The network for 'mesenchymal cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mesenchymal cell development

The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.

NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
NOTCH1notch 10.999
SMAD3SMAD family member 30.999
JAG1jagged 10.999
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.999
COL1A1collagen, type I, alpha 10.998
SMAD1SMAD family member 10.996
SMAD4SMAD family member 40.996
TGFB1transforming growth factor, beta 10.991
EGFRepidermal growth factor receptor0.991
SMAD7SMAD family member 70.988
TP53tumor protein p530.987
EP300E1A binding protein p3000.982
SMURF2SMAD specific E3 ubiquitin protein ligase 20.979
SMAD2SMAD family member 20.972
PAX3paired box 30.970
ARandrogen receptor0.970
CREBBPCREB binding protein0.968
SOX10SRY (sex determining region Y)-box 100.950
SKILSKI-like oncogene0.948
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.944
COL5A1collagen, type V, alpha 10.916
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.878
FKBP1AFK506 binding protein 1A, 12kDa0.876
NOTCH3notch 30.874
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.869
POU3F2POU class 3 homeobox 20.868
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.862
POU5F1POU class 5 homeobox 10.844
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.833
FN1fibronectin 10.819
GATA4GATA binding protein 40.818
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.808
COL4A1collagen, type IV, alpha 10.805
PTK2PTK2 protein tyrosine kinase 20.792
FSTL1follistatin-like 10.788
ENGendoglin0.781
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.758
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.741
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.740
BMP2bone morphogenetic protein 20.720
NRP1neuropilin 10.689
SMAD5SMAD family member 50.680
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.647
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.615
COL3A1collagen, type III, alpha 10.606
RBPMSRNA binding protein with multiple splicing0.606
COL4A2collagen, type IV, alpha 20.602
GRB7growth factor receptor-bound protein 70.594
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.563
COL5A2collagen, type V, alpha 20.558
FHL2four and a half LIM domains 20.554
LTBP2latent transforming growth factor beta binding protein 20.544
CXXC5CXXC finger protein 50.541
TBX5T-box 50.529
COL1A2collagen, type I, alpha 20.525
FGF3fibroblast growth factor 30.519
FZD1frizzled homolog 1 (Drosophila)0.508
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.491
ZFYVE9zinc finger, FYVE domain containing 90.487
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.487
RUNX1runt-related transcription factor 10.479
THBS1thrombospondin 10.467
GSK3Bglycogen synthase kinase 3 beta0.458
COL2A1collagen, type II, alpha 10.454
TGFB3transforming growth factor, beta 30.453
QKIquaking homolog, KH domain RNA binding (mouse)0.446
BMP7bone morphogenetic protein 70.438
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.432
AXIN1axin 10.417
MYOD1myogenic differentiation 10.408
NCOR1nuclear receptor corepressor 10.401
COL6A1collagen, type VI, alpha 10.400
SOX1SRY (sex determining region Y)-box 10.399
WNT1wingless-type MMTV integration site family, member 10.392
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.381
POSTNperiostin, osteoblast specific factor0.371
MAP3K5mitogen-activated protein kinase kinase kinase 50.370
TP73tumor protein p730.370
BMPR1Abone morphogenetic protein receptor, type IA0.369
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.368
SMAD9SMAD family member 90.361
LIMS1LIM and senescent cell antigen-like domains 10.359
APCadenomatous polyposis coli0.354
FOXF2forkhead box F20.353
PAX8paired box 80.351
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.350
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.346
WWP2WW domain containing E3 ubiquitin protein ligase 20.338
NCK2NCK adaptor protein 20.332
FZD8frizzled homolog 8 (Drosophila)0.329
FGF1fibroblast growth factor 1 (acidic)0.325
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.321
TCF4transcription factor 40.312
SETD8SET domain containing (lysine methyltransferase) 80.310
HIPK2homeodomain interacting protein kinase 20.309
HIC1hypermethylated in cancer 10.299
PTBP1polypyrimidine tract binding protein 10.298
PAPPApregnancy-associated plasma protein A, pappalysin 10.295
ACVR1activin A receptor, type I0.293
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
aldh1a2aldehyde dehydrogenase 1 family, member A20.988
shhasonic hedgehog a0.986
cdh2cadherin 2, neuronal0.966
foxd3forkhead box D30.963
tbx1T-box 10.948
foxa3forkhead box A30.940
gscgoosecoid0.920
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.910
crestincrestin0.884
bmp2bbone morphogenetic protein 2b0.859
mibmind bomb0.851
mecomMDS1 and EVI1 complex locus0.849
tgfb3transforming growth factor, beta 30.838
tfap2atranscription factor AP-2 alpha0.833
lef1lymphocyte enhancer binding factor 10.830
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.813
eya1eyes absent homolog 10.809
sox10SRY-box containing gene 100.805
dlcdeltaC0.781
sox2SRY-box containing gene 20.751
notch3notch homolog 30.723
mitfamicrophthalmia-associated transcription factor a0.721
foxi1forkhead box I10.721
osr2odd-skipped related 2 (Drosophila)0.721
pax6bpaired box gene 6b0.715
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.712
shhbsonic hedgehog b0.710
wu:fv91b12wu:fv91b120.709
eomesaeomesodermin homolog a0.697
her6hairy-related 60.681
grem2gremlin 2, cysteine knot superfamily0.668
cdh6cadherin 60.648
emx3empty spiracles homeobox 30.615
pax2apaired box gene 2a0.615
kitakit receptor a0.602
wnt11wingless-type MMTV integration site family, member 110.587
rspo3R-spondin 3 homolog (Xenopus laevis)0.577
gpr126G protein-coupled receptor 1260.546
dlddeltaD0.543
traf4atnf receptor-associated factor 4a0.537
fgf8afibroblast growth factor 8 a0.536
lhx5LIM homeobox 50.529
cdx4caudal type homeo box transcription factor 40.518
hey1hairy/enhancer-of-split related with YRPW motif 10.504
msxemuscle segment homeobox E0.489
cxcr4achemokine (C-X-C motif) receptor 4a0.485
gata3GATA-binding protein 30.480
six3asine oculis homeobox homolog 3a0.465
tll1tolloid-like 10.461
gyltl1bglycosyltransferase-like 1b0.444
gro1groucho 10.443
ndr2nodal-related 20.440
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.437
rargaretinoic acid receptor gamma a0.435
crabp2acellular retinoic acid binding protein 2, a0.432
plod2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 20.429
pax6apaired box gene 6a0.425
twist1atwist1a0.425
prdm5PR domain containing 50.424
neurodneurogenic differentiation0.423
her1hairy-related 10.417
sox1aSRY-box containing gene 1a0.415
otx2orthodenticle homolog 20.413
tp53tumor protein p530.413
fzd7bfrizzled homolog 7b0.409
dbx1adeveloping brain homeobox 1a0.399
supt6hsuppressor of Ty 6 homolog0.390
hnf1baHNF1 homeobox Ba0.385
pcdh18bprotocadherin 18b0.384
flhfloating head0.380
tfectranscription factor EC0.371
smad1MAD homolog 1 (Drosophila)0.371
gria1aglutamate receptor, ionotropic, AMPA 1a0.355
fgf10afibroblast growth factor 10a0.354
notch1bnotch homolog 1b0.349
pitx3paired-like homeodomain transcription factor 30.343
gdf6agrowth differentiation factor 6a0.342
gria3bglutamate receptor, ionotrophic, AMPA 3b0.336
pax7apaired box gene 7a0.336
col15a1bcollagen, type XV, alpha 1b0.333
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.329
nrp1aneuropilin 1a0.326
igf1rbinsulin-like growth factor 1b receptor0.321
pitx2paired-like homeodomain transcription factor 20.312
gria4bglutamate receptor, ionotropic, AMPA 4b0.312
ascl1aachaete-scute complex-like 1a (Drosophila)0.309
twist3twist30.307
bmp4bone morphogenetic protein 40.307
oepone-eyed pinhead0.305
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.297
tp63tumor protein p630.293
sema3dsemaphorin 3d0.293
zic1zic family member 1 (odd-paired homolog, Drosophila)0.290
rx2retinal homeobox gene 20.289
zeb2azinc finger E-box binding homeobox 2a0.285
fzd7afrizzled homolog 7a0.276
six3bsine oculis homeobox homolog 3b0.273
dctdopachrome tautomerase0.272
dlx3bdistal-less homeobox gene 3b0.271
fgf3fibroblast growth factor 30.267
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
NNotch0.446
hthhomothorax0.393
Ras85DRas oncogene at 85D0.338
nkdnaked cuticle0.327
ttvtout-velu0.326
cicubitus interruptus0.305
wgwingless0.299
MadMothers against dpp0.267
ushu-shaped0.230
gcmglial cells missing0.184
EgfrEpidermal growth factor receptor0.184
Pi3K92ECG4141 gene product from transcript CG4141-RB0.178
bazbazooka0.178
rapretina aberrant in pattern0.166
Stat92ESignal-transducer and activator of transcription protein at 92E0.160
hhhedgehog0.156
shgshotgun0.155
Eip74EFEcdysone-induced protein 74EF0.154
shnschnurri0.149
dmdiminutive0.131
dshdishevelled0.126
hpohippo0.120
slouslouch0.119
kluklumpfuss0.116
putpunt0.113
inscinscuteable0.109
enengrailed0.109
dppdecapentaplegic0.106
Mef2Myocyte enhancer factor 20.100
numbCG3779 gene product from transcript CG3779-RB0.097
SmoxSmad on X0.096
KrKruppel0.095
pnrpannier0.093
CG11347CG11347 gene product from transcript CG11347-RE0.091
LanB2Laminin B20.087
emcextra macrochaetae0.085
exexpanded0.084
apapterous0.083
myoglianinCG1838 gene product from transcript CG1838-RD0.083
SoxNSoxNeuro0.081
AntpAntennapedia0.080
osaCG7467 gene product from transcript CG7467-RD0.079
Akt1CG4006 gene product from transcript CG4006-RA0.079
bowlbrother of odd with entrails limited0.078
slp1sloppy paired 10.077
eyaeyes absent0.077
crbcrumbs0.073
babobaboon0.071
pxbCG33207 gene product from transcript CG33207-RB0.069
nocno ocelli0.069
wtswarts0.068
jingCG9397 gene product from transcript CG9397-RI0.068
Sema-1aCG18405 gene product from transcript CG18405-RD0.067
fasfaint sausage0.067
tintinman0.067
GscGoosecoid0.066
eygeyegone0.063
MED19Mediator complex subunit 190.061
DadDaughters against dpp0.060
ash2absent, small, or homeotic discs 20.060
CG8765CG8765 gene product from transcript CG8765-RA0.059
nabCG33545 gene product from transcript CG33545-RC0.058
eIF3-S8CG4954 gene product from transcript CG4954-RA0.058
grngrain0.058
sdscalloped0.057
l(2)gd1lethal (2) giant discs 10.057
dlg1discs large 10.057
cwoclockwork orange0.056
tldtolloid0.056
CG12424CG12424 gene product from transcript CG12424-RC0.054
kibrakibra ortholog0.054
E(z)Enhancer of zeste0.053
grogroucho0.053
E(spl)Enhancer of split0.053
lblladybird late0.052
pr-set7CG3307 gene product from transcript CG3307-RC0.052
lbeladybird early0.051
gcm2CG3858 gene product from transcript CG3858-RA0.050
FsFollistatin0.050
stumpsCG31317 gene product from transcript CG31317-RC0.050
ecdecdysoneless0.049
eveeven skipped0.049
slp2sloppy paired 20.048
Tsc1CG6147 gene product from transcript CG6147-RA0.048
snasnail0.048
twstwins0.048
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.046
trbltribbles0.046
mminiature0.046
naunautilus0.045
cnccap-n-collar0.045
Pka-C1cAMP-dependent protein kinase 10.044
bynbrachyenteron0.044
fngfringe0.043
twitwist0.043
Hr4CG16902 gene product from transcript CG16902-RC0.043
UbxUltrabithorax0.043
CG13349CG13349 gene product from transcript CG13349-RA0.042
lablabial0.042
slmbsupernumerary limbs0.042
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Foxc1forkhead box C11.000
Shhsonic hedgehog1.000
Pax3paired box gene 31.000
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Bmp4bone morphogenetic protein 41.000
Pax2paired box gene 21.000
Pax6paired box gene 61.000
Tgfb2transforming growth factor, beta 21.000
Tcfap2atranscription factor AP-2, alpha1.000
Otx2orthodenticle homolog 2 (Drosophila)0.999
Pitx2paired-like homeodomain transcription factor 20.999
Hand1heart and neural crest derivatives expressed transcript 10.999
Fgf8fibroblast growth factor 80.999
Jag1jagged 10.999
Vegfavascular endothelial growth factor A0.998
Fgfr1fibroblast growth factor receptor 10.998
Nodalnodal0.998
Rargretinoic acid receptor, gamma0.997
Eya1eyes absent 1 homolog (Drosophila)0.997
Hoxa1homeobox A10.997
Hand2heart and neural crest derivatives expressed transcript 20.997
Dlx5distal-less homeobox 50.994
Bcl2B-cell leukemia/lymphoma 20.994
Prrx1paired related homeobox 10.994
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.993
Foxc2forkhead box C20.992
Msx2homeobox, msh-like 20.992
Efnb2ephrin B20.992
Chrdchordin0.991
Lhx1LIM homeobox protein 10.990
Sox9SRY-box containing gene 90.990
Retret proto-oncogene0.988
Isl1ISL1 transcription factor, LIM/homeodomain0.986
Nognoggin0.984
Snai1snail homolog 1 (Drosophila)0.982
Runx2runt related transcription factor 20.982
Ednraendothelin receptor type A0.981
Msx1homeobox, msh-like 10.981
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.980
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.979
Smosmoothened homolog (Drosophila)0.978
Gli2GLI-Kruppel family member GLI20.977
Acvr1activin A receptor, type 10.977
Lmx1aLIM homeobox transcription factor 1 alpha0.976
Foxg1forkhead box G10.973
Notch1Notch gene homolog 1 (Drosophila)0.970
Gata4GATA binding protein 40.968
Ror2receptor tyrosine kinase-like orphan receptor 20.967
Bmp7bone morphogenetic protein 70.965
Prrx2paired related homeobox 20.962
Fgf10fibroblast growth factor 100.958
Zic3zinc finger protein of the cerebellum 30.954
Ptpn11protein tyrosine phosphatase, non-receptor type 110.953
Lef1lymphoid enhancer binding factor 10.951
Pitx1paired-like homeodomain transcription factor 10.950
Tlx3T-cell leukemia, homeobox 30.948
Alx4aristaless-like homeobox 40.948
Hoxd13homeobox D130.940
Tgfbr2transforming growth factor, beta receptor II0.938
Hey2hairy/enhancer-of-split related with YRPW motif 20.933
Gdnfglial cell line derived neurotrophic factor0.924
Gbx2gastrulation brain homeobox 20.922
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.919
Smad3MAD homolog 3 (Drosophila)0.919
Rarbretinoic acid receptor, beta0.918
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.916
Ntf3neurotrophin 30.909
Tbx1T-box 10.908
Meox2mesenchyme homeobox 20.905
Pax9paired box gene 90.891
Ascl1achaete-scute complex homolog 1 (Drosophila)0.883
Atoh7atonal homolog 7 (Drosophila)0.881
Twist2twist homolog 2 (Drosophila)0.870
Pou3f3POU domain, class 3, transcription factor 30.866
Chd7chromodomain helicase DNA binding protein 70.864
Emx1empty spiracles homolog 1 (Drosophila)0.859
Pbx1pre B-cell leukemia transcription factor 10.848
Hoxd11homeobox D110.845
Tbx3T-box 30.835
Ece1endothelin converting enzyme 10.831
Pthlhparathyroid hormone-like peptide0.831
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.831
Rxraretinoid X receptor alpha0.830
Hes1hairy and enhancer of split 1 (Drosophila)0.829
Gdf11growth differentiation factor 110.827
Axin1axin 10.827
Gata6GATA binding protein 60.822
Col2a1collagen, type II, alpha 10.819
Ptf1apancreas specific transcription factor, 1a0.800
Wnt6wingless-related MMTV integration site 60.783
Hes5hairy and enhancer of split 5 (Drosophila)0.780
Sox2SRY-box containing gene 20.778
Sox3SRY-box containing gene 30.778
En1engrailed 10.763
Smad4MAD homolog 4 (Drosophila)0.754
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.749
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.746
Ctnnb1catenin (cadherin associated protein), beta 10.737
Bnc1basonuclin 10.732
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Metmet proto-oncogene0.013
Dchs1dachsous 1 (Drosophila)0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism