The network for 'negative regulation of hydrolase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of hydrolase activity

Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.

NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide1.000
GSK3Bglycogen synthase kinase 3 beta0.972
ACTBactin, beta0.889
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.885
NCF1neutrophil cytosolic factor 10.834
AKT1v-akt murine thymoma viral oncogene homolog 10.784
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.763
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.757
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 20.699
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.648
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.623
PTPRCprotein tyrosine phosphatase, receptor type, C0.568
SH3RF1SH3 domain containing ring finger 10.520
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.504
MAPK1mitogen-activated protein kinase 10.496
FGBfibrinogen beta chain0.495
BADBCL2-associated agonist of cell death0.494
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.482
TNNC1troponin C type 1 (slow)0.480
CTSBcathepsin B0.456
VEGFAvascular endothelial growth factor A0.450
TSSK2testis-specific serine kinase 20.448
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.425
APOEapolipoprotein E0.421
GBP2guanylate binding protein 2, interferon-inducible0.408
DUSP1dual specificity phosphatase 10.406
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.405
APPamyloid beta (A4) precursor protein0.404
XIAPX-linked inhibitor of apoptosis0.400
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.394
PLAUplasminogen activator, urokinase0.387
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.385
MAP3K5mitogen-activated protein kinase kinase kinase 50.378
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.366
MAP3K3mitogen-activated protein kinase kinase kinase 30.360
NRP1neuropilin 10.354
IFITM2interferon induced transmembrane protein 2 (1-8D)0.348
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.344
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.328
AFF4AF4/FMR2 family, member 40.307
IFIT1interferon-induced protein with tetratricopeptide repeats 10.306
HDGFhepatoma-derived growth factor0.305
IQGAP1IQ motif containing GTPase activating protein 10.304
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.303
BCL2B-cell CLL/lymphoma 20.297
UBQLN1ubiquilin 10.291
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.290
LRRK2leucine-rich repeat kinase 20.288
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.286
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.284
CALM1calmodulin 1 (phosphorylase kinase, delta)0.283
LCKlymphocyte-specific protein tyrosine kinase0.275
TBCDtubulin folding cofactor D0.274
LRP1low density lipoprotein receptor-related protein 10.273
NOXA1NADPH oxidase activator 10.271
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.267
CASP8caspase 8, apoptosis-related cysteine peptidase0.261
SH3KBP1SH3-domain kinase binding protein 10.256
SOD1superoxide dismutase 1, soluble0.254
RB1retinoblastoma 10.242
S100A10S100 calcium binding protein A100.238
TP53BP2tumor protein p53 binding protein, 20.238
PLAURplasminogen activator, urokinase receptor0.233
GDAguanine deaminase0.229
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.229
TGFB1transforming growth factor, beta 10.228
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.221
BIRC2baculoviral IAP repeat containing 20.220
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)0.219
MMP14matrix metallopeptidase 14 (membrane-inserted)0.218
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.213
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.211
RGS2regulator of G-protein signaling 2, 24kDa0.211
MAPTmicrotubule-associated protein tau0.205
PRMT6protein arginine methyltransferase 60.203
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.203
PRF1perforin 1 (pore forming protein)0.202
CDHR2cadherin-related family member 20.198
IFIT3interferon-induced protein with tetratricopeptide repeats 30.196
TIMP3TIMP metallopeptidase inhibitor 30.194
PFN1profilin 10.194
ATXN3ataxin 30.191
MTORmechanistic target of rapamycin (serine/threonine kinase)0.187
YAP1Yes-associated protein 10.185
TIMP2TIMP metallopeptidase inhibitor 20.184
VAC14Vac14 homolog (S. cerevisiae)0.181
KPNA1karyopherin alpha 1 (importin alpha 5)0.178
TK1thymidine kinase 1, soluble0.177
EMP1epithelial membrane protein 10.176
MAP2K1mitogen-activated protein kinase kinase 10.175
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.174
PSEN1presenilin 10.173
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.172
DLG4discs, large homolog 4 (Drosophila)0.169
PKM2pyruvate kinase, muscle0.169
FGAfibrinogen alpha chain0.168
KLHL3kelch-like 3 (Drosophila)0.168
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.319
bhmtbetaine-homocysteine methyltransferase0.252
sepp1bselenoprotein P, plasma, 1b0.242
adipor2adiponectin receptor 20.176
adipoqladiponectin, C1Q and collagen domain containing, like0.136
furinafurin (paired basic amino acid cleaving enzyme) a0.109
mcl1bmyeloid cell leukemia sequence 1b0.092
prdx5peroxiredoxin 50.079
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.070
mcl1amyeloid cell leukemia sequence 1a0.067
rnasel1ribonuclease like 10.056
s1pr3sphingosine-1-phosphate receptor 30.055
ihhaIndian hedgehog homolog a0.047
foxe3forkhead box E30.042
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.041
adipoql2adiponectin, C1Q and collagen domain containing, like 20.036
mpp6bmembrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)0.036
pcsk7proprotein convertase subtilisin/kexin type 70.034
atp5gATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)0.032
ccng1cyclin G10.032
pcsk5bproprotein convertase subtilisin/kexin type 5b0.031
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.030
cdh4cadherin 4, retinal0.029
ces2carboxylesterase 2 (intestine, liver)0.026
fcho2FCH domain only 20.026
adipor1badiponectin receptor 1b0.026
uqcrbubiquinol-cytochrome c reductase binding protein0.025
fgf20afibroblast growth factor 20a0.025
mbnl1muscleblind-like (Drosophila)0.024
trpv6transient receptor potential cation channel, subfamily V, member 60.024
oc90otoconin 900.023
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.023
rbm17RNA binding motif protein 170.023
nadl1.1neural adhesion molecule L1.10.022
insrbinsulin receptor b0.021
c6orf115c6orf115 homolog (H. sapiens)0.021
chac1ChaC, cation transport regulator-like 10.021
xylt1xylosyltransferase 10.020
mgaMAX gene associated0.020
nf1aneurofibromin 1a0.020
per2period homolog 2 (Drosophila)0.019
agtr2angiotensin II receptor, type 20.019
LOC564872monocarboxylate transporter 7-like0.019
hhiphedgehog interacting protein0.019
pcsk1proprotein convertase subtilisin/kexin type 10.018
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.017
ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.017
pou3f2POU class 3 homeobox 20.017
ascl1aachaete-scute complex-like 1a (Drosophila)0.017
ripk2receptor-interacting serine-threonine kinase 20.017
pcsk2proprotein convertase subtilisin/kexin type 20.016
copebcore promoter element binding protein0.016
bmp1abone morphogenetic protein 1a0.016
ppp3caprotein phosphatase 3, catalytic subunit, alpha isozyme0.016
myh11amyosin, heavy polypeptide 11, smooth muscle a0.016
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.016
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.015
henmt1HEN1 methyltransferase homolog 1 (Arabidopsis)0.015
ncoa2nuclear receptor coactivator 20.015
rrp15ribosomal RNA processing 15 homolog (S. cerevisiae)0.015
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.015
cntfrciliary neurotrophic factor receptor0.014
itgb1bintegrin, beta 1b0.014
ppp4cbprotein phosphatase 4 (formerly X), catalytic subunit b0.014
lmx1b.1LIM homeobox transcription factor 1, beta 10.014
ednraendothelin receptor type A0.014
vwfvon Willebrand factor0.014
ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.014
nrg1neuregulin 10.014
ldb1aLIM-domain binding factor 1a0.013
pcsk9proprotein convertase subtilisin/kexin type 90.013
igfbp1binsulin-like growth factor binding protein 1b0.013
bbc3BCL2 binding component 30.013
mtmr8myotubularin related protein 80.013
LOC100007758novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3)0.012
fgbfibrinogen, B beta polypeptide0.012
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.012
idh3bisocitrate dehydrogenase 3 (NAD+) beta0.012
atp5dATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit0.012
tspan7btetraspanin 7b0.012
brp44brain protein 440.012
ctsbacathepsin B, a0.012
bmp15bone morphogenetic protein 150.011
sod2superoxide dismutase 2, mitochondrial0.011
fkbp5FK506 binding protein 50.011
sec23ipSEC23 interacting protein0.011
rhagRhesus blood group-associated glycoprotein0.011
wnt8awingless-type MMTV integration site family, member 8a0.011
appaamyloid beta (A4) precursor protein a0.011
numblnumb homolog (Drosophila)-like0.011
hbbe1.1hemoglobin beta embryonic-1.10.011
usp5ubiquitin specific protease 50.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
drddrop dead0.016
par-1CG8201 gene product from transcript CG8201-RA0.013
Hsp68Heat shock protein 680.011
Rac2CG8556 gene product from transcript CG8556-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.974
Apoa1apolipoprotein A-I0.897
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.808
Vegfavascular endothelial growth factor A0.796
Drd2dopamine receptor D20.769
Il10interleukin 100.768
Retret proto-oncogene0.764
Leprleptin receptor0.756
Mndalmyeloid nuclear differentiation antigen like0.726
Fggfibrinogen gamma chain0.721
Ctla2acytotoxic T lymphocyte-associated protein 2 alpha0.716
Cxcl13chemokine (C-X-C motif) ligand 130.692
Dab1disabled homolog 1 (Drosophila)0.666
Vdrvitamin D receptor0.638
Sfrp1secreted frizzled-related protein 10.637
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.607
Arrb2arrestin, beta 20.604
Ctla2bcytotoxic T lymphocyte-associated protein 2 beta0.600
Hspa1aheat shock protein 1A0.592
Ptgs2prostaglandin-endoperoxide synthase 20.591
Fgafibrinogen alpha chain0.552
Thbs2thrombospondin 20.537
Fgbfibrinogen beta chain0.438
Ifnginterferon gamma0.436
Tlr4toll-like receptor 40.431
Spry2sprouty homolog 2 (Drosophila)0.426
Arrb1arrestin, beta 10.418
Itgb1integrin beta 1 (fibronectin receptor beta)0.415
Osmroncostatin M receptor0.385
Apoeapolipoprotein E0.382
AxlAXL receptor tyrosine kinase0.381
Itih4inter alpha-trypsin inhibitor, heavy chain 40.358
Nos1nitric oxide synthase 1, neuronal0.358
Gdnfglial cell line derived neurotrophic factor0.357
Il1r1interleukin 1 receptor, type I0.356
Vhlvon Hippel-Lindau tumor suppressor0.356
Ighimmunoglobulin heavy chain complex0.353
Ambpalpha 1 microglobulin/bikunin0.349
Ccl7chemokine (C-C motif) ligand 70.346
Prkceprotein kinase C, epsilon0.345
Lama5laminin, alpha 50.340
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.333
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.333
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.333
Agxtalanine-glyoxylate aminotransferase0.332
Spry4sprouty homolog 4 (Drosophila)0.326
Sfrp2secreted frizzled-related protein 20.322
Cficomplement component factor i0.321
Cdkn1bcyclin-dependent kinase inhibitor 1B0.318
Fgfr1fibroblast growth factor receptor 10.316
Igf1insulin-like growth factor 10.315
Egfrepidermal growth factor receptor0.313
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.311
Nf1neurofibromatosis 10.309
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.303
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.297
Dkk1dickkopf homolog 1 (Xenopus laevis)0.294
Apomapolipoprotein M0.286
Ifi203interferon activated gene 2030.284
Foxc1forkhead box C10.282
Ltblymphotoxin B0.277
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.274
Gsk3bglycogen synthase kinase 3 beta0.273
Krt5keratin 50.268
Mndamyeloid cell nuclear differentiation antigen0.263
Plcg2phospholipase C, gamma 20.258
Ccl2chemokine (C-C motif) ligand 20.257
Il6interleukin 60.253
Tgfatransforming growth factor alpha0.252
Apoc4apolipoprotein C-IV0.252
Lyz2lysozyme 20.248
F2coagulation factor II0.247
Rarbretinoic acid receptor, beta0.246
Akr1c6aldo-keto reductase family 1, member C60.242
Dnm1dynamin 10.239
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.238
Lhx1LIM homeobox protein 10.233
Esr1estrogen receptor 1 (alpha)0.228
F9coagulation factor IX0.227
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.224
Ctskcathepsin K0.222
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.222
FasFas (TNF receptor superfamily member 6)0.221
Htra3HtrA serine peptidase 30.220
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.216
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.214
Dusp1dual specificity phosphatase 10.208
Lifleukemia inhibitory factor0.205
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.204
C1racomplement component 1, r subcomponent A0.203
Emx2empty spiracles homolog 2 (Drosophila)0.202
Apobapolipoprotein B0.201
Serpina3mserine (or cysteine) peptidase inhibitor, clade A, member 3M0.197
Nrp1neuropilin 10.193
Wnt3awingless-related MMTV integration site 3A0.193
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa2annexin A20.038
S100a10S100 calcium binding protein A100.036
Lgals3lectin, galactoside-binding, soluble, 30.027
S100a6S100 calcium binding protein A60.024
Procprotein C0.018
Fgafibrinogen alpha chain0.018
Taok1TAO kinase 10.018
Cd63Cd63 molecule0.017
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.017
Arpc1bactin related protein 2/3 complex, subunit 1B0.016
Cd9CD9 molecule0.016
F2coagulation factor II (thrombin)0.016
Anxa1annexin A10.015
Anxa5annexin A50.015
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.015
S100a4S100 calcium-binding protein A40.014
Ptgs2prostaglandin-endoperoxide synthase 20.014
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.014
Spink3serine peptidase inhibitor, Kazal type 30.014
Serpinf2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.014
Pea15aphosphoprotein enriched in astrocytes 15A0.013
Tmsb4xthymosin beta 4, X-linked0.013
Mbl1mannose-binding lectin (protein A) 10.013
Serpina4serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 40.013
Kng2kininogen 20.013
Pfn1profilin 10.013
Spp2secreted phosphoprotein 20.013
Syngr2synaptogyrin 20.013
Itih4inter alpha-trypsin inhibitor, heavy chain 40.013
Tdo2tryptophan 2,3-dioxygenase0.012
Spink1serine peptidase inhibitor, Kazal type 10.012
Rarres2retinoic acid receptor responder (tazarotene induced) 20.012
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.012
Nr4a3nuclear receptor subfamily 4, group A, member 30.012
Pthparathyroid hormone0.012
C4bpbcomplement component 4 binding protein, beta0.012
Baatbile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)0.012
Asgr1asialoglycoprotein receptor 10.012
Tuba1ctubulin, alpha 1C0.012
Itgb1integrin, beta 10.012
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.012
C4bpacomplement component 4 binding protein, alpha0.011
Apcsamyloid P component, serum0.011
Rhoaras homolog gene family, member A0.011
Apohapolipoprotein H (beta-2-glycoprotein I)0.011
Fggfibrinogen gamma chain0.011
Apoa2apolipoprotein A-II0.011
Rhocras homolog gene family, member C0.011
Tpm2tropomyosin 2, beta0.011
Gna12guanine nucleotide binding protein (G protein) alpha 120.011
Fgfr2fibroblast growth factor receptor 20.011
A1i3alpha-1-inhibitor III0.011
Mpripmyosin phosphatase Rho interacting protein0.011
Sh3bgrl3SH3 domain binding glutamic acid-rich protein-like 30.011
Apoa5apolipoprotein A-V0.011
Ddr1discoidin domain receptor tyrosine kinase 10.011
Ifitm2interferon induced transmembrane protein 20.011
Gstp1glutathione S-transferase pi 10.011
Map3k3mitogen activated protein kinase kinase kinase 30.011
Fabp1fatty acid binding protein 1, liver0.011
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.011
Actg1actin, gamma 10.011
Myl6lmyosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like0.011
Pftk1PFTAIRE protein kinase 10.011
Esr1estrogen receptor 10.010
Ifitm3interferon induced transmembrane protein 30.010
Cd99CD99 antigen0.010
Usf2upstream transcription factor 2, c-fos interacting0.010
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.010
C1qccomplement component 1, q subcomponent, C chain0.010
S100a11S100 calcium binding protein A11 (calizzarin)0.010
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.010
Myl9myosin, light chain 9, regulatory0.010
Clic1chloride intracellular channel 10.010
Tpm3tropomyosin 3, gamma0.010
Prdx1peroxiredoxin 10.010
Ambpalpha-1-microglobulin/bikunin precursor0.010
Cfl1cofilin 1, non-muscle0.010
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism