.089
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.084
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.084
RXRBretinoid X receptor, beta0.084
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.079
SOCS2suppressor of cytokine signaling 20.079
ITGB1BP2integrin beta 1 binding protein (melusin) 20.077
PTPN3protein tyrosine phosphatase, non-receptor type 30.077
GAB2GRB2-associated binding protein 20.076
PGRMC1progesterone receptor membrane component 10.076
LOXlysyl oxidase0.075
MEF2Amyocyte enhancer factor 2A0.072
MMP16matrix metallopeptidase 16 (membrane-inserted)0.071
VEGFAvascular endothelial growth factor A0.070
SHC1SHC (Src homology 2 domain containing) transforming protein 10.069
COL7A1collagen, type VII, alpha 10.068
ESR1estrogen receptor 10.068
PTPN2protein tyrosine phosphatase, non-receptor type 20.067
DLL1delta-like 1 (Drosophila)0.066
HDAC9histone deacetylase 90.065
HMGA2high mobility group AT-hook 20.065
IGFBP5insulin-like growth factor binding protein 50.064
TNK2tyrosine kinase, non-receptor, 20.060
SOX11SRY (sex determining region Y)-box 110.059
HIPK2homeodomain interacting protein kinase 20.059
PTPN9protein tyrosine phosphatase, non-receptor type 90.058
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.057
EGR1early growth response 10.057
MARCKSL1MARCKS-like 10.057
HOXA10homeobox A100.056
LIMK1LIM domain kinase 10.056
MFAP2microfibrillar-associated protein 20.055
COL2A1collagen, type II, alpha 10.053
NTRK1neurotrophic tyrosine kinase, receptor, type 10.053
FBLN2fibulin 20.052
C17orf28chromosome 17 open reading frame 280.051
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.051
ZFYVE9zinc finger, FYVE domain containing 90.050
RUNX1runt-related transcription factor 10.050
FOXG1forkhead box G10.048
COL6A2collagen, type VI, alpha 20.046
DUSP7dual specificity phosphatase 70.046
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.046
HDAC7histone deacetylase 70.045
TGFBR1transforming growth factor, beta receptor 10.045
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gli2aGLI-Kruppel family member GLI2a0.969
sox9aSRY-box containing gene 9a0.967
wu:fv91b12wu:fv91b120.913
foxi1forkhead box I10.842
col5a1procollagen, type V, alpha 10.782
sox10SRY-box containing gene 100.655
efnb2aephrin B2a0.653
gdf6agrowth differentiation factor 6a0.591
bmp2bbone morphogenetic protein 2b0.582
col1a2collagen, type I, alpha 20.508
prdm1aPR domain containing 1a, with ZNF domain0.501
jag1bjagged 1b0.489
edn1endothelin 10.474
shhasonic hedgehog a0.359
raraaretinoic acid receptor, alpha a0.319
col12a1collagen, type XII, alpha 10.313
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.282
lect1leukocyte cell derived chemotaxin 10.268
notch1anotch homolog 1a0.248
bmperBMP binding endothelial regulator0.246
lmx1b.1LIM homeobox transcription factor 1, beta 10.220
cmncalymmin0.187
mdkamidkine-related growth factor0.185
col9a3collagen, type IX, alpha 30.175
foxa2forkhead box A20.169
nkx3.2NK3 homeobox 20.154
tfe3btranscription factor binding to IGHM enhancer 3b0.143
col5a2lcollagen, type V, alpha 2-like0.128
myod1myogenic differentiation 10.119
twist2twist20.106
ctgfconnective tissue growth factor0.103
dlx2adistal-less homeobox gene 2a0.094
barx1BarH-like homeobox 10.092
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.088
pax7apaired box gene 7a0.082
gbx2gastrulation brain homeo box 20.071
lmo4aLIM domain only 4a0.070
runx3runt-related transcription factor 30.066
rereaarginine-glutamic acid dipeptide (RE) repeats a0.065
bmp4bone morphogenetic protein 40.062
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.060
foxa3forkhead box A30.056
tp63tumor protein p630.056
eya1eyes absent homolog 10.053
fgf3fibroblast growth factor 30.052
pkd2polycystic kidney disease 20.052
msxcmuscle segment homeobox C0.052
tbx5aT-box 5a0.049
runx2arunt-related transcription factor 2a0.049
col9a2procollagen, type IX, alpha 20.047
dcndecorin0.047
fgfr2fibroblast growth factor receptor 20.043
foxi3bforkhead box I3b0.043
foxc1aforkhead box C1a0.043
cdx4caudal type homeo box transcription factor 40.043
pxnpaxillin0.043
hoxa10bhomeo box A10b0.038
col1a1acollagen, type I, alpha 1a0.037
sox2SRY-box containing gene 20.036
ntlano tail a0.036
foxa1forkhead box A10.036
si:xx-bac7cse.2si:xx-bac7cse.20.035
matn4matrilin 40.035
ascl1aachaete-scute complex-like 1a (Drosophila)0.035
dnmt4DNA (cytosine-5-)-methyltransferase 40.034
cdoncell adhesion molecule-related/down-regulated by oncogenes0.033
pcsk5bproprotein convertase subtilisin/kexin type 5b0.032
hoxd12ahomeo box D12a0.032
neurog1neurogenin 10.032
twist1btwist1b0.031
hoxd10ahomeo box D10a0.030
otx2orthodenticle homolog 20.030
cart1cartilage paired-class homeoprotein 10.030
si:ch211-173b8.2si:ch211-173b8.20.030
tfap2atranscription factor AP-2 alpha0.029
tbx24T-box 240.028
foxi3aforkhead box I3a0.028
pax6apaired box gene 6a0.028
rbp4retinol binding protein 4, plasma0.028
rlbp1aretinaldehyde binding protein 1a0.028
crestincrestin0.027
grhl1grainyhead-like 1 (Drosophila)0.026
foxb1.1forkhead box B1.10.026
ptch2patched 20.026
fn1fibronectin 10.025
hapln1ahyaluronan and proteoglycan link protein 1a0.025
pax7bpaired box gene 7b0.025
rxrabretinoid x receptor, alpha b0.024
ehd2EH-domain containing 20.024
dlddeltaD0.023
notch3notch homolog 30.022
sparcsecreted acidic cysteine rich glycoprotein0.022
fgfrl1afibroblast growth factor receptor-like 1a0.022
gpr126G protein-coupled receptor 1260.022
fgf8bfibroblast growth factor 8 b0.022
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.022
hoxd13ahomeo box D13a0.022
mgpmatrix Gla protein0.022
zgc:85866zgc:858660.021
hand2heart and neural crest derivatives expressed transcript 20.021
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 11.000
Shhsonic hedgehog0.999
Hand1heart and neural crest derivatives expressed transcript 10.997
Hand2heart and neural crest derivatives expressed transcript 20.996
Fgf8fibroblast growth factor 80.996
Fgfr2fibroblast growth factor receptor 20.995
Prrx1paired related homeobox 10.991
Gli3GLI-Kruppel family member GLI30.989
Fgfr1fibroblast growth factor receptor 10.984
Pax3paired box gene 30.982
Fgfr3fibroblast growth factor receptor 30.979
Foxc1forkhead box C10.979
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.977
Gli2GLI-Kruppel family member GLI20.976
Tgfb2transforming growth factor, beta 20.974
Prrx2paired related homeobox 20.969
Ror2receptor tyrosine kinase-like orphan receptor 20.969
Runx2runt related transcription factor 20.962
Mrc2mannose receptor, C type 20.957
Tgfbr2transforming growth factor, beta receptor II0.941
Smosmoothened homolog (Drosophila)0.937
Fbn1fibrillin 10.920
Hoxd11homeobox D110.904
Ascl1achaete-scute complex homolog 1 (Drosophila)0.903
Thrathyroid hormone receptor alpha0.902
Sox9SRY-box containing gene 90.892
Pax2paired box gene 20.891
Rararetinoic acid receptor, alpha0.878
Ptenphosphatase and tensin homolog0.872
Hoxa11homeobox A110.871
Rargretinoic acid receptor, gamma0.867
Eya1eyes absent 1 homolog (Drosophila)0.858
Acvr1activin A receptor, type 10.854
Nos3nitric oxide synthase 3, endothelial cell0.849
Hoxd13homeobox D130.847
Smad3MAD homolog 3 (Drosophila)0.847
Otx2orthodenticle homolog 2 (Drosophila)0.844
Pkd1polycystic kidney disease 1 homolog0.838
Col1a2collagen, type I, alpha 20.810
Gdf3growth differentiation factor 30.809
Ctnnb1catenin (cadherin associated protein), beta 10.809
Vegfavascular endothelial growth factor A0.808
En1engrailed 10.807
Nodalnodal0.799
Tcfap2atranscription factor AP-2, alpha0.797
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.796
Apcadenomatosis polyposis coli0.785
Col11a1collagen, type XI, alpha 10.785
Snai1snail homolog 1 (Drosophila)0.778
Col2a1collagen, type II, alpha 10.775
Trp53transformation related protein 530.761
Hoxa1homeobox A10.753
Lhx1LIM homeobox protein 10.749
Chrdchordin0.714
Meox2mesenchyme homeobox 20.709
Msx1homeobox, msh-like 10.692
Tgfb1transforming growth factor, beta 10.692
Egr2early growth response 20.651
Isl1ISL1 transcription factor, LIM/homeodomain0.641
Msx2homeobox, msh-like 20.638
Tbx15T-box 150.637
Gdf5growth differentiation factor 50.630
Bmpr1abone morphogenetic protein receptor, type 1A0.626
Zic3zinc finger protein of the cerebellum 30.601
Rspo2R-spondin 2 homolog (Xenopus laevis)0.593
Pitx2paired-like homeodomain transcription factor 20.565
Bmp4bone morphogenetic protein 40.564
Gata4GATA binding protein 40.556
Alx3aristaless-like homeobox 30.553
Alx4aristaless-like homeobox 40.551
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.550
Twist1twist homolog 1 (Drosophila)0.538
Neurod1neurogenic differentiation 10.537
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.526
Bmp7bone morphogenetic protein 70.525
Col5a1collagen, type V, alpha 10.519
Col3a1collagen, type III, alpha 10.510
Gdnfglial cell line derived neurotrophic factor0.509
Foxc2forkhead box C20.502
Pax8paired box gene 80.501
Pbx1pre B-cell leukemia transcription factor 10.496
Robo3roundabout homolog 3 (Drosophila)0.487
Grem1gremlin 10.487
Emid2EMI domain containing 20.486
Twist2twist homolog 2 (Drosophila)0.474
Tbx2T-box 20.471
Dlx5distal-less homeobox 50.444
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.441
Hes1hairy and enhancer of split 1 (Drosophila)0.441
Smad7MAD homolog 7 (Drosophila)0.425
Gbx2gastrulation brain homeobox 20.423
Wt1Wilms tumor 1 homolog0.421
Wnt6wingless-related MMTV integration site 60.411
Neurog3neurogenin 30.408
Gscgoosecoid homeobox0.405
Loxlysyl oxidase0.398
Smad6MAD homolog 6 (Drosophila)0.388
Col6a2collagen, type VI, alpha 20.384
Dlx1distal-less homeobox 10.376
Neurog2neurogenin 20.375
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.998
Col1a2collagen, type I, alpha 20.996
Col3a1collagen, type III, alpha 10.986
Col5a1collagen, type V, alpha 10.883
Col5a2collagen, type V, alpha 20.785
Postnperiostin, osteoblast specific factor0.385
Fstl1follistatin-like 10.311
Col12a1collagen, type XII, alpha 10.254
Fbn1fibrillin 10.246
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.226
Bgnbiglycan0.209
Elnelastin0.145
Loxl1lysyl oxidase-like 10.139
Col15a1collagen, type XV, alpha 10.114
Lumlumican0.097
Pcolceprocollagen C-endopeptidase enhancer0.092
Ccdc80coiled-coil domain containing 800.089
Col6a2collagen, type VI, alpha 20.077
Dab2disabled homolog 2 (Drosophila)0.066
Col4a1collagen, type IV, alpha 10.044
Mfap4microfibrillar-associated protein 40.042
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.037
Pxdnperoxidasin homolog (Drosophila)0.035
Emcnendomucin0.034
Fn1fibronectin 10.033
Nid2nidogen 20.031
Elk3ELK3, ETS-domain protein0.027
Col4a2collagen, type IV, alpha 20.025
Myl9myosin, light chain 9, regulatory0.023
Cyyr1cysteine/tyrosine-rich 10.022
Col14a1collagen, type XIV, alpha 10.021
Fgfr2fibroblast growth factor receptor 20.019
Plxnd1plexin D10.019
Lamc1laminin, gamma 10.018
Crtapcartilage associated protein0.017
Col4a5collagen, type IV, alpha 50.017
Acanaggrecan0.017
Aspnasporin0.016
Nr2f2nuclear receptor subfamily 2, group F, member 20.016
Kdrkinase insert domain receptor0.015
LOC686539similar to immunoglobulin superfamily containing leucine-rich repeat0.015
Lect1leukocyte cell derived chemotaxin 10.014
Fkbp10FK506 binding protein 100.014
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.013
RGD1310423similar to hypothetical protein FLJ317370.013
Lef1lymphoid enhancer binding factor 10.013
Lama2laminin, alpha 20.013
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.013
Chadchondroadherin0.011
Arhgef15Rho guanine nucleotide exchange factor (GEF) 150.011
RGD1565043similar to Rho guanine nucleotide exchange factor (GEF) 100.011
Miamelanoma inhibitory activity0.011
Shox2short stature homeobox 20.011
Enpepglutamyl aminopeptidase0.010
Prrx1paired related homeobox 10.010
Loxlysyl oxidase0.010
Stard8StAR-related lipid transfer (START) domain containing 80.010
Aebp1AE binding protein 10.010
Sod3superoxide dismutase 3, extracellular0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism