The network for 'melanocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

melanocyte differentiation

The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.

NameDescriptionProbabilityFunc Analog Organism
HDAC2histone deacetylase 20.734
BCL2L1BCL2-like 10.643
EP300E1A binding protein p3000.527
RAB27ARAB27A, member RAS oncogene family0.331
POU5F1POU class 5 homeobox 10.325
PAX3paired box 30.316
POU3F2POU class 3 homeobox 20.136
YY1YY1 transcription factor0.134
ESR1estrogen receptor 10.120
FLNBfilamin B, beta0.117
APH1Aanterior pharynx defective 1 homolog A (C. elegans)0.106
BLOC1S1biogenesis of lysosomal organelles complex-1, subunit 10.102
SIN3ASIN3 homolog A, transcription regulator (yeast)0.099
SMAD4SMAD family member 40.093
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.081
KITLGKIT ligand0.079
BAZ2Bbromodomain adjacent to zinc finger domain, 2B0.076
ARRB1arrestin, beta 10.067
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.065
DTNBP1dystrobrevin binding protein 10.064
SF3B14splicing factor 3B, 14 kDa subunit0.056
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.053
MUTEDmuted homolog (mouse)0.052
MTA3metastasis associated 1 family, member 30.048
MEOX2mesenchyme homeobox 20.043
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.039
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.037
WWP2WW domain containing E3 ubiquitin protein ligase 20.035
MYO5Amyosin VA (heavy chain 12, myoxin)0.035
MAP3K1mitogen-activated protein kinase kinase kinase 10.033
RBBP4retinoblastoma binding protein 40.032
TCF4transcription factor 40.032
EPS15epidermal growth factor receptor pathway substrate 150.032
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.031
BLOC1S3biogenesis of lysosomal organelles complex-1, subunit 30.031
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.031
RBM17RNA binding motif protein 170.031
TGIF1TGFB-induced factor homeobox 10.030
AGGF1angiogenic factor with G patch and FHA domains 10.029
STK36serine/threonine kinase 360.029
EPAS1endothelial PAS domain protein 10.029
MTA2metastasis associated 1 family, member 20.028
PMLpromyelocytic leukemia0.028
SMAD1SMAD family member 10.027
MEF2Amyocyte enhancer factor 2A0.025
MECP2methyl CpG binding protein 2 (Rett syndrome)0.025
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.024
HDAC4histone deacetylase 40.024
MARCKSmyristoylated alanine-rich protein kinase C substrate0.023
CIB1calcium and integrin binding 1 (calmyrin)0.023
SNAPINSNAP-associated protein0.023
SPTBN1spectrin, beta, non-erythrocytic 10.023
SOX2SRY (sex determining region Y)-box 20.023
KCTD1potassium channel tetramerisation domain containing 10.022
NRIP1nuclear receptor interacting protein 10.022
TRIM32tripartite motif containing 320.021
BECN1beclin 1, autophagy related0.021
RIC8Aresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)0.020
MBD2methyl-CpG binding domain protein 20.020
BCAS2breast carcinoma amplified sequence 20.020
NR4A1nuclear receptor subfamily 4, group A, member 10.019
TRIM8tripartite motif containing 80.019
AMBRA1autophagy/beclin-1 regulator 10.019
PRMT2protein arginine methyltransferase 20.018
ZFPM1zinc finger protein, multitype 10.017
SKIv-ski sarcoma viral oncogene homolog (avian)0.017
AGTR1angiotensin II receptor, type 10.017
RBBP7retinoblastoma binding protein 70.016
DNAJB2DnaJ (Hsp40) homolog, subfamily B, member 20.016
CELF2CUGBP, Elav-like family member 20.016
CHD4chromodomain helicase DNA binding protein 40.016
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.016
FHL2four and a half LIM domains 20.016
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.016
MAP3K5mitogen-activated protein kinase kinase kinase 50.015
PPT1palmitoyl-protein thioesterase 10.015
PMP22peripheral myelin protein 220.015
PROX1prospero homeobox 10.014
HIC1hypermethylated in cancer 10.014
PLRG1pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)0.014
WSB1WD repeat and SOCS box containing 10.014
BIKBCL2-interacting killer (apoptosis-inducing)0.014
DPYSL2dihydropyrimidinase-like 20.013
SUGP1SURP and G patch domain containing 10.013
SH3BP4SH3-domain binding protein 40.013
MBD3methyl-CpG binding domain protein 30.013
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.013
UBE2Zubiquitin-conjugating enzyme E2Z0.013
GATAD2BGATA zinc finger domain containing 2B0.013
EXOC8exocyst complex component 80.012
ATXN3ataxin 30.012
AHRaryl hydrocarbon receptor0.012
MNAT1menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)0.012
HK2hexokinase 20.012
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.012
CWC15CWC15 spliceosome-associated protein homolog (S. cerevisiae)0.012
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kitakit receptor a0.998
mitfamicrophthalmia-associated transcription factor a0.983
slc24a5solute carrier family 24, member 50.976
sox10SRY-box containing gene 100.967
mibmind bomb0.962
tfap2atranscription factor AP-2 alpha0.926
sox2SRY-box containing gene 20.874
pmelapremelanosome protein a0.862
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.861
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.823
foxi1forkhead box I10.811
trpm7transient receptor potential cation channel, subfamily M, member 70.747
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.704
foxd3forkhead box D30.587
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.572
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.532
eya1eyes absent homolog 10.470
flhfloating head0.453
tfectranscription factor EC0.437
slc45a2solute carrier family 45, member 20.424
tfap2etranscription factor AP-2 epsilon0.401
tfe3btranscription factor binding to IGHM enhancer 3b0.389
csf1racolony stimulating factor 1 receptor, a0.301
notch1anotch homolog 1a0.297
otx2orthodenticle homolog 20.293
dctdopachrome tautomerase0.271
ltkleukocyte tyrosine kinase0.266
gata3GATA-binding protein 30.258
prdm1aPR domain containing 1a, with ZNF domain0.227
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.211
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.210
cx41.8connexin 41.80.209
tyrp1tyrosinase-related protein 10.200
gdf6agrowth differentiation factor 6a0.196
mitfbmicrophthalmia-associated transcription factor b0.173
six4bsine oculis homeobox homolog 4b0.169
pnp4apurine nucleoside phosphorylase 4a0.166
tp63tumor protein p630.159
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.155
rx3retinal homeobox gene 30.151
cdx4caudal type homeo box transcription factor 40.151
sox19aSRY-box containing gene 19a0.149
sox7SRY-box containing gene 70.147
tyrp1btyrosinase-related protein 1b0.138
etv2ets variant gene 20.133
nf1aneurofibromin 1a0.131
tp53tumor protein p530.129
hoxb3ahomeo box B3a0.126
jag1bjagged 1b0.124
zic6zic family member 60.116
pax6bpaired box gene 6b0.116
mlphbmelanophilin b0.108
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.108
nr2f5nuclear receptor subfamily 2, group F, member 50.105
cdh5cadherin 50.101
mab21l2mab-21-like 20.100
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.092
grhl1grainyhead-like 1 (Drosophila)0.092
kctd15apotassium channel tetramerisation domain containing 15a0.091
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.088
sprasepiapterin reductase a0.087
lef1lymphocyte enhancer binding factor 10.086
six3bsine oculis homeobox homolog 3b0.077
slc4a1bsolute carrier family 4, anion exchanger, member 1b0.076
crb2acrumbs homolog 2a0.071
notch3notch homolog 30.070
supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.068
raraaretinoic acid receptor, alpha a0.068
hesx1homeo box (expressed in ES cells) 10.066
grhl2bgrainyhead-like 2b (Drosophila)0.064
disp1dispatched homolog 1 (Drosophila)0.064
aldh1a2aldehyde dehydrogenase 1 family, member A20.058
foxi3aforkhead box I3a0.058
rargaretinoic acid receptor gamma a0.057
sox9aSRY-box containing gene 9a0.056
sox1aSRY-box containing gene 1a0.056
zic4zic family member 40.055
kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.053
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.052
furinafurin (paired basic amino acid cleaving enzyme) a0.051
edn1endothelin 10.051
slc13a3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 30.051
gata2aGATA-binding protein 2a0.050
mdkbmidkine-related growth factor b0.048
foxc1aforkhead box C1a0.048
ednrb1endothelin receptor B0.045
egr2bearly growth response 2b0.044
kitbkit receptor b0.043
fgfrl1bfibroblast growth factor receptor-like 1b0.040
trpv6transient receptor potential cation channel, subfamily V, member 60.039
col2a1acollagen type II, alpha-1a0.039
bhlhe22basic helix-loop-helix family, member e220.039
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mitfmicrophthalmia-associated transcription factor1.000
Lystlysosomal trafficking regulator1.000
Kitkit oncogene1.000
Trp53transformation related protein 530.998
Pax3paired box gene 30.997
Rab27aRAB27A, member RAS oncogene family0.996
Gli3GLI-Kruppel family member GLI30.996
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.996
Tyrp1tyrosinase-related protein 10.996
Pax6paired box gene 60.990
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.990
Sox9SRY-box containing gene 90.987
Ednrbendothelin receptor type B0.984
Oca2oculocutaneous albinism II0.961
Prrx1paired related homeobox 10.958
Sox2SRY-box containing gene 20.953
Bmp4bone morphogenetic protein 40.937
Vegfavascular endothelial growth factor A0.929
Fgfr2fibroblast growth factor receptor 20.906
Runx2runt related transcription factor 20.906
Kdrkinase insert domain protein receptor0.895
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.883
Tcfap2atranscription factor AP-2, alpha0.877
Fgf8fibroblast growth factor 80.854
Foxc2forkhead box C20.841
Psen1presenilin 10.812
Hps6Hermansky-Pudlak syndrome 60.807
Pou5f1POU domain, class 5, transcription factor 10.793
Ptenphosphatase and tensin homolog0.791
Notch2Notch gene homolog 2 (Drosophila)0.756
Pitx2paired-like homeodomain transcription factor 20.740
BaxBCL2-associated X protein0.725
Hand1heart and neural crest derivatives expressed transcript 10.671
Rarbretinoic acid receptor, beta0.663
Meox2mesenchyme homeobox 20.645
Gli2GLI-Kruppel family member GLI20.635
Msx2homeobox, msh-like 20.623
Ap3d1adaptor-related protein complex 3, delta 1 subunit0.606
Tgfb2transforming growth factor, beta 20.585
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.550
Mef2cmyocyte enhancer factor 2C0.548
Msx1homeobox, msh-like 10.540
Bcl2B-cell leukemia/lymphoma 20.523
Foxc1forkhead box C10.520
Shhsonic hedgehog0.515
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.492
Prf1perforin 1 (pore forming protein)0.489
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.439
Cd2apCD2-associated protein0.397
Tgfb1transforming growth factor, beta 10.370
Notch1Notch gene homolog 1 (Drosophila)0.364
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.354
Fgfr1fibroblast growth factor receptor 10.311
Sall4sal-like 4 (Drosophila)0.308
Hdac4histone deacetylase 40.301
Ror2receptor tyrosine kinase-like orphan receptor 20.297
Prrx2paired related homeobox 20.279
Rspo2R-spondin 2 homolog (Xenopus laevis)0.270
Kitlkit ligand0.258
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.257
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.255
Eya1eyes absent 1 homolog (Drosophila)0.245
Alx4aristaless-like homeobox 40.241
Myo5amyosin VA0.239
Csf1colony stimulating factor 1 (macrophage)0.227
Rasip1Ras interacting protein 10.226
Ren1renin 1 structural0.203
Pmelpremelanosome protein0.201
Bmp7bone morphogenetic protein 70.189
Isl1ISL1 transcription factor, LIM/homeodomain0.178
CblCasitas B-lineage lymphoma0.174
Fzd4frizzled homolog 4 (Drosophila)0.171
Ctnnb1catenin (cadherin associated protein), beta 10.162
Smosmoothened homolog (Drosophila)0.147
Mn1meningioma 10.140
Sox10SRY-box containing gene 100.129
Usp8ubiquitin specific peptidase 80.127
Hand2heart and neural crest derivatives expressed transcript 20.125
Retret proto-oncogene0.125
Cdh5cadherin 50.120
BmperBMP-binding endothelial regulator0.120
Pbx1pre B-cell leukemia transcription factor 10.119
Nf1neurofibromatosis 10.115
Sox11SRY-box containing gene 110.115
Sox4SRY-box containing gene 40.097
Acvr1activin A receptor, type 10.091
Rararetinoic acid receptor, alpha0.091
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.088
Wdr26WD repeat domain 260.087
Flt4FMS-like tyrosine kinase 40.082
Vegfcvascular endothelial growth factor C0.080
Fgf10fibroblast growth factor 100.080
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Aqp4aquaporin 40.078
Calcrlcalcitonin receptor-like0.066
Il1r1interleukin 1 receptor, type I0.061
Gfapglial fibrillary acidic protein0.056
Tcf4transcription factor 40.046
Igfbp5insulin-like growth factor binding protein 50.042
Magmyelin-associated glycoprotein0.040
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.039
Gja5gap junction protein, alpha 50.038
Pde5aphosphodiesterase 5A, cGMP-specific0.037
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.036
Pld1phospholipase D10.036
Scn7asodium channel, voltage-gated, type VII, alpha0.034
Slc1a3solute carrier family 1 (glial high affinity glutamate transporter), member 30.030
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.029
A3galt2alpha 1,3-galactosyltransferase 20.027
F13a1coagulation factor XIII, A1 polypeptide0.026
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.025
Tgfbr3transforming growth factor, beta receptor III0.024
Sp4Sp4 transcription factor0.023
Creb1cAMP responsive element binding protein 10.023
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.022
Cyth3cytohesin 30.022
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.021
Pax6paired box 60.020
Lrrc4bleucine rich repeat containing 4B0.020
Leprleptin receptor0.019
Map3k3mitogen activated protein kinase kinase kinase 30.019
Bcl2l1Bcl2-like 10.019
Dchs1dachsous 1 (Drosophila)0.018
Efnb1ephrin B10.018
Igsf1immunoglobulin superfamily, member 10.017
Itga6integrin, alpha 60.017
Ddr2discoidin domain receptor tyrosine kinase 20.017
Elf1E74-like factor 10.017
Tgfbr2transforming growth factor, beta receptor II0.016
Gpr116G protein-coupled receptor 1160.016
Olr1654olfactory receptor 16540.016
Fgl2fibrinogen-like 20.016
Flt1FMS-related tyrosine kinase 10.016
Tmod2tropomodulin 20.016
Eif2c2eukaryotic translation initiation factor 2C, 20.015
Cnp2',3'-cyclic nucleotide 3' phosphodiesterase0.014
Oprm1opioid receptor, mu 10.014
Cldn11claudin 110.014
Fbxo32F-box protein 320.014
Dgkgdiacylglycerol kinase, gamma0.013
RGD1564327similar to integrin alpha 80.013
Plp1proteolipid protein 10.013
Gfra2GDNF family receptor alpha 20.013
Ptgfrprostaglandin F receptor0.012
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.012
Slc14a1solute carrier family 14 (urea transporter), member 10.012
Col9a2collagen, type IX, alpha 20.012
Chrna7cholinergic receptor, nicotinic, alpha 70.012
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.012
Slc4a4solute carrier family 4, sodium bicarbonate cotransporter, member 40.011
Mbpmyelin basic protein0.011
Sfrp1secreted frizzled-related protein 10.011
Atp4aATPase, H+/K+ exchanging, alpha polypeptide0.011
Soat1sterol O-acyltransferase 10.011
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.010
S1pr2sphingosine-1-phosphate receptor 20.010
Plekha6pleckstrin homology domain containing, family A member 60.010
Sept8septin 80.010
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.010
Pld2phospholipase D20.010
Pcdh17protocadherin 170.010
Lman1lectin, mannose-binding, 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism