The network for 'estrogen catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

estrogen catabolic process

The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.

NameDescriptionProbabilityFunc Analog Organism
UGT2B15UDP glucuronosyltransferase 2 family, polypeptide B150.978
UGT2B17UDP glucuronosyltransferase 2 family, polypeptide B170.971
UGT1A1UDP glucuronosyltransferase 1 family, polypeptide A10.876
GABRA3gamma-aminobutyric acid (GABA) A receptor, alpha 30.651
NR1H4nuclear receptor subfamily 1, group H, member 40.347
UGT1A3UDP glucuronosyltransferase 1 family, polypeptide A30.164
PRLRprolactin receptor0.150
UGT2B4UDP glucuronosyltransferase 2 family, polypeptide B40.148
LRRC31leucine rich repeat containing 310.085
CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 70.082
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 20.079
SIsucrase-isomaltase (alpha-glucosidase)0.075
SLCO1B3solute carrier organic anion transporter family, member 1B30.074
UGT2B10UDP glucuronosyltransferase 2 family, polypeptide B100.073
UGT2A3UDP glucuronosyltransferase 2 family, polypeptide A30.069
SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.056
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.048
CYP7A1cytochrome P450, family 7, subfamily A, polypeptide 10.048
HAO1hydroxyacid oxidase (glycolate oxidase) 10.044
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.042
MAPK14mitogen-activated protein kinase 140.041
ALDOBaldolase B, fructose-bisphosphate0.039
GSTA3glutathione S-transferase alpha 30.038
AADACarylacetamide deacetylase (esterase)0.036
MTTPmicrosomal triglyceride transfer protein0.036
SLC26A3solute carrier family 26, member 30.035
CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 80.034
F13Bcoagulation factor XIII, B polypeptide0.034
TATtyrosine aminotransferase0.033
PDZK1PDZ domain containing 10.032
HNF4Ghepatocyte nuclear factor 4, gamma0.030
MBL2mannose-binding lectin (protein C) 2, soluble0.029
ADH6alcohol dehydrogenase 6 (class V)0.026
PAHphenylalanine hydroxylase0.026
ADH4alcohol dehydrogenase 4 (class II), pi polypeptide0.024
SULT1E1sulfotransferase family 1E, estrogen-preferring, member 10.023
OTCornithine carbamoyltransferase0.023
ZNF157zinc finger protein 1570.023
GYS2glycogen synthase 2 (liver)0.023
SLC30A10solute carrier family 30, member 100.023
TSPAN8tetraspanin 80.022
ACE2angiotensin I converting enzyme (peptidyl-dipeptidase A) 20.022
TPH1tryptophan hydroxylase 10.022
SULT1C2sulfotransferase family, cytosolic, 1C, member 20.022
FRKfyn-related kinase0.022
G6PCglucose-6-phosphatase, catalytic subunit0.021
ENTPD5ectonucleoside triphosphate diphosphohydrolase 50.021
AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)0.021
ANXA10annexin A100.021
UGT2B28UDP glucuronosyltransferase 2 family, polypeptide B280.021
CPB2carboxypeptidase B2 (plasma)0.020
CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 180.020
MEP1Bmeprin A, beta0.020
SOSTDC1sclerostin domain containing 10.019
UGT1A7UDP glucuronosyltransferase 1 family, polypeptide A70.019
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.019
HSD17B6hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)0.019
MSTNmyostatin0.019
C9complement component 90.019
HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)0.018
ACPPacid phosphatase, prostate0.018
DDCdopa decarboxylase (aromatic L-amino acid decarboxylase)0.018
LGSNlengsin, lens protein with glutamine synthetase domain0.018
HRGhistidine-rich glycoprotein0.017
CCDC68coiled-coil domain containing 680.017
NPY1Rneuropeptide Y receptor Y10.017
AGR2anterior gradient homolog 2 (Xenopus laevis)0.017
UGT1A9UDP glucuronosyltransferase 1 family, polypeptide A90.016
CDH17cadherin 17, LI cadherin (liver-intestine)0.016
CLDN8claudin 80.016
ALBalbumin0.016
AKAP7A kinase (PRKA) anchor protein 70.016
MAP2K6mitogen-activated protein kinase kinase 60.016
SLCO1B1solute carrier organic anion transporter family, member 1B10.015
HGDhomogentisate 1,2-dioxygenase0.015
AFPalpha-fetoprotein0.015
FMO5flavin containing monooxygenase 50.015
IL26interleukin 260.015
NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase)0.015
FGGfibrinogen gamma chain0.015
ACSM2Aacyl-CoA synthetase medium-chain family member 2A0.014
KNG1kininogen 10.014
NTSneurotensin0.014
NR5A2nuclear receptor subfamily 5, group A, member 20.014
IYDiodotyrosine deiodinase0.014
CRISP3cysteine-rich secretory protein 30.014
SLC25A21solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 210.014
SLITRK6SLIT and NTRK-like family, member 60.014
CPS1carbamoyl-phosphate synthase 1, mitochondrial0.014
FGL1fibrinogen-like 10.013
HEPACAM2HEPACAM family member 20.013
AKR1C4aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)0.013
AFMafamin0.013
ALDH8A1aldehyde dehydrogenase 8 family, member A10.013
GSTT1glutathione S-transferase theta 10.013
GAS2growth arrest-specific 20.013
HTN3histatin 30.013
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.013
TMEM27transmembrane protein 270.012
MOSC1MOCO sulphurase C-terminal domain containing 10.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.925
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.635
LOC100361547Cytochrome P450, family 2, subfamily c, polypeptide 7-like0.555
Ugt1a3UDP glycosyltransferase 1 family, polypeptide A30.540
Gsta5glutathione S-transferase Yc2 subunit0.468
Sult2al1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring-like 10.408
Mgst2microsomal glutathione S-transferase 20.345
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.311
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.302
Ugt1a5UDP glucuronosyltransferase 1 family, polypeptide A50.298
LOC494499LOC494499 protein0.170
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.149
Nat2N-acetyltransferase 20.148
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.138
Abcc2ATP-binding cassette, subfamily C (CFTR/MRP), member 20.134
Olr1530olfactory receptor 15300.113
Ugt1a2UDP glucuronosyltransferase 1 family, polypeptide A20.107
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.079
LOC100361864UDP-glucuronosyltransferase 2B3-like0.075
Otcornithine carbamoyltransferase0.073
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.065
Rag1recombination activating gene 10.064
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.062
Slc13a1solute carrier family 13 (sodium/sulfate symporters), member 10.061
Cyp2b2cytochrome P450, family 2, subfamily b, polypeptide 20.060
Akr1c14aldo-keto reductase family 1, member C140.057
Ugt1a8UDP glycosyltransferase 1 family, polypeptide A80.055
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.048
RGD1305347similar to RIKEN cDNA 2610528J110.048
Fuca1fucosidase, alpha-L- 1, tissue0.045
Crygfcrystallin, gamma F0.045
Dmgdhdimethylglycine dehydrogenase0.042
Acaa1bacetyl-Coenzyme A acyltransferase 1B0.040
Col4a3collagen, type IV, alpha 30.040
Cyp4a2cytochrome P450, family 4, subfamily a, polypeptide 20.038
Akap14A kinase (PRKA) anchor protein 140.037
Gsta2glutathione S-transferase A20.037
Slc17a3solute carrier family 17 (sodium phosphate), member 30.036
LOC100361724cytochrome P450 2B3-like0.035
Pigrpolymeric immunoglobulin receptor0.035
L3mbtl3l(3)mbt-like 3 (Drosophila)0.033
Kif11kinesin family member 110.032
Olr1347olfactory receptor 13470.032
LOC690507similar to Vomeromodulin0.030
Pctk3PCTAIRE protein kinase 30.029
Snai2snail homolog 2 (Drosophila)0.029
Olr1468olfactory receptor 14680.029
Ces1ecarboxylesterase 1E0.028
Tph1tryptophan hydroxylase 10.028
Vom2r50vomeronasal 2 receptor, 500.028
Serpinb5serpin peptidase inhibitor, clade B (ovalbumin), member 50.027
Sult2a2sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 20.027
Clca4chloride channel accessory 40.026
Egfrepidermal growth factor receptor0.025
Il7interleukin 70.024
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.023
Pctpphosphatidylcholine transfer protein0.022
Ephx1epoxide hydrolase 1, microsomal0.022
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.022
Acsm2acyl-CoA synthetase medium-chain family member 20.022
Mbl2mannose-binding lectin (protein C) 20.022
Galnt5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)0.021
Itgb3integrin, beta 30.021
Nat1N-acetyltransferase 10.020
Ces1fcarboxylesterase 1F0.020
RGD1559532RGD15595320.020
Ugt1a1UDP glucuronosyltransferase 1 family, polypeptide A10.020
Ddx4DEAD (Asp-Glu-Ala-Asp) box polypeptide 40.019
Olr1697olfactory receptor 16970.019
RT1-DObRT1 class II, locus DOb0.019
LOC293989cytochrome P450-like0.018
Ottovary testis transcribed0.018
Anpepalanyl (membrane) aminopeptidase0.018
Olr1226olfactory receptor 12260.017
LOC100365195rCG64293-like0.017
Golga1golgi autoantigen, golgin subfamily a, 10.016
Vcsa2variable coding sequence A20.016
Olr1191olfactory receptor 11910.016
Cftrcystic fibrosis transmembrane conductance regulator homolog (human)0.016
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.016
Fusip1FUS interacting protein (serine-arginine rich) 10.015
Adh7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide0.015
Cyp3a9cytochrome P450, family 3, subfamily a, polypeptide 90.015
Cdh8cadherin 80.014
Akr1d1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)0.014
Slc22a18solute carrier family 22, member 180.013
Il9rinterleukin 9 receptor0.013
Apobapolipoprotein B0.013
Cyp17a1cytochrome P450, family 17, subfamily a, polypeptide 10.013
Spink1serine peptidase inhibitor, Kazal type 10.013
Olr1606olfactory receptor 16060.012
RT1-M4RT1 class Ib, locus M40.012
Rya3antimicrobial peptide RYA30.012
Abcb1bATP-binding cassette, subfamily B (MDR/TAP), member 1B0.012
Sisucrase-isomaltase (alpha-glucosidase)0.012
Fabp1fatty acid binding protein 1, liver0.012
Anxa4annexin A40.012
Hspg2heparan sulfate proteoglycan 20.012
Rarbretinoic acid receptor, beta0.012
Cd14CD14 molecule0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism