The network for 'positive regulation of response to external stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.

NameDescriptionProbabilityFunc Analog Organism
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)1.000
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.997
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.989
NCF1neutrophil cytosolic factor 10.988
S100BS100 calcium binding protein B0.973
IL8interleukin 80.968
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.966
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.959
CCR5chemokine (C-C motif) receptor 50.953
S100A6S100 calcium binding protein A60.948
PTPN1protein tyrosine phosphatase, non-receptor type 10.939
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.919
SQSTM1sequestosome 10.904
TLR4toll-like receptor 40.894
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.882
VEGFAvascular endothelial growth factor A0.872
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.868
MAP3K7mitogen-activated protein kinase kinase kinase 70.857
EGFRepidermal growth factor receptor0.843
IL1Binterleukin 1, beta0.833
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.823
AXLAXL receptor tyrosine kinase0.822
S100A9S100 calcium binding protein A90.801
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.782
CCR1chemokine (C-C motif) receptor 10.782
CCL2chemokine (C-C motif) ligand 20.748
CXCL2chemokine (C-X-C motif) ligand 20.743
PLAUplasminogen activator, urokinase0.735
DPP4dipeptidyl-peptidase 40.725
METmet proto-oncogene (hepatocyte growth factor receptor)0.721
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.716
CCR2chemokine (C-C motif) receptor 20.715
SNAP23synaptosomal-associated protein, 23kDa0.715
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.683
MAPK8mitogen-activated protein kinase 80.668
TNIP2TNFAIP3 interacting protein 20.664
TLR2toll-like receptor 20.650
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.648
JAK2Janus kinase 20.625
CCL8chemokine (C-C motif) ligand 80.594
CCL5chemokine (C-C motif) ligand 50.576
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.570
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.532
CXCL3chemokine (C-X-C motif) ligand 30.530
NRP1neuropilin 10.524
MYD88myeloid differentiation primary response gene (88)0.523
S100A14S100 calcium binding protein A140.501
CCL19chemokine (C-C motif) ligand 190.490
S100A8S100 calcium binding protein A80.480
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.479
CXCL9chemokine (C-X-C motif) ligand 90.479
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.471
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.460
S100A16S100 calcium binding protein A160.453
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.452
CCL4chemokine (C-C motif) ligand 40.448
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.446
NCF4neutrophil cytosolic factor 4, 40kDa0.444
CRYABcrystallin, alpha B0.441
LATlinker for activation of T cells0.430
PLAURplasminogen activator, urokinase receptor0.405
GRAP2GRB2-related adaptor protein 20.404
CXCL5chemokine (C-X-C motif) ligand 50.404
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.403
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.402
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.401
ICAM1intercellular adhesion molecule 10.396
SYKspleen tyrosine kinase0.383
IL6interleukin 6 (interferon, beta 2)0.376
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.364
TLR1toll-like receptor 10.352
S100A12S100 calcium binding protein A120.352
CTNND1catenin (cadherin-associated protein), delta 10.347
IL2RBinterleukin 2 receptor, beta0.345
TNFtumor necrosis factor0.335
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.316
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.315
FN1fibronectin 10.312
CD163CD163 molecule0.310
SOCS3suppressor of cytokine signaling 30.293
CYBBcytochrome b-245, beta polypeptide0.291
ANXA2annexin A20.291
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.287
SOX10SRY (sex determining region Y)-box 100.285
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.283
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.282
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.278
GAS6growth arrest-specific 60.274
PTPRJprotein tyrosine phosphatase, receptor type, J0.274
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.272
AREGamphiregulin0.272
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.265
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.262
GABARAPGABA(A) receptor-associated protein0.262
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.257
RNASE6ribonuclease, RNase A family, k60.254
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.249
CCL7chemokine (C-C motif) ligand 70.240
CCL22chemokine (C-C motif) ligand 220.239
CD86CD86 molecule0.237
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
hlh-1Protein HLH-10.067
Y82E9BR.13Protein Y82E9BR.130.048
pha-4Protein PHA-40.035
ceh-13Protein CEH-130.034
egl-18Protein EGL-180.030
F57F5.1Protein F57F5.10.026
egl-46Protein EGL-460.025
asah-1Protein ASAH-10.024
unc-73Protein UNC-730.021
elt-6Protein ELT-60.020
tbb-4Protein TBB-40.019
cnd-1Protein CND-10.018
lag-1Protein LAG-10.017
tbc-3Protein TBC-30.017
gba-4Protein GBA-40.016
daf-11Protein DAF-110.016
CELE_C17F4.7Protein C17F4.70.015
T10B5.7Protein T10B5.70.015
ced-9Protein CED-90.014
scl-2Protein SCL-20.014
nhr-31Protein NHR-310.014
apr-1Protein APR-10.014
K01A2.9Protein K01A2.90.013
ptc-1Protein PTC-10.013
F54E4.3Protein F54E4.30.013
F27E5.1Protein F27E5.10.012
fli-1Protein FLI-10.012
lin-12Protein LIN-120.010
unc-41Protein UNC-410.010
H41C03.3Protein H41C03.30.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nrp1aneuropilin 1a0.681
mmp9matrix metalloproteinase 90.447
slit3slit (Drosophila) homolog 30.404
sema3dsemaphorin 3d0.380
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.368
ptgs2aprostaglandin-endoperoxide synthase 2a0.305
il1binterleukin 1, beta and interleukin 1, beta0.194
fn1fibronectin 10.192
tgfbitransforming growth factor, beta-induced0.186
cdh5cadherin 50.185
il8interleukin 80.167
csf1racolony stimulating factor 1 receptor, a0.144
epas1bendothelial PAS domain protein 1b0.141
vegfcvascular endothelial growth factor c0.112
ptgs1prostaglandin-endoperoxide synthase 10.109
tlr3toll-like receptor 30.101
tnfatumor necrosis factor a (TNF superfamily, member 2)0.097
foxa1forkhead box A10.094
kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.093
flhfloating head0.089
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.085
nod1nucleotide-binding oligomerization domain containing 10.084
wnt4awingless-type MMTV integration site family, member 4a0.082
lta4hleukotriene A4 hydrolase0.078
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.074
pou5f1POU domain, class 5, transcription factor 10.073
cdh2cadherin 2, neuronal0.071
ptpn6protein tyrosine phosphatase, non-receptor type 60.070
fabp11afatty acid binding protein 11a0.069
igf1rainsulin-like growth factor 1a receptor0.063
spon1bspondin 1b0.059
notch2notch homolog 20.059
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.058
lrrc17leucine rich repeat containing 170.058
bmp2bbone morphogenetic protein 2b0.058
hlxb9lahomeo box HB9 like a0.058
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.054
ptrfbpolymerase I and transcript release factor b0.053
LOC557072caspase recruitment domain-containing protein 11-like0.052
col12a1collagen, type XII, alpha 10.051
prrx1apaired related homeobox 1a0.049
tnctenascin C0.049
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.048
ptger2aprostaglandin E receptor 2a (subtype EP2)0.047
twist1atwist1a0.044
nrp2aneuropilin 2a0.043
thtyrosine hydroxylase0.042
prox1prospero-related homeobox gene 10.041
pdcd2programmed cell death 20.040
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.040
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.039
postnperiostin, osteoblast specific factor0.039
adora2aaadenosine A2a receptor a0.039
crhcorticotropin releasing hormone0.038
rbm22RNA binding motif protein 220.037
stc1lstanniocalcin 1, like0.036
sulf2lsulfatase 2, like0.035
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.035
hlxb9lbhomeo box HB9 like b0.034
m17IL-6 subfamily cytokine M170.034
socs3asuppressor of cytokine signaling 3a0.033
plcg1phospholipase C, gamma 10.033
alkanaplastic lymphoma kinase (Ki-1)0.032
ripk2receptor-interacting serine-threonine kinase 20.032
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.032
otpaorthopedia homolog a0.030
ecscrendothelial cell-specific chemotaxis regulator0.030
dscamDown syndrome cell adhesion molecule0.030
il6rinterleukin 6 receptor0.030
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.030
plxnd1plexin D10.030
tbx1T-box 10.029
mapk4mitogen-activated protein kinase 40.029
slc24a5solute carrier family 24, member 50.028
calcrlacalcitonin receptor-like a0.027
shhasonic hedgehog a0.027
olig2oligodendrocyte lineage transcription factor 20.026
col5a2lcollagen, type V, alpha 2-like0.026
hdac4histone deacetylase 40.026
mcambmelanoma cell adhesion molecule b0.026
efnb2aephrin B2a0.026
mnx1motor neuron and pancreas homeobox 10.026
myod1myogenic differentiation 10.025
inspreproinsulin0.025
ythdf1YTH domain family, member 10.025
tyrp1btyrosinase-related protein 1b0.025
xgbx globin0.024
si:dkey-12o15.1si:dkey-12o15.10.024
lppLIM domain containing preferred translocation partner in lipoma0.024
vcanbversican b0.024
cdh1cadherin 1, epithelial0.024
sardhsarcosine dehydrogenase0.023
chrm2acholinergic receptor, muscarinic 2a0.023
tyrtyrosinase0.023
csf3rcolony stimulating factor 3 receptor (granulocyte)0.023
runx3runt-related transcription factor 30.023
ctbp2lC-terminal binding protein 2, like0.023
hspb9heat shock protein, alpha-crystallin-related, 90.022
bnc2basonuclin 20.022
vegfabvascular endothelial growth factor Ab0.022
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PGRP-LCPeptidoglycan recognition protein LC0.987
RelRelish0.984
Spn27ASerpin 27A0.944
PGRP-SDCG7496 gene product from transcript CG7496-RA0.761
ird5immune response deficient 50.605
Sp7Serine protease 70.587
DreddDeath related ced-3/Nedd2-like protein0.580
Spn1Serine protease inhibitor 10.552
grimCG4345 gene product from transcript CG4345-RA0.546
SPESpatzle-Processing Enzyme0.539
fonfondue0.501
Spn28DSerpin 28D0.486
grassGram-positive Specific Serine protease0.473
PGRP-SAPeptidoglycan recognition protein SA0.472
spzspatzle0.446
timtimeless0.287
Pi3K92ECG4141 gene product from transcript CG4141-RB0.263
Atg13Autophagy-specific gene 130.260
drkdownstream of receptor kinase0.239
imdimmune deficiency0.238
AttAAttacin-A0.234
Rab7Rab-protein 70.207
pntpointed0.196
X11LCG5675 gene product from transcript CG5675-RB0.194
GNBP3Gram-negative bacteria binding protein 30.190
rutrutabaga0.186
Spn77BaSerpin 77Ba0.173
KrnKeren0.161
Sir2CG5216 gene product from transcript CG5216-RA0.158
PvrPDGF- and VEGF-receptor related0.158
MP1Melanization Protease 10.157
NFATNFAT homolog0.144
pllpelle0.143
ThorCG8846 gene product from transcript CG8846-RA0.140
nubnubbin0.138
Sema-1aCG18405 gene product from transcript CG18405-RD0.136
TlToll0.134
rprreaper0.133
SdcSyndecan0.132
G-salpha60AG protein salpha 60A0.131
rinrasputin0.126
CG12766CG12766 gene product from transcript CG12766-RA0.124
pshpersephone0.122
CG9184CG9184 gene product from transcript CG9184-RB0.119
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.118
bifbifocal0.117
EcREcdysone receptor0.112
perperiod0.109
GltGlutactin0.109
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.109
Df31Decondensation factor 310.104
SnooSno oncogene0.102
IrcImmune-regulated catalase0.100
rgrugose0.097
slislit0.097
dibdisembodied0.096
sqzsqueeze0.096
necnecrotic0.094
pirkpoor Imd response upon knock-in0.090
comtcomatose0.090
CG7910CG7910 gene product from transcript CG7910-RA0.090
modSPmodular serine protease0.089
ImpIGF-II mRNA-binding protein0.089
reporeversed polarity0.082
amosabsent MD neurons and olfactory sensilla0.082
kiskismet0.080
BG4CG12297 gene product from transcript CG12297-RA0.075
AGO2Argonaute 20.075
Ptp69DProtein tyrosine phosphatase 69D0.072
Sox14Sox box protein 140.072
keykenny0.070
Ced-12CG5336 gene product from transcript CG5336-RA0.068
su(Hw)suppressor of Hairy wing0.067
enaenabled0.066
mavmaverick0.065
spinspinster0.064
GNBP1Gram-negative bacteria binding protein 10.063
Aplip1APP-like protein interacting protein 10.063
InRInsulin-like receptor0.063
StamSignal transducing adaptor molecule0.061
CG15917CG15917 gene product from transcript CG15917-RA0.061
foxoforkhead box, sub-group O0.061
Cdc42CG12530 gene product from transcript CG12530-RA0.061
drprdraper0.060
tlltailless0.060
Lis-1Lissencephaly-10.060
Iap2Inhibitor of apoptosis 20.060
debcldeath executioner Bcl-2 homologue0.060
panpangolin0.059
tnatonalli0.059
Nrx-IVNeurexin IV0.058
Six4CG3871 gene product from transcript CG3871-RA0.058
Smg5CG8954 gene product from transcript CG8954-RA0.057
dawdawdle0.057
faxfailed axon connections0.057
ScmSex comb on midleg0.055
TBPHCG10327 gene product from transcript CG10327-RC0.055
Atg2Autophagy-specific gene 20.054
hipkhomeodomain interacting protein kinase0.054
zetaTryzetaTrypsin0.054
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd14CD14 molecule0.727
Il8rbinterleukin 8 receptor, beta0.712
S100a9S100 calcium binding protein A90.461
Ccl2chemokine (C-C motif) ligand 20.439
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.388
Ccl20chemokine (C-C motif) ligand 200.275
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.271
Il1binterleukin 1 beta0.267
S100a8S100 calcium binding protein A80.237
C5ar1complement component 5a receptor 10.231
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.229
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.223
Mmp10matrix metallopeptidase 100.212
Il1r1interleukin 1 receptor, type I0.210
Cd4Cd4 molecule0.205
Fgfr2fibroblast growth factor receptor 20.202
Cgaglycoprotein hormones, alpha polypeptide0.198
Slco2b1solute carrier organic anion transporter family, member 2b10.197
Calcrlcalcitonin receptor-like0.195
Rps20ribosomal protein S200.187
Pdia4protein disulfide isomerase family A, member 40.182
LOC100363783rCG53773-like0.182
Cenpicentromere protein I0.172
Jak2Janus kinase 20.160
Ccl3chemokine (C-C motif) ligand 30.155
Bcl2B-cell CLL/lymphoma 20.155
Cxcl3chemokine (C-X-C motif) ligand 30.149
Gzmbgranzyme B0.148
Ptafrplatelet-activating factor receptor0.145
Ccl7chemokine (C-C motif) ligand 70.143
Calcbcalcitonin-related polypeptide, beta0.141
Cxcl10chemokine (C-X-C motif) ligand 100.139
RT1-BaRT1 class II, locus Ba0.134
Tgm1transglutaminase 1, K polypeptide0.133
Rab20RAB20, member RAS oncogene family0.132
Ier3immediate early response 30.131
Nek9NIMA (never in mitosis gene a)- related kinase 90.129
Il6interleukin 60.128
Ptger4prostaglandin E receptor 4 (subtype EP4)0.128
Icam1intercellular adhesion molecule 10.125
Oas1a2'-5' oligoadenylate synthetase 1A0.125
Plekpleckstrin0.124
Cxcl2chemokine (C-X-C motif) ligand 20.124
Metmet proto-oncogene0.122
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.120
Slit3slit homolog 3 (Drosophila)0.120
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.117
Socs3suppressor of cytokine signaling 30.114
Creb1cAMP responsive element binding protein 10.109
F13a1coagulation factor XIII, A1 polypeptide0.109
Agtr1aangiotensin II receptor, type 1a0.108
Efnb1ephrin B10.108
Fibcd1fibrinogen C domain containing 10.107
Lst1leukocyte specific transcript 10.106
Il1r2interleukin 1 receptor, type II0.105
Ccr1chemokine (C-C motif) receptor 10.105
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.105
Grk1G protein-coupled receptor kinase 10.105
Cd86CD86 molecule0.103
Eef2eukaryotic translation elongation factor 20.102
Thbdthrombomodulin0.101
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.100
RT1-DaRT1 class II, locus Da0.100
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.098
Vcanversican0.097
Reg3bregenerating islet-derived 3 beta0.096
Hpgdshematopoietic prostaglandin D synthase0.096
Ccl4chemokine (C-C motif) ligand 40.094
Sstsomatostatin0.094
Arandrogen receptor0.093
Ccr2chemokine (C-C motif) receptor 20.092
Tnftumor necrosis factor (TNF superfamily, member 2)0.090
Cd3gCD3 molecule, gamma0.089
Casp1caspase 10.088
Flt1FMS-related tyrosine kinase 10.087
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.087
Igsf6immunoglobulin superfamily, member 60.086
Prrx1paired related homeobox 10.085
Il4interleukin 40.084
Ifitm3interferon induced transmembrane protein 30.083
Gpr83G protein-coupled receptor 830.082
LOC24906RoBo-10.081
Cybbcytochrome b-245, beta polypeptide0.080
Cx3cl1chemokine (C-X3-C motif) ligand 10.080
Csnk1dcasein kinase 1, delta0.079
Cd38CD38 molecule0.078
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.077
Htra3HtrA serine peptidase 30.074
Aqp5aquaporin 50.074
Nfibnuclear factor I/B0.074
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.074
Gas7growth arrest specific 70.073
Gna12guanine nucleotide binding protein (G protein) alpha 120.072
Fgf7fibroblast growth factor 70.072
Il1ainterleukin 1 alpha0.071
Jak1Janus kinase 10.071
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.069
Ednraendothelin receptor type A0.069
Wisp1WNT1 inducible signaling pathway protein 10.069
Mmp3matrix metallopeptidase 30.068
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YKR015Chypothetical protein0.029
SLG1Slg1p0.024
SNF1Snf1p0.024
MIG1Mig1p0.021
SNT1Snt1p0.020
HHO1Hho1p0.020
PCL2Pcl2p0.017
SEC2Sec2p0.017
GAT2Gat2p0.017
EAF1Eaf1p0.016
VID24Vid24p0.015
HXT3Hxt3p0.015
ATG11Atg11p0.014
KIC1Kic1p0.013
YKR075Chypothetical protein0.013
ATG4Atg4p0.012
YPT1Ypt1p0.012
FPK1Fpk1p0.012
MET4Met4p0.012
ATG13Atg13p0.012
CKA1Cka1p0.012
ROX1Rox1p0.012
VPS27Vps27p0.012
YAK1Yak1p0.012
ATG9Atg9p0.012
VAC7Vac7p0.010
YPT32Ypt32p0.010
GIS4Gis4p0.010
HOS4Hos4p0.010
CPR1Cpr1p0.010