The network for 'regulation of t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of t cell activation

Any process that modulates the frequency, rate or extent of T cell activation.

NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.996
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.995
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.952
PTPN1protein tyrosine phosphatase, non-receptor type 10.922
HLA-Bmajor histocompatibility complex, class I, B0.917
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.914
HLA-Cmajor histocompatibility complex, class I, C0.904
B2Mbeta-2-microglobulin0.885
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.883
SYKspleen tyrosine kinase0.877
HLA-Fmajor histocompatibility complex, class I, F0.867
HLA-Amajor histocompatibility complex, class I, A0.864
CD2CD2 molecule0.852
CD247CD247 molecule0.847
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.846
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.830
HLA-Gmajor histocompatibility complex, class I, G0.800
CD6CD6 molecule0.797
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.795
CD86CD86 molecule0.779
CCR7chemokine (C-C motif) receptor 70.776
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.776
SHC1SHC (Src homology 2 domain containing) transforming protein 10.723
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.715
EGFRepidermal growth factor receptor0.707
BTN3A1butyrophilin, subfamily 3, member A10.702
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.689
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.687
HLA-Emajor histocompatibility complex, class I, E0.685
CCL22chemokine (C-C motif) ligand 220.642
BTN3A3butyrophilin, subfamily 3, member A30.636
HLA-DMBmajor histocompatibility complex, class II, DM beta0.635
CCR5chemokine (C-C motif) receptor 50.633
CD80CD80 molecule0.630
TRAF1TNF receptor-associated factor 10.629
BTN3A2butyrophilin, subfamily 3, member A20.622
CXCL10chemokine (C-X-C motif) ligand 100.619
IL2RBinterleukin 2 receptor, beta0.599
BCL10B-cell CLL/lymphoma 100.597
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.589
IL1R1interleukin 1 receptor, type I0.585
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.558
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.557
LTAlymphotoxin alpha (TNF superfamily, member 1)0.540
CASP8caspase 8, apoptosis-related cysteine peptidase0.528
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.507
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.502
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.494
SIGLEC7sialic acid binding Ig-like lectin 70.490
JAK2Janus kinase 20.468
LATlinker for activation of T cells0.447
ICAM1intercellular adhesion molecule 10.406
HLA-DRB5major histocompatibility complex, class II, DR beta 50.388
CXCL9chemokine (C-X-C motif) ligand 90.388
CTLA4cytotoxic T-lymphocyte-associated protein 40.386
SH2D1ASH2 domain containing 1A0.371
IL16interleukin 16 (lymphocyte chemoattractant factor)0.370
HK3hexokinase 3 (white cell)0.360
FCN1ficolin (collagen/fibrinogen domain containing) 10.356
NCOR2nuclear receptor corepressor 20.353
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.352
BMPR1Abone morphogenetic protein receptor, type IA0.347
PTPRCprotein tyrosine phosphatase, receptor type, C0.343
SLAMF1signaling lymphocytic activation molecule family member 10.342
CSKc-src tyrosine kinase0.338
CCL4chemokine (C-C motif) ligand 40.334
CAV1caveolin 1, caveolae protein, 22kDa0.326
TFF1trefoil factor 10.325
CCL5chemokine (C-C motif) ligand 50.324
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.319
NLRC4NLR family, CARD domain containing 40.300
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.299
BIRC3baculoviral IAP repeat containing 30.293
PRKCQprotein kinase C, theta0.289
CD52CD52 molecule0.285
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.277
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.274
SOCS3suppressor of cytokine signaling 30.273
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.272
IL10RAinterleukin 10 receptor, alpha0.270
HCKhemopoietic cell kinase0.270
IL2RGinterleukin 2 receptor, gamma0.261
CLEC10AC-type lectin domain family 10, member A0.259
CASP9caspase 9, apoptosis-related cysteine peptidase0.250
NLRP3NLR family, pyrin domain containing 30.250
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.249
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.245
BBS10Bardet-Biedl syndrome 100.245
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.242
LAIR1leukocyte-associated immunoglobulin-like receptor 10.235
SASH3SAM and SH3 domain containing 30.234
MEFVMediterranean fever0.230
TRAF3IP3TRAF3 interacting protein 30.229
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.224
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.223
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.222
CCL2chemokine (C-C motif) ligand 20.222
FSTL1follistatin-like 10.219
GHRgrowth hormone receptor0.215
IRF4interferon regulatory factor 40.214
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.995
Cd40CD40 antigen0.994
Tnftumor necrosis factor0.992
Ptpn11protein tyrosine phosphatase, non-receptor type 110.989
Cd28CD28 antigen0.987
FasFas (TNF receptor superfamily member 6)0.984
Icosinducible T-cell co-stimulator0.979
Stat3signal transducer and activator of transcription 30.968
Ltalymphotoxin A0.965
Jak2Janus kinase 20.959
Ifnginterferon gamma0.951
Egfrepidermal growth factor receptor0.950
Rargretinoic acid receptor, gamma0.938
Batfbasic leucine zipper transcription factor, ATF-like0.937
Casp4caspase 4, apoptosis-related cysteine peptidase0.933
Tnfaip3tumor necrosis factor, alpha-induced protein 30.929
Stat5asignal transducer and activator of transcription 5A0.920
Lyz2lysozyme 20.911
CblCasitas B-lineage lymphoma0.900
Foxp3forkhead box P30.893
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.885
Ikzf1IKAROS family zinc finger 10.881
Rnf2ring finger protein 20.874
Il2rbinterleukin 2 receptor, beta chain0.871
H2-Aahistocompatibility 2, class II antigen A, alpha0.864
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.856
Stat1signal transducer and activator of transcription 10.851
Stat5bsignal transducer and activator of transcription 5B0.848
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.846
Il1binterleukin 1 beta0.844
Map3k14mitogen-activated protein kinase kinase kinase 140.844
Il6stinterleukin 6 signal transducer0.829
Cishcytokine inducible SH2-containing protein0.828
H2-Ab1histocompatibility 2, class II antigen A, beta 10.826
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.821
Il1r1interleukin 1 receptor, type I0.819
Traf6TNF receptor-associated factor 60.818
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.816
Grb2growth factor receptor bound protein 20.815
Rxraretinoid X receptor alpha0.812
ItkIL2-inducible T-cell kinase0.791
Smad4MAD homolog 4 (Drosophila)0.786
RybpRING1 and YY1 binding protein0.784
Socs1suppressor of cytokine signaling 10.783
Csf1colony stimulating factor 1 (macrophage)0.782
Jak1Janus kinase 10.780
Sfpi1SFFV proviral integration 10.770
Tnfrsf18tumor necrosis factor receptor superfamily, member 180.762
Ltblymphotoxin B0.758
BtkBruton agammaglobulinemia tyrosine kinase0.758
Ubdubiquitin D0.753
Ighimmunoglobulin heavy chain complex0.752
Bcl3B-cell leukemia/lymphoma 30.750
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.749
Cd80CD80 antigen0.747
Cd86CD86 antigen0.744
Tbx21T-box 210.732
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.719
Lcklymphocyte protein tyrosine kinase0.713
Ccr7chemokine (C-C motif) receptor 70.709
Ciitaclass II transactivator0.702
Itgaxintegrin alpha X0.699
Il27rainterleukin 27 receptor, alpha0.699
Ntf3neurotrophin 30.693
Igf1rinsulin-like growth factor I receptor0.681
Nlrp3NLR family, pyrin domain containing 30.679
Nf1neurofibromatosis 10.674
Prf1perforin 1 (pore forming protein)0.672
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.665
Inpp5dinositol polyphosphate-5-phosphatase D0.657
Cd4CD4 antigen0.655
Ccr6chemokine (C-C motif) receptor 60.655
Zap70zeta-chain (TCR) associated protein kinase0.654
Pdcd1programmed cell death 10.638
FynFyn proto-oncogene0.633
Itgb2integrin beta 20.625
Klrg1killer cell lectin-like receptor subfamily G, member 10.624
Ctnnb1catenin (cadherin associated protein), beta 10.614
Runx1runt related transcription factor 10.610
Sox2SRY-box containing gene 20.607
Klrd1killer cell lectin-like receptor, subfamily D, member 10.607
Myd88myeloid differentiation primary response gene 880.604
Cxcr5chemokine (C-X-C motif) receptor 50.604
H2-DMb2histocompatibility 2, class II, locus Mb20.603
Adam17a disintegrin and metallopeptidase domain 170.602
Cxcl13chemokine (C-X-C motif) ligand 130.593
Dok1docking protein 10.592
Hhexhematopoietically expressed homeobox0.592
Ccl2chemokine (C-C motif) ligand 20.591
Ccr2chemokine (C-C motif) receptor 20.587
Cd44CD44 antigen0.587
Ifnb1interferon beta 1, fibroblast0.586
Zeb1zinc finger E-box binding homeobox 10.581
Ccr5chemokine (C-C motif) receptor 50.578
Pou2af1POU domain, class 2, associating factor 10.573
Ccr1chemokine (C-C motif) receptor 10.567
Il7interleukin 70.564
Birc3baculoviral IAP repeat-containing 30.563
Hspa9heat shock protein 90.547
Rac1RAS-related C3 botulinum substrate 10.547
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.910
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.873
RT1-BbRT1 class II, locus Bb0.846
RT1-BaRT1 class II, locus Ba0.743
RT1-DMbRT1 class II, locus DMb0.709
Cd37CD37 molecule0.486
RT1-Db1RT1 class II, locus Db10.431
Cd247Cd247 molecule0.226
Spnsialophorin0.168
Cd5Cd5 molecule0.117
Il2rbinterleukin 2 receptor, beta0.106
Anxa2annexin A20.088
Cd2Cd2 molecule0.069
Ptprcprotein tyrosine phosphatase, receptor type, C0.067
RT1-DMaRT1 class II, locus DMa0.066
Il1binterleukin 1 beta0.064
Cd53Cd53 molecule0.062
Laptm5lysosomal protein transmembrane 50.061
Lyz2lysozyme 20.056
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.055
TcrbT-cell receptor beta chain0.054
Gzmkgranzyme K0.051
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.047
Ciitaclass II, major histocompatibility complex, transactivator0.046
Casp1caspase 10.045
Aif1allograft inflammatory factor 10.042
Cd3gCD3 molecule, gamma0.040
Ctsscathepsin S0.037
Sellselectin L0.034
Igh-6immunoglobulin heavy chain 60.031
NrarpNotch-regulated ankyrin repeat protein0.030
Il17rainterleukin 17 receptor A0.030
Cd44Cd44 molecule0.029
Fgfr2fibroblast growth factor receptor 20.028
Nkg7natural killer cell group 7 sequence0.028
Slfn2schlafen 20.027
Iappislet amyloid polypeptide0.027
C1qbcomplement component 1, q subcomponent, B chain0.026
Itgb7integrin, beta 70.026
Cxcr4chemokine (C-X-C motif) receptor 40.024
Bmp7bone morphogenetic protein 70.024
Il6interleukin 60.024
Hckhemopoietic cell kinase0.024
Efhd2EF-hand domain family, member D20.022
Cd83CD83 molecule0.021
Arhgap4Rho GTPase activating protein 40.021
Vom2r31vomeronasal 2 receptor, 310.021
RT1-A3RT1 class I, locus A30.020
Ptprqprotein tyrosine phosphatase, receptor type, Q0.020
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.019
Icosinducible T-cell co-stimulator0.019
MGC112715hypothetical protein LOC6908990.019
Arrb2arrestin, beta 20.019
Laptm4alysosomal protein transmembrane 4 alpha0.019
Ece1endothelin converting enzyme 10.019
Stat6signal transducer and activator of transcription 60.018
Bin2bridging integrator 20.018
Icam1intercellular adhesion molecule 10.018
Clec10aC-type lectin domain family 10, member A0.018
Mylk2myosin light chain kinase 20.018
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.017
Ctla4cytotoxic T-lymphocyte-associated protein 40.017
Calcrlcalcitonin receptor-like0.017
Hcsthematopoietic cell signal transducer0.017
Fgbfibrinogen beta chain0.017
Socs3suppressor of cytokine signaling 30.017
Cd38CD38 molecule0.017
Latlinker for activation of T cells0.016
Map3k3mitogen activated protein kinase kinase kinase 30.016
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.016
Klra22killer cell lectin-like receptor subfamily A, member 220.016
Ccr5chemokine (C-C motif) receptor 50.016
Hbp1HMG-box transcription factor 10.016
Sqstm1sequestosome 10.016
Il7rinterleukin 7 receptor0.015
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.015
Xcl1chemokine (C motif) ligand 10.015
Ccl5chemokine (C-C motif) ligand 50.015
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.015
Alox5aparachidonate 5-lipoxygenase activating protein0.015
Ptger4prostaglandin E receptor 4 (subtype EP4)0.015
Jak1Janus kinase 10.015
Cd3dCD3 molecule, delta0.014
Fmnl1formin-like 10.014
Zap70zeta-chain (TCR) associated protein kinase0.014
Leprleptin receptor0.014
Gimap4GTPase, IMAP family member 40.014
Nek9NIMA (never in mitosis gene a)- related kinase 90.014
Cd200r1CD200 receptor 10.014
Jak2Janus kinase 20.013
Cd8aCD8a molecule0.013
Ncr1natural cytotoxicity triggering receptor 10.013
Gpr176G protein-coupled receptor 1760.013
Cd3eCD3 molecule, epsilon0.013
Add2adducin 2 (beta)0.013
Prrx1paired related homeobox 10.013
Cxcl3chemokine (C-X-C motif) ligand 30.012
Fgfr1Fibroblast growth factor receptor 10.012
Klrk1killer cell lectin-like receptor subfamily K, member 10.012
Dnase1l3deoxyribonuclease 1-like 30.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism