The network for 'regulation of cyclic nucleotide phosphodiesterase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cyclic nucleotide phosphodiesterase activity

Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.

NameDescriptionProbabilityFunc Analog Organism
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.155
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.112
KIAA1683KIAA16830.086
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.068
VHLvon Hippel-Lindau tumor suppressor0.062
FKBP8FK506 binding protein 8, 38kDa0.058
MYO10myosin X0.034
EPAS1endothelial PAS domain protein 10.023
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.021
RALBP1ralA binding protein 10.019
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.017
EGLN3egl nine homolog 3 (C. elegans)0.016
DYNLL1dynein, light chain, LC8-type 10.014
IFNAR2interferon (alpha, beta and omega) receptor 20.012
EIF3Deukaryotic translation initiation factor 3, subunit D0.011
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Atp5oATP synthase, H+ transporting, mitochondrial F1 complex, O subunit0.068
Ndufs5NADH dehydrogenase (ubiquinone) Fe-S protein 50.041
Uqcr11ubiquinol-cytochrome c reductase, complex III subunit XI0.039
LOC100363539mitochondrial ribosomal protein L33-like0.038
Atp5j2ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F20.031
Myeov2myeloma overexpressed 20.026
Mrpl13mitochondrial ribosomal protein L130.024
Tomm7translocase of outer mitochondrial membrane 7 homolog (yeast)0.024
Tceb1transcription elongation factor B (SIII), polypeptide 10.021
Tomm6translocase of outer mitochondrial membrane 6 homolog (yeast)0.020
Ndufa2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 20.020
Mrps21mitochondrial ribosomal protein S210.020
Cox7ccytochrome c oxidase, subunit VIIc0.020
Atp5eATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit0.020
Cox7a2cytochrome c oxidase subunit VIIa polypeptide 20.019
Srp9signal recognition particle 90.019
Timm8btranslocase of inner mitochondrial membrane 8 homolog b (yeast)0.019
Psma2proteasome (prosome, macropain) subunit, alpha type 20.018
Uqcrqubiquinol-cytochrome c reductase, complex III subunit VII0.018
Chchd1coiled-coil-helix-coiled-coil-helix domain containing 10.018
Lsmd1LSM domain containing 10.018
Tceb2transcription elongation factor B (SIII), polypeptide 20.017
Psmb4proteasome (prosome, macropain) subunit, beta type 40.016
Fkbp3FK506 binding protein 30.016
LOC301124hypothetical LOC3011240.016
LOC100366237prefoldin subunit 4-like0.015
Mrpl18mitochondrial ribosomal protein L180.015
Romo1reactive oxygen species modulator 10.015
HypkHuntingtin interacting protein K0.015
Usmg5up-regulated during skeletal muscle growth 5 homolog (mouse)0.014
Psma5proteasome (prosome, macropain) subunit, alpha type 50.014
Psma3proteasome (prosome, macropain) subunit, alpha type 30.014
Atp5lATP synthase, H+ transporting, mitochondrial F0 complex, subunit G0.014
RGD1304704similar to Hypothetical protein CGI-990.014
Ndufb5NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 50.014
Cops5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.014
Mcts1malignant T cell amplified sequence 10.013
Edf1endothelial differentiation-related factor 10.013
Ndufb3NADH dehydrogenase (ubiquinone) 1 beta subcomplex 30.013
LOC687029similar to differentially expressed in B16F10 10.012
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.012
Psma6proteasome (prosome, macropain) subunit, alpha type 60.012
Pompproteasome maturation protein0.012
Ndufb10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 100.012
Uqcrhubiquinol-cytochrome c reductase hinge protein0.012
Dpy30dpy-30 homolog (C. elegans)0.012
Pfdn5prefoldin subunit 50.012
Magohmago-nashi homolog, proliferation-associated (Drosophila)0.011
Cox7bcytochrome c oxidase subunit VIIb0.011
Ndufs6NADH dehydrogenase (ubiquinone) Fe-S protein 60.011
Wdr61WD repeat domain 610.011
Grpel1GrpE-like 1, mitochondrial0.011
Ndufc2NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 20.011
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.011
LOC100188932dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 40.011
Uchl3ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)0.010
Ndufa1NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10.010
Ndufc1NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 10.010
Ndufa4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 40.010
Psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism