The network for 'regulation of tumor necrosis factor superfamily cytokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of tumor necrosis factor superfamily cytokine production

Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production.

NameDescriptionProbabilityFunc Analog Organism
IRAK2interleukin-1 receptor-associated kinase 21.000
MYD88myeloid differentiation primary response gene (88)1.000
C1QAcomplement component 1, q subcomponent, A chain0.999
CCR1chemokine (C-C motif) receptor 10.977
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.975
BIRC3baculoviral IAP repeat containing 30.938
IRAK1interleukin-1 receptor-associated kinase 10.933
IRAK3interleukin-1 receptor-associated kinase 30.924
TLR2toll-like receptor 20.918
CXCL9chemokine (C-X-C motif) ligand 90.904
CD163CD163 molecule0.896
RXRAretinoid X receptor, alpha0.889
IL10RAinterleukin 10 receptor, alpha0.849
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.827
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.824
CXCL10chemokine (C-X-C motif) ligand 100.812
AXLAXL receptor tyrosine kinase0.812
SYKspleen tyrosine kinase0.749
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.710
CD14CD14 molecule0.670
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.664
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.647
CCL8chemokine (C-C motif) ligand 80.606
CYBBcytochrome b-245, beta polypeptide0.588
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)0.554
GAS6growth arrest-specific 60.550
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.542
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.527
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.520
C1QBcomplement component 1, q subcomponent, B chain0.456
RUNX1runt-related transcription factor 10.450
HSF1heat shock transcription factor 10.439
CREBBPCREB binding protein0.427
CD86CD86 molecule0.424
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.418
CXCL11chemokine (C-X-C motif) ligand 110.415
CCL4chemokine (C-C motif) ligand 40.408
NLRC4NLR family, CARD domain containing 40.407
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.403
TNFtumor necrosis factor0.399
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.395
LAIR1leukocyte-associated immunoglobulin-like receptor 10.388
SETD8SET domain containing (lysine methyltransferase) 80.386
MSR1macrophage scavenger receptor 10.372
S100A9S100 calcium binding protein A90.358
CCR2chemokine (C-C motif) receptor 20.345
CCL5chemokine (C-C motif) ligand 50.332
CCR5chemokine (C-C motif) receptor 50.326
TRADDTNFRSF1A-associated via death domain0.326
TRAF5TNF receptor-associated factor 50.310
CCL2chemokine (C-C motif) ligand 20.305
IGSF6immunoglobulin superfamily, member 60.299
MARCOmacrophage receptor with collagenous structure0.298
S100A12S100 calcium binding protein A120.296
FASFas (TNF receptor superfamily, member 6)0.291
TLR4toll-like receptor 40.287
CXCL3chemokine (C-X-C motif) ligand 30.284
PMLpromyelocytic leukemia0.280
CXCL2chemokine (C-X-C motif) ligand 20.276
CD48CD48 molecule0.274
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.274
VSIG4V-set and immunoglobulin domain containing 40.273
TRAF6TNF receptor-associated factor 60.267
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.259
TFECtranscription factor EC0.257
FADDFas (TNFRSF6)-associated via death domain0.257
MED15mediator complex subunit 150.248
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.240
MED25mediator complex subunit 250.238
SLAMF8SLAM family member 80.238
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.237
CD33CD33 molecule0.237
NCOA1nuclear receptor coactivator 10.228
TRIM34tripartite motif containing 340.225
IDEinsulin-degrading enzyme0.224
HK3hexokinase 3 (white cell)0.223
APOEapolipoprotein E0.222
FCGR3BFc fragment of IgG, low affinity IIIb, receptor (CD16b)0.218
MPEG1macrophage expressed 10.216
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.214
F13A1coagulation factor XIII, A1 polypeptide0.211
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.207
PILRApaired immunoglobin-like type 2 receptor alpha0.202
LY86lymphocyte antigen 860.198
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.196
MS4A4Amembrane-spanning 4-domains, subfamily A, member 40.188
SOCS3suppressor of cytokine signaling 30.185
TYMPthymidine phosphorylase0.184
FCN1ficolin (collagen/fibrinogen domain containing) 10.184
PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)0.183
CXCL5chemokine (C-X-C motif) ligand 50.178
SIGLEC7sialic acid binding Ig-like lectin 70.177
FPR3formyl peptide receptor 30.174
CMKLR1chemokine-like receptor 10.174
ESR1estrogen receptor 10.172
CLEC7AC-type lectin domain family 7, member A0.172
RARAretinoic acid receptor, alpha0.170
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.164
SH3BP2SH3-domain binding protein 20.163
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Myd88myeloid differentiation primary response gene 880.999
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.945
Cd44CD44 antigen0.919
Tlr4toll-like receptor 40.913
Lyz2lysozyme 20.899
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.893
Ccl2chemokine (C-C motif) ligand 20.882
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.860
Klrk1killer cell lectin-like receptor subfamily K, member 10.816
Ccr2chemokine (C-C motif) receptor 20.795
Tlr2toll-like receptor 20.783
Otx2orthodenticle homolog 2 (Drosophila)0.781
Pax6paired box gene 60.777
Clec4dC-type lectin domain family 4, member d0.776
Gnrh1gonadotropin releasing hormone 10.774
Neurod1neurogenic differentiation 10.770
C3ar1complement component 3a receptor 10.767
Ccr1chemokine (C-C motif) receptor 10.747
Ccl3chemokine (C-C motif) ligand 30.724
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.722
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.692
Ikzf1IKAROS family zinc finger 10.669
Map3k8mitogen-activated protein kinase kinase kinase 80.663
Tnftumor necrosis factor0.624
Klra9killer cell lectin-like receptor subfamily A, member 90.596
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.570
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.555
Traf6TNF receptor-associated factor 60.550
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.547
AF251705cDNA sequence AF2517050.546
Ascl1achaete-scute complex homolog 1 (Drosophila)0.522
AxlAXL receptor tyrosine kinase0.504
Map3k14mitogen-activated protein kinase kinase kinase 140.504
Socs1suppressor of cytokine signaling 10.503
Ccl4chemokine (C-C motif) ligand 40.485
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.473
Cd300ldCD300 molecule-like family member d0.459
Neurog2neurogenin 20.448
BlkB lymphoid kinase0.436
FaslFas ligand (TNF superfamily, member 6)0.428
Stat3signal transducer and activator of transcription 30.410
Gzmagranzyme A0.401
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.386
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.376
Cd180CD180 antigen0.356
Cd7CD7 antigen0.344
Gcet2germinal center expressed transcript 20.344
Tnip1TNFAIP3 interacting protein 10.323
Xcl1chemokine (C motif) ligand 10.313
Clec4nC-type lectin domain family 4, member n0.310
Itgaxintegrin alpha X0.286
Snai1snail homolog 1 (Drosophila)0.279
Il2rginterleukin 2 receptor, gamma chain0.279
Klrg1killer cell lectin-like receptor subfamily G, member 10.278
Ptprcprotein tyrosine phosphatase, receptor type, C0.274
Ccr7chemokine (C-C motif) receptor 70.273
Klrd1killer cell lectin-like receptor, subfamily D, member 10.272
Ifngr1interferon gamma receptor 10.268
Lhx9LIM homeobox protein 90.266
Ccr5chemokine (C-C motif) receptor 50.265
Ggt5gamma-glutamyltransferase 50.263
Pax2paired box gene 20.261
Ccr6chemokine (C-C motif) receptor 60.261
Gab1growth factor receptor bound protein 2-associated protein 10.247
Il2rbinterleukin 2 receptor, beta chain0.246
Cybbcytochrome b-245, beta polypeptide0.234
Ncr1natural cytotoxicity triggering receptor 10.228
Emx2empty spiracles homolog 2 (Drosophila)0.227
Pou4f2POU domain, class 4, transcription factor 20.226
Klra2killer cell lectin-like receptor, subfamily A, member 20.225
Il12binterleukin 12b0.224
Gzmkgranzyme K0.209
Il1rninterleukin 1 receptor antagonist0.207
Pyhin1pyrin and HIN domain family, member 10.202
Lhx3LIM homeobox protein 30.199
Flt3FMS-like tyrosine kinase 30.198
FcrlaFc receptor-like A0.198
Pou2f2POU domain, class 2, transcription factor 20.196
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.193
Cxcr3chemokine (C-X-C motif) receptor 30.192
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.190
Socs3suppressor of cytokine signaling 30.190
Prf1perforin 1 (pore forming protein)0.190
Cyldcylindromatosis (turban tumor syndrome)0.181
Ntf3neurotrophin 30.179
Casp8caspase 80.177
Ear2eosinophil-associated, ribonuclease A family, member 20.170
Gzmbgranzyme B0.169
TcraT-cell receptor alpha chain0.168
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.163
Folr2folate receptor 2 (fetal)0.162
Neurod4neurogenic differentiation 40.160
Tnfaip3tumor necrosis factor, alpha-induced protein 30.158
Kiss1KiSS-1 metastasis-suppressor0.157
Il7rinterleukin 7 receptor0.156
Lair1leukocyte-associated Ig-like receptor 10.156
Ccl9chemokine (C-C motif) ligand 90.155
Hcsthematopoietic cell signal transducer0.153
Slamf8SLAM family member 80.153
Mmp12matrix metallopeptidase 120.153
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccl7chemokine (C-C motif) ligand 70.336
Ccl2chemokine (C-C motif) ligand 20.320
Cd14CD14 molecule0.193
Cxcl2chemokine (C-X-C motif) ligand 20.129
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.120
Icam1intercellular adhesion molecule 10.119
Il1binterleukin 1 beta0.097
Stat3signal transducer and activator of transcription 30.066
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.062
Myd88myeloid differentiation primary response gene 880.061
C5ar1complement component 5a receptor 10.059
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.058
Ccl3chemokine (C-C motif) ligand 30.048
Hpgdshematopoietic prostaglandin D synthase0.046
Plauplasminogen activator, urokinase0.045
Junbjun B proto-oncogene0.041
Aldh3a1aldehyde dehydrogenase 3 family, member A10.039
Arl11ADP-ribosylation factor-like 110.039
Rgs1regulator of G-protein signaling 10.038
Il6interleukin 60.038
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.037
Igsf6immunoglobulin superfamily, member 60.036
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.036
Cxcl10chemokine (C-X-C motif) ligand 100.035
Ccl4chemokine (C-C motif) ligand 40.035
Il2rbinterleukin 2 receptor, beta0.034
Mmp12matrix metallopeptidase 120.033
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.033
Adrb2adrenergic, beta-2-, receptor, surface0.032
Klrd1killer cell lectin-like receptor, subfamily D, member 10.028
Muskmuscle, skeletal, receptor tyrosine kinase0.028
Nraddneurotrophin receptor associated death domain0.028
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.028
Xdhxanthine dehydrogenase0.026
Reg3bregenerating islet-derived 3 beta0.025
Tmem88transmembrane protein 880.025
Itgamintegrin, alpha M0.025
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.025
Igsf7immunoglobulin superfamily, member 70.024
Clec9aC-type lectin domain family 9, member a0.024
Tbxas1thromboxane A synthase 1, platelet0.024
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.024
Gzmkgranzyme K0.023
Tspan4tetraspanin 40.023
Lpllipoprotein lipase0.022
Ccr1chemokine (C-C motif) receptor 10.022
Ccr2chemokine (C-C motif) receptor 20.022
Tlr2toll-like receptor 20.022
Il1r2interleukin 1 receptor, type II0.021
Selpselectin P0.021
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.021
Cd44Cd44 molecule0.020
Hmox1heme oxygenase (decycling) 10.020
Irak3interleukin-1 receptor-associated kinase 30.019
Ier3immediate early response 30.019
Cd8aCD8a molecule0.019
Folr2folate receptor 2 (fetal)0.019
Plscr1phospholipid scramblase 10.019
Krt14keratin 140.019
Cybbcytochrome b-245, beta polypeptide0.018
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.018
Bcl3B-cell CLL/lymphoma 30.018
Cideacell death-inducing DFFA-like effector a0.018
Cfdcomplement factor D (adipsin)0.017
Tbc1d2bTBC1 domain family, member 2B0.017
Sellselectin L0.016
Il1ainterleukin 1 alpha0.016
Il8rbinterleukin 8 receptor, beta0.016
Cd2Cd2 molecule0.016
Lrg1leucine-rich alpha-2-glycoprotein 10.016
Ch25hcholesterol 25-hydroxylase0.016
Lgals3lectin, galactoside-binding, soluble, 30.015
Rhojras homolog gene family, member J0.015
LOC500300similar to hypothetical protein MGC68350.015
Slpisecretory leukocyte peptidase inhibitor0.015
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.015
Adamts4ADAM metallopeptidase with thrombospondin type 1 motif, 40.015
Alox5aparachidonate 5-lipoxygenase activating protein0.015
Rab32RAB32, member RAS oncogene family0.015
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.014
Ptger4prostaglandin E receptor 4 (subtype EP4)0.014
C1qccomplement component 1, q subcomponent, C chain0.014
Lamb2laminin, beta 20.013
Calcbcalcitonin-related polypeptide, beta0.013
C3ar1complement component 3a receptor 10.013
Litaflipopolysaccharide-induced TNF factor0.013
Ifi204interferon activated gene 2040.013
Nkg7natural killer cell group 7 sequence0.013
Fosl1fos-like antigen 10.013
Lcn2lipocalin 20.013
Il1rl1interleukin 1 receptor-like 10.012
Cd40CD40 molecule, TNF receptor superfamily member 50.012
Smad1SMAD family member 10.012
Fabp4fatty acid binding protein 4, adipocyte0.012
Glt25d1glycosyltransferase 25 domain containing 10.012
Pionpigeon homolog (Drosophila)0.012
Caprin1cell cycle associated protein 10.012
Steap1six transmembrane epithelial antigen of the prostate 10.012
Il9rinterleukin 9 receptor0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism