The network for 'heart induction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heart induction

The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart.

NameDescriptionProbabilityFunc Analog Organism
DVL1dishevelled, dsh homolog 1 (Drosophila)0.999
DVL3dishevelled, dsh homolog 3 (Drosophila)0.982
CSNK1Ecasein kinase 1, epsilon0.976
SP1Sp1 transcription factor0.970
BMPR1Abone morphogenetic protein receptor, type IA0.943
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.939
FOXD3forkhead box D30.929
AXIN1axin 10.908
LRP6low density lipoprotein receptor-related protein 60.905
LRRK2leucine-rich repeat kinase 20.841
APCadenomatous polyposis coli0.819
NCOA2nuclear receptor coactivator 20.672
SOX10SRY (sex determining region Y)-box 100.627
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.501
GSK3Bglycogen synthase kinase 3 beta0.484
HCFC1host cell factor C1 (VP16-accessory protein)0.484
WWP2WW domain containing E3 ubiquitin protein ligase 20.470
PAX3paired box 30.461
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.446
SOX2SRY (sex determining region Y)-box 20.434
CTNNBIP1catenin, beta interacting protein 10.416
FSTL1follistatin-like 10.380
ZFYVE9zinc finger, FYVE domain containing 90.359
CEP164centrosomal protein 164kDa0.335
WT1Wilms tumor 10.325
GLIS2GLIS family zinc finger 20.293
ZNF512Bzinc finger protein 512B0.282
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.270
FZD1frizzled homolog 1 (Drosophila)0.228
TCF4transcription factor 40.144
SMAD7SMAD family member 70.111
EP300E1A binding protein p3000.100
MYST2MYST histone acetyltransferase 20.092
SMAD3SMAD family member 30.085
RHOXF2Rhox homeobox family, member 20.084
PSEN1presenilin 10.065
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.064
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.061
HMGA1high mobility group AT-hook 10.059
CSNK1Dcasein kinase 1, delta0.058
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.054
FBXW11F-box and WD repeat domain containing 110.053
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.048
PITX1paired-like homeodomain 10.046
HTThuntingtin0.046
BTRCbeta-transducin repeat containing0.046
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.044
MCCmutated in colorectal cancers0.044
SNIP1Smad nuclear interacting protein 10.041
BAHD1bromo adjacent homology domain containing 10.041
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.039
FERMT2fermitin family member 20.036
FZD8frizzled homolog 8 (Drosophila)0.035
CTNND1catenin (cadherin-associated protein), delta 10.035
DIDO1death inducer-obliterator 10.035
SOX1SRY (sex determining region Y)-box 10.034
SOX11SRY (sex determining region Y)-box 110.034
SOX21SRY (sex determining region Y)-box 210.033
TAOK1TAO kinase 10.032
NOGnoggin0.031
OTPorthopedia homeobox0.028
NKD2naked cuticle homolog 2 (Drosophila)0.028
ADARB1adenosine deaminase, RNA-specific, B10.028
DPPA4developmental pluripotency associated 40.028
FAM110Afamily with sequence similarity 110, member A0.028
CADM4cell adhesion molecule 40.027
CREBBPCREB binding protein0.026
JUPjunction plakoglobin0.026
TP73tumor protein p730.025
FOXO1forkhead box O10.024
MAP2K6mitogen-activated protein kinase kinase 60.024
EMDemerin0.024
YAP1Yes-associated protein 10.023
NR0B1nuclear receptor subfamily 0, group B, member 10.023
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.023
ARandrogen receptor0.023
C9orf100chromosome 9 open reading frame 1000.023
POU3F2POU class 3 homeobox 20.023
HIC1hypermethylated in cancer 10.022
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.022
DVL2dishevelled, dsh homolog 2 (Drosophila)0.022
MDFIMyoD family inhibitor0.022
NOVA2neuro-oncological ventral antigen 20.021
ASCL1achaete-scute complex homolog 1 (Drosophila)0.021
ELF1E74-like factor 1 (ets domain transcription factor)0.021
FOXE1forkhead box E1 (thyroid transcription factor 2)0.021
POU3F3POU class 3 homeobox 30.021
ZBTB8Azinc finger and BTB domain containing 8A0.021
C16orf48chromosome 16 open reading frame 480.020
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.020
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.020
ZMYND8zinc finger, MYND-type containing 80.020
SRRM2serine/arginine repetitive matrix 20.019
DDI1DNA-damage inducible 1 homolog 1 (S. cerevisiae)0.019
PDX1pancreatic and duodenal homeobox 10.019
OCLNoccludin0.018
POU3F1POU class 3 homeobox 10.018
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.018
FAM110Cfamily with sequence similarity 110, member C0.018
PTK7PTK7 protein tyrosine kinase 70.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
wgwingless1.000
hhhedgehog0.999
EgfrEpidermal growth factor receptor0.976
NNotch0.947
armarmadillo0.889
eyaeyes absent0.291
Ras85DRas oncogene at 85D0.285
dppdecapentaplegic0.284
sdscalloped0.261
Rab11Rab-protein 110.236
DlDelta0.225
dshdishevelled0.223
tkvthickveins0.209
hthhomothorax0.192
SerSerrate0.159
enengrailed0.145
panpangolin0.128
fzfrizzled0.126
sqhspaghetti squash0.116
spispitz0.101
cicubitus interruptus0.093
HHairless0.089
fz2frizzled 20.072
Cdc42CG12530 gene product from transcript CG12530-RA0.067
bazbazooka0.066
pntpointed0.065
gbbglass bottom boat0.057
dallydivision abnormally delayed0.038
fngfringe0.031
aopanterior open0.029
brkbrinker0.023
rhorhomboid0.021
argosCG4531 gene product from transcript CG4531-RA0.020
araaraucan0.019
ixintersex0.018
DDichaete0.018
otkoff-track0.018
UbxUltrabithorax0.018
hephemipterous0.017
ptcpatched0.017
mxcmulti sex combs0.016
sogshort gastrulation0.016
tldtolloid0.016
CG8965CG8965 gene product from transcript CG8965-RA0.014
bnlbranchless0.013
dlpdally-like0.013
kniknirps0.012
rtvretroactive0.011
porporcupine0.011
dydusky0.011
dsxdoublesex0.011
ftfat0.011
btlbreathless0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Dvl3dishevelled 3, dsh homolog (Drosophila)0.982
Shhsonic hedgehog0.978
Fgf8fibroblast growth factor 80.978
Dvl2dishevelled 2, dsh homolog (Drosophila)0.974
Fgfr2fibroblast growth factor receptor 20.961
Rargretinoic acid receptor, gamma0.895
Tbx1T-box 10.886
Pitx2paired-like homeodomain transcription factor 20.870
Foxc1forkhead box C10.860
Hand2heart and neural crest derivatives expressed transcript 20.855
Vangl1vang-like 1 (van gogh, Drosophila)0.851
Pax3paired box gene 30.829
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.792
Otx2orthodenticle homolog 2 (Drosophila)0.772
Foxc2forkhead box C20.722
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.676
Rxraretinoid X receptor alpha0.657
Fgfr1fibroblast growth factor receptor 10.576
Gata4GATA binding protein 40.561
Smosmoothened homolog (Drosophila)0.535
Vegfavascular endothelial growth factor A0.454
Chrdchordin0.438
Wnt3awingless-related MMTV integration site 3A0.437
Ptpn11protein tyrosine phosphatase, non-receptor type 110.427
Gli3GLI-Kruppel family member GLI30.421
Sox9SRY-box containing gene 90.399
Hand1heart and neural crest derivatives expressed transcript 10.384
Bmp7bone morphogenetic protein 70.371
Psen1presenilin 10.368
Apcadenomatosis polyposis coli0.324
Lmx1bLIM homeobox transcription factor 1 beta0.315
Acvr1activin A receptor, type 10.312
Sall4sal-like 4 (Drosophila)0.302
Rararetinoic acid receptor, alpha0.289
Tcfap2atranscription factor AP-2, alpha0.277
Tgfb2transforming growth factor, beta 20.226
Lrp6low density lipoprotein receptor-related protein 60.201
Gscgoosecoid homeobox0.186
Ece1endothelin converting enzyme 10.163
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.160
Mark4MAP/microtubule affinity-regulating kinase 40.156
Gbx2gastrulation brain homeobox 20.146
Nodalnodal0.139
Pax1paired box gene 10.135
Tgfbr2transforming growth factor, beta receptor II0.128
Pax2paired box gene 20.123
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.113
Hoxa2homeobox A20.112
Gata6GATA binding protein 60.106
Alx4aristaless-like homeobox 40.105
Smad3MAD homolog 3 (Drosophila)0.095
Runx2runt related transcription factor 20.094
Hoxa3homeobox A30.094
Smad4MAD homolog 4 (Drosophila)0.092
Axin1axin 10.087
Tcfcp2l1transcription factor CP2-like 10.085
Sall3sal-like 3 (Drosophila)0.084
Pax8paired box gene 80.083
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.081
Dlx6distal-less homeobox 60.076
Tbrachyury0.075
Hoxa13homeobox A130.075
Rarbretinoic acid receptor, beta0.071
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.068
NanogNanog homeobox0.067
Utf1undifferentiated embryonic cell transcription factor 10.066
Emx1empty spiracles homolog 1 (Drosophila)0.065
Thegtesticular haploid expressed gene0.064
Bmpr1abone morphogenetic protein receptor, type 1A0.063
Gpr50G-protein-coupled receptor 500.063
Msx1homeobox, msh-like 10.063
Hoxa1homeobox A10.060
Dlx5distal-less homeobox 50.060
Ptenphosphatase and tensin homolog0.059
Wnt1wingless-related MMTV integration site 10.058
Hmx1H6 homeobox 10.057
Lef1lymphoid enhancer binding factor 10.056
Lhx1LIM homeobox protein 10.054
Ednraendothelin receptor type A0.053
Smad6MAD homolog 6 (Drosophila)0.053
Isl1ISL1 transcription factor, LIM/homeodomain0.052
Hes3hairy and enhancer of split 3 (Drosophila)0.052
Wnt6wingless-related MMTV integration site 60.052
Pax6paired box gene 60.050
Fgf15fibroblast growth factor 150.050
Foxe3forkhead box E30.050
Smurf2SMAD specific E3 ubiquitin protein ligase 20.049
Gsk3bglycogen synthase kinase 3 beta0.048
Trp73transformation related protein 730.047
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.046
Ntf3neurotrophin 30.045
Foxb1forkhead box B10.044
Esrrbestrogen related receptor, beta0.043
Pitx3paired-like homeodomain transcription factor 30.041
Hist1h1thistone cluster 1, H1t0.040
Itgb1integrin beta 1 (fibronectin receptor beta)0.039
Ptch1patched homolog 10.039
Gata5GATA binding protein 50.039
Otx1orthodenticle homolog 1 (Drosophila)0.038
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism