The network for 'positive regulation of neuron death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of neuron death

Any process that activates or increases the frequency, rate or extent of neuron death.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.877
CREBBPCREB binding protein0.832
CASP3caspase 3, apoptosis-related cysteine peptidase0.812
TP53tumor protein p530.693
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.655
BCL2L11BCL2-like 11 (apoptosis facilitator)0.618
XIAPX-linked inhibitor of apoptosis0.558
BCL2L1BCL2-like 10.501
BADBCL2-associated agonist of cell death0.486
BAXBCL2-associated X protein0.467
MAPK8mitogen-activated protein kinase 80.381
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.364
ARandrogen receptor0.215
JUNjun proto-oncogene0.207
MDM2Mdm2 p53 binding protein homolog (mouse)0.196
BIDBH3 interacting domain death agonist0.193
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.167
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.126
LDLRlow density lipoprotein receptor0.119
NCOA3nuclear receptor coactivator 30.104
APAF1apoptotic peptidase activating factor 10.101
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.089
NCOA2nuclear receptor coactivator 20.086
KAT2BK(lysine) acetyltransferase 2B0.083
CASP9caspase 9, apoptosis-related cysteine peptidase0.072
ATF3activating transcription factor 30.065
MAP3K1mitogen-activated protein kinase kinase kinase 10.059
APPamyloid beta (A4) precursor protein0.054
AKT1v-akt murine thymoma viral oncogene homolog 10.052
S100BS100 calcium binding protein B0.050
IER2immediate early response 20.049
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.047
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.047
BAK1BCL2-antagonist/killer 10.047
HIPK2homeodomain interacting protein kinase 20.046
MEF2Amyocyte enhancer factor 2A0.045
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.045
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.044
BAIAP2BAI1-associated protein 20.038
VAC14Vac14 homolog (S. cerevisiae)0.036
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.035
FOSFBJ murine osteosarcoma viral oncogene homolog0.034
SH3BP4SH3-domain binding protein 40.034
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.033
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.033
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.032
WASLWiskott-Aldrich syndrome-like0.032
HPhaptoglobin0.032
ARRB1arrestin, beta 10.031
A2Malpha-2-macroglobulin0.030
DAXXdeath-domain associated protein0.030
ZNF3zinc finger protein 30.029
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.028
HUWE1HECT, UBA and WWE domain containing 10.027
EP300E1A binding protein p3000.027
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.026
APOC1apolipoprotein C-I0.026
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.026
DIABLOdiablo, IAP-binding mitochondrial protein0.026
ENGendoglin0.026
MAP2K1mitogen-activated protein kinase kinase 10.024
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.024
CCDC6coiled-coil domain containing 60.024
DDIT3DNA-damage-inducible transcript 30.023
MAPK9mitogen-activated protein kinase 90.023
FGF1fibroblast growth factor 1 (acidic)0.021
ALKanaplastic lymphoma receptor tyrosine kinase0.021
TP53BP2tumor protein p53 binding protein, 20.021
NCOA1nuclear receptor coactivator 10.019
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.018
SKA3spindle and kinetochore associated complex subunit 30.018
SNAI1snail homolog 1 (Drosophila)0.018
TRIB3tribbles homolog 3 (Drosophila)0.017
BIKBCL2-interacting killer (apoptosis-inducing)0.017
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.016
TP53BP1tumor protein p53 binding protein 10.016
TCF4transcription factor 40.016
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.016
CHERPcalcium homeostasis endoplasmic reticulum protein0.016
SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1-like0.016
FASFas (TNF receptor superfamily, member 6)0.016
FADDFas (TNFRSF6)-associated via death domain0.015
ATF2activating transcription factor 20.015
LRDDleucine-rich repeats and death domain containing0.015
MUL1mitochondrial E3 ubiquitin protein ligase 10.015
BECN1beclin 1, autophagy related0.015
PAK4p21 protein (Cdc42/Rac)-activated kinase 40.015
TTRtransthyretin0.015
BBC3BCL2 binding component 30.014
BTRCbeta-transducin repeat containing0.014
MAP3K2mitogen-activated protein kinase kinase kinase 20.014
BIRC2baculoviral IAP repeat containing 20.014
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.014
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.013
TNFtumor necrosis factor0.013
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.013
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.013
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.013
KRT8keratin 80.013
RIPK2receptor-interacting serine-threonine kinase 20.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mcl1amyeloid cell leukemia sequence 1a0.334
ptgs2aprostaglandin-endoperoxide synthase 2a0.219
tbx1T-box 10.205
cdkn1acyclin-dependent kinase inhibitor 1A0.188
LOC567131calcitonin gene-related peptide type 1 receptor-like0.186
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.183
bbc3BCL2 binding component 30.175
bactin1bactin10.174
socs3asuppressor of cytokine signaling 3a0.138
mcl1bmyeloid cell leukemia sequence 1b0.131
atf3activating transcription factor 30.118
bcl2l1bcl2-like 10.114
mmp2matrix metalloproteinase 20.099
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.099
s1pr2sphingosine-1-phosphate receptor 20.099
ccng1cyclin G10.096
baxabcl2-associated X protein, a0.096
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.096
pcdh19protocadherin 190.095
gbx2gastrulation brain homeo box 20.093
bactin2bactin20.089
mycbp2MYC binding protein 20.081
jag1bjagged 1b0.079
egr2aearly growth response 2a0.079
csnk1dacasein kinase 1, delta a0.079
rhoabras homolog gene family, member Ab0.078
bidaBH3 interacting domain death agonist0.075
tp53tumor protein p530.075
hoxb1ahomeo box B1a0.075
prdm14PR domain containing 140.071
zgc:92851zgc:928510.070
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.070
epas1bendothelial PAS domain protein 1b0.069
zgc:162126zgc:1621260.068
igfbp3insulin-like growth factor binding protein 30.068
pcdh18bprotocadherin 18b0.068
smad1MAD homolog 1 (Drosophila)0.066
sox9aSRY-box containing gene 9a0.066
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.066
pitx3paired-like homeodomain transcription factor 30.065
eya1eyes absent homolog 10.065
mfn2mitofusin 20.062
mesp2mesoderm posterior 2 homolog (mouse)0.061
adipor1aadiponectin receptor 1a0.061
slc1a2bsolute carrier family 1 (glial high affinity glutamate transporter), member 2b0.060
casp8caspase 8, apoptosis-related cysteine peptidase0.059
lamb2laminin, beta 2 (laminin S)0.059
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.059
fmr1fragile X mental retardation 10.058
wu:fq26c12wu:fq26c120.058
acheacetylcholinesterase0.057
dzip1DAZ interacting protein 10.057
pcsk1proprotein convertase subtilisin/kexin type 10.056
adipor2adiponectin receptor 20.056
fhlafour and a half LIM domains a0.056
appaamyloid beta (A4) precursor protein a0.055
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.053
robo2roundabout homolog 20.051
faddFas (tnfrsf6)-associated via death domain0.049
junbjun B proto-oncogene0.047
copebcore promoter element binding protein0.047
zgc:101724zgc:1017240.047
junjun proto-oncogene0.046
cdc42cell division cycle 420.045
igf2ainsulin-like growth factor 2a0.044
mmp9matrix metalloproteinase 90.044
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.044
odz4odd Oz/ten-m homolog 40.044
per2period homolog 2 (Drosophila)0.043
LOC566020Gig2-like protein DreO0.043
foxo3bforkhead box O3b0.043
gna12guanine nucleotide binding protein (G protein) alpha 120.042
hoxb3ahomeo box B3a0.042
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.042
atp2b4ATPase, Ca++ transporting, plasma membrane 40.042
wu:fj39b01wu:fj39b010.042
sox11bSRY-box containing gene 11b0.042
igf1rbinsulin-like growth factor 1b receptor0.042
bocbrother of CDO0.041
uxs1UDP-glucuronic acid decarboxylase 10.041
chrndcholinergic receptor, nicotinic, delta polypeptide0.041
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.041
hbegfaheparin-binding EGF-like growth factor a0.040
edn1endothelin 10.040
lhx2bLIM homeobox 2b0.040
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.040
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.039
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.039
LOC100000332e3 ubiquitin-protein ligase RNF182-like0.039
cap1Cap1 CAP, adenylate cyclase-associated protein 10.039
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.039
nadl1.2neural adhesion molecule L1.20.039
LOC100148845neurogenin-1-like0.039
elk4ELK4, ETS-domain protein0.038
lmo7aLIM domain only 7a0.038
grnagranulin a0.038
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.037
gdf11growth differentiation factor 110.037
LOC100331484hypothetical protein LOC1003314840.037
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.037
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.021
p53CG33336 gene product from transcript CG33336-RB0.020
DadDaughters against dpp0.017
pydpolychaetoid0.012
amosabsent MD neurons and olfactory sensilla0.012
CG11786CG11786 gene product from transcript CG11786-RB0.011
BG4CG12297 gene product from transcript CG12297-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.980
Ptenphosphatase and tensin homolog0.919
Rb1retinoblastoma 10.867
Sox9SRY-box containing gene 90.860
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.829
Map3k7mitogen-activated protein kinase kinase kinase 70.795
Ren1renin 1 structural0.679
BaxBCL2-associated X protein0.666
Lyz2lysozyme 20.643
Bcl2B-cell leukemia/lymphoma 20.643
Itgb1integrin beta 1 (fibronectin receptor beta)0.592
Il1binterleukin 1 beta0.583
FasFas (TNF receptor superfamily member 6)0.574
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.540
Foxc1forkhead box C10.532
Casp4caspase 4, apoptosis-related cysteine peptidase0.518
Ptgs2prostaglandin-endoperoxide synthase 20.471
Gli2GLI-Kruppel family member GLI20.469
Ptch1patched homolog 10.463
Retret proto-oncogene0.440
Mcl1myeloid cell leukemia sequence 10.435
Nos3nitric oxide synthase 3, endothelial cell0.384
Tnftumor necrosis factor0.362
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.359
Gli3GLI-Kruppel family member GLI30.356
Ccl12chemokine (C-C motif) ligand 120.356
Ccr1chemokine (C-C motif) receptor 10.338
Casp1caspase 10.327
Shhsonic hedgehog0.306
Ephb2Eph receptor B20.288
Leprleptin receptor0.272
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.261
Hif1ahypoxia inducible factor 1, alpha subunit0.256
FosFBJ osteosarcoma oncogene0.234
Mdm4transformed mouse 3T3 cell double minute 40.226
SkilSKI-like0.223
Ptpn11protein tyrosine phosphatase, non-receptor type 110.211
Efnb2ephrin B20.206
Mapk8mitogen-activated protein kinase 80.204
Ikbkginhibitor of kappaB kinase gamma0.195
Ccl2chemokine (C-C motif) ligand 20.194
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.193
Runx2runt related transcription factor 20.193
Cdkn1bcyclin-dependent kinase inhibitor 1B0.192
Prrx1paired related homeobox 10.190
Ccl8chemokine (C-C motif) ligand 80.186
Fgfr2fibroblast growth factor receptor 20.164
Kitkit oncogene0.163
Socs1suppressor of cytokine signaling 10.162
BrafBraf transforming gene0.154
Ccl4chemokine (C-C motif) ligand 40.154
Bmp7bone morphogenetic protein 70.153
Ccl7chemokine (C-C motif) ligand 70.148
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.148
Fcgr1Fc receptor, IgG, high affinity I0.145
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.144
Msx2homeobox, msh-like 20.141
Epha4Eph receptor A40.139
Vhlvon Hippel-Lindau tumor suppressor0.139
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.136
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.135
Tgfb1transforming growth factor, beta 10.127
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.126
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.113
Bcl2l1BCL2-like 10.112
Hey2hairy/enhancer-of-split related with YRPW motif 20.109
Fcgr2bFc receptor, IgG, low affinity IIb0.109
Sh3gl2SH3-domain GRB2-like 20.107
Trib3tribbles homolog 3 (Drosophila)0.106
Col2a1collagen, type II, alpha 10.105
Apcadenomatosis polyposis coli0.102
Galgalanin0.101
Ctnnb1catenin (cadherin associated protein), beta 10.100
Mef2dmyocyte enhancer factor 2D0.098
Esr1estrogen receptor 1 (alpha)0.098
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.097
Atf3activating transcription factor 30.090
Ror2receptor tyrosine kinase-like orphan receptor 20.086
En1engrailed 10.082
Pthlhparathyroid hormone-like peptide0.081
Brca2breast cancer 20.081
Bdnfbrain derived neurotrophic factor0.080
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.079
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.078
Zeb1zinc finger E-box binding homeobox 10.077
Notch1Notch gene homolog 1 (Drosophila)0.076
Ch25hcholesterol 25-hydroxylase0.076
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.075
Apoeapolipoprotein E0.074
Ntf3neurotrophin 30.069
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.069
Nfe2l2nuclear factor, erythroid derived 2, like 20.069
CrebbpCREB binding protein0.068
Abl2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)0.067
Ephb3Eph receptor B30.067
Mdm2transformed mouse 3T3 cell double minute 20.065
Rnd3Rho family GTPase 30.064
Mmp12matrix metallopeptidase 120.063
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.062
Il18interleukin 180.061
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
FosFBJ osteosarcoma oncogene0.678
Ier2immediate early response 20.098
Nr4a1nuclear receptor subfamily 4, group A, member 10.095
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.091
Grip1glutamate receptor interacting protein 10.083
HrasHarvey rat sarcoma virus oncogene0.079
Opcmlopioid binding protein/cell adhesion molecule-like0.077
Klf4Kruppel-like factor 4 (gut)0.073
Cdk4cyclin-dependent kinase 40.072
Mapre1microtubule-associated protein, RP/EB family, member 10.071
Scamp2secretory carrier membrane protein 20.067
Asna1arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)0.066
Junbjun B proto-oncogene0.065
Rnf4ring finger protein 40.065
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.062
Pick1protein interacting with PRKCA 10.059
Gria2glutamate receptor, ionotropic, AMPA 20.055
Dctn4dynactin 40.051
Leprleptin receptor0.050
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.050
Dusp6dual specificity phosphatase 60.047
Mapk8mitogen-activated protein kinase 80.047
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.043
Lrp10low-density lipoprotein receptor-related protein 100.042
Egr1early growth response 10.040
Il1r1interleukin 1 receptor, type I0.039
Csnk1g3casein kinase 1, gamma 30.039
Tnftumor necrosis factor (TNF superfamily, member 2)0.039
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.038
Ccdc124coiled-coil domain containing 1240.038
Tbxa2rthromboxane A2 receptor0.037
Gria1glutamate receptor, ionotropic, AMPA 10.035
TriobpTRIO and F-actin binding protein0.035
Mapk1mitogen activated protein kinase 10.034
Ppfia4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 40.033
Egr2early growth response 20.033
Coro1bcoronin, actin-binding protein, 1B0.033
Tpm3tropomyosin 3, gamma0.033
Adam10ADAM metallopeptidase domain 100.031
Robo1roundabout homolog 1 (Drosophila)0.030
Bap1BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)0.030
Ap2s1adaptor-related protein complex 2, sigma 1 subunit0.030
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.029
Ptprcprotein tyrosine phosphatase, receptor type, C0.029
Dll3delta-like 3 (Drosophila)0.029
Adam17ADAM metallopeptidase domain 170.029
Klf6Kruppel-like factor 60.029
Grm5glutamate receptor, metabotropic 50.028
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.028
Dlgap1discs, large (Drosophila) homolog-associated protein 10.028
Prelid1PRELI domain containing 10.028
Map3k1mitogen activated protein kinase kinase kinase 10.027
Dusp1dual specificity phosphatase 10.027
Col9a1collagen, type IX, alpha 10.027
Casp8caspase 80.027
Ms4a6bmembrane-spanning 4-domains, subfamily A, member 6B0.027
Rnf207ring finger protein 2070.026
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.026
Arl6ip4ADP-ribosylation-like factor 6 interacting protein 40.026
Agtr2angiotensin II receptor, type 20.026
Nesnestin0.026
Atp6v1fATPase, H transporting, lysosomal V1 subunit F0.026
Htr75-hydroxytryptamine (serotonin) receptor 70.025
Dlg4discs, large homolog 4 (Drosophila)0.025
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.025
Btg2BTG family, member 20.025
Msnmoesin0.025
Cxcr4chemokine (C-X-C motif) receptor 40.024
Nrxn3neurexin 30.024
Tbcbtubulin folding cofactor B0.024
Tpm4tropomyosin 40.024
Cd44Cd44 molecule0.024
Guk1guanylate kinase 10.024
Slc6a15solute carrier family 6 (neutral amino acid transporter), member 150.023
Dusp4dual specificity phosphatase 40.023
Lrrc33leucine rich repeat containing 330.023
Sec1secretory blood group 10.023
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.023
Slfn8schlafen 80.023
Ercc1excision repair cross-complementing rodent repair deficiency, complementation group 10.022
Accn2amiloride-sensitive cation channel 2, neuronal0.022
Myh9myosin, heavy chain 9, non-muscle0.022
Clic4chloride intracellular channel 40.022
Olfml2bolfactomedin-like 2B0.022
Cskc-src tyrosine kinase0.022
Notch1Notch homolog 1, translocation-associated (Drosophila)0.022
Smad1SMAD family member 10.022
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.022
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.022
Ccr5chemokine (C-C motif) receptor 50.021
Map2microtubule-associated protein 20.021
Hoxc4homeo box C40.021
Nr4a3nuclear receptor subfamily 4, group A, member 30.021
Mapk6mitogen-activated protein kinase 60.021
Ctsjcathepsin J0.021
Ripk3receptor-interacting serine-threonine kinase 30.021
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.021
XiapX-linked inhibitor of apoptosis0.020
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.020
Cntn3contactin 3 (plasmacytoma associated)0.020
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism