The network for 'establishment of protein localization to plasma membrane' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of protein localization to plasma membrane

The directed movement of a protein to a specific location in the plasma membrane.

NameDescriptionProbabilityFunc Analog Organism
BCL2L1BCL2-like 10.993
ACTBactin, beta0.984
FHL2four and a half LIM domains 20.983
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.946
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.927
S100A6S100 calcium binding protein A60.899
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.889
ITGB4integrin, beta 40.788
SNAP23synaptosomal-associated protein, 23kDa0.775
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.756
FLNAfilamin A, alpha0.753
FLOT2flotillin 20.745
KRT6Bkeratin 6B0.732
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.715
KRT14keratin 140.679
S100A9S100 calcium binding protein A90.621
BCL2B-cell CLL/lymphoma 20.613
RAB5ARAB5A, member RAS oncogene family0.581
FN1fibronectin 10.563
S100BS100 calcium binding protein B0.550
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.542
S100A8S100 calcium binding protein A80.534
EXOC7exocyst complex component 70.529
APCadenomatous polyposis coli0.484
EHD1EH-domain containing 10.482
IER3immediate early response 30.439
S100A1S100 calcium binding protein A10.413
ANXA2annexin A20.403
PTPRCprotein tyrosine phosphatase, receptor type, C0.386
KRT8keratin 80.383
CTNND1catenin (cadherin-associated protein), delta 10.379
BBS4Bardet-Biedl syndrome 40.374
MDM2Mdm2 p53 binding protein homolog (mouse)0.360
FLOT1flotillin 10.351
DSG2desmoglein 20.350
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.349
BAK1BCL2-antagonist/killer 10.347
SNAP25synaptosomal-associated protein, 25kDa0.347
PSEN2presenilin 2 (Alzheimer disease 4)0.344
LMNAlamin A/C0.329
EXOC4exocyst complex component 40.313
KRT6Akeratin 6A0.276
CD63CD63 molecule0.274
MARK3MAP/microtubule affinity-regulating kinase 30.263
GGA3golgi-associated, gamma adaptin ear containing, ARF binding protein 30.262
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.247
NCF4neutrophil cytosolic factor 4, 40kDa0.243
GDAguanine deaminase0.242
LCKlymphocyte-specific protein tyrosine kinase0.240
KLHL3kelch-like 3 (Drosophila)0.235
SORBS3sorbin and SH3 domain containing 30.233
S100A4S100 calcium binding protein A40.230
S100A11S100 calcium binding protein A110.223
BADBCL2-associated agonist of cell death0.218
LGALS1lectin, galactoside-binding, soluble, 10.213
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.205
IGF1Rinsulin-like growth factor 1 receptor0.202
PTK2BPTK2B protein tyrosine kinase 2 beta0.199
JUPjunction plakoglobin0.194
KRT15keratin 150.190
SMOsmoothened homolog (Drosophila)0.176
NCF1neutrophil cytosolic factor 10.174
AKT1v-akt murine thymoma viral oncogene homolog 10.172
PSEN1presenilin 10.164
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.162
KRT5keratin 50.159
TMED10transmembrane emp24-like trafficking protein 10 (yeast)0.159
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.156
STX6syntaxin 60.154
RAB1ARAB1A, member RAS oncogene family0.153
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.152
AHNAKAHNAK nucleoprotein0.152
LMAN1lectin, mannose-binding, 10.151
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.149
EPS8epidermal growth factor receptor pathway substrate 80.148
NOXA1NADPH oxidase activator 10.146
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.143
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.136
FLNBfilamin B, beta0.135
EXOC8exocyst complex component 80.134
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.132
BAXBCL2-associated X protein0.131
CYTH1cytohesin 10.129
PKP3plakophilin 30.127
ALDOBaldolase B, fructose-bisphosphate0.123
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.123
EXOC1exocyst complex component 10.121
RANBP9RAN binding protein 90.118
EMP3epithelial membrane protein 30.116
BBS1Bardet-Biedl syndrome 10.116
CLPTM1cleft lip and palate associated transmembrane protein 10.115
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
itgb1b.2integrin, beta 1b.20.970
ccz1CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)0.323
esyt3extended synaptotagmin-like protein 30.314
itgb1aintegrin, beta 1a0.310
rbpms2RNA binding protein with multiple splicing 20.284
tuba1tubulin, alpha 10.222
gna12guanine nucleotide binding protein (G protein) alpha 120.210
cdh2cadherin 2, neuronal0.208
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.196
vps26bvacuolar protein sorting 26 homolog B0.191
phlda2pleckstrin homology-like domain, family A, member 20.179
igfbp6ainsulin-like growth factor binding protein 6a0.166
itgb1b.1integrin, beta 1b.10.163
mmp14bmatrix metalloproteinase 14b (membrane-inserted)0.149
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.149
ef1aelongation factor 1-alpha0.145
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.145
tcea2transcription elongation factor A (SII), 20.144
acvr1bactivin A receptor, type IB0.140
spint1aserine peptidase inhibitor, Kunitz type 1 a0.135
rrasrelated RAS viral (r-ras) oncogene homolog0.135
sypl2bsynaptophysin-like 2b0.127
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.124
slc4a2asolute carrier family 4, anion exchanger, member 2a0.121
krt8keratin 80.118
sdf2stromal cell-derived factor 20.116
slc4a4asolute carrier family 4, member 4a0.113
rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.112
trappc5trafficking protein particle complex 50.109
igfbp6binsulin-like growth factor binding protein 6b0.107
krt4keratin 40.107
prkaa1protein kinase, AMP-activated, alpha 1 catalytic subunit0.106
ube2g2ubiquitin-conjugating enzyme E2G 20.104
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.101
llgl2lethal giant larvae homolog 2 (Drosophila)0.101
iqgap1IQ motif containing GTPase activating protein 10.100
jkampjnk1/mapk8-associated membrane protein0.098
trim55atripartite motif-containing 55a0.097
frylfurry homolog-like (Drosophila)0.096
zfpl1zinc finger protein-like 10.093
dspadesmoplakin a0.091
uchl1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.090
gnaiaguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a0.090
LOC567131calcitonin gene-related peptide type 1 receptor-like0.089
sec11aSEC11 homolog A (S. cerevisiae)0.088
ext2exostoses (multiple) 20.087
derl1Der1-like domain family, member 10.084
asb8ankyrin repeat and SOCS box-containing 80.084
metrnlmeteorin, glial cell differentiation regulator-like0.084
pak2ap21 (CDKN1A)-activated kinase 2a0.082
dnajb12DnaJ (Hsp40) homolog, subfamily B, member 120.081
slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.080
slc2a1bsolute carrier family 2 (facilitated glucose transporter), member 1b0.079
cisd2CDGSH iron sulfur domain 20.078
anxa2aannexin A2a0.078
msxdmuscle segment homeobox D0.077
cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.076
ccdc80coiled-coil domain containing 800.076
rap1bRAS related protein 1b0.075
cyfip2cytoplasmic FMR1 interacting protein 20.075
rab1aRAB1A, member RAS oncogene family0.074
slc30a7solute carrier family 30 (zinc transporter), member 70.074
vps26avacuolar protein sorting 26 homolog A (yeast)0.073
arf1ADP-ribosylation factor 10.073
sept2septin 20.073
alcambactivated leukocyte cell adhesion molecule b0.073
csrp1acysteine and glycine-rich protein 1a0.072
tpm3tropomyosin 30.069
vamp4vesicle-associated membrane protein 40.069
aslargininosuccinate lyase0.069
slc26a1solute carrier family 26 (sulfate transporter), member 10.068
ms4a17a.5membrane-spanning 4-domains, subfamily A, member 17A.50.068
itgb1bintegrin, beta 1b0.066
osr2odd-skipped related 2 (Drosophila)0.066
laptm4alysosomal-associated protein transmembrane 4 alpha0.065
b3galt2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 20.065
flot2aflotillin 2a0.065
cdh1cadherin 1, epithelial0.065
