The network for 'regulation of neuron death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of neuron death

Any process that modulates the frequency, rate or extent of neuron death.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.972
ESR1estrogen receptor 10.954
EGFRepidermal growth factor receptor0.899
CAV1caveolin 1, caveolae protein, 22kDa0.858
EP300E1A binding protein p3000.804
BCL2L1BCL2-like 10.747
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.622
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.621
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.605
TP53tumor protein p530.570
CREBBPCREB binding protein0.568
BCL2L11BCL2-like 11 (apoptosis facilitator)0.459
SHC1SHC (Src homology 2 domain containing) transforming protein 10.436
VEGFAvascular endothelial growth factor A0.435
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.431
MAPTmicrotubule-associated protein tau0.352
MAPK8mitogen-activated protein kinase 80.352
SOCS3suppressor of cytokine signaling 30.343
APPamyloid beta (A4) precursor protein0.330
NCF1neutrophil cytosolic factor 10.294
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.265
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.256
JUNjun proto-oncogene0.253
BADBCL2-associated agonist of cell death0.246
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.231
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.215
NR4A1nuclear receptor subfamily 4, group A, member 10.201
DAXXdeath-domain associated protein0.200
MAPK6mitogen-activated protein kinase 60.199
ARandrogen receptor0.194
FKBP8FK506 binding protein 8, 38kDa0.187
CALM1calmodulin 1 (phosphorylase kinase, delta)0.174
ZNF746zinc finger protein 7460.166
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.166
PDZD11PDZ domain containing 110.163
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.156
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.155
EPAS1endothelial PAS domain protein 10.153
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.149
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.140
APAF1apoptotic peptidase activating factor 10.137
CASP3caspase 3, apoptosis-related cysteine peptidase0.136
FOSFBJ murine osteosarcoma viral oncogene homolog0.133
SP1Sp1 transcription factor0.131
BIDBH3 interacting domain death agonist0.129
MAP3K7mitogen-activated protein kinase kinase kinase 70.128
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.127
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.126
APLFaprataxin and PNKP like factor0.123
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.122
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.121
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.120
XIAPX-linked inhibitor of apoptosis0.114
KAT2BK(lysine) acetyltransferase 2B0.113
VHLvon Hippel-Lindau tumor suppressor0.112
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.109
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.109
ATF3activating transcription factor 30.109
CCL4chemokine (C-C motif) ligand 40.103
FASFas (TNF receptor superfamily, member 6)0.103
GH1growth hormone 10.102
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.101
NTRK1neurotrophic tyrosine kinase, receptor, type 10.093
PTPN23protein tyrosine phosphatase, non-receptor type 230.092
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.090
CCR5chemokine (C-C motif) receptor 50.090
IL1Binterleukin 1, beta0.089
SMAD3SMAD family member 30.087
AGAP5ArfGAP with GTPase domain, ankyrin repeat and PH domain 50.083
KHDRBS1KH domain containing, RNA binding, signal transduction associated 10.082
AGAP7ArfGAP with GTPase domain, ankyrin repeat and PH domain 70.081
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.079
MAP3K1mitogen-activated protein kinase kinase kinase 10.077
INSRinsulin receptor0.077
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.077
BAXBCL2-associated X protein0.077
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.076
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.076
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.074
DDIT3DNA-damage-inducible transcript 30.074
MDM2Mdm2 p53 binding protein homolog (mouse)0.072
GAS6growth arrest-specific 60.072
TRIB3tribbles homolog 3 (Drosophila)0.072
YARStyrosyl-tRNA synthetase0.069
TEKTEK tyrosine kinase, endothelial0.069
NRP1neuropilin 10.067
RPL18Aribosomal protein L18a0.067
NCOR2nuclear receptor corepressor 20.067
SOS1son of sevenless homolog 1 (Drosophila)0.065
SKIv-ski sarcoma viral oncogene homolog (avian)0.065
NGFnerve growth factor (beta polypeptide)0.064
HIPK2homeodomain interacting protein kinase 20.064
NR4A3nuclear receptor subfamily 4, group A, member 30.064
ARRB1arrestin, beta 10.063
IER2immediate early response 20.063
SMAD4SMAD family member 40.063
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.062
NCK1NCK adaptor protein 10.062
NOXA1NADPH oxidase activator 10.062
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.046
dlx5adistal-less homeobox gene 5a0.040
pitx3paired-like homeodomain transcription factor 30.026
nrp2bneuropilin 2b0.023
epas1bendothelial PAS domain protein 1b0.022
piwil2piwi-like 2 (Drosophila)0.020
sulf2lsulfatase 2, like0.019
nf1aneurofibromin 1a0.019
foxo3bforkhead box O3b0.018
trpv6transient receptor potential cation channel, subfamily V, member 60.017
mcl1amyeloid cell leukemia sequence 1a0.017
gbx2gastrulation brain homeo box 20.016
bnc2basonuclin 20.015
mt2metallothionein 20.015
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.015
cnr1cannabinoid receptor 10.014
hhiphedgehog interacting protein0.014
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.014
traf4atnf receptor-associated factor 4a0.013
birc2baculoviral IAP repeat-containing 20.013
bcl2B-cell leukemia/lymphoma 20.012
trpm7transient receptor potential cation channel, subfamily M, member 70.012
atoh1aatonal homolog 1a0.012
pcdh17protocadherin 170.012
msxdmuscle segment homeobox D0.011
wwp2WW domain containing E3 ubiquitin protein ligase 20.011
psen1presenilin 10.011
spon1bspondin 1b0.011
otpaorthopedia homolog a0.011
ptgs2aprostaglandin-endoperoxide synthase 2a0.011
nrp2aneuropilin 2a0.011
myf6myogenic factor 60.011
lmx1b.1LIM homeobox transcription factor 1, beta 10.011
msi1musashi homolog 1 (Drosophila)0.010
appaamyloid beta (A4) precursor protein a0.010
nos2bnitric oxide synthase 2b, inducible0.010
sox9aSRY-box containing gene 9a0.010
ghragrowth hormone receptor a0.010
cx39.9connexin 39.90.010
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
p53CG33336 gene product from transcript CG33336-RB0.536
eyaeyes absent0.325
PvrPDGF- and VEGF-receptor related0.322
Fmr1CG6203 gene product from transcript CG6203-RC0.259
Rac1CG2248 gene product from transcript CG2248-RA0.238
CG8155CG8155 gene product from transcript CG8155-RA0.209
Arp66BActin-related protein 66B0.134
CG11347CG11347 gene product from transcript CG11347-RE0.132
reporeversed polarity0.123
Pink1PTEN-induced putative kinase 10.117
mspsmini spindles0.116
CG11786CG11786 gene product from transcript CG11786-RB0.116
nabCG33545 gene product from transcript CG33545-RC0.111
mei-41meiotic 410.105
Mpk2CG5475 gene product from transcript CG5475-RB0.104
cpacapping protein alpha0.100
aopanterior open0.099
Syx1ASyntaxin 1A0.097
Ras85DRas oncogene at 85D0.097
MicalMolecule interacting with CasL0.096
l(3)82FdCG32464 gene product from transcript CG32464-RR0.095
Sir2CG5216 gene product from transcript CG5216-RA0.094
p120ctnAdherens junction protein p1200.090
GripGlutamate receptor binding protein0.089
awdabnormal wing discs0.080
ThorCG8846 gene product from transcript CG8846-RA0.077
vimarvisceral mesodermal armadillo-repeats0.071
RicRas which interacts with Calmodulin0.068
CG32528CG32528 gene product from transcript CG32528-RA0.068
Src42ASrc oncogene at 42A0.065
fhfrataxin homolog0.063
Jafrac1thioredoxin peroxidase 10.063
HLHm5E(spl) region transcript m50.063
Su(H)Suppressor of Hairless0.062
Atf-2Activating transcription factor-20.059
RpL5Ribosomal protein L50.059
mus201mutagen-sensitive 2010.057
Gyc76CGuanylyl cyclase at 76C0.057
CapsCalcium activated protein for secretion0.054
drkdownstream of receptor kinase0.051
EphrinCG1862 gene product from transcript CG1862-RA0.051
Vap-33-1CG5014 gene product from transcript CG5014-RB0.050
Akt1CG4006 gene product from transcript CG4006-RA0.049
tomosynCG17762 gene product from transcript CG17762-RB0.047
ird1immune response deficient 10.047
CaMKIICalcium/calmodulin-dependent protein kinase II0.047
PgdPhosphogluconate dehydrogenase0.047
SpdSSpermidine Synthase0.045
Dcp-1Death caspase-10.045
eIF-4EEukaryotic initiation factor 4E0.044
cln3CG5582 gene product from transcript CG5582-RA0.044
mbcmyoblast city0.044
witwishful thinking0.044
SmoxSmad on X0.044
C15CG7937 gene product from transcript CG7937-RA0.043
trpmltransient receptor potential mucolipin0.043
CG8176CG8176 gene product from transcript CG8176-RD0.043
wbwing blister0.043
Myo31DFMyosin 31DF0.042
Ulp1CG12359 gene product from transcript CG12359-RA0.041
tefutelomere fusion0.041
inaEinactivation no afterpotential E0.041
S6kRPS6-p70-protein kinase0.041
elavembryonic lethal abnormal vision0.041
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nos3nitric oxide synthase 3, endothelial cell0.916
Ptgs2prostaglandin-endoperoxide synthase 20.891
Pax3paired box gene 30.889
Phox2apaired-like homeobox 2a0.872
Nr3c1nuclear receptor subfamily 3, group C, member 10.858
Leprleptin receptor0.842
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.826
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.811
Vhlvon Hippel-Lindau tumor suppressor0.807
Trp53transformation related protein 530.759
Vegfavascular endothelial growth factor A0.757
Prnpprion protein0.751
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.748
Apoeapolipoprotein E0.745
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.729
Stat3signal transducer and activator of transcription 30.725
Emx1empty spiracles homolog 1 (Drosophila)0.698
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.676
Lifleukemia inhibitory factor0.675
FasFas (TNF receptor superfamily member 6)0.661
Ptenphosphatase and tensin homolog0.639
Eya1eyes absent 1 homolog (Drosophila)0.620
Pthlhparathyroid hormone-like peptide0.619
Neurog2neurogenin 20.618
Sox2SRY-box containing gene 20.605
Mt1metallothionein 10.604
Mt2metallothionein 20.603
Mef2dmyocyte enhancer factor 2D0.593
Grid1glutamate receptor, ionotropic, delta 10.592
BaxBCL2-associated X protein0.589
Stx1asyntaxin 1A (brain)0.577
Tgfbr1transforming growth factor, beta receptor I0.575
Bcl2B-cell leukemia/lymphoma 20.575
Otx2orthodenticle homolog 2 (Drosophila)0.563
Gabrb2gamma-aminobutyric acid (GABA) A receptor, subunit beta 20.562
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.561
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.547
Pax2paired box gene 20.541
Gabra2gamma-aminobutyric acid (GABA) A receptor, subunit alpha 20.539
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.538
Sox10SRY-box containing gene 100.529
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.525
Pax6paired box gene 60.522
Dlx1distal-less homeobox 10.520
Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)0.517
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.517
Mdm2transformed mouse 3T3 cell double minute 20.516
Rb1retinoblastoma 10.509
Drd2dopamine receptor D20.504
Retret proto-oncogene0.503
AxlAXL receptor tyrosine kinase0.502
Hif1ahypoxia inducible factor 1, alpha subunit0.498
Tlr4toll-like receptor 40.489
Cnr1cannabinoid receptor 1 (brain)0.484
Npc1Niemann Pick type C10.482
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.472
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.468
Neurod1neurogenic differentiation 10.468
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.466
Lhx3LIM homeobox protein 30.458
Ptpn11protein tyrosine phosphatase, non-receptor type 110.451
UncxUNC homeobox0.447
Isl1ISL1 transcription factor, LIM/homeodomain0.446
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.441
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.441
Casp1caspase 10.429
Msx3homeobox, msh-like 30.427
Bcl7aB-cell CLL/lymphoma 7A0.425
Gabrg2gamma-aminobutyric acid (GABA) A receptor, subunit gamma 20.414
Il1r1interleukin 1 receptor, type I0.408
Adam17a disintegrin and metallopeptidase domain 170.405
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.400
Ascl1achaete-scute complex homolog 1 (Drosophila)0.396
Gdnfglial cell line derived neurotrophic factor0.396
Rac1RAS-related C3 botulinum substrate 10.395
Neurog3neurogenin 30.385
Shhsonic hedgehog0.382
Nos1nitric oxide synthase 1, neuronal0.376
Ren1renin 1 structural0.374
Egr1early growth response 10.367
Wnt1wingless-related MMTV integration site 10.365
Epas1endothelial PAS domain protein 10.364
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.360
Phox2bpaired-like homeobox 2b0.359
Gli1GLI-Kruppel family member GLI10.359
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.356
B3galt1UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 10.352
Col2a1collagen, type II, alpha 10.349
Stat5asignal transducer and activator of transcription 5A0.345
Irs2insulin receptor substrate 20.344
Socs1suppressor of cytokine signaling 10.343
Insm1insulinoma-associated 10.343
Prkceprotein kinase C, epsilon0.340
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.327
Esr1estrogen receptor 1 (alpha)0.322
Sall3sal-like 3 (Drosophila)0.322
Epha8Eph receptor A80.319
Stat5bsignal transducer and activator of transcription 5B0.316
Mmp24matrix metallopeptidase 240.312
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccl2chemokine (C-C motif) ligand 20.478
Gria2glutamate receptor, ionotropic, AMPA 20.449
Dusp1dual specificity phosphatase 10.393
FosFBJ osteosarcoma oncogene0.342
Cdk4cyclin-dependent kinase 40.308
Prkcbprotein kinase C, beta0.287
Il1r1interleukin 1 receptor, type I0.282
Gucy2dguanylate cyclase 2d0.272
Cd86CD86 molecule0.266
Bcl2B-cell CLL/lymphoma 20.259
Tnftumor necrosis factor (TNF superfamily, member 2)0.254
Cxcr4chemokine (C-X-C motif) receptor 40.250
St13suppression of tumorigenicity 130.245
Cd14CD14 molecule0.238
Nrxn3neurexin 30.234
Prdm2PR domain containing 2, with ZNF domain0.230
Nr4a1nuclear receptor subfamily 4, group A, member 10.228
Cxcl10chemokine (C-X-C motif) ligand 100.226
Il1binterleukin 1 beta0.221
Egr1early growth response 10.214
Ccl4chemokine (C-C motif) ligand 40.210
Dnase1l3deoxyribonuclease 1-like 30.207
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.206
Smad1SMAD family member 10.202
Inpp5dinositol polyphosphate-5-phosphatase D0.200
Socs3suppressor of cytokine signaling 30.198
Reg3gregenerating islet-derived 3 gamma0.192
Adam17ADAM metallopeptidase domain 170.183
Grip1glutamate receptor interacting protein 10.178
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.171
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.169
Gna12guanine nucleotide binding protein (G protein) alpha 120.168
Ddr1discoidin domain receptor tyrosine kinase 10.165
Shox2short stature homeobox 20.164
Ccr5chemokine (C-C motif) receptor 50.162
Crhbpcorticotropin releasing hormone binding protein0.160
TcrbT-cell receptor beta chain0.159
C1scomplement component 1, s subcomponent0.157
Agtr1aangiotensin II receptor, type 1a0.155
Gzmbgranzyme B0.154
Notch1Notch homolog 1, translocation-associated (Drosophila)0.153
Acot12acyl-CoA thioesterase 120.153
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.152
Ednrbendothelin receptor type B0.152
HrasHarvey rat sarcoma virus oncogene0.148
C1rcomplement component 1, r subcomponent0.148
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.143
Asna1arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)0.141
Egr2early growth response 20.139
XiapX-linked inhibitor of apoptosis0.138
Adam9ADAM metallopeptidase domain 9 (meltrin gamma)0.135
Robo1roundabout homolog 1 (Drosophila)0.135
Adora2aadenosine A2a receptor0.133
Cx3cl1chemokine (C-X3-C motif) ligand 10.133
Prl6a1prolactin family 6, subfamily a, member 10.132
Ptprcprotein tyrosine phosphatase, receptor type, C0.132
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.130
Smad3SMAD family member 30.127
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.126
Epas1endothelial PAS domain protein 10.126
Ifnginterferon gamma0.125
Nkx6-1NK6 homeobox 10.124
Neurod2neurogenic differentiation 20.123
Ccl5chemokine (C-C motif) ligand 50.123
Rnf207ring finger protein 2070.122
Zfp36zinc finger protein 360.121
Il9rinterleukin 9 receptor0.121
Fkbp4FK506 binding protein 40.119
Cd3gCD3 molecule, gamma0.119
Galr3galanin receptor 30.117
Neurl3neuralized homolog 3 (Drosophila)0.117
Ecel1endothelin converting enzyme-like 10.116
Cd8bCD8b molecule0.115
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.115
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.114
Lphn2latrophilin 20.114
Junbjun B proto-oncogene0.114
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.113
Madcam1mucosal vascular addressin cell adhesion molecule 10.113
Casp8caspase 80.112
Dock8dedicator of cytokinesis 80.112
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.111
Clic4chloride intracellular channel 40.109
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.108
Tlr4toll-like receptor 40.107
Ccdc124coiled-coil domain containing 1240.106
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.106
Slco2b1solute carrier organic anion transporter family, member 2b10.106
Prl3d1Prolactin family 3, subfamily d, member 10.106
Pde3aphosphodiesterase 3A, cGMP inhibited0.105
Map3k1mitogen activated protein kinase kinase kinase 10.104
Cacng2calcium channel, voltage-dependent, gamma subunit 20.104
Gifgastric intrinsic factor0.104
Slc22a1solute carrier family 22 (organic cation transporter), member 10.104
Hckhemopoietic cell kinase0.103
Drp2dystrophin related protein 20.103
Fgf7fibroblast growth factor 70.103
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism