The network for 'protein targeting to mitochondrion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein targeting to mitochondrion

The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.

NameDescriptionProbabilityFunc Analog Organism
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.999
HSPA8heat shock 70kDa protein 80.705
NUB1negative regulator of ubiquitin-like proteins 10.462
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.443
TOMM22translocase of outer mitochondrial membrane 22 homolog (yeast)0.418
TIMM10translocase of inner mitochondrial membrane 10 homolog (yeast)0.387
PPIDpeptidylprolyl isomerase D0.367
MARCH5membrane-associated ring finger (C3HC4) 50.315
TIMM13translocase of inner mitochondrial membrane 13 homolog (yeast)0.258
STIP1stress-induced-phosphoprotein 10.242
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.201
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.198
TIMM8Btranslocase of inner mitochondrial membrane 8 homolog B (yeast)0.126
DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 10.126
BAXBCL2-associated X protein0.116
MAPK8mitogen-activated protein kinase 80.108
SKA3spindle and kinetochore associated complex subunit 30.097
HSPH1heat shock 105kDa/110kDa protein 10.090
TCP1t-complex 10.086
PINK1PTEN induced putative kinase 10.069
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.066
PAM16presequence translocase-associated motor 16 homolog (S. cerevisiae)0.063
AHSA1AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)0.060
PPIFpeptidylprolyl isomerase F0.060
MRPL24mitochondrial ribosomal protein L240.054
FKBP4FK506 binding protein 4, 59kDa0.054
HSPE1heat shock 10kDa protein 1 (chaperonin 10)0.052
MAP2K4mitogen-activated protein kinase kinase 40.050
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.048
HSPA1Aheat shock 70kDa protein 1A0.047
BAK1BCL2-antagonist/killer 10.045
MEOX2mesenchyme homeobox 20.044
VDAC1voltage-dependent anion channel 10.041
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)0.040
TIMM44translocase of inner mitochondrial membrane 44 homolog (yeast)0.038
TIMM9translocase of inner mitochondrial membrane 9 homolog (yeast)0.035
HSPA1Bheat shock 70kDa protein 1B0.034
ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)0.033
IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha0.031
PRDX5peroxiredoxin 50.029
MRPS7mitochondrial ribosomal protein S70.029
ATP5G3ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)0.027
BCL2L1BCL2-like 10.027
BAG2BCL2-associated athanogene 20.027
UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.027
HSPA9heat shock 70kDa protein 9 (mortalin)0.025
BAG3BCL2-associated athanogene 30.025
TOMM7translocase of outer mitochondrial membrane 7 homolog (yeast)0.024
TIMM23translocase of inner mitochondrial membrane 23 homolog (yeast) and translocase of inner mitochondrial membrane 23 homolog (yeast)0.023
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.023
MRPL11mitochondrial ribosomal protein L110.023
DNAJC19DnaJ (Hsp40) homolog, subfamily C, member 190.022
TUBA1Atubulin, alpha 1a0.021
ARMC6armadillo repeat containing 60.021
CIAPIN1cytokine induced apoptosis inhibitor 10.020
TUSC2tumor suppressor candidate 20.020
C19orf70chromosome 19 open reading frame 700.019
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.019
EIF5eukaryotic translation initiation factor 50.019
MRPL28mitochondrial ribosomal protein L280.019
BAG1BCL2-associated athanogene0.018
HCCSholocytochrome c synthase0.018
PMVKphosphomevalonate kinase0.018
CHCHD8coiled-coil-helix-coiled-coil-helix domain containing 80.018
ROMO1reactive oxygen species modulator 10.017
MRPL46mitochondrial ribosomal protein L460.017
MRPS12mitochondrial ribosomal protein S120.017
BADBCL2-associated agonist of cell death0.016
GFM2G elongation factor, mitochondrial 20.016
PHBprohibitin0.016
C1orf43chromosome 1 open reading frame 430.016
SUPV3L1suppressor of var1, 3-like 1 (S. cerevisiae)0.016
DNM1Ldynamin 1-like0.015
TTC1tetratricopeptide repeat domain 10.015
ATP5G1ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)0.015
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.014
KIF5Bkinesin family member 5B0.014
RPRD1Aregulation of nuclear pre-mRNA domain containing 1A0.014
MCATmalonyl CoA:ACP acyltransferase (mitochondrial)0.014
G3BP2GTPase activating protein (SH3 domain) binding protein 20.014
CHCHD4coiled-coil-helix-coiled-coil-helix domain containing 40.014
MAP3K1mitogen-activated protein kinase kinase kinase 10.014
TXN2thioredoxin 20.014
TUBB2Btubulin, beta 2B0.014
TOMM20translocase of outer mitochondrial membrane 20 homolog (yeast)0.013
TOMM70Atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)0.013
MAP3K7mitogen-activated protein kinase kinase kinase 70.013
MRPL27mitochondrial ribosomal protein L270.013
TP53BP2tumor protein p53 binding protein, 20.013
NTPCRnucleoside-triphosphatase, cancer-related0.013
LDHAlactate dehydrogenase A0.013
ZNF593zinc finger protein 5930.013
DNAJA2DnaJ (Hsp40) homolog, subfamily A, member 20.013
BZW1basic leucine zipper and W2 domains 10.013
GRSF1G-rich RNA sequence binding factor 10.013
PEX19peroxisomal biogenesis factor 190.012
CHUKconserved helix-loop-helix ubiquitous kinase0.012
AIFM1apoptosis-inducing factor, mitochondrion-associated, 10.012
IARS2isoleucyl-tRNA synthetase 2, mitochondrial0.012
HSPBP1HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 10.012
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
fkb-6Protein FKB-60.351
cct-4Protein CCT-40.299
hsp-1Protein HSP-10.273
C30C11.4Protein C30C11.40.259
cct-1Protein CCT-10.258
eif-3.KProtein EIF-3.K0.215
tomm-7Protein TOMM-70.193
tin-9.1Protein TIN-9.10.191
hsp-4Protein HSP-40.190
cct-2Protein CCT-20.170
mrps-33Protein MRPS-330.169
ddp-1Protein DDP-10.156
cdc-48.2Protein CDC-48.20.140
cct-6Protein CCT-60.138
cra-1Protein CRA-10.135
tbb-2Protein TBB-20.132
dnj-13Protein DNJ-130.131
scpl-4Protein SCPL-40.120
C34C12.8Protein C34C12.80.112
ttll-12Protein TTLL-120.095
mrps-14Protein MRPS-140.089
rmo-1Protein RMO-10.089
CELE_F45H11.5Protein F45H11.50.086
dnj-21Protein DNJ-210.083
sti-1Protein STI-10.082
pbs-6Protein PBS-60.077
C01A2.3Protein C01A2.30.070
cct-5Protein CCT-50.070
tin-13Protein TIN-130.061
T06D8.5Protein T06D8.50.059
F56D1.2Protein F56D1.20.057
pdl-1Protein PDL-10.057
CELE_Y105E8A.11Protein Y105E8A.110.056
dnj-12Protein DNJ-120.053
tomm-40Protein TOMM-400.053
hap-1Protein HAP-10.047
Y39A3CL.3Protein Y39A3CL.30.046
R07E5.13Protein R07E5.130.045
F35D11.5Protein F35D11.50.044
hpo-22Protein HPO-220.044
hint-1Protein HINT-10.043
CELE_K08F4.2Protein K08F4.20.042
CELE_Y116A8C.30Protein Y116A8C.300.040
ztf-7Protein ZTF-70.040
nol-5Protein NOL-50.039
sax-7Protein SAX-70.039
mrpl-49Protein MRPL-490.036
prp-8Protein PRP-80.035
fars-3Protein FARS-30.034
Y22D7AL.10Protein Y22D7AL.100.034
mrps-28Protein MRPS-280.034
mrps-12Protein MRPS-120.032
rpn-1Protein RPN-10.032
mrps-21Protein MRPS-210.031
F10G8.8Protein F10G8.80.031
K05C4.2Protein K05C4.20.028
tba-1Protein TBA-10.028
glrx-5Protein GLRX-50.028
moag-4Protein MOAG-40.028
tag-210Protein TAG-2100.028
spk-1Protein SPK-10.027
mrpl-12Protein MRPL-120.026
F45G2.8Protein F45G2.80.026
uba-1Protein UBA-10.026
daf-21Protein DAF-210.025
Y56A3A.19Protein Y56A3A.190.024
F35G2.2Protein F35G2.20.024
CELE_Y53F4B.14Protein Y53F4B.140.024
mrpl-19Protein MRPL-190.024
nuo-6Protein NUO-60.023
F40G9.2Protein F40G9.20.023
T09B4.9Protein T09B4.90.023
F31D4.2Protein F31D4.20.022
cyn-7Protein CYN-70.022
tomm-22Protein TOMM-220.021
H17B01.4Protein H17B01.40.021
adr-1Protein ADR-10.021
cct-7Protein CCT-70.021
nduf-6Protein NDUF-60.021
tin-10Protein TIN-100.020
ostb-1Protein OSTB-10.020
R90.1Protein R90.10.020
mrpl-30Protein MRPL-300.019
icd-1Protein ICD-10.019
CELE_Y69A2AR.3Protein Y69A2AR.30.019
T19A5.1Protein T19A5.10.019
paa-1Protein PAA-10.019
cyn-1Protein CYN-10.019
metr-1Protein METR-10.018
K10B2.4Protein K10B2.40.018
C52E12.1Protein C52E12.10.018
hsp-6Protein HSP-60.018
clk-1Protein CLK-10.018
qars-1Protein QARS-10.018
T08A11.1Protein T08A11.10.017
mrpl-32Protein MRPL-320.017
F35D11.4Protein F35D11.40.017
ima-3Protein IMA-30.017
coq-8Protein COQ-80.017
mrps-23Protein MRPS-230.016
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
borbelphegor0.030
CG8443CG8443 gene product from transcript CG8443-RA0.026
Drp1Dynamin related protein 10.024
CG8531CG8531 gene product from transcript CG8531-RA0.020
CG6412CG6412 gene product from transcript CG6412-RA0.019
l(1)G0136lethal (1) G01360.016
Hsp83Heat shock protein 830.016
CG6878CG6878 gene product from transcript CG6878-RA0.015
CG7770CG7770 gene product from transcript CG7770-RA0.015
l(2)tidlethal (2) tumorous imaginal discs0.014
CctgammaCG8977 gene product from transcript CG8977-RC0.013
CG5323CG5323 gene product from transcript CG5323-RA0.013
CG12736CG12736 gene product from transcript CG12736-RA0.013
PbgsPorphobilinogen synthase0.013
CG8728CG8728 gene product from transcript CG8728-RA0.012
Tcp-1etaCG8351 gene product from transcript CG8351-RA0.012
mRpL30mitochondrial ribosomal protein L300.011
miltmilton0.010
CG6565CG6565 gene product from transcript CG6565-RA0.010
CG7048CG7048 gene product from transcript CG7048-RB0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hspd1heat shock protein 1 (chaperonin)0.998
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.995
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.989
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.986
Hspa9heat shock protein 90.926
Hspa8heat shock protein 80.915
Hsph1heat shock 105kDa/110kDa protein 10.910
Rpgrip1lRpgrip1-like0.853
Iqcb1IQ calmodulin-binding motif containing 10.783
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.720
Tomm70atranslocase of outer mitochondrial membrane 70 homolog A (yeast)0.516
Lrpprcleucine-rich PPR-motif containing0.427
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.374
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.369
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.335
Hspe1heat shock protein 1 (chaperonin 10)0.323
Hspa5heat shock protein 50.287
Ndufaf4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 40.261
Cacybpcalcyclin binding protein0.200
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.191
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.158
Timm8a1translocase of inner mitochondrial membrane 8 homolog a1 (yeast)0.135
Ahi1Abelson helper integration site 10.114
Dnaja3DnaJ (Hsp40) homolog, subfamily A, member 30.097
Mrpl50mitochondrial ribosomal protein L500.059
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.054
Immtinner membrane protein, mitochondrial0.043
Ptges3prostaglandin E synthase 3 (cytosolic)0.035
Aifm1apoptosis-inducing factor, mitochondrion-associated 10.034
Mks1Meckel syndrome, type 10.033
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.033
Eprsglutamyl-prolyl-tRNA synthetase0.031
Dlddihydrolipoamide dehydrogenase0.030
Hsp90b1heat shock protein 90, beta (Grp94), member 10.029
Mrps22mitochondrial ribosomal protein S220.028
Dnm1ldynamin 1-like0.026
1110002N22RikRIKEN cDNA 1110002N22 gene0.026
Stip1stress-induced phosphoprotein 10.023
Hibch3-hydroxyisobutyryl-Coenzyme A hydrolase0.022
Cdc34cell division cycle 34 homolog (S. cerevisiae)0.022
Canxcalnexin0.022
1700021F05RikRIKEN cDNA 1700021F05 gene0.021
Ndufaf1NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 10.021
Nol8nucleolar protein 80.019
Rabep1rabaptin, RAB GTPase binding effector protein 10.019
Nclnucleolin0.017
Cycscytochrome c, somatic0.017
Aasdhpptaminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase0.017
Hspa4heat shock protein 40.017
Hccsholocytochrome c synthetase0.016
Pdhxpyruvate dehydrogenase complex, component X0.015
Eif3jeukaryotic translation initiation factor 3, subunit J0.015
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.015
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.014
Fam136afamily with sequence similarity 136, member A0.014
Asna1arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)0.014
Mat2amethionine adenosyltransferase II, alpha0.014
Nap1l2nucleosome assembly protein 1-like 20.013
Cct6achaperonin containing Tcp1, subunit 6a (zeta)0.013
Hspa4lheat shock protein 4 like0.013
Gcshglycine cleavage system protein H (aminomethyl carrier)0.013
Bag2BCL2-associated athanogene 20.013
Caprin1cell cycle associated protein 10.013
Tmem70transmembrane protein 700.013
Ahsa1AHA1, activator of heat shock protein ATPase homolog 1 (yeast)0.013
Rrp1ribosomal RNA processing 1 homolog (S. cerevisiae)0.013
Akt1thymoma viral proto-oncogene 10.013
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.012
Tuba1atubulin, alpha 1A0.012
Nudt3nudix (nucleotide diphosphate linked moiety X)-type motif 30.012
Afg3l2AFG3(ATPase family gene 3)-like 2 (yeast)0.011
NapbN-ethylmaleimide sensitive fusion protein attachment protein beta0.011
Ptpmt1protein tyrosine phosphatase, mitochondrial 10.011
Serbp1serpine1 mRNA binding protein 10.011
Opa1optic atrophy 1 homolog (human)0.010
Pex13peroxisomal biogenesis factor 130.010
Sdhaf2succinate dehydrogenase complex assembly factor 20.010
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.010
Mtch2mitochondrial carrier homolog 2 (C. elegans)0.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hspd1heat shock protein 1 (chaperonin)0.101
Hsph1heat shock 105/110 protein 10.076
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.033
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.030
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.028
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.028
Hspa8heat shock protein 80.015
Stip1stress-induced phosphoprotein 10.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
TIM23Tim23p1.000
TOM22Tom22p1.000
TOM40Tom40p1.000
TOM70Tom70p1.000
SSC1Ssc1p1.000
TIM44Tim44p1.000
MIA40Mia40p1.000
TOM20Tom20p1.000
TIM10Tim10p1.000
TIM17Tim17p1.000
TIM18Tim18p0.999
TIM50Tim50p0.999
SAM35Sam35p0.997
TIM9Tim9p0.997
PAM18Pam18p0.996
FCJ1Fcj1p0.993
SAM50Sam50p0.991
TIM54Tim54p0.989
PAM16Pam16p0.985
TIM13Tim13p0.974
TOM5Tom5p0.966
SSA1Ssa1p0.964
TIM22Tim22p0.958
MIM1Mim1p0.936
SSA2Ssa2p0.917
TIM8Tim8p0.912
STI1Sti1p0.873
TIM12Tim12p0.862
MGR2Mgr2p0.808
MAS2Mas2p0.780
ERV1Erv1p0.730
TIM21Tim21p0.726
SSA4Ssa4p0.689
MGE1Mge1p0.648
SSA3Ssa3p0.597
YDJ1Ydj1p0.582
TOM7Tom7p0.563
MAS1Mas1p0.457
YLR099W-Ahypothetical protein0.410
HSP60Hsp60p0.400
MDM10Mdm10p0.395
PAM17Pam17p0.388
ATP12Atp12p0.366
UPS1Ups1p0.364
SIS1Sis1p0.345
SAM37Sam37p0.314
YTA12Yta12p0.279
AHA1Aha1p0.262
MGR3Mgr3p0.247
KAR2Kar2p0.243
UGO1Ugo1p0.230
BTN2Btn2p0.227
MDJ1Mdj1p0.194
GRX5Grx5p0.193
CPR6Cpr6p0.190
DNM1Dnm1p0.185
ALO1Alo1p0.183
YLR253Whypothetical protein0.158
YFH1Yfh1p0.154
CLU1Clu1p0.149
MDM35Mdm35p0.136
HDA2Hda2p0.133
ATG13Atg13p0.119
NTG1Ntg1p0.116
RDL2Rdl2p0.114
IMP1Imp1p0.110
CUE4Cue4p0.105
SSE1Sse1p0.103
ALT1Alt1p0.103
HSC82Hsc82p0.100
PHB1Phb1p0.097
GAL7Gal7p0.085
CUR1Cur1p0.084
ACP1Acp1p0.077
HSP104Hsp104p0.077
TOM6Tom6p0.077
SOM1Som1p0.077
RNR3Rnr3p0.075
IMP2Imp2p0.070
CPR3Cpr3p0.069
JEM1Jem1p0.063
FES1Fes1p0.061
FMP30Fmp30p0.061
COX2Cox2p0.058
ICP55Icp55p0.055
BFR1Bfr1p0.054
SOV1Sov1p0.054
AIM43Aim43p0.053
HSP78Hsp78p0.053
HCH1Hch1p0.052
YLR132Chypothetical protein0.048
ZIM17Zim17p0.048
AIM36Aim36p0.047
YCL057C-Ahypothetical protein0.047
YAH1Yah1p0.046
MDM32Mdm32p0.046
ATG2Atg2p0.046
HXT3Hxt3p0.046
ALD6Ald6p0.045
YBL039W-Bhypothetical protein0.045