The network for 'columnar cuboidal epithelial cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

columnar cuboidal epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TAL1T-cell acute lymphocytic leukemia 10.991
HNF4Ahepatocyte nuclear factor 4, alpha0.755
HDAC2histone deacetylase 20.753
EP300E1A binding protein p3000.672
RUNX1runt-related transcription factor 10.588
MDM2Mdm2 p53 binding protein homolog (mouse)0.574
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.517
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.461
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.460
TSC2tuberous sclerosis 20.398
PAX3paired box 30.390
PSEN1presenilin 10.342
TP53tumor protein p530.272
PDX1pancreatic and duodenal homeobox 10.247
FGF1fibroblast growth factor 1 (acidic)0.212
BMPR1Abone morphogenetic protein receptor, type IA0.189
POU3F2POU class 3 homeobox 20.176
POU5F1POU class 5 homeobox 10.165
MED25mediator complex subunit 250.155
SFNstratifin0.150
RAB27ARAB27A, member RAS oncogene family0.144
CREBBPCREB binding protein0.131
ESR1estrogen receptor 10.123
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.120
MLPHmelanophilin0.117
NCOA1nuclear receptor coactivator 10.115
TCF4transcription factor 40.107
JAG1jagged 10.103
TNRC6Btrinucleotide repeat containing 6B0.097
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.082
CLOCKclock homolog (mouse)0.081
STK3serine/threonine kinase 30.081
FGFR1fibroblast growth factor receptor 10.077
RARAretinoic acid receptor, alpha0.077
BCL2L1BCL2-like 10.073
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.072
FLNBfilamin B, beta0.068
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.067
HNF1AHNF1 homeobox A0.063
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.063
NCOA3nuclear receptor coactivator 30.062
NR4A1nuclear receptor subfamily 4, group A, member 10.060
HIPK2homeodomain interacting protein kinase 20.060
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.059
BMPR1Bbone morphogenetic protein receptor, type IB0.058
NKX3-1NK3 homeobox 10.056
FGF10fibroblast growth factor 100.054
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.054
NOTCH3notch 30.052
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.051
CTNND1catenin (cadherin-associated protein), delta 10.051
APEX1APEX nuclease (multifunctional DNA repair enzyme) 10.049
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.048
ARandrogen receptor0.048
ARRB1arrestin, beta 10.043
CCND1cyclin D10.039
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.038
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.038
GRB7growth factor receptor-bound protein 70.037
EPAS1endothelial PAS domain protein 10.037
NCSTNnicastrin0.036
EIF2C2eukaryotic translation initiation factor 2C, 20.034
KAT2BK(lysine) acetyltransferase 2B0.033
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.032
EIF2C1eukaryotic translation initiation factor 2C, 10.032
SOX2SRY (sex determining region Y)-box 20.031
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.031
ONECUT1one cut homeobox 10.030
FOXA2forkhead box A20.028
CDX2caudal type homeobox 20.028
ZFYVE9zinc finger, FYVE domain containing 90.027
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.027
MTA3metastasis associated 1 family, member 30.025
GATA2GATA binding protein 20.025
AHRaryl hydrocarbon receptor0.024
ZFPM1zinc finger protein, multitype 10.024
HIC1hypermethylated in cancer 10.023
RAXretina and anterior neural fold homeobox0.023
NOGnoggin0.023
FGF8fibroblast growth factor 8 (androgen-induced)0.022
AKT1v-akt murine thymoma viral oncogene homolog 10.022
BAZ2Bbromodomain adjacent to zinc finger domain, 2B0.021
PMLpromyelocytic leukemia0.021
HOXD12homeobox D120.021
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.020
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.020
MEOX2mesenchyme homeobox 20.020
SATB2SATB homeobox 20.019
SIRT1sirtuin 10.019
PROX1prospero homeobox 10.018
MYOD1myogenic differentiation 10.018
STRADASTE20-related kinase adaptor alpha0.018
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.018
EGLN1egl nine homolog 1 (C. elegans)0.018
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.018
TBX5T-box 50.018
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.018
BMP4bone morphogenetic protein 40.017
SFRP5secreted frizzled-related protein 50.017
TNRC6Atrinucleotide repeat containing 6A0.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.994
sox10SRY-box containing gene 100.969
bmp2bbone morphogenetic protein 2b0.969
tfap2atranscription factor AP-2 alpha0.963
foxa3forkhead box A30.947
notch1anotch homolog 1a0.943
mibmind bomb0.940
isl1islet10.866
gdf6agrowth differentiation factor 6a0.857
tp53tumor protein p530.856
tyrtyrosinase0.851
kitakit receptor a0.832
bmp4bone morphogenetic protein 40.817
trpm7transient receptor potential cation channel, subfamily M, member 70.811
cdx4caudal type homeo box transcription factor 40.725
pax6apaired box gene 6a0.710
fgf8afibroblast growth factor 8 a0.709
lef1lymphocyte enhancer binding factor 10.678
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.639
sox2SRY-box containing gene 20.639
otx2orthodenticle homolog 20.623
foxi1forkhead box I10.618
mitfamicrophthalmia-associated transcription factor a0.614
sox1aSRY-box containing gene 1a0.585
pax6bpaired box gene 6b0.565
gata3GATA-binding protein 30.531
jag1bjagged 1b0.531
hoxb3ahomeo box B3a0.528
pmelapremelanosome protein a0.518
jag2jagged 20.498
six3asine oculis homeobox homolog 3a0.481
sox9bSRY-box containing gene 9b0.449
mnx1motor neuron and pancreas homeobox 10.434
foxa2forkhead box A20.426
tbx2bT-box 2b0.426
olig2oligodendrocyte lineage transcription factor 20.419
inspreproinsulin0.417
pax2apaired box gene 2a0.404
foxd3forkhead box D30.392
sox19aSRY-box containing gene 19a0.392
dladeltaA0.390
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.365
ptch2patched 20.365
evx1even-skipped homeobox 10.363
foxi3aforkhead box I3a0.361
tfebtranscription factor EB0.358
hlxb9lahomeo box HB9 like a0.358
otpborthopedia homolog b0.344
six3bsine oculis homeobox homolog 3b0.341
gbx1gastrulation brain homeobox 10.324
msxbmuscle segment homeobox B0.310
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.310
neurodneurogenic differentiation0.309
slc45a2solute carrier family 45, member 20.309
notch3notch homolog 30.307
nkx2.2aNK2 transcription factor related 2a0.305
pdx1pancreatic and duodenal homeobox 10.304
gata2aGATA-binding protein 2a0.301
irx3airoquois homeobox protein 3a0.295
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.291
mecp2methyl CpG binding protein 20.288
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.276
wu:fv91b12wu:fv91b120.274
rx3retinal homeobox gene 30.272
hoxd11ahomeo box D11a0.270
mecomMDS1 and EVI1 complex locus0.260
vsx2visual system homeobox 20.258
nkx6.2NK6 transcription factor related, locus 20.236
rargaretinoic acid receptor gamma a0.229
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.222
dlcdeltaC0.222
flhfloating head0.216
sox3SRY-box containing gene 30.202
eya1eyes absent homolog 10.199
pitx2paired-like homeodomain transcription factor 20.199
tp63tumor protein p630.196
dlx2adistal-less homeobox gene 2a0.192
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.191
dlx3bdistal-less homeobox gene 3b0.183
lmx1b.2LIM homeobox transcription factor 1, beta 20.183
hmx4H6 family homeobox 40.182
foxg1aforkhead box G1a0.181
ndr2nodal-related 20.171
dlddeltaD0.169
slc24a5solute carrier family 24, member 50.168
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.163
supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.159
hoxd13ahomeo box D13a0.159
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.148
osr1odd-skipped related 1 (Drosophila)0.147
otx1borthodenticle homolog 1b0.147
tfectranscription factor EC0.145
tbx1T-box 10.144
lmo4aLIM domain only 4a0.139
mab21l2mab-21-like 20.137
lhx1aLIM homeobox 1a0.137
raraaretinoic acid receptor, alpha a0.129
ntlano tail a0.129
gli2aGLI-Kruppel family member GLI2a0.124
nf1aneurofibromin 1a0.124
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rac1CG2248 gene product from transcript CG2248-RA1.000
ttktramtrack1.000
domedomeless1.000
NNotch1.000
RalaRas-related protein1.000
Stat92ESignal-transducer and activator of transcription protein at 92E0.999
Ras85DRas oncogene at 85D0.999
sqhspaghetti squash0.999
hpohippo0.999
bazbazooka0.998
par-6CG5884 gene product from transcript CG5884-RA0.997
mbcmyoblast city0.997
BicDBicaudal D0.997
aopanterior open0.997
EgfrEpidermal growth factor receptor0.997
phlpole hole0.995
rheaCG6831 gene product from transcript CG6831-RA0.994
alpha-Catalpha Catenin0.993
par-1CG8201 gene product from transcript CG8201-RA0.993
ykiyorkie0.990
Rab5Rab-protein 50.987
Lis-1Lissencephaly-10.986
shgshotgun0.986
cicubitus interruptus0.984
CortactinCG3637 gene product from transcript CG3637-RA0.984
osoutstretched0.982
eyaeyes absent0.981
Rho1CG8416 gene product from transcript CG8416-RB0.980
chicchickadee0.979
Ets97DEts at 97D0.977
diadiaphanous0.977
Ced-12CG5336 gene product from transcript CG5336-RA0.973
rlrolled0.972
emcextra macrochaetae0.969
kibrakibra ortholog0.969
gbbglass bottom boat0.966
jingCG9397 gene product from transcript CG9397-RI0.963
bskbasket0.963
cindrCIN85 and CD2AP orthologue0.961
spn-Bspindle B0.960
CG8155CG8155 gene product from transcript CG8155-RA0.959
wtswarts0.957
dppdecapentaplegic0.951
grkgurken0.950
E(spl)Enhancer of split0.949
Dhc64CDynein heavy chain 64C0.948
KhcKinesin heavy chain0.939
kugkugelei0.936
putpunt0.934
kuzkuzbanian0.931
enaenabled0.930
tkvthickveins0.930
ShcSHC-adaptor protein0.929
fzfrizzled0.926
exexpanded0.926
Src42ASrc oncogene at 42A0.926
dshdishevelled0.925
CalpBCalpain-B0.922
ecdecdysoneless0.918
escextra sexcombs0.912
Doc2Dorsocross20.907
pntpointed0.905
cpbcapping protein beta0.904
zipzipper0.898
dlg1discs large 10.897
pydpolychaetoid0.889
sggshaggy0.889
panpangolin0.887
yuCG3249 gene product from transcript CG3249-RA0.883
rokRho-kinase0.880
p53CG33336 gene product from transcript CG33336-RB0.879
rprreaper0.874
spn-Aspindle A0.873
MrtfMyocardin-related transcription factor0.870
KrnKeren0.867
staustaufen0.865
mysmyospheroid0.861
EcREcdysone receptor0.859
babobaboon0.857
brkbrinker0.856
Tm1Tropomyosin 10.855
CG14869CG14869 gene product from transcript CG14869-RB0.853
shishibire0.853
fs(1)M3female sterile (1) M30.852
hdhumpty dumpty0.852
PtenCG5671 gene product from transcript CG5671-RB0.850
nmonemo0.849
psdpalisade0.841
PvrPDGF- and VEGF-receptor related0.835
Socs36ESuppressor of cytokine signaling at 36E0.834
Pi3K92ECG4141 gene product from transcript CG4141-RB0.833
mus301mutagen-sensitive 3010.833
tlltailless0.828
MadMothers against dpp0.828
CG6509CG6509 gene product from transcript CG6509-RB0.825
cortoCG2530 gene product from transcript CG2530-RA0.824
srpserpent0.823
KrKruppel0.818
senssenseless0.815
HemHEM-protein0.813
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Ptenphosphatase and tensin homolog1.000
Pax3paired box gene 31.000
Fgf8fibroblast growth factor 81.000
Otx2orthodenticle homolog 2 (Drosophila)0.999
Fgfr2fibroblast growth factor receptor 20.999
Tcfap2atranscription factor AP-2, alpha0.999
Foxc1forkhead box C10.998
Sox9SRY-box containing gene 90.998
Gli3GLI-Kruppel family member GLI30.998
Foxc2forkhead box C20.997
Foxa2forkhead box A20.997
Pax8paired box gene 80.997
Meox2mesenchyme homeobox 20.997
Mitfmicrophthalmia-associated transcription factor0.997
Isl1ISL1 transcription factor, LIM/homeodomain0.996
Fgfr1fibroblast growth factor receptor 10.995
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.994
Gli2GLI-Kruppel family member GLI20.994
Trp53transformation related protein 530.994
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.993
Hand2heart and neural crest derivatives expressed transcript 20.991
Hes1hairy and enhancer of split 1 (Drosophila)0.989
Pitx2paired-like homeodomain transcription factor 20.988
Tbx1T-box 10.981
Psen1presenilin 10.979
Vegfavascular endothelial growth factor A0.977
Kitkit oncogene0.972
Ctnnb1catenin (cadherin associated protein), beta 10.970
Ikzf1IKAROS family zinc finger 10.966
Rargretinoic acid receptor, gamma0.964
Bmp7bone morphogenetic protein 70.962
Ascl1achaete-scute complex homolog 1 (Drosophila)0.961
Ptpn11protein tyrosine phosphatase, non-receptor type 110.954
anonagouti0.954
Lystlysosomal trafficking regulator0.954
Nodalnodal0.950
Pax6paired box gene 60.948
Bmp4bone morphogenetic protein 40.948
Lhx1LIM homeobox protein 10.947
Pou5f1POU domain, class 5, transcription factor 10.947
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.946
Notch2Notch gene homolog 2 (Drosophila)0.944
Pax2paired box gene 20.931
Ror2receptor tyrosine kinase-like orphan receptor 20.927
Tal1T-cell acute lymphocytic leukemia 10.927
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.923
Rararetinoic acid receptor, alpha0.916
Nkx2-1NK2 homeobox 10.914
Lhx3LIM homeobox protein 30.900
Prrx1paired related homeobox 10.894
Sox2SRY-box containing gene 20.893
Ahraryl-hydrocarbon receptor0.889
Eya1eyes absent 1 homolog (Drosophila)0.886
Hoxd3homeobox D30.875
Zic3zinc finger protein of the cerebellum 30.874
Hoxa3homeobox A30.866
Hoxa5homeobox A50.863
Hoxb3homeobox B30.858
Kitlkit ligand0.854
Hoxb4homeobox B40.842
Insm1insulinoma-associated 10.840
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.839
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.834
Wnt3awingless-related MMTV integration site 3A0.823
Grb10growth factor receptor bound protein 100.819
Fgf10fibroblast growth factor 100.818
Pthlhparathyroid hormone-like peptide0.814
Retret proto-oncogene0.814
Emx1empty spiracles homolog 1 (Drosophila)0.812
Rarbretinoic acid receptor, beta0.809
Emx2empty spiracles homolog 2 (Drosophila)0.808
FynFyn proto-oncogene0.800
Gata4GATA binding protein 40.799
Hoxa11homeobox A110.791
Pou3f3POU domain, class 3, transcription factor 30.789
Nognoggin0.786
Hand1heart and neural crest derivatives expressed transcript 10.777
Chrdchordin0.777
En1engrailed 10.772
Chd7chromodomain helicase DNA binding protein 70.764
Neurod1neurogenic differentiation 10.760
Ptf1apancreas specific transcription factor, 1a0.759
Tyrp1tyrosinase-related protein 10.751
Sox10SRY-box containing gene 100.748
Gbx2gastrulation brain homeobox 20.745
Csf1colony stimulating factor 1 (macrophage)0.740
Vangl2vang-like 2 (van gogh, Drosophila)0.736
Fgf15fibroblast growth factor 150.721
Arntlaryl hydrocarbon receptor nuclear translocator-like0.717
Hoxa13homeobox A130.706
Msx1homeobox, msh-like 10.706
Ednrbendothelin receptor type B0.683
Eporerythropoietin receptor0.682
Hoxa1homeobox A10.678
Nos3nitric oxide synthase 3, endothelial cell0.670
Msx2homeobox, msh-like 20.662
Notch1Notch gene homolog 1 (Drosophila)0.658
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.658
Tcf15transcription factor 150.656
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tcf4transcription factor 40.126
Gsk3bglycogen synthase kinase 3 beta0.057
Abcc1ATP-binding cassette, subfamily C (CFTR/MRP), member 10.031
Dpm3dolichyl-phosphate mannosyltransferase polypeptide 30.029
Pax6paired box 60.026
Igfbp5insulin-like growth factor binding protein 50.023
Mid1midline 10.023
Ednrbendothelin receptor type B0.020
Calcrlcalcitonin receptor-like0.019
Tgfbr2transforming growth factor, beta receptor II0.019
Bbxbobby sox homolog (Drosophila)0.017
Pparaperoxisome proliferator activated receptor alpha0.017
Efnb1ephrin B10.017
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.016
Nek9NIMA (never in mitosis gene a)- related kinase 90.015
Il1r1interleukin 1 receptor, type I0.014
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.014
Igsf1immunoglobulin superfamily, member 10.014
Ppm1fprotein phosphatase 1F (PP2C domain containing)0.014
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.013
Elof1elongation factor 1 homolog (S. cerevisiae)0.013
Sp4Sp4 transcription factor0.013
Whsc2Wolf-Hirschhorn syndrome candidate 2 (human)0.012
Hrh2histamine receptor H 20.011
Adam10ADAM metallopeptidase domain 100.011
Lig3ligase III, DNA, ATP-dependent0.011
Cdk2cyclin dependent kinase 20.010
Cpmcarboxypeptidase M0.010
Itpr2inositol 1,4,5-triphosphate receptor, type 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism