The network for 'leukotriene production involved in inflammatory response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukotriene production involved in inflammatory response

The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.

NameDescriptionProbabilityFunc Analog Organism
PLAUplasminogen activator, urokinase1.000
COTL1coactosin-like 1 (Dictyostelium)1.000
PLATplasminogen activator, tissue0.998
PLAURplasminogen activator, urokinase receptor0.994
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.837
ALOX5AParachidonate 5-lipoxygenase-activating protein0.283
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.228
PHLDA1pleckstrin homology-like domain, family A, member 10.225
ALOX5arachidonate 5-lipoxygenase0.211
CYR61cysteine-rich, angiogenic inducer, 610.197
NCF2neutrophil cytosolic factor 20.087
SPHK1sphingosine kinase 10.082
OSMRoncostatin M receptor0.064
TIMP1TIMP metallopeptidase inhibitor 10.054
NNMTnicotinamide N-methyltransferase0.043
EMP1epithelial membrane protein 10.039
IL8interleukin 80.033
TNCtenascin C0.033
COL5A2collagen, type V, alpha 20.032
FOSL1FOS-like antigen 10.028
HCKhemopoietic cell kinase0.028
GPRC5AG protein-coupled receptor, family C, group 5, member A0.028
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.028
ACTN1actinin, alpha 10.026
INHBAinhibin, beta A0.024
COL4A1collagen, type IV, alpha 10.024
S100A8S100 calcium binding protein A80.022
FADS3fatty acid desaturase 30.022
THBS1thrombospondin 10.022
UPP1uridine phosphorylase 10.021
KLF6Kruppel-like factor 60.019
LCP1lymphocyte cytosolic protein 1 (L-plastin)0.017
PDLIM4PDZ and LIM domain 40.017
FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)0.016
NCF4neutrophil cytosolic factor 4, 40kDa0.016
GEMGTP binding protein overexpressed in skeletal muscle0.016
PXDNperoxidasin homolog (Drosophila)0.014
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.014
CAV2caveolin 20.014
TNFAIP6tumor necrosis factor, alpha-induced protein 60.014
MICAL2microtubule associated monoxygenase, calponin and LIM domain containing 20.013
TGFB1I1transforming growth factor beta 1 induced transcript 10.013
TUBB6tubulin, beta 60.013
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.013
TFPI2tissue factor pathway inhibitor 20.013
SPP1secreted phosphoprotein 10.012
NT5E5'-nucleotidase, ecto (CD73)0.012
S100A9S100 calcium binding protein A90.012
RAI14retinoic acid induced 140.012
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 10.011
ENTPD1ectonucleoside triphosphate diphosphohydrolase 10.011
TBXAS1thromboxane A synthase 1 (platelet)0.011
HBEGFheparin-binding EGF-like growth factor0.011
PIK3CGphosphoinositide-3-kinase, catalytic, gamma polypeptide0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Alox5arachidonate 5-lipoxygenase0.941
Alox5aparachidonate 5-lipoxygenase activating protein0.804
Orai1ORAI calcium release-activated calcium modulator 10.632
Ptgesprostaglandin E synthase0.565
TyrobpTYRO protein tyrosine kinase binding protein0.435
Ccl6chemokine (C-C motif) ligand 60.133
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.125
Col17a1collagen, type XVII, alpha 10.112
Krt15keratin 150.092
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.078
Asprv1aspartic peptidase, retroviral-like 10.073
Pf4platelet factor 40.070
Htra3HtrA serine peptidase 30.067
Krtdapkeratinocyte differentiation associated protein0.058
Cfdcomplement factor D (adipsin)0.056
C1qacomplement component 1, q subcomponent, alpha polypeptide0.056
Tmem40transmembrane protein 400.056
Tnni2troponin I, skeletal, fast 20.055
Cma1chymase 1, mast cell0.051
Lefty1left right determination factor 10.049
Padi4peptidyl arginine deiminase, type IV0.048
Rab25RAB25, member RAS oncogene family0.045
Ly6g6clymphocyte antigen 6 complex, locus G6C0.044
Krt13keratin 130.044
Gp9glycoprotein 9 (platelet)0.044
Fcnaficolin A0.041
Ucp1uncoupling protein 1 (mitochondrial, proton carrier)0.041
Anxa8annexin A80.040
Alox15arachidonate 15-lipoxygenase0.040
Sftpbsurfactant associated protein B0.040
S100a4S100 calcium binding protein A40.037
Expiextracellular proteinase inhibitor0.036
Slurp1secreted Ly6/Plaur domain containing 10.035
Maffv-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)0.035
Ch25hcholesterol 25-hydroxylase0.033
Fesfeline sarcoma oncogene0.033
Folr2folate receptor 2 (fetal)0.032
Cideccell death-inducing DFFA-like effector c0.031
Map3k6mitogen-activated protein kinase kinase kinase 60.031
Treml1triggering receptor expressed on myeloid cells-like 10.031
Gna15guanine nucleotide binding protein, alpha 150.031
Mst1rmacrophage stimulating 1 receptor (c-met-related tyrosine kinase)0.030
Cbr2carbonyl reductase 20.030
Fxyd2FXYD domain-containing ion transport regulator 20.028
Lgals7lectin, galactose binding, soluble 70.027
Clic3chloride intracellular channel 30.027
Cd68CD68 antigen0.027
Fxyd5FXYD domain-containing ion transport regulator 50.027
Lyl1lymphoblastomic leukemia 10.026
C5ar1complement component 5a receptor 10.026
Apoc1apolipoprotein C-I0.025
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.025
Ccl11chemokine (C-C motif) ligand 110.024
Mybphmyosin binding protein H0.023
Slpisecretory leukocyte peptidase inhibitor0.023
Fcgr3Fc receptor, IgG, low affinity III0.022
Hspb7heat shock protein family, member 7 (cardiovascular)0.022
Irs3insulin receptor substrate 30.022
Cd14CD14 antigen0.022
Plin4perilipin 40.022
Adora2badenosine A2b receptor0.022
Ms4a6dmembrane-spanning 4-domains, subfamily A, member 6D0.021
Gata1GATA binding protein 10.021
Timp1tissue inhibitor of metalloproteinase 10.021
Il1r2interleukin 1 receptor, type II0.021
Adam8a disintegrin and metallopeptidase domain 80.021
Calm4calmodulin 40.021
Nrapnebulin-related anchoring protein0.020
Il34interleukin 340.020
S100a6S100 calcium binding protein A6 (calcyclin)0.019
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.019
Ctgfconnective tissue growth factor0.019
Aoc3amine oxidase, copper containing 30.019
F13a1coagulation factor XIII, A1 subunit0.019
Ccl24chemokine (C-C motif) ligand 240.018
Slfn4schlafen 40.018
Ckmt2creatine kinase, mitochondrial 20.018
Ccl2chemokine (C-C motif) ligand 20.018
Clec3bC-type lectin domain family 3, member b0.018
Sfrp4secreted frizzled-related protein 40.018
Csf1rcolony stimulating factor 1 receptor0.018
Trim47tripartite motif-containing 470.017
C1qbcomplement component 1, q subcomponent, beta polypeptide0.017
Tnfrsf17tumor necrosis factor receptor superfamily, member 170.017
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.017
Eporerythropoietin receptor0.017
Ccl9chemokine (C-C motif) ligand 90.017
Pdcd1programmed cell death 10.017
Pi16peptidase inhibitor 160.016
Ier3immediate early response 30.016
Foxd2forkhead box D20.016
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism