The network for 'tube morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tube morphogenesis

The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
ESR1estrogen receptor 11.000
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
FLNAfilamin A, alpha1.000
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.999
FN1fibronectin 10.999
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.999
EGFRepidermal growth factor receptor0.998
YAP1Yes-associated protein 10.996
FGFR2fibroblast growth factor receptor 20.993
SMAD3SMAD family member 30.993
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.993
RB1retinoblastoma 10.990
SMAD2SMAD family member 20.990
MDM2Mdm2 p53 binding protein homolog (mouse)0.986
SP1Sp1 transcription factor0.986
APCadenomatous polyposis coli0.984
COL1A1collagen, type I, alpha 10.982
JAG1jagged 10.978
TP53tumor protein p530.977
GSK3Bglycogen synthase kinase 3 beta0.977
SMAD4SMAD family member 40.976
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.974
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.964
CREBBPCREB binding protein0.963
NOTCH1notch 10.960
RBBP4retinoblastoma binding protein 40.954
EP300E1A binding protein p3000.939
FGFR1fibroblast growth factor receptor 10.934
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.934
PRKCZprotein kinase C, zeta0.933
SMAD7SMAD family member 70.913
UBCubiquitin C0.903
THBS1thrombospondin 10.903
COL5A1collagen, type V, alpha 10.888
JUNjun proto-oncogene0.886
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.872
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.872
VEGFAvascular endothelial growth factor A0.868
RUNX1runt-related transcription factor 10.867
NR4A1nuclear receptor subfamily 4, group A, member 10.863
SIN3ASIN3 homolog A, transcription regulator (yeast)0.863
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.843
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.843
LAMC1laminin, gamma 1 (formerly LAMB2)0.833
CFL1cofilin 1 (non-muscle)0.829
COL4A2collagen, type IV, alpha 20.828
COL1A2collagen, type I, alpha 20.821
ERBB2IPerbb2 interacting protein0.804
BCL6B-cell CLL/lymphoma 60.799
COL6A1collagen, type VI, alpha 10.790
IQGAP1IQ motif containing GTPase activating protein 10.789
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.789
ITGB4integrin, beta 40.758
METmet proto-oncogene (hepatocyte growth factor receptor)0.755
PBX1pre-B-cell leukemia homeobox 10.752
CTGFconnective tissue growth factor0.737
TSC2tuberous sclerosis 20.735
TP63tumor protein p630.734
POU3F2POU class 3 homeobox 20.733
IL1R1interleukin 1 receptor, type I0.729
DDR2discoidin domain receptor tyrosine kinase 20.727
NCOR1nuclear receptor corepressor 10.721
HDAC1histone deacetylase 10.709
COL2A1collagen, type II, alpha 10.705
GATA4GATA binding protein 40.698
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.681
C1QAcomplement component 1, q subcomponent, A chain0.678
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.677
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.672
CASP3caspase 3, apoptosis-related cysteine peptidase0.671
HOXA10homeobox A100.670
STK4serine/threonine kinase 40.667
SORBS3sorbin and SH3 domain containing 30.663
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.656
EGR1early growth response 10.656
RXRAretinoid X receptor, alpha0.650
PTPN1protein tyrosine phosphatase, non-receptor type 10.639
FHL2four and a half LIM domains 20.637
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.637
LAMB1laminin, beta 10.633
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.631
ZNF512Bzinc finger protein 512B0.629
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.624
SFNstratifin0.623
XIAPX-linked inhibitor of apoptosis0.609
FOXD3forkhead box D30.601
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.598
TGFB2transforming growth factor, beta 20.596
TIMP3TIMP metallopeptidase inhibitor 30.595
MEIS1Meis homeobox 10.594
WNK4WNK lysine deficient protein kinase 40.593
CAV1caveolin 1, caveolae protein, 22kDa0.592
FOXF2forkhead box F20.588
PRKCIprotein kinase C, iota0.584
MAPK1mitogen-activated protein kinase 10.578
MYOD1myogenic differentiation 10.570
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.570
SOCS1suppressor of cytokine signaling 10.554
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.553
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.947
pha-4Protein PHA-40.940
atn-1Protein ATN-10.935
pop-1Protein POP-10.849
elt-6Protein ELT-60.832
cam-1Protein CAM-10.824
act-4Protein ACT-40.811
egl-46Protein EGL-460.808
bar-1Protein BAR-10.802
hlh-2Protein HLH-20.787
egl-15Protein EGL-150.762
eya-1Protein EYA-10.741
lin-36Protein LIN-360.730
hlh-1Protein HLH-10.724
mig-6Protein MIG-60.668
lin-12Protein LIN-120.665
egl-27Protein EGL-270.647
zip-7Protein ZIP-70.645
hmg-1.2Protein HMG-1.20.627
unc-62Protein UNC-620.616
epi-1Protein EPI-10.608
glp-1Protein GLP-10.589
nhr-67Protein NHR-670.535
lin-25Protein LIN-250.521
fkh-2Protein FKH-20.506
emb-9Protein EMB-90.505
hbl-1Protein HBL-10.442
ten-1Protein TEN-10.441
vab-1Protein VAB-10.397
trim-9Protein TRIM-90.390
unc-6Protein UNC-60.389
mls-2Protein MLS-20.354
xpo-1Protein XPO-10.351
mab-5Protein MAB-50.350
mep-1Protein MEP-10.338
egl-13Protein EGL-130.335
flt-1Protein FLT-10.332
odd-2Protein ODD-20.321
unc-98Protein UNC-980.316
lag-1Protein LAG-10.307
sem-5Protein SEM-50.305
osm-5Protein OSM-50.305
F39B2.1Protein F39B2.10.289
che-13Protein CHE-130.269
sdn-1Protein SDN-10.265
syd-2Protein SYD-20.263
rig-6Protein RIG-60.260
lin-17Protein LIN-170.257
madf-5Protein MADF-50.252
myo-3Protein MYO-30.246
hnd-1Protein HND-10.245
prp-8Protein PRP-80.244
hda-1Protein HDA-10.237
ceh-27Protein CEH-270.230
lin-40Protein LIN-400.228
kal-1Protein KAL-10.227
crt-1Protein CRT-10.225
flh-1Protein FLH-10.225
sma-9Protein SMA-90.220
hsp-3Protein HSP-30.220
mig-5Protein MIG-50.217
unc-52Protein UNC-520.215
patr-1Protein PATR-10.212
apb-1Protein APB-10.211
unc-73Protein UNC-730.207
dre-1Protein DRE-10.203
pat-3Protein PAT-30.201
fbxc-32Protein FBXC-320.199
Y82E9BR.13Protein Y82E9BR.130.194
fln-2Protein FLN-20.189
unc-53Protein UNC-530.184
elt-2Protein ELT-20.181
tbx-9Protein TBX-90.176
daf-12Protein DAF-120.175
flh-2Protein FLH-20.173
ztf-2Protein ZTF-20.173
unc-130Protein UNC-1300.172
let-2Protein LET-20.170
C14F11.2Protein C14F11.20.168
let-60Protein LET-600.165
lin-29Protein LIN-290.161
F44B9.2Protein F44B9.20.161
eat-18Protein EAT-180.161
spc-1Protein SPC-10.159
zfp-1Protein ZFP-10.155
ceh-20Protein CEH-200.154
syd-9Protein SYD-90.151
vab-3Protein VAB-30.151
T28F4.1Protein T28F4.10.149
igcm-3Protein IGCM-30.147
bre-1Protein BRE-10.145
ajm-1Protein AJM-10.144
mnp-1Protein MNP-10.144
pes-1Protein PES-10.144
pry-1Protein PRY-10.140
CELE_F54D5.5Protein F54D5.50.140
eif-3.BProtein EIF-3.B0.140
pac-1Protein PAC-10.139
psa-3Protein PSA-30.137
F36D4.5Protein F36D4.50.137
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin1.000
kdrlkinase insert domain receptor like1.000
tbx1T-box 10.998
shhasonic hedgehog a0.996
hnf1baHNF1 homeobox Ba0.995
fgf3fibroblast growth factor 30.988
crabp2acellular retinoic acid binding protein 2, a0.986
tal1T-cell acute lymphocytic leukemia 10.984
cdh1cadherin 1, epithelial0.984
gscgoosecoid0.984
gro1groucho 10.983
lft1lefty10.980
ntlano tail a0.978
fzd7bfrizzled homolog 7b0.977
ndr2nodal-related 20.974
fgf10afibroblast growth factor 10a0.969
sox32SRY-box containing gene 320.968
epha4aeph receptor A4a0.965
pax2apaired box gene 2a0.964
snai1asnail homolog 1a (Drosophila)0.961
alcambactivated leukocyte cell adhesion molecule b0.961
egr2bearly growth response 2b0.960
tll1tolloid-like 10.959
spns2spinster homolog 2 (Drosophila)0.957
wt1bwilms tumor 1b0.953
twist3twist30.952
ttnatitin a0.951
aldh1a2aldehyde dehydrogenase 1 family, member A20.951
wnt11rwingless-type MMTV integration site family, member 11, related0.951
wnt11wingless-type MMTV integration site family, member 110.951
tbx20T-box 200.949
gata3GATA-binding protein 30.947
dusp6dual specificity phosphatase 60.947
tp53tumor protein p530.946
six4bsine oculis homeobox homolog 4b0.942
sox19aSRY-box containing gene 19a0.942
yrkYes-related kinase0.938
lrrc6leucine rich repeat containing 60.935
lft2lefty20.932
eya1eyes absent homolog 10.931
hhiphedgehog interacting protein0.927
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.920
itgavintegrin, alpha V0.919
sema3aasemaphorin 3aa0.917
mecomMDS1 and EVI1 complex locus0.914
pou3f3bPOU class 3 homeobox 3b0.912
bmp2abone morphogenetic protein 2a0.909
hoxa2bhomeo box A2b0.908
fezf2FEZ family zinc finger 20.905
ptgs2aprostaglandin-endoperoxide synthase 2a0.903
voxventral homeobox0.902
sulf1sulfatase 10.900
lfnglunatic fringe homolog0.898
sox2SRY-box containing gene 20.895
dccdeleted in colorectal carcinoma0.895
nkx2.5NK2 transcription factor related 50.892
ptgs1prostaglandin-endoperoxide synthase 10.891
tbx16T-box gene 160.890
rfx2regulatory factor X, 2 (influences HLA class II expression)0.889
meis2.1myeloid ecotropic viral integration site 2.10.888
coblcordon-bleu homolog (mouse)0.888
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.883
notch3notch homolog 30.881
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.881
bmpr1aabone morphogenetic protein receptor, type 1aa0.880
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.875
gbx2gastrulation brain homeo box 20.873
pcdh8protocadherin 80.868
gli2aGLI-Kruppel family member GLI2a0.864
fgf4fibroblast growth factor 40.864
bmp4bone morphogenetic protein 40.862
cdh2cadherin 2, neuronal0.860
nrarpanotch-regulated ankyrin repeat protein a0.858
sim1asingle-minded homolog 1a (Drosophila)0.858
ift88intraflagellar transport 88 homolog0.855
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.855
wnt4awingless-type MMTV integration site family, member 4a0.851
drldraculin0.846
foxi1forkhead box I10.845
fgfr4fibroblast growth factor receptor 40.842
pcdh18bprotocadherin 18b0.841
plcg1phospholipase C, gamma 10.841
mibmind bomb0.840
flhfloating head0.839
atp1b2bATPase, Na+/K+ transporting, beta 2b polypeptide0.836
eomesaeomesodermin homolog a0.835
ventventral expressed homeobox0.833
hey2hairy/enhancer-of-split related with YRPW motif 20.827
tbx18T-box 180.827
pax3apaired box gene 3a0.825
oepone-eyed pinhead0.824
cdoncell adhesion molecule-related/down-regulated by oncogenes0.823
cc2d2acoiled-coil and C2 domain containing 2A0.816
jag2jagged 20.812
lmx1b.1LIM homeobox transcription factor 1, beta 10.810
wnt3wingless-type MMTV integration site family, member 30.807
smad5MAD homolog 5 (Drosophila)0.806
gata2aGATA-binding protein 2a0.804
tbx6T-box gene 60.799
rarabretinoic acid receptor, alpha b0.792
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
wgwingless1.000
shnschnurri1.000
mewmultiple edematous wings1.000
armarmadillo0.999
cicubitus interruptus0.999
bazbazooka0.998
ttvtout-velu0.996
EgfrEpidermal growth factor receptor0.996
tkvthickveins0.996
shgshotgun0.995
E(spl)Enhancer of split0.994
msnmisshapen0.991
fz2frizzled 20.990
cswcorkscrew0.990
MadMothers against dpp0.990
CycACyclin A0.988
Ras85DRas oncogene at 85D0.987
tgotango0.987
Rho1CG8416 gene product from transcript CG8416-RB0.986
saxsaxophone0.986
atoatonal0.983
btlbreathless0.982
crbcrumbs0.980
pntpointed0.977
hephemipterous0.974
smosmoothened0.973
Rac1CG2248 gene product from transcript CG2248-RA0.969
edechinoid0.966
LanB2Laminin B20.961
pydpolychaetoid0.956
stumpsCG31317 gene product from transcript CG31317-RC0.954
Src42ASrc oncogene at 42A0.947
argosCG4531 gene product from transcript CG4531-RA0.934
coracoracle0.933
emcextra macrochaetae0.930
DadDaughters against dpp0.927
HLHm7E(spl) region transcript m70.926
jingCG9397 gene product from transcript CG9397-RI0.924
snasnail0.923
slp1sloppy paired 10.922
MrtfMyocardin-related transcription factor0.917
panpangolin0.915
slmbsupernumerary limbs0.911
nmonemo0.908
mysmyospheroid0.905
Nrx-IVNeurexin IV0.904
l(2)gllethal (2) giant larvae0.902
ribribbon0.898
ftz-f1ftz transcription factor 10.896
cnocanoe0.895
hkbhuckebein0.892
wtswarts0.883
Syx1ASyntaxin 1A0.882
bibbig brain0.876
rawCG12437 gene product from transcript CG12437-RB0.872
nejnejire0.868
kniknirps0.864
zipzipper0.855
bskbasket0.848
Akt1CG4006 gene product from transcript CG4006-RA0.848
SosSon of sevenless0.845
esgescargot0.838
rstroughest0.836
twitwist0.830
linlines0.830
RalaRas-related protein0.827
dshdishevelled0.827
rlrolled0.824
salmspalt major0.818
McrMacroglobulin complement-related0.817
dmdiminutive0.814
htlheartless0.810
aPKCatypical protein kinase C0.805
PknProtein kinase related to protein kinase N0.803
uspultraspiracle0.799
tintinman0.798
trctricornered0.789
Rab5Rab-protein 50.783
gsbgooseberry0.783
frcfringe connection0.782
Pp2B-14DProtein phosphatase 2B at 14D0.781
LanB1CG7123 gene product from transcript CG7123-RA0.778
sdscalloped0.777
klarklarsicht0.771
GugGrunge0.770
ifinflated0.767
babobaboon0.761
Traf4TNF-receptor-associated factor 40.757
HLHmdeltaE(spl) region transcript mdelta0.739
Nsf2NEM-sensitive fusion protein 20.738
vvlventral veins lacking0.733
ptcpatched0.733
sflsulfateless0.728
snssticks and stones0.725
wbwing blister0.721
CycECyclin E0.717
drprdraper0.711
ftfat0.709
CatsupCatecholamines up0.706
LanALaminin A0.705
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dchs1dachsous 1 (Drosophila)0.196
Pfn1profilin 10.168
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.146
Sirpasignal-regulatory protein alpha0.142
Bcl2B-cell CLL/lymphoma 20.129
Fgfr1Fibroblast growth factor receptor 10.117
Tgfbr2transforming growth factor, beta receptor II0.080
Lamc1laminin, gamma 10.078
Calcrlcalcitonin receptor-like0.066
Gna12guanine nucleotide binding protein (G protein) alpha 120.064
Acta2smooth muscle alpha-actin0.064
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.063
Nek9NIMA (never in mitosis gene a)- related kinase 90.062
Tgfbr3transforming growth factor, beta receptor III0.061
Tnctenascin C0.060
Itpr2inositol 1,4,5-triphosphate receptor, type 20.060
Fstl1follistatin-like 10.051
Smad7SMAD family member 70.047
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.046
Bgnbiglycan0.046
Vcanversican0.046
Akap1A kinase (PRKA) anchor protein 10.046
Arntaryl hydrocarbon receptor nuclear translocator0.046
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.044
S1pr2sphingosine-1-phosphate receptor 20.044
Sox17SRY (sex determining region Y)-box 170.044
Unc5bunc-5 homolog B (C. elegans)0.043
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.040
Dmddystrophin0.039
Stxbp2syntaxin binding protein 20.038
Stat5bsignal transducer and activator of transcription 5B0.037
Twist2twist homolog 2 (Drosophila)0.036
Foxd3forkhead box D30.036
Mapk9mitogen-activated protein kinase 90.036
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.033
Ebf1early B-cell factor 10.033
RGD1564327similar to integrin alpha 80.032
Gja5gap junction protein, alpha 50.032
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.031
Acvr1activin A receptor, type I0.030
Fgfr2fibroblast growth factor receptor 20.030
Myo9amyosin IXA0.029
Shc2SHC (Src homology 2 domain containing) transforming protein 20.029
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.029
Loxl1lysyl oxidase-like 10.029
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.028
Dab2disabled homolog 2 (Drosophila)0.028
Ptger4prostaglandin E receptor 4 (subtype EP4)0.027
Fn1fibronectin 10.027
Lig3ligase III, DNA, ATP-dependent0.026
Ptpn12protein tyrosine phosphatase, non-receptor type 120.025
Sardhsarcosine dehydrogenase0.025
Muc1mucin 1, cell surface associated0.025
Igfbp3insulin-like growth factor binding protein 30.025
Reg3aregenerating islet-derived 3 alpha0.025
Rps6ka1ribosomal protein S6 kinase polypeptide 10.024
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.024
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.024
Col12a1collagen, type XII, alpha 10.024
Znf598zinc finger protein 5980.024
Glra1glycine receptor, alpha 10.024
Nppcnatriuretic peptide precursor C0.023
Jak1Janus kinase 10.023
Prrx1paired related homeobox 10.023
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.023
Gpc1glypican 10.023
Creb1cAMP responsive element binding protein 10.023
Hoxb7homeo box B70.023
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.022
Myo1bmyosin Ib0.022
LOC286992peptide HP (rs14)0.022
Enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.022
Aif1lallograft inflammatory factor 1-like0.022
Capn6calpain 60.022
Postnperiostin, osteoblast specific factor0.022
Nrp2neuropilin 20.022
Sh2b1SH2B adaptor protein 10.021
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.021
Slc20a2solute carrier family 20 (phosphate transporter), member 20.021
Adam17ADAM metallopeptidase domain 170.021
Tgfb3transforming growth factor, beta 30.021
Il1r1interleukin 1 receptor, type I0.021
Ednrbendothelin receptor type B0.020
Vegfavascular endothelial growth factor A0.020
Clec9aC-type lectin domain family 9, member a0.020
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.020
Cyth3cytohesin 30.020
Avpr2arginine vasopressin receptor 20.019
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.019
Emp1epithelial membrane protein 10.019
Itpr3inositol 1,4,5-triphosphate receptor, type 30.019
Esr1estrogen receptor 10.019
LOC246267resection-induced TPI (rs11)0.019
Edn1endothelin 10.019
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.019
Plagl1pleiomorphic adenoma gene-like 10.019
Vimvimentin0.019
Itgb1integrin, beta 10.019
Add3adducin 3 (gamma)0.019
P2ry12purinergic receptor P2Y, G-protein coupled, 120.019
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism