The network for 'peptidyl lysine modification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peptidyl lysine modification

The modification of peptidyl-lysine.

NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p531.000
WDR5WD repeat domain 51.000
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.997
ACTL6Aactin-like 6A0.994
C20orf20chromosome 20 open reading frame 200.991
TAF4TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa0.985
CBX5chromobox homolog 50.979
TRRAPtransformation/transcription domain-associated protein0.977
KAT2BK(lysine) acetyltransferase 2B0.964
CREBBPCREB binding protein0.956
NCOA6nuclear receptor coactivator 60.956
JUNjun proto-oncogene0.949
KAT2AK(lysine) acetyltransferase 2A0.943
MEN1multiple endocrine neoplasia I0.941
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.930
ARandrogen receptor0.928
SIN3ASIN3 homolog A, transcription regulator (yeast)0.924
HDAC1histone deacetylase 10.917
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.916
HDAC2histone deacetylase 20.915
FOSFBJ murine osteosarcoma viral oncogene homolog0.910
MAPK14mitogen-activated protein kinase 140.909
DUSP1dual specificity phosphatase 10.903
TADA3transcriptional adaptor 30.886
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.881
RB1retinoblastoma 10.878
VPS72vacuolar protein sorting 72 homolog (S. cerevisiae)0.856
MYST1MYST histone acetyltransferase 10.852
HIST1H3Bhistone cluster 1, H3b0.841
MYST3MYST histone acetyltransferase (monocytic leukemia) 30.836
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.833
SIRT1sirtuin 10.832
USP22ubiquitin specific peptidase 220.818
EP300E1A binding protein p3000.818
POLE3polymerase (DNA directed), epsilon 3 (p17 subunit)0.817
YY1YY1 transcription factor0.797
TAF10TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa0.793
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.771
KDM1Alysine (K)-specific demethylase 1A0.767
MRFAP1Morf4 family associated protein 10.761
ESR1estrogen receptor 10.755
MBIPMAP3K12 binding inhibitory protein 10.749
MAPK3mitogen-activated protein kinase 30.740
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.687
SMN1survival of motor neuron 1, telomeric0.681
CFL1cofilin 1 (non-muscle)0.676
MORF4L1mortality factor 4 like 10.665
DAXXdeath-domain associated protein0.647
CCDC101coiled-coil domain containing 1010.639
SETD7SET domain containing (lysine methyltransferase) 70.629
NCOA1nuclear receptor coactivator 10.624
IKBKAPinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein0.610
BRCA1breast cancer 1, early onset0.571
HDAC4histone deacetylase 40.564
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.546
ING3inhibitor of growth family, member 30.545
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.545
TAF9TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa0.534
PCNAproliferating cell nuclear antigen0.525
SETD8SET domain containing (lysine methyltransferase) 80.523
LRIF1ligand dependent nuclear receptor interacting factor 10.521
EPC2enhancer of polycomb homolog 2 (Drosophila)0.514
KAT5K(lysine) acetyltransferase 50.493
MAP3K5mitogen-activated protein kinase kinase kinase 50.487
KLF6Kruppel-like factor 60.481
SMAD7SMAD family member 70.480
ELP2elongation protein 2 homolog (S. cerevisiae)0.478
EHMT2euchromatic histone-lysine N-methyltransferase 20.472
RBBP4retinoblastoma binding protein 40.470
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.444
MECP2methyl CpG binding protein 2 (Rett syndrome)0.434
NCOR2nuclear receptor corepressor 20.421
HCFC1host cell factor C1 (VP16-accessory protein)0.419
NCOA2nuclear receptor coactivator 20.413
HDAC6histone deacetylase 60.412
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.402
CUX1cut-like homeobox 10.402
CTBP1C-terminal binding protein 10.395
PDZD11PDZ domain containing 110.394
TWIST1twist homolog 1 (Drosophila)0.392
RBBP5retinoblastoma binding protein 50.385
MDM4Mdm4 p53 binding protein homolog (mouse)0.384
HGShepatocyte growth factor-regulated tyrosine kinase substrate0.378
BCL6B-cell CLL/lymphoma 60.364
KLF4Kruppel-like factor 4 (gut)0.354
MAPK8mitogen-activated protein kinase 80.354
MEF2Cmyocyte enhancer factor 2C0.347
RSBN1round spermatid basic protein 10.346
ADNPactivity-dependent neuroprotector homeobox0.338
PAFAH1B3platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)0.332
EPC1enhancer of polycomb homolog 1 (Drosophila)0.316
PAXIP1PAX interacting (with transcription-activation domain) protein 10.315
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.315
CSNK1Ecasein kinase 1, epsilon0.311
PAX3paired box 30.307
SMURF1SMAD specific E3 ubiquitin protein ligase 10.306
NCOR1nuclear receptor corepressor 10.305
RING1ring finger protein 10.304
POU3F2POU class 3 homeobox 20.303
ZNF496zinc finger protein 4960.301
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
hda-2Protein HDA-20.122
trr-1Protein TRR-10.060
CELE_B0238.11Protein B0238.110.033
F44E2.8Protein F44E2.80.024
F33E11.3Protein F33E11.30.023
CELE_Y54G11A.11Protein Y54G11A.110.020
R07G3.7Protein R07G3.70.017
attf-2Protein ATTF-20.016
lin-5Protein LIN-50.016
baf-1Protein BAF-10.016
sas-4Protein SAS-40.015
npp-7Protein NPP-70.014
tim-1Protein TIM-10.013
swsn-6Protein SWSN-60.013
apr-1Protein APR-10.012
Y48G1A.2Protein Y48G1A.20.012
spr-5Protein SPR-50.012
R05D3.2Protein R05D3.20.011
Y87G2A.1Protein Y87G2A.10.010
dcr-1Protein DCR-10.010
eya-1Protein EYA-10.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
smyd2aSET and MYND domain containing 2a0.024
prdm11PR domain containing 110.017
ezh2enhancer of zeste homolog 2 (Drosophila)0.016
rbb4retinoblastoma binding protein 40.014
tal1T-cell acute lymphocytic leukemia 10.013
suv420h1suppressor of variegation 4-20 homolog 1 (Drosophila)0.013
setdb1aSET domain, bifurcated 1a0.012
smyd5SMYD family member 50.011
prdm2bPR domain containing 2, with ZNF domain b0.011
cbx5chromobox homolog 5 (HP1 alpha homolog, Drosophila)0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
HcfHost cell factor1.000
Snr1Snf5-related 10.997
CG10414CG10414 gene product from transcript CG10414-RA0.989
Rpd3CG7471 gene product from transcript CG7471-RA0.974
PcafCG4107 gene product from transcript CG4107-RA0.968
notnon-stop0.948
ash1absent, small, or homeotic discs 10.946
Atac1ATAC component 10.943
dikdiskette0.939
mofmales absent on the first0.898
msl-3male-specific lethal 30.844
wdswill die slowly0.841
CG3363CG3363 gene product from transcript CG3363-RB0.774
PcPolycomb0.765
domdomino0.760
msl-1male-specific lethal 10.707
Nf-YBNuclear factor Y-box B0.634
Mocs2Molybdopterin synthase 20.619
MRG15CG6363 gene product from transcript CG6363-RA0.606
D12CG13400 gene product from transcript CG13400-RA0.591
Spt5CG7626 gene product from transcript CG7626-RA0.466
Saf6SAGA factor-like TAF60.460
eggeggless0.453
lidlittle imaginal discs0.442
Sgf29CG30390 gene product from transcript CG30390-RA0.437
cgcombgap0.397
dalaoCG7055 gene product from transcript CG7055-RA0.381
Su(var)3-7Suppressor of variegation 3-70.372
CG4400CG4400 gene product from transcript CG4400-RA0.369
Su(var)3-3Suppressor of variegation 3-30.356
wtswarts0.334
noinoisette0.329
mod(mdg4)modifier of mdg40.325
ph-dpolyhomeotic distal0.325
enokenoki mushroom0.313
ScmSex comb on midleg0.310
Bap55Brahma associated protein 55kD0.305
Caf1-180CG12109 gene product from transcript CG12109-RB0.298
Deaf1Deformed epidermal autoregulatory factor-10.292
Taf6TBP-associated factor 60.292
ordorientation disruptor0.271
l(3)mbtlethal (3) malignant brain tumor0.270
Sam-SS-adenosylmethionine Synthetase0.264
waplwings apart-like0.259
brmbrahma0.259
Chrac-14CG13399 gene product from transcript CG13399-RA0.253
Su(H)Suppressor of Hairless0.252
Sir2CG5216 gene product from transcript CG5216-RA0.248
droshaCG8730 gene product from transcript CG8730-RA0.241
CG10107CG10107 gene product from transcript CG10107-RA0.237
polybromoCG11375 gene product from transcript CG11375-RA0.222
mlemaleless0.219
me31Bmaternal expression at 31B0.208
O-fut1O-fucosyltransferase 10.195
KrKruppel0.194
kiskismet0.192
Bap170Brahma associated protein 170kD0.186
Su(z)2Suppressor of zeste 20.186
Pka-C1cAMP-dependent protein kinase 10.184
NC2alphaCG10318 gene product from transcript CG10318-RA0.182
HP1cCG6990 gene product from transcript CG6990-RA0.155
fzyfizzy0.149
Suv4-20CG13363 gene product from transcript CG13363-RA0.148
ushu-shaped0.145
e(y)2enhancer of yellow 20.145
l(2)35Dflethal (2) 35Df0.144
MadMothers against dpp0.141
RgaRegena0.137
simjsimjang0.134
MED16Mediator complex subunit 160.132
tsutsunagi0.130
msl-2male-specific lethal 20.127
Cdk8Cyclin-dependent kinase 80.127
CG5669CG5669 gene product from transcript CG5669-RA0.126
snostrawberry notch0.126
NC2betaCG4185 gene product from transcript CG4185-RA0.125
wbwing blister0.123
domedomeless0.122
defldeflated0.121
CG10880CG10880 gene product from transcript CG10880-RA0.120
l(2)37Cblethal (2) 37Cb0.116
wocwithout children0.116
Nipped-ACG33554 gene product from transcript CG33554-RE0.116
bonbonus0.114
Vps36Vacuolar protein sorting 360.111
wdnwings down0.111
mRpL36mitochondrial ribosomal protein L360.109
osaCG7467 gene product from transcript CG7467-RD0.109
Mes2CG11100 gene product from transcript CG11100-RB0.102
CG32343CG32343 gene product from transcript CG32343-RB0.099
HLH54FCG5005 gene product from transcript CG5005-RA0.098
gloglorund0.097
Chrac-16CG15736 gene product from transcript CG15736-RA0.097
U2af38U2 small nuclear riboprotein auxiliary factor 380.097
Fs(2)KetFemale sterile (2) Ketel0.097
PclPolycomblike0.096
AtuAnother transcription unit0.094
e(y)3enhancer of yellow 30.093
CG4699CG4699 gene product from transcript CG4699-RJ0.093
matsmob as tumor suppressor0.090
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rnf2ring finger protein 20.999
RybpRING1 and YY1 binding protein0.990
Arid1aAT rich interactive domain 1A (SWI-like)0.989
Trraptransformation/transcription domain-associated protein0.976
Kat2aK(lysine) acetyltransferase 2A0.967
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.966
Ezh2enhancer of zeste homolog 2 (Drosophila)0.950
Ep300E1A binding protein p3000.944
Runx1runt related transcription factor 10.910
Tcfcp2l1transcription factor CP2-like 10.885
Kdm1alysine (K)-specific demethylase 1A0.857
Kdm2blysine (K)-specific demethylase 2B0.855
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.832
CrebbpCREB binding protein0.826
Wdr5WD repeat domain 50.812
Tal1T-cell acute lymphocytic leukemia 10.810
Zeb1zinc finger E-box binding homeobox 10.787
Suz12suppressor of zeste 12 homolog (Drosophila)0.750
Ep400E1A binding protein p4000.747
Sin3atranscriptional regulator, SIN3A (yeast)0.725
Trp53transformation related protein 530.715
Pou5f1POU domain, class 5, transcription factor 10.694
Yeats2YEATS domain containing 20.689
Jarid2jumonji, AT rich interactive domain 20.677
Hdac2histone deacetylase 20.612
Rxraretinoid X receptor alpha0.582
Dmap1DNA methyltransferase 1-associated protein 10.575
Smc3structural maintenace of chromosomes 30.551
Cry2cryptochrome 2 (photolyase-like)0.543
Ptf1apancreas specific transcription factor, 1a0.531
Gata4GATA binding protein 40.524
Tgfbr2transforming growth factor, beta receptor II0.506
MgaMAX gene associated0.497
Rbbp4retinoblastoma binding protein 40.462
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.458
Tada2atranscriptional adaptor 2A0.458
Brca2breast cancer 20.442
Apcadenomatosis polyposis coli0.439
Rbl2retinoblastoma-like 20.429
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.426
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.425
Tcf4transcription factor 40.415
Smad5MAD homolog 5 (Drosophila)0.410
Klf4Kruppel-like factor 4 (gut)0.408
Mdm4transformed mouse 3T3 cell double minute 40.406
Vegfavascular endothelial growth factor A0.406
BcorBCL6 interacting corepressor0.399
Ascl1achaete-scute complex homolog 1 (Drosophila)0.398
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.395
Slc4a1solute carrier family 4 (anion exchanger), member 10.394
Mef2dmyocyte enhancer factor 2D0.384
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.373
Pum1pumilio 1 (Drosophila)0.371
Morf4l1mortality factor 4 like 10.365
Chd4chromodomain helicase DNA binding protein 40.357
Gli2GLI-Kruppel family member GLI20.351
Arid2AT rich interactive domain 2 (ARID, RFX-like)0.350
Neurod1neurogenic differentiation 10.345
Kat5K(lysine) acetyltransferase 50.319
Ncoa3nuclear receptor coactivator 30.315
Plxnd1plexin D10.312
Mll2myeloid/lymphoid or mixed-lineage leukemia 20.310
Brca1breast cancer 10.299
Mcl1myeloid cell leukemia sequence 10.294
Rbbp7retinoblastoma binding protein 70.289
Creb1cAMP responsive element binding protein 10.283
Kdm5blysine (K)-specific demethylase 5B0.280
Ehmt1euchromatic histone methyltransferase 10.279
Mll5myeloid/lymphoid or mixed-lineage leukemia 50.279
Bag6BCL2-associated athanogene 60.269
Ncor1nuclear receptor co-repressor 10.268
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.265
Foxp1forkhead box P10.259
Cbx8chromobox homolog 8 (Drosophila Pc class)0.257
Ciccapicua homolog (Drosophila)0.253
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.241
Atmataxia telangiectasia mutated homolog (human)0.240
Ruvbl2RuvB-like protein 20.240
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.238
Rararetinoic acid receptor, alpha0.237
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.234
Tcf7transcription factor 7, T-cell specific0.231
Tbx3T-box 30.230
Tgfb1transforming growth factor, beta 10.229
En1engrailed 10.228
Nbnnibrin0.228
Trim28tripartite motif-containing 280.225
Inhbainhibin beta-A0.223
Arid1bAT rich interactive domain 1B (SWI-like)0.222
Dlx2distal-less homeobox 20.221
Trim24tripartite motif-containing 240.221
Ncoa6nuclear receptor coactivator 60.219
Myod1myogenic differentiation 10.219
Gata1GATA binding protein 10.212
Phf21aPHD finger protein 21A0.210
Mtf2metal response element binding transcription factor 20.208
Mapk1mitogen-activated protein kinase 10.207
Sertad2SERTA domain containing 20.206
Prkceprotein kinase C, epsilon0.205
Brd4bromodomain containing 40.204
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Actbactin, beta0.017
Actg1actin, gamma 10.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
TRA1Tra1p1.000
ADA2Ada2p0.998
TAF6Taf6p0.998
SPT8Spt8p0.995
GCN5Gcn5p0.994
TAF12Taf12p0.978
NGG1Ngg1p0.976
HHT1Hht1p0.969
RTF1Rtf1p0.969
BDF1Bdf1p0.952
EPL1Epl1p0.924
HFI1Hfi1p0.922
SPT7Spt7p0.917
SWD3Swd3p0.907
ARP4Arp4p0.863
YAF9Yaf9p0.835
YNG2Yng2p0.783
EAF1Eaf1p0.783
SGF29Sgf29p0.653
TAF5Taf5p0.617
SDC1Sdc1p0.611
SPT3Spt3p0.584
SPP1Spp1p0.545
TAF10Taf10p0.527
TAF9Taf9p0.492
HAT1Hat1p0.438
SET2Set2p0.437
SWC4Swc4p0.434
TAF3Taf3p0.430
SPT20Spt20p0.426
HIF1Hif1p0.423
ASF1Asf1p0.422
SPT15Spt15p0.420
ESA1Esa1p0.412
ISW1Isw1p0.411
SAS4Sas4p0.409
SAS5Sas5p0.396
ELP6Elp6p0.394
EAF3Eaf3p0.389
SWD1Swd1p0.379
HAT2Hat2p0.368
SGF73Sgf73p0.357
EAF6Eaf6p0.353
LEO1Leo1p0.328
SUS1Sus1p0.319
EAF5Eaf5p0.288
SAS3Sas3p0.266
RTT106Rtt106p0.261
YNG1Yng1p0.231
AHC2Ahc2p0.220
RTT109Rtt109p0.218
SWI1Swi1p0.207
PSH1Psh1p0.197
HHF1Hhf1p0.188
SNF5Snf5p0.186
HIR1Hir1p0.185
RPD3Rpd3p0.173
HIR2Hir2p0.173
SWI3Swi3p0.170
HDA1Hda1p0.160
ELP4Elp4p0.156
RSC2Rsc2p0.152
SGF11Sgf11p0.151
UBP8Ubp8p0.151
BRE2Bre2p0.150
RCO1Rco1p0.149
NOP10Nop10p0.149
CKB1Ckb1p0.147
ELP2Elp2p0.136
TAF1Taf1p0.134
TAF4Taf4p0.134
YAT1Yat1p0.116
CAC2Cac2p0.109
FUS3Fus3p0.104
SET1Set1p0.103
IKI1Iki1p0.093
HPC2Hpc2p0.092
YPL068Chypothetical protein0.091
REI1Rei1p0.089
ANB1Anb1p0.083
AHC1Ahc1p0.083
ORC4Orc4p0.082
RMT2Rmt2p0.080
RSC4Rsc4p0.079
URA6Ura6p0.077
POL2Pol2p0.076
YCR051Whypothetical protein0.074
WWM1Wwm1p0.072
NSA1Nsa1p0.072
FMP52Fmp52p0.070
TMA16Tma16p0.070
DST1Dst1p0.069
RSC1Rsc1p0.068
RXT2Rxt2p0.068
ADR1Adr1p0.067
SAS2Sas2p0.066
POP6Pop6p0.066
PFD1Pfd1p0.062
MED1Med1p0.062
ARP8Arp8p0.061