mobkl1aaMOB1, Mps One Binder kinase activator-like 1A (yeast), genome duplicate a0.064
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.063
mmp13amatrix metalloproteinase 13a0.063
s1pr2sphingosine-1-phosphate receptor 20.063
gnai2lguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like0.062
LOC100003330melanocortin-2 receptor accessory protein 2-like0.060
ass1argininosuccinate synthetase 10.060
tia1lcytotoxic granule-associated RNA binding protein 1, like0.060
fam3cfamily with sequence similarity 3, member C0.060
epcamepithelial cell adhesion molecule0.059
elovl1belongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b0.059
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rab11Rab-protein 110.825
cpbcapping protein beta0.536
MadMothers against dpp0.516
sec6CG5341 gene product from transcript CG5341-RA0.452
DlicDynein light intermediate chain0.422
shotshort stop0.222
l(2)gllethal (2) giant larvae0.222
LnkCG17367 gene product from transcript CG17367-RC0.192
CG3033CG3033 gene product from transcript CG3033-RA0.128
hydhyperplastic discs0.124
rheaCG6831 gene product from transcript CG6831-RA0.116
Cdc42CG12530 gene product from transcript CG12530-RA0.110
Snap25Synapse protein 250.109
CG13089CG13089 gene product from transcript CG13089-RA0.105
Tsc1CG6147 gene product from transcript CG6147-RA0.081
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.078
Syx1ASyntaxin 1A0.078
PtenCG5671 gene product from transcript CG5671-RB0.075
PP2A-B'CG7913 gene product from transcript CG7913-RK0.075
Fas2Fasciclin 20.071
G-oalpha47AG protein oalpha 47A0.069
CspCysteine string protein0.068
poepurity of essence0.065
par-1CG8201 gene product from transcript CG8201-RA0.064
trioCG18214 gene product from transcript CG18214-RA0.061
LanB1CG7123 gene product from transcript CG7123-RA0.061
unc-104CG8566 gene product from transcript CG8566-RB0.060
WASpCG1520 gene product from transcript CG1520-RA0.057
Arc-p34CG10954 gene product from transcript CG10954-RA0.054
Vap-33-1CG5014 gene product from transcript CG5014-RB0.050
neuroliginCG13772 gene product from transcript CG13772-RA0.047
Nrx-IVNeurexin IV0.044
CG12945CG12945 gene product from transcript CG12945-RB0.037
pashapartner of drosha0.037
RhebCG1081 gene product from transcript CG1081-RA0.037
HDAC6CG6170 gene product from transcript CG6170-RA0.037
Arf79FADP ribosylation factor 79F0.036
Rac1CG2248 gene product from transcript CG2248-RA0.036
cpacapping protein alpha0.033
Rip11Rab11 interacting protein0.033
nwknervous wreck0.033
EphrinCG1862 gene product from transcript CG1862-RA0.033
Tsp86DTetraspanin 86D0.032
lolallola like0.032
CG12001CG12001 gene product from transcript CG12001-RA0.029
Gprk2G protein-coupled receptor kinase 20.028
frcfringe connection0.025
didumdilute class unconventional myosin0.024
Cip4CG15015 gene product from transcript CG15015-RA0.024
RhoGAP68FCG6811 gene product from transcript CG6811-RA0.023
Ank2Ankyrin 20.023
aPKCatypical protein kinase C0.021
ChcClathrin heavy chain0.021
Rme-8Receptor mediated endocytosis 80.019
unc-13CG2999 gene product from transcript CG2999-RA0.019
sec5CG8843 gene product from transcript CG8843-RA0.018
CG15609CG15609 gene product from transcript CG15609-RE0.018
KhcKinesin heavy chain0.018
fz2frizzled 20.017
CG12077CG12077 gene product from transcript CG12077-RB0.017
eIF4Geukaryotic translation initiation factor 4G0.016
CG32486CG32486 gene product from transcript CG32486-RD0.016
CG5412CG5412 gene product from transcript CG5412-RA0.016
alpha-Specalpha Spectrin0.016
Upf2CG2253 gene product from transcript CG2253-RA0.015
neroCG2245 gene product from transcript CG2245-RA0.015
Kap-alpha3karyopherin alpha30.015
CG31120CG31120 gene product from transcript CG31120-RB0.013
cicubitus interruptus0.013
Hr39Hormone receptor-like in 390.013
hipkhomeodomain interacting protein kinase0.013
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lama5laminin, alpha 50.950
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.893
Cd151CD151 antigen0.681
Vegfavascular endothelial growth factor A0.607
Ptrfpolymerase I and transcript release factor0.556
Rargretinoic acid receptor, gamma0.515
Lhx1LIM homeobox protein 10.496
Itga3integrin alpha 30.452
Itgb1integrin beta 1 (fibronectin receptor beta)0.367
Hbb-b1hemoglobin, beta adult major chain0.331
Vhlvon Hippel-Lindau tumor suppressor0.264
Krt8keratin 80.253
Nrxn1neurexin I0.248
Bcl2B-cell leukemia/lymphoma 20.243
Ilkintegrin linked kinase0.232
Nrxn3neurexin III0.224
Fgf8fibroblast growth factor 80.211
Ctnnd1catenin (cadherin associated protein), delta 10.174
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.170
Nphs2nephrosis 2 homolog, podocin (human)0.148
Fgfr1fibroblast growth factor receptor 10.141
Col4a3collagen, type IV, alpha 30.136
S100a11S100 calcium binding protein A11 (calgizzarin)0.135
Ldb3LIM domain binding 30.134
Add2adducin 2 (beta)0.131
Krt19keratin 190.130
Nrxn2neurexin II0.128
Slc34a1solute carrier family 34 (sodium phosphate), member 10.122
Sema3bsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B0.117
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.112
Lmx1bLIM homeobox transcription factor 1 beta0.112
Ctnnb1catenin (cadherin associated protein), beta 10.110
Fliiflightless I homolog (Drosophila)0.106
Kif3akinesin family member 3A0.104
Shhsonic hedgehog0.103
Add1adducin 1 (alpha)0.100
Stx7syntaxin 70.099
Lmnalamin A0.099
Gsk3bglycogen synthase kinase 3 beta0.096
Myo1cmyosin IC0.095
Ehd4EH-domain containing 40.086
Gdnfglial cell line derived neurotrophic factor0.085
S100a6S100 calcium binding protein A6 (calcyclin)0.084
Tsc1tuberous sclerosis 10.079
Clasp1CLIP associating protein 10.079
L1camL1 cell adhesion molecule0.078
Spnb2spectrin beta 20.077
Gja1gap junction protein, alpha 10.077
Cldn7claudin 70.077
Capn2calpain 20.075
Fjx1four jointed box 1 (Drosophila)0.071
Capn1calpain 10.071
Nf2neurofibromatosis 20.070
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.067
Bmp7bone morphogenetic protein 70.066
Anxa2annexin A20.066
Rrm2bribonucleotide reductase M2 B (TP53 inducible)0.066
Nos3nitric oxide synthase 3, endothelial cell0.065
Krt7keratin 70.065
Mark4MAP/microtubule affinity-regulating kinase 40.063
Ptprbprotein tyrosine phosphatase, receptor type, B0.063
RrasHarvey rat sarcoma oncogene, subgroup R0.063
Dync1h1dynein cytoplasmic 1 heavy chain 10.063
Fgfr2fibroblast growth factor receptor 20.062
Ctnna1catenin (cadherin associated protein), alpha 10.062
Wfdc2WAP four-disulfide core domain 20.061
Zfp651zinc finger protein 6510.058
Itga6integrin alpha 60.057
Dlg4discs, large homolog 4 (Drosophila)0.057
Capns1calpain, small subunit 10.055
Arvcfarmadillo repeat gene deleted in velo-cardio-facial syndrome0.054
Lamc1laminin, gamma 10.054
Flot2flotillin 20.054
Spint1serine protease inhibitor, Kunitz type 10.052
Nos1nitric oxide synthase 1, neuronal0.052
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.052
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.051
Cldn3claudin 30.051
Wnt4wingless-related MMTV integration site 40.050
Egln1EGL nine homolog 1 (C. elegans)0.049
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.047
Wbp2WW domain binding protein 20.047
Crb3crumbs homolog 3 (Drosophila)0.046
Akt2thymoma viral proto-oncogene 20.045
Flot1flotillin 10.045
Fbln1fibulin 10.045
Dmddystrophin, muscular dystrophy0.044
Ap2a1adaptor protein complex AP-2, alpha 1 subunit0.044
Wasf2WAS protein family, member 20.044
Lamb2laminin, beta 20.044
Spnb1spectrin beta 10.044
Rbl2retinoblastoma-like 20.044
Stxbp5syntaxin binding protein 5 (tomosyn)0.043
Apc2adenomatosis polyposis coli 20.043
Hif1ahypoxia inducible factor 1, alpha subunit0.043
Spna1spectrin alpha 10.042
Ash1lash1 (absent, small, or homeotic)-like (Drosophila)0.042
Syplsynaptophysin-like protein0.042
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism