The network for 'phospholipid biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

phospholipid biosynthetic process

The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.

NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.993
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.880
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.858
FGFR2fibroblast growth factor receptor 20.798
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.601
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.424
MPDZmultiple PDZ domain protein0.388
PLCG1phospholipase C, gamma 10.376
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.367
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.318
ALBalbumin0.312
VEGFAvascular endothelial growth factor A0.298
FGFR1fibroblast growth factor receptor 10.297
A2Malpha-2-macroglobulin0.292
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.274
GRB2growth factor receptor-bound protein 20.209
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.193
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.192
NOS1nitric oxide synthase 1 (neuronal)0.184
PIGTphosphatidylinositol glycan anchor biosynthesis, class T0.183
IRS1insulin receptor substrate 10.181
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.177
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.152
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.142
APOA1apolipoprotein A-I0.134
SC4MOLsterol-C4-methyl oxidase-like0.123
NRP1neuropilin 10.104
ABI1abl-interactor 10.103
APOC1apolipoprotein C-I0.102
DCTN1dynactin 10.100
CD63CD63 molecule0.076
GMFBglia maturation factor, beta0.068
PGFplacental growth factor0.066
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.062
SYKspleen tyrosine kinase0.059
GPAA1glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)0.056
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.055
CD81CD81 molecule0.052
PTPN1protein tyrosine phosphatase, non-receptor type 10.050
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.050
FGF7fibroblast growth factor 70.049
NCK1NCK adaptor protein 10.049
SPAG9sperm associated antigen 90.048
CMIPc-Maf-inducing protein0.047
KPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.046
CD9CD9 molecule0.046
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.046
PDGFAplatelet-derived growth factor alpha polypeptide0.046
BECN1beclin 1, autophagy related0.042
LYPLA1lysophospholipase I0.041
UVRAGUV radiation resistance associated gene0.041
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.041
NUP153nucleoporin 153kDa0.039
CUTAcutA divalent cation tolerance homolog (E. coli)0.039
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.038
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.038
STARD4StAR-related lipid transfer (START) domain containing 40.037
INSIG1insulin induced gene 10.034
LCATlecithin-cholesterol acyltransferase0.033
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.032
LDLRlow density lipoprotein receptor0.031
PINX1PIN2/TERF1 interacting, telomerase inhibitor 10.031
CHMP2Bchromatin modifying protein 2B0.031
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.031
PTPRBprotein tyrosine phosphatase, receptor type, B0.031
LIN7Clin-7 homolog C (C. elegans)0.030
SORBS3sorbin and SH3 domain containing 30.030
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.030
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 10.030
SQLEsqualene epoxidase0.029
PDGFCplatelet derived growth factor C0.028
CFL1cofilin 1 (non-muscle)0.028
SNAI1snail homolog 1 (Drosophila)0.027
C17orf28chromosome 17 open reading frame 280.027
ATG14ATG14 autophagy related 14 homolog (S. cerevisiae)0.027
PNPLA2patatin-like phospholipase domain containing 20.027
IPO11importin 110.026
SHC1SHC (Src homology 2 domain containing) transforming protein 10.026
PIKFYVEphosphoinositide kinase, FYVE finger containing0.026
TTC35tetratricopeptide repeat domain 350.026
TMEM41Btransmembrane protein 41B0.026
ERRFI1ERBB receptor feedback inhibitor 10.026
DUSP11dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)0.026
TMEM38Btransmembrane protein 38B0.025
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.025
SORBS1sorbin and SH3 domain containing 10.025
YRDCyrdC domain containing (E. coli)0.025
FIG4FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)0.024
XPOTexportin, tRNA (nuclear export receptor for tRNAs)0.024
XPO5exportin 50.024
TMEM33transmembrane protein 330.024
AP2A2adaptor-related protein complex 2, alpha 2 subunit0.023
PHRF1PHD and ring finger domains 10.023
EZRezrin0.023
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.023
NRBF2nuclear receptor binding factor 20.023
HN1hematological and neurological expressed 10.022
ATMINATM interactor0.022
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.022
TUBA1Btubulin, alpha 1b0.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
elo-6Protein ELO-60.041
ran-2Protein RAN-20.035
dct-18Protein DCT-180.031
sur-5Protein SUR-50.029
pssy-1Protein PSSY-10.027
F54D12.4Protein F54D12.40.027
elo-5Protein ELO-50.024
ubl-5Protein UBL-50.022
F13E6.5Protein F13E6.50.022
pho-1Protein PHO-10.019
tpxl-1Protein TPXL-10.018
sptl-2Protein SPTL-20.014
C45E5.1Protein C45E5.10.014
elo-2Protein ELO-20.013
kin-4Protein KIN-40.012
CELE_F54D7.2Protein F54D7.20.012
alh-12Protein ALH-120.012
T03G11.4Protein T03G11.40.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ppargperoxisome proliferator activated receptor gamma0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.834
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.599
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.456
Elovl1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 10.344
Pdcd6ipprogrammed cell death 6 interacting protein0.247
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.180
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.162
Pik3r3phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)0.155
Alox5aparachidonate 5-lipoxygenase activating protein0.151
Nfe2l2nuclear factor, erythroid derived 2, like 20.123
Pdlim4PDZ and LIM domain 40.110
BlnkB-cell linker0.101
Ttrtransthyretin0.095
Pik3r2phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)0.087
Mta1metastasis associated 10.087
Cd40CD40 antigen0.086
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.079
Orai1ORAI calcium release-activated calcium modulator 10.071
Itm2cintegral membrane protein 2C0.065
Pcsk1proprotein convertase subtilisin/kexin type 10.063
BtkBruton agammaglobulinemia tyrosine kinase0.061
Sorbs3sorbin and SH3 domain containing 30.060
Pdgfcplatelet-derived growth factor, C polypeptide0.059
Becn1beclin 1, autophagy related0.059
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.056
CblCasitas B-lineage lymphoma0.056
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.055
Sh3d19SH3 domain protein D190.055
Gab1growth factor receptor bound protein 2-associated protein 10.051
Lig4ligase IV, DNA, ATP-dependent0.050
Bscl2Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)0.048
Apobapolipoprotein B0.047
Inpp5dinositol polyphosphate-5-phosphatase D0.046
Itsn1intersectin 1 (SH3 domain protein 1A)0.045
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.045
Rab34RAB34, member of RAS oncogene family0.044
Lratlecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)0.043
Ptpn13protein tyrosine phosphatase, non-receptor type 130.042
FynFyn proto-oncogene0.041
Parvgparvin, gamma0.041
Hook2hook homolog 2 (Drosophila)0.040
Btbd2BTB (POZ) domain containing 20.040
Sh3kbp1SH3-domain kinase binding protein 10.039
Irs1insulin receptor substrate 10.039
Ep300E1A binding protein p3000.039
Dok1docking protein 10.039
Mdm2transformed mouse 3T3 cell double minute 20.038
Wwtr1WW domain containing transcription regulator 10.037
Ptgesprostaglandin E synthase0.037
0610007C21RikRIKEN cDNA 0610007C21 gene0.036
Tmem38btransmembrane protein 38B0.036
Cd36CD36 antigen0.035
Nsun2NOL1/NOP2/Sun domain family member 20.035
Cideccell death-inducing DFFA-like effector c0.035
Tnfsf15tumor necrosis factor (ligand) superfamily, member 150.033
Kpna2karyopherin (importin) alpha 20.033
Lpllipoprotein lipase0.033
Iduaiduronidase, alpha-L-0.032
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.032
Abhd5abhydrolase domain containing 50.032
Abca3ATP-binding cassette, sub-family A (ABC1), member 30.031
Sh3gl1SH3-domain GRB2-like 10.030
5730494N06RikRIKEN cDNA 5730494N06 gene0.030
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.030
3110056O03RikRIKEN cDNA 3110056O03 gene0.029
Iqcb1IQ calmodulin-binding motif containing 10.029
Flnafilamin, alpha0.029
Odc1ornithine decarboxylase, structural 10.029
Rock2Rho-associated coiled-coil containing protein kinase 20.029
Fcgr2bFc receptor, IgG, low affinity IIb0.028
Hmg20bhigh mobility group 20 B0.028
Plcg2phospholipase C, gamma 20.028
Adigadipogenin0.028
Pik3r6phosphoinositide-3-kinase, regulatory subunit 60.027
Plekhg2pleckstrin homology domain containing, family G (with RhoGef domain) member 20.027
Capn9calpain 90.027
Apoeapolipoprotein E0.027
Pdpk13-phosphoinositide dependent protein kinase 10.027
Itgb5integrin beta 50.027
Rbmy1a1RNA binding motif protein, Y chromosome, family 1, member A10.027
Dmrt1doublesex and mab-3 related transcription factor 10.026
Fam129bfamily with sequence similarity 129, member B0.026
Rhbdf1rhomboid family 1 (Drosophila)0.026
Anapc7anaphase promoting complex subunit 70.026
Lzts2leucine zipper, putative tumor suppressor 20.026
Tnfaip1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.025
Sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.025
Prkciprotein kinase C, iota0.025
Klhl24kelch-like 24 (Drosophila)0.025
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.025
Dynlt1bdynein light chain Tctex-type 1D0.025
Fbxw5F-box and WD-40 domain protein 50.025
Appl2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 20.025
Adipoqadiponectin, C1Q and collagen domain containing0.024
Grb2growth factor receptor bound protein 20.024
Kifc3kinesin family member C30.024
Trip6thyroid hormone receptor interactor 60.024
Lmf1lipase maturation factor 10.024
RbpmsRNA binding protein gene with multiple splicing0.024
Dok2docking protein 20.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fdft1farnesyl diphosphate farnesyl transferase 10.161
Acat3acetyl-Coenzyme A acetyltransferase 30.115
Tff3trefoil factor 3, intestinal0.104
Irs1insulin receptor substrate 10.075
Cyp51cytochrome P450, family 510.061
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.057
Rcvrnrecoverin0.049
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.045
Fcer2Fc fragment of IgE, low affinity II, receptor for (CD23)0.045
Tmem59transmembrane protein 590.037
Clca4chloride channel accessory 40.036
Cd36CD36 molecule (thrombospondin receptor)0.035
Mvdmevalonate (diphospho) decarboxylase0.034
Mea1male-enhanced antigen 10.034
Nrasneuroblastoma ras oncogene0.033
Idi1isopentenyl-diphosphate delta isomerase 10.033
Klk8kallikrein related-peptidase 80.033
Olr837olfactory receptor 8370.031
Dctn1dynactin 10.031
Ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.030
Ush1cUsher syndrome 1C homolog (human)0.030
Pcyt2phosphate cytidylyltransferase 2, ethanolamine0.030
Aqp7aquaporin 70.029
Edn2endothelin 20.029
Foxe1forkhead box E1 (thyroid transcription factor 2)0.029
Obp1fodorant binding protein I f0.029
Itm2bintegral membrane protein 2B0.028
Engaseendo-beta-N-acetylglucosaminidase0.028
Adipor2adiponectin receptor 20.028
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.028
Atp6v0e2ATPase, H+ transporting V0 subunit e20.027
Thrbthyroid hormone receptor beta0.027
Mvkmevalonate kinase0.026
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.026
Slc6a8solute carrier family 6 (neurotransmitter transporter, creatine), member 80.025
Gtf2a1general transcription factor IIA, 10.025
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.025
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.025
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.025
Sqlesqualene epoxidase0.024
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.024
Npdc1neural proliferation, differentiation and control, 10.024
Padi3peptidyl arginine deiminase, type III0.024
Npy5rneuropeptide Y receptor Y50.023
Kcne1potassium voltage-gated channel, Isk-related family, member 10.023
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.023
Rnf123ring finger protein 1230.023
Gipgastric inhibitory polypeptide0.022
Rab11aRAB11a, member RAS oncogene family0.022
Foxc1forkhead box C10.022
Pfn1profilin 10.022
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.022
Nrapnebulin-related anchoring protein0.021
Galnt10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)0.021
Trim3tripartite motif-containing 30.021
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.021
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.021
Ppm1jprotein phosphatase 1J0.021
Cd5Cd5 molecule0.021
Insrinsulin receptor0.021
Hsd17b12hydroxysteroid (17-beta) dehydrogenase 120.021
Pla2g2cphospholipase A2, group IIC0.020
Kcnk1potassium channel, subfamily K, member 10.020
RGD1566083similar to hypothetical protein MGC240470.020
Cltcclathrin, heavy chain (Hc)0.020
Phf7PHD finger protein 70.020
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.019
Tmem163transmembrane protein 1630.019
Adam2ADAM metallopeptidase domain 20.019
Hspbp1HSPA binding protein, cytoplasmic cochaperone 10.019
Ptp4a1protein tyrosine phosphatase type IVA, member 10.019
Pnpla2patatin-like phospholipase domain containing 20.019
Cluclusterin0.018
Igh-6immunoglobulin heavy chain 60.018
Nae1NEDD8 activating enzyme E1 subunit 10.018
Nmuneuromedin U0.018
Fgf1fibroblast growth factor 10.018
Kcnd2potassium voltage-gated channel, Shal-related subfamily, member 20.018
Acmsdaminocarboxymuconate semialdehyde decarboxylase0.018
Ap3m1adaptor-related protein complex 3, mu 1 subunit0.018
Rer1RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)0.018
Tspan3tetraspanin 30.017
Ccdc97coiled-coil domain containing 970.017
Cpt1bcarnitine palmitoyltransferase 1b, muscle0.017
Tkttransketolase0.017
Il1r1interleukin 1 receptor, type I0.017
Acot12acyl-CoA thioesterase 120.016
Pex11aperoxisomal biogenesis factor 11 alpha0.016
Slc25a1solute carrier family 25 (mitochondrial carrier, citrate transporter), member 10.016
Ltb4r2leukotriene B4 receptor 20.016
Pitpnaphosphatidylinositol transfer protein, alpha0.016
Usp33ubiquitin specific peptidase 330.016
Dhrs9dehydrogenase/reductase (SDR family) member 90.016
Nr5a2nuclear receptor subfamily 5, group A, member 20.016
Tpc1808tropic 18080.016
Sirt2sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)0.016
Mapk15mitogen-activated protein kinase 150.016
Ap2m1adaptor-related protein complex 2, mu 1 subunit0.016
Phkg1phosphorylase kinase, gamma 10.016
GperG protein-coupled estrogen receptor 10.016
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
GPI17Gpi17p0.802
GAA1Gaa1p0.800
OPI3Opi3p0.760
GWT1Gwt1p0.757
MDM35Mdm35p0.707
CDS1Cds1p0.617
INO2Ino2p0.588
GPI8Gpi8p0.574
LAS21Las21p0.527
PSD1Psd1p0.448
MCD4Mcd4p0.435
SLC1Slc1p0.424
GPI16Gpi16p0.422
PDR17Pdr17p0.419
PER1Per1p0.385
GLO3Glo3p0.328
FAT1Fat1p0.324
CTI6Cti6p0.298
SAM2Sam2p0.296
GAB1Gab1p0.281
YGR205Whypothetical protein0.262
TGL2Tgl2p0.255
EHT1Eht1p0.249
MID1Mid1p0.249
PLB2Plb2p0.247
MSC7Msc7p0.225
TGL1Tgl1p0.225
PEX29Pex29p0.223
SPF1Spf1p0.195
PSD2Psd2p0.193
YJR015Whypothetical protein0.184
GUP1Gup1p0.171
GPI2Gpi2p0.160
DIE2Die2p0.157
IMD2Imd2p0.154
HTD2Htd2p0.153
ARE2Are2p0.152
MDM32Mdm32p0.151
CHO1Cho1p0.149
UPS3Ups3p0.142
MDS3Mds3p0.142
FIS1Fis1p0.136
RFT1Rft1p0.136
GOT1Got1p0.136
RER2Rer2p0.135
ITR1Itr1p0.135
PFA4Pfa4p0.134
ARV1Arv1p0.129
IZH4Izh4p0.128
SDS3Sds3p0.128
PMT2Pmt2p0.127
FAB1Fab1p0.127
YNL035Chypothetical protein0.123
SPT14Spt14p0.122
TVP38Tvp38p0.122
YHB1Yhb1p0.118
IWR1Iwr1p0.117
ERG13Erg13p0.115
YAP7Yap7p0.107
PMT3Pmt3p0.104
GPI13Gpi13p0.103
OPI1Opi1p0.103
PTC7Ptc7p0.102
PPZ2Ppz2p0.101
ALG6Alg6p0.100
NMT1Nmt1p0.100
IST2Ist2p0.097
XPT1Xpt1p0.095
ACS2Acs2p0.095
PMT1Pmt1p0.093
YLR132Chypothetical protein0.090
YDR307Whypothetical protein0.089
GRH1Grh1p0.089
GEF1Gef1p0.088
WAR1War1p0.084
YOR338Whypothetical protein0.083
CHO2Cho2p0.083
YBR063Chypothetical protein0.083
STF1Stf1p0.083
PHS1Phs1p0.083
RBD2Rbd2p0.082
EPT1Ept1p0.082
SCJ1Scj1p0.081
MOG1Mog1p0.077
ATP22Atp22p0.077
KES1Kes1p0.076
CBK1Cbk1p0.076
YGL082Whypothetical protein0.076
YJL055Whypothetical protein0.076
PMR1Pmr1p0.075
ECM9Ecm9p0.074
INO1Ino1p0.074
GIS3Gis3p0.074
OAF1Oaf1p0.073
TIF1Tif1p0.073
YGL140Chypothetical protein0.072
DGK1Dgk1p0.071
SCT1Sct1p0.071
ERG8Erg8p0.071
UPS1Ups1p0.071