The network for 'response to cadmium ion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to cadmium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.

NameDescriptionProbabilityFunc Analog Organism
MT2Ametallothionein 2A0.993
MAPK8mitogen-activated protein kinase 80.947
MT1Fmetallothionein 1F0.931
MT1Hmetallothionein 1H0.867
MT1Emetallothionein 1E0.854
MT1Xmetallothionein 1X0.773
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.551
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.244
ATF2activating transcription factor 20.217
MAPK1mitogen-activated protein kinase 10.157
MAP2K4mitogen-activated protein kinase kinase 40.149
MT1Gmetallothionein 1G0.133
DUSP1dual specificity phosphatase 10.091
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.088
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.069
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.062
JUNjun proto-oncogene0.049
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.040
MCM2minichromosome maintenance complex component 20.037
MAPK14mitogen-activated protein kinase 140.037
BCL2B-cell CLL/lymphoma 20.030
FTH1ferritin, heavy polypeptide 10.026
AP1M1adaptor-related protein complex 1, mu 1 subunit0.026
CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 70.025
BCL2L1BCL2-like 10.022
BRCA1breast cancer 1, early onset0.022
BAK1BCL2-antagonist/killer 10.022
GPR50G protein-coupled receptor 500.020
MCM6minichromosome maintenance complex component 60.018
ALAS1aminolevulinate, delta-, synthase 10.017
MAP3K1mitogen-activated protein kinase kinase kinase 10.016
MT1Bmetallothionein 1B0.016
CPNE6copine VI (neuronal)0.015
SP1Sp1 transcription factor0.015
GADD45GIP1growth arrest and DNA-damage-inducible, gamma interacting protein 10.013
MT1Mmetallothionein 1M0.011
ARRB1arrestin, beta 10.011
MT1Ametallothionein 1A0.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cyp-35A2Protein CYP-35A20.033
W01A11.1Protein W01A11.10.019
ftn-1Protein FTN-10.019
F08G5.6Protein F08G5.60.017
cyp-35A4Protein CYP-35A40.014
F47B8.4Protein F47B8.40.011
CELE_K09C4.5Protein K09C4.50.011
T22F3.3Protein T22F3.30.011
pes-9Protein PES-90.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.975
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.723
mcl1amyeloid cell leukemia sequence 1a0.610
bcl2l1bcl2-like 10.504
hsp90a.2heat shock protein 90-alpha 20.372
junbjun B proto-oncogene0.317
bidaBH3 interacting domain death agonist0.198
ntn2netrin 20.170
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.164
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.156
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.153
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.149
pcnaproliferating cell nuclear antigen0.147
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.147
socs3asuppressor of cytokine signaling 3a0.144
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.138
mcm4MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)0.133
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.127
bbc3BCL2 binding component 30.126
igfbp1ainsulin-like growth factor binding protein 1a0.124
copebcore promoter element binding protein0.122
atf3activating transcription factor 30.112
atp1a1a.5ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide0.107
mcl1bmyeloid cell leukemia sequence 1b0.104
btg2B-cell translocation gene 20.104
socs1suppressor of cytokine signaling 10.101
baxabcl2-associated X protein, a0.100
mybl2myeloblastosis oncogene-like 20.091
gapdhglyceraldehyde-3-phosphate dehydrogenase0.087
mapk6mitogen-activated protein kinase 60.087
nrg1neuregulin 10.078
mapk3mitogen-activated protein kinase 30.072
etv5aets variant 5a0.069
psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.066
bcl2B-cell leukemia/lymphoma 20.062
fbln4fibulin 40.059
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.055
mapk7mitogen-activated protein kinase 70.054
dusp4dual specificity phosphatase 40.052
whsc1Wolf-Hirschhorn syndrome candidate 10.052
dnajb1bDnaJ (Hsp40) homolog, subfamily B, member 1b0.052
LOC100000332e3 ubiquitin-protein ligase RNF182-like0.051
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.051
mt2metallothionein 20.050
prox2prospero homeobox 20.049
ercc2excision repair cross-complementing rodent repair deficiency, complementation group 20.048
cygb2cytoglobin 20.044
birc5abaculoviral IAP repeat-containing 5a0.042
sgk1serum/glucocorticoid regulated kinase 10.041
dusp1dual specificity phosphatase 10.041
ptgdsprostaglandin D2 synthase0.041
pdlim1PDZ and LIM domain 1 (elfin)0.040
mvpmajor vault protein0.038
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.036
fkbp5FK506 binding protein 50.035
cyp1acytochrome P450, family 1, subfamily A0.035
LOC565839tumor necrosis factor alpha-induced protein 2-like0.035
vtg1vitellogenin 10.034
map2k4bmitogen-activated protein kinase kinase 4b0.034
comtacatechol-O-methyltransferase a0.033
rbp4retinol binding protein 4, plasma0.030
cx32.3connexin 32.30.030
hsp70heat shock cognate 70-kd protein0.030
hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.030
xbp1X-box binding protein 10.030
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.030
tgfbr2transforming growth factor, beta receptor II0.029
ccng1cyclin G10.029
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.028
cd63Cd63 antigen0.027
vcanaversican a0.027
trim25tripartite motif-containing 250.027
cldn15laclaudin 15-like a0.027
junjun proto-oncogene0.026
sat1aspermidine/spermine N1-acetyltransferase 1a0.026
bikBCL2-interacting killer (apoptosis-inducing)0.026
hspa4aheat shock protein 4a0.025
junbljun B proto-oncogene, like0.025
cyp1c2cytochrome P450, family 1, subfamily C, polypeptide 20.025
lgals2blectin, galactoside-binding, soluble, 2b0.025
baxbbcl2-associated X protein, b0.024
wnt5awingless-type MMTV integration site family, member 5a0.024
vdac2voltage-dependent anion channel 20.024
hbegfaheparin-binding EGF-like growth factor a0.023
zbtb4zinc finger and BTB domain containing 40.023
col7a1lcollagen type VII alpha 1-like0.023
hibadhb3-hydroxyisobutyrate dehydrogenase b0.023
trim71tripartite motif-containing 710.022
insl5ainsulin-like 5a0.022
abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 50.022
nap1l1nucleosome assembly protein 1, like 10.021
rrm1ribonucleotide reductase M1 polypeptide0.021
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ugt35aUDP-glycosyltransferase 35a0.102
EpacCG34392 gene product from transcript CG34392-RC0.035
Cyp6a9Cytochrome P450-6a90.032
Cyp12a4CG6042 gene product from transcript CG6042-RA0.028
CG12672CG12672 gene product from transcript CG12672-RA0.018
Cyp6a23CG10242 gene product from transcript CG10242-RA0.018
Cyp12a5CG11821 gene product from transcript CG11821-RA0.017
CG1927CG1927 gene product from transcript CG1927-RA0.016
Cyp9b2Cytochrome P450-9b20.015
Cyp12e1CG14680 gene product from transcript CG14680-RC0.014
Cyp6a2Cytochrome P450-6a20.013
Cyp6a21CG10247 gene product from transcript CG10247-RA0.013
Cyp4e2Cytochrome P450-4e20.013
CG10562CG10562 gene product from transcript CG10562-RA0.011
CG10560CG10560 gene product from transcript CG10560-RA0.011
PHGPxCG12013 gene product from transcript CG12013-RC0.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mt1metallothionein 10.903
Mt2metallothionein 20.885
Atf2activating transcription factor 20.691
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.577
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.541
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.490
Cps1carbamoyl-phosphate synthetase 10.430
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.414
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.406
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.340
Cyp2b9cytochrome P450, family 2, subfamily b, polypeptide 90.326
Otcornithine transcarbamylase0.310
Hrghistidine-rich glycoprotein0.304
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.282
Ccna2cyclin A20.281
Cyp2c54cytochrome P450, family 2, subfamily c, polypeptide 540.268
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.259
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.258
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.238
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.233
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.230
F9coagulation factor IX0.228
Akr1c6aldo-keto reductase family 1, member C60.185
Aadacarylacetamide deacetylase (esterase)0.183
Mapk14mitogen-activated protein kinase 140.181
Ptenphosphatase and tensin homolog0.171
Mapk1mitogen-activated protein kinase 10.160
Mup5major urinary protein 50.157
Sult1d1sulfotransferase family 1D, member 10.154
Cyp2b13cytochrome P450, family 2, subfamily b, polypeptide 130.136
Prkceprotein kinase C, epsilon0.125
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.111
Apohapolipoprotein H0.108
Nr1i3nuclear receptor subfamily 1, group I, member 30.106
TapbpTAP binding protein0.105
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.102
Cyp2c39cytochrome P450, family 2, subfamily c, polypeptide 390.099
Rdh7retinol dehydrogenase 70.098
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.098
Hsd3b3hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 30.081
Mapk8mitogen-activated protein kinase 80.081
Mbl2mannose-binding lectin (protein C) 20.077
Sult1b1sulfotransferase family 1B, member 10.073
G6pcglucose-6-phosphatase, catalytic0.070
Apoc4apolipoprotein C-IV0.069
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.066
Upp2uridine phosphorylase 20.064
Mtap2microtubule-associated protein 20.063
Pon1paraoxonase 10.063
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.063
Abcb1aATP-binding cassette, sub-family B (MDR/TAP), member 1A0.060
Adh4alcohol dehydrogenase 4 (class II), pi polypeptide0.060
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.059
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.058
Mknk2MAP kinase-interacting serine/threonine kinase 20.056
Sult2a2sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 20.056
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.054
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.054
Keg1kidney expressed gene 10.054
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.053
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.052
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.050
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.050
Abcb11ATP-binding cassette, sub-family B (MDR/TAP), member 110.046
Ces1ccarboxylesterase 1C0.045
Tdo2tryptophan 2,3-dioxygenase0.045
Abcb1bATP-binding cassette, sub-family B (MDR/TAP), member 1B0.044
Mug1murinoglobulin 10.043
Nfe2l2nuclear factor, erythroid derived 2, like 20.042
Slc22a1solute carrier family 22 (organic cation transporter), member 10.041
Inmtindolethylamine N-methyltransferase0.041
Cyp2c37cytochrome P450, family 2. subfamily c, polypeptide 370.041
Bmp4bone morphogenetic protein 40.041
Elovl3elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 30.040
Mup3major urinary protein 30.040
Rac1RAS-related C3 botulinum substrate 10.040
Ednraendothelin receptor type A0.039
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.038
CrpC-reactive protein, pentraxin-related0.038
Cyp2g1cytochrome P450, family 2, subfamily g, polypeptide 10.037
Klc1kinesin light chain 10.037
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.036
Pea15aphosphoprotein enriched in astrocytes 15A0.035
Car1carbonic anhydrase 10.033
Mknk1MAP kinase-interacting serine/threonine kinase 10.032
Cyp3a13cytochrome P450, family 3, subfamily a, polypeptide 130.031
Tgfbr2transforming growth factor, beta receptor II0.031
Akr1d1aldo-keto reductase family 1, member D10.031
Ces1gcarboxylesterase 1G0.030
Hgdhomogentisate 1, 2-dioxygenase0.030
F13bcoagulation factor XIII, beta subunit0.030
Trp53transformation related protein 530.029
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.029
Tmprss15transmembrane protease, serine 150.029
Pik3c2gphosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide0.028
Nr1i2nuclear receptor subfamily 1, group I, member 20.028
Mapk9mitogen-activated protein kinase 90.028
C9complement component 90.028
Abcb4ATP-binding cassette, sub-family B (MDR/TAP), member 40.026
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
COX1cytochrome c oxidase subunit 10.604
Cyb5acytochrome b5 type A (microsomal)0.430
ND1NADH dehydrogenase subunit 10.387
Ubbubiquitin B0.318
Akr1c18aldo-keto reductase family 1, member C180.313
Ephx1epoxide hydrolase 1, microsomal0.183
Sisucrase-isomaltase (alpha-glucosidase)0.165
Fth1ferritin, heavy polypeptide 10.159
Vdac1voltage-dependent anion channel 10.146
Prdx1peroxiredoxin 10.128
Hmbshydroxymethylbilane synthase0.127
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.126
Dhfrdihydrofolate reductase0.123
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.120
Sod2superoxide dismutase 2, mitochondrial0.116
Nr5a2nuclear receptor subfamily 5, group A, member 20.105
Gna12guanine nucleotide binding protein (G protein) alpha 120.104
ND3NADH dehydrogenase subunit 30.103
Fkbp4FK506 binding protein 40.103
Chpcalcium binding protein p220.096
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.096
Zadh2zinc binding alcohol dehydrogenase, domain containing 20.095
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.078
SnrkSNF related kinase0.076
ND2NADH dehydrogenase subunit 20.073
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.073
Hat1histone acetyltransferase 10.072
Rpa2replication protein A20.072
Adkadenosine kinase0.072
Hes2hairy and enhancer of split 2 (Drosophila)0.072
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.064
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.063
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.063
Mettl7bmethyltransferase like 7B0.059
Starsteroidogenic acute regulatory protein0.055
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.054
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.054
Tpt1tumor protein, translationally-controlled 10.053
Hdlbphigh density lipoprotein binding protein0.053
Clca4chloride channel accessory 40.049
Cyb5r1cytochrome b5 reductase 10.048
LOC293989cytochrome P450-like0.047
Me1malic enzyme 1, NADP(+)-dependent, cytosolic0.047
Cpecarboxypeptidase E0.047
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.046
Mgst1microsomal glutathione S-transferase 10.045
FosFBJ osteosarcoma oncogene0.043
Akt2v-akt murine thymoma viral oncogene homolog 20.043
Apobapolipoprotein B0.040
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.040
Mcm6minichromosome maintenance complex component 60.039
Vom1r105vomeronasal 1 receptor 1050.038
Cyb5bcytochrome b5 type B (outer mitochondrial membrane)0.038
Obp3alpha-2u globulin PGCL40.038
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.037
Dctn4dynactin 40.037
Hbg1hemoglobin, gamma A0.037
Ces1fcarboxylesterase 1F0.035
Timp2TIMP metallopeptidase inhibitor 20.035
Rfc4replication factor C (activator 1) 40.035
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.035
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.035
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.035
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.034
Stip1stress-induced phosphoprotein 10.033
ATP6ATPase subunit 60.033
Hist1h1ahistone cluster 1, H1a0.033
Cd81Cd81 molecule0.033
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.033
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.032
Zfp706zinc finger protein 7060.032
Selenbp1selenium binding protein 10.032
Mapk1mitogen activated protein kinase 10.031
Myo1amyosin IA0.031
RhdRh blood group, D antigen0.031
Ccnb1cyclin B10.031
Aqp9aquaporin 90.031
DdtD-dopachrome tautomerase0.031
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.030
Jak1Janus kinase 10.030
Ubqln1ubiquilin 10.030
Fut9fucosyltransferase 9 (alpha (1,3) fucosyltransferase)0.030
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.029
Ptgr1prostaglandin reductase 10.029
Slc31a1solute carrier family 31 (copper transporters), member 10.028
Syt4synaptotagmin IV0.028
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.028
Lig3ligase III, DNA, ATP-dependent0.028
Ghrlghrelin/obestatin prepropeptide0.028
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.027
Tgoln1trans-golgi network protein0.027
Nploc4nuclear protein localization 4 homolog (S. cerevisiae)0.027
Cd46CD46 molecule, complement regulatory protein0.026
Cdk1cyclin-dependent kinase 10.026
Lhcgrluteinizing hormone/choriogonadotropin receptor0.026
Bpnt13'(2'), 5'-bisphosphate nucleotidase 10.026
Pnlippancreatic lipase0.025
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism