The network for 'negative regulation of ion transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of ion transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NameDescriptionProbabilityFunc Analog Organism
GSTM1glutathione S-transferase mu 10.981
FYNFYN oncogene related to SRC, FGR, YES0.973
INSRinsulin receptor0.906
TGFB1transforming growth factor, beta 10.897
MAPTmicrotubule-associated protein tau0.896
GSTM2glutathione S-transferase mu 2 (muscle)0.890
ACTN2actinin, alpha 20.822
A2Malpha-2-macroglobulin0.781
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.764
SMURF2SMAD specific E3 ubiquitin protein ligase 20.657
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.618
GSTM4glutathione S-transferase mu 40.586
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.560
CSKc-src tyrosine kinase0.554
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.544
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.537
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.525
MED15mediator complex subunit 150.480
TGFBR1transforming growth factor, beta receptor 10.470
CALM1calmodulin 1 (phosphorylase kinase, delta)0.461
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.446
SMAD2SMAD family member 20.425
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.422
CAB39calcium binding protein 390.399
ADORA2Aadenosine A2a receptor0.385
IL1R1interleukin 1 receptor, type I0.380
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.378
ADAM15ADAM metallopeptidase domain 150.370
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.351
NOXA1NADPH oxidase activator 10.339
HPhaptoglobin0.319
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.313
BCAR1breast cancer anti-estrogen resistance 10.311
PTPN6protein tyrosine phosphatase, non-receptor type 60.302
ACTN4actinin, alpha 40.297
MTORmechanistic target of rapamycin (serine/threonine kinase)0.293
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.287
SMURF1SMAD specific E3 ubiquitin protein ligase 10.271
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.258
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.230
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.228
TRIM39tripartite motif containing 390.224
ZYXzyxin0.220
SPG20spastic paraplegia 20 (Troyer syndrome)0.215
ACTBactin, beta0.208
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.204
SMAD7SMAD family member 70.191
DCTN1dynactin 10.181
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.177
PTPN1protein tyrosine phosphatase, non-receptor type 10.169
PKM2pyruvate kinase, muscle0.167
ZNF263zinc finger protein 2630.163
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.163
IL1RNinterleukin 1 receptor antagonist0.163
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.163
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.162
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.159
CRHcorticotropin releasing hormone0.158
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.156
ZFYVE9zinc finger, FYVE domain containing 90.153
NEDD4neural precursor cell expressed, developmentally down-regulated 40.153
TNFAIP6tumor necrosis factor, alpha-induced protein 60.151
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.145
VAC14Vac14 homolog (S. cerevisiae)0.143
SMAD3SMAD family member 30.140
MYOZ1myozenin 10.138
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.134
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.132
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.127
WWP1WW domain containing E3 ubiquitin protein ligase 10.127
RNF11ring finger protein 110.124
SH3RF1SH3 domain containing ring finger 10.123
PTAFRplatelet-activating factor receptor0.123
PILRApaired immunoglobin-like type 2 receptor alpha0.122
GRB10growth factor receptor-bound protein 100.120
PDCD6IPprogrammed cell death 6 interacting protein0.119
IL8interleukin 80.109
ACVR1Bactivin A receptor, type IB0.108
BCL2L1BCL2-like 10.105
APOBapolipoprotein B (including Ag(x) antigen)0.099
NCF1neutrophil cytosolic factor 10.098
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.098
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.096
EPORerythropoietin receptor0.095
MYH9myosin, heavy chain 9, non-muscle0.094
FLNAfilamin A, alpha0.092
SMAD4SMAD family member 40.089
NR4A1nuclear receptor subfamily 4, group A, member 10.085
TSC22D1TSC22 domain family, member 10.085
APLP1amyloid beta (A4) precursor-like protein 10.084
PSEN2presenilin 2 (Alzheimer disease 4)0.083
IL6interleukin 6 (interferon, beta 2)0.082
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.080
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.079
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.079
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.078
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.077
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.076
CAPZBcapping protein (actin filament) muscle Z-line, beta0.074
PRKCAprotein kinase C, alpha0.074
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
vab-3Protein VAB-30.053
srv-1Protein SRV-10.041
cam-1Protein CAM-10.040
eat-4Protein EAT-40.039
inx-12Protein INX-120.038
mec-2Protein MEC-20.034
inx-4Protein INX-40.028
glr-5Protein GLR-50.026
ifd-1Protein IFD-10.022
inx-3Protein INX-30.021
unc-7Protein UNC-70.020
gcy-28Protein GCY-280.020
F52C12.4Protein F52C12.40.018
inx-17Protein INX-170.017
sdz-28Protein SDZ-280.013
H24G06.1Protein H24G06.10.013
tbh-1Protein TBH-10.013
F39G3.5Protein F39G3.50.012
unc-36Protein UNC-360.011
vha-15Protein VHA-150.011
K10D6.2Protein K10D6.20.011
mec-1Protein MEC-10.011
madd-4Protein MADD-40.011
F42C5.9Protein F42C5.90.010
egl-19Protein EGL-190.010
efn-2Protein EFN-20.010
che-3Protein CHE-30.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
G-salpha60AG protein salpha 60A0.011
myoglianinCG1838 gene product from transcript CG1838-RD0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.683
Nos3nitric oxide synthase 3, endothelial cell0.544
Drd2dopamine receptor D20.527
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.525
Leprleptin receptor0.517
Ptgs2prostaglandin-endoperoxide synthase 20.501
Lyz2lysozyme 20.461
Nos1nitric oxide synthase 1, neuronal0.457
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.456
Ppargperoxisome proliferator activated receptor gamma0.394
Ascl1achaete-scute complex homolog 1 (Drosophila)0.346
Ldb3LIM domain binding 30.342
Tlr4toll-like receptor 40.341
Ccl2chemokine (C-C motif) ligand 20.314
Neurod1neurogenic differentiation 10.307
Ryr2ryanodine receptor 2, cardiac0.303
Slc34a1solute carrier family 34 (sodium phosphate), member 10.280
Trp53transformation related protein 530.260
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.258
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.212
Adora2aadenosine A2a receptor0.207
Ren1renin 1 structural0.194
Kcnk3potassium channel, subfamily K, member 30.176
Ccr2chemokine (C-C motif) receptor 20.150
Slc12a1solute carrier family 12, member 10.150
Nos2nitric oxide synthase 2, inducible0.148
Mmp9matrix metallopeptidase 90.141
Pnpla2patatin-like phospholipase domain containing 20.137
Ptenphosphatase and tensin homolog0.134
Adrb1adrenergic receptor, beta 10.132
Neurog2neurogenin 20.128
Dmddystrophin, muscular dystrophy0.127
Cav1caveolin 1, caveolae protein0.127
Lepleptin0.109
Bdnfbrain derived neurotrophic factor0.107
Grm1glutamate receptor, metabotropic 10.106
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.105
Tgfb1transforming growth factor, beta 10.104
Umoduromodulin0.104
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.100
Slc17a1solute carrier family 17 (sodium phosphate), member 10.099
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.099
Prox1prospero-related homeobox 10.096
BaxBCL2-associated X protein0.093
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.090
Hrh1histamine receptor H10.089
Ptpn18protein tyrosine phosphatase, non-receptor type 180.086
Rac1RAS-related C3 botulinum substrate 10.086
Foxd2forkhead box D20.079
Cd44CD44 antigen0.079
Npy5rneuropeptide Y receptor Y50.076
Nr3c1nuclear receptor subfamily 3, group C, member 10.075
Pax6paired box gene 60.073
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.073
Lhx6LIM homeobox protein 60.071
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.070
Dtnadystrobrevin alpha0.070
Neurog3neurogenin 30.068
Vdrvitamin D receptor0.065
Oprk1opioid receptor, kappa 10.065
BtkBruton agammaglobulinemia tyrosine kinase0.065
Pkd1polycystic kidney disease 1 homolog0.064
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.063
Maptmicrotubule-associated protein tau0.063
Prkceprotein kinase C, epsilon0.063
Onecut1one cut domain, family member 10.062
Cyldcylindromatosis (turban tumor syndrome)0.061
Cntn4contactin 40.061
Emx1empty spiracles homolog 1 (Drosophila)0.060
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.060
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.060
MecomMDS1 and EVI1 complex locus0.060
Hrhairless0.059
Wt1Wilms tumor 1 homolog0.058
Fbn1fibrillin 10.058
Ptf1apancreas specific transcription factor, 1a0.057
Mdm2transformed mouse 3T3 cell double minute 20.056
Clockcircadian locomotor output cycles kaput0.056
Syn2synapsin II0.055
Il6stinterleukin 6 signal transducer0.055
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.054
Col1a1collagen, type I, alpha 10.052
Pcdh12protocadherin 120.051
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.050
Zfpm2zinc finger protein, multitype 20.049
Cckbrcholecystokinin B receptor0.049
Klklotho0.049
Gsx1GS homeobox 10.049
Itgb1integrin beta 1 (fibronectin receptor beta)0.047
Platplasminogen activator, tissue0.047
Slc6a18solute carrier family 6 (neurotransmitter transporter), member 180.045
Upp2uridine phosphorylase 20.045
Bcl2B-cell leukemia/lymphoma 20.045
Ccr1l1chemokine (C-C motif) receptor 1-like 10.044
Agtr1aangiotensin II receptor, type 1a0.043
Il6interleukin 60.043
Vhlvon Hippel-Lindau tumor suppressor0.042
Plauplasminogen activator, urokinase0.041
Fgf13fibroblast growth factor 130.041
Cd33CD33 antigen0.040
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.485
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.451
Insrrinsulin receptor-related receptor0.437
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.293
Strnstriatin, calmodulin binding protein0.245
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.214
Gna12guanine nucleotide binding protein (G protein) alpha 120.199
Teddm1transmembrane epididymal protein 10.187
Slc6a7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.187
Cckarcholecystokinin A receptor0.178
KlKlotho0.172
Adora1adenosine A1 receptor0.160
Grm5glutamate receptor, metabotropic 50.158
Oxtroxytocin receptor0.157
Cx3cr1chemokine (C-X3-C motif) receptor 10.157
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.144
Gja1gap junction protein, alpha 10.143
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.131
Cnga1cyclic nucleotide gated channel alpha 10.131
Adra1aadrenergic, alpha-1A-, receptor0.126
Dmddystrophin0.122
Kcnd3potassium voltage-gated channel, Shal-related subfamily, member 30.118
Maoamonoamine oxidase A0.115
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.115
Lim2lens intrinsic membrane protein 20.111
Cela2achymotrypsin-like elastase family, member 2A0.111
Ifrd1interferon-related developmental regulator 10.108
Acmsdaminocarboxymuconate semialdehyde decarboxylase0.108
Csf1colony stimulating factor 1 (macrophage)0.105
Csrp3cysteine and glycine-rich protein 30.104
Grm7glutamate receptor, metabotropic 70.102
Myl1myosin, light chain 10.099
Eef2eukaryotic translation elongation factor 20.095
Fgf10fibroblast growth factor 100.093
Atp7bATPase, Cu++ transporting, beta polypeptide0.091
Adora2aadenosine A2a receptor0.090
Mchr1melanin-concentrating hormone receptor 10.090
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.090
Ptafrplatelet-activating factor receptor0.088
Slc6a18solute carrier family 6, member 180.087
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.087
Vom2r27vomeronasal 2 receptor, 270.084
Adrb1adrenergic, beta-1-, receptor0.084
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.084
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.083
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.083
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.083
LOC100362824caveolin 2-like0.083
Npy1rneuropeptide Y receptor Y10.082
Hoxb7homeo box B70.081
Grifingalectin-related inter-fiber protein0.081
Oprk1opioid receptor, kappa 10.081
RorbRAR-related orphan receptor B0.080
Trhrthyrotropin releasing hormone receptor0.080
Mmp8matrix metallopeptidase 80.078
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.076
Nr4a3nuclear receptor subfamily 4, group A, member 30.076
Cd79bCd79b molecule, immunoglobulin-associated beta0.075
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.075
Cd46CD46 molecule, complement regulatory protein0.074
Oprm1opioid receptor, mu 10.074
Slc22a2solute carrier family 22 (organic cation transporter), member 20.073
Hrh3histamine receptor H30.073
Errfi1ERBB receptor feedback inhibitor 10.073
Fcer2Fc fragment of IgE, low affinity II, receptor for (CD23)0.073
Gucy2dguanylate cyclase 2d0.072
Prkcgprotein kinase C, gamma0.072
Htr65-hydroxytryptamine (serotonin) receptor 60.072
Ptp4a1protein tyrosine phosphatase type IVA, member 10.071
Gng7guanine nucleotide binding protein (G protein), gamma 70.071
Prp15proline-rich protein 150.070
Egr3early growth response 30.070
Trhr2thyrotropin releasing hormone receptor 20.069
Il2rainterleukin 2 receptor, alpha0.069
Chrna3cholinergic receptor, nicotinic, alpha 30.069
Pecam1platelet/endothelial cell adhesion molecule 10.068
Cd247Cd247 molecule0.066
Slc14a2solute carrier family 14 (urea transporter), member 20.065
Gpr83G protein-coupled receptor 830.063
Ncr1natural cytotoxicity triggering receptor 10.063
Olr1078olfactory receptor 10780.063
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.062
Gad2glutamate decarboxylase 20.062
Cst12cystatin 120.061
Tacr1tachykinin receptor 10.061
Prol1proline rich, lacrimal 10.061
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.061
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.060
Nlrp6NLR family, pyrin domain containing 60.059
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.059
Rab1bRAB1B, member RAS oncogene family0.059
MosMoloney sarcoma oncogene0.059
Nckap1NCK-associated protein 10.059
Tbx1T-box 10.059
Prrx1paired related homeobox 10.058
Nptxrneuronal pentraxin receptor0.058
Giprgastric inhibitory polypeptide receptor0.058
Fgf2fibroblast growth factor 20.058
Hcrtr2hypocretin (orexin) receptor 20.057
Gja3gap junction protein, alpha 30.057
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism