The network for 'activation of cysteine type endopeptidase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of cysteine type endopeptidase activity

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.999
CASP8caspase 8, apoptosis-related cysteine peptidase0.999
MDM2Mdm2 p53 binding protein homolog (mouse)0.998
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.995
RB1retinoblastoma 10.994
CASP3caspase 3, apoptosis-related cysteine peptidase0.988
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.977
TP53tumor protein p530.959
BCL2L11BCL2-like 11 (apoptosis facilitator)0.945
CASP10caspase 10, apoptosis-related cysteine peptidase0.939
BCL2L1BCL2-like 10.934
S100A6S100 calcium binding protein A60.929
XIAPX-linked inhibitor of apoptosis0.926
FASFas (TNF receptor superfamily, member 6)0.903
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.873
SMAD1SMAD family member 10.814
BAXBCL2-associated X protein0.814
CASP2caspase 2, apoptosis-related cysteine peptidase0.804
S100BS100 calcium binding protein B0.795
CASP9caspase 9, apoptosis-related cysteine peptidase0.785
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.765
HNRNPKheterogeneous nuclear ribonucleoprotein K0.748
SMN1survival of motor neuron 1, telomeric0.743
NCK1NCK adaptor protein 10.729
S100A9S100 calcium binding protein A90.682
CAV1caveolin 1, caveolae protein, 22kDa0.660
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.654
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.594
HIPK2homeodomain interacting protein kinase 20.585
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.583
S100A8S100 calcium binding protein A80.566
MDM4Mdm4 p53 binding protein homolog (mouse)0.557
CFLARCASP8 and FADD-like apoptosis regulator0.535
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.534
BADBCL2-associated agonist of cell death0.526
EIF3Eeukaryotic translation initiation factor 3, subunit E0.521
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.519
SP100SP100 nuclear antigen0.412
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.391
S100A1S100 calcium binding protein A10.375
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.357
APAF1apoptotic peptidase activating factor 10.353
S100A4S100 calcium binding protein A40.348
ANXA2annexin A20.341
PYCARDPYD and CARD domain containing0.337
SMAD2SMAD family member 20.337
BIDBH3 interacting domain death agonist0.336
GAS7growth arrest-specific 70.331
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.330
SMAD3SMAD family member 30.314
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.308
COL4A1collagen, type IV, alpha 10.304
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.303
VDAC2voltage-dependent anion channel 20.296
SMAD9SMAD family member 90.275
EIF3Leukaryotic translation initiation factor 3, subunit L0.270
NCOR2nuclear receptor corepressor 20.252
SKILSKI-like oncogene0.248
RXRAretinoid X receptor, alpha0.240
NLRC4NLR family, CARD domain containing 40.224
BAK1BCL2-antagonist/killer 10.221
LCKlymphocyte-specific protein tyrosine kinase0.210
PMLpromyelocytic leukemia0.208
FASLGFas ligand (TNF superfamily, member 6)0.205
SMAD4SMAD family member 40.198
PELP1proline, glutamate and leucine rich protein 10.194
DAXXdeath-domain associated protein0.191
SMURF2SMAD specific E3 ubiquitin protein ligase 20.190
IFITM3interferon induced transmembrane protein 3 (1-8U)0.190
SYKspleen tyrosine kinase0.189
COL4A2collagen, type IV, alpha 20.187
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.184
S100A2S100 calcium binding protein A20.176
SMAD7SMAD family member 70.173
HCKhemopoietic cell kinase0.158
SOCS1suppressor of cytokine signaling 10.156
PSIP1PC4 and SFRS1 interacting protein 10.154
RIPK2receptor-interacting serine-threonine kinase 20.148
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.145
PRMT6protein arginine methyltransferase 60.144
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.132
PTENphosphatase and tensin homolog0.132
ESR1estrogen receptor 10.127
CDK2cyclin-dependent kinase 20.126
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.125
COL4A4collagen, type IV, alpha 40.123
ARandrogen receptor0.122
HDAC2histone deacetylase 20.119
ASB2ankyrin repeat and SOCS box containing 20.114
GRB2growth factor receptor-bound protein 20.114
CREBBPCREB binding protein0.111
EGFRepidermal growth factor receptor0.109
EGLN3egl nine homolog 3 (C. elegans)0.106
CARD11caspase recruitment domain family, member 110.106
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.105
FMR1fragile X mental retardation 10.103
AKT1v-akt murine thymoma viral oncogene homolog 10.099
YY1YY1 transcription factor0.098
BLNKB-cell linker0.097
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DscamDown syndrome cell adhesion molecule0.719
IceCG7788 gene product from transcript CG7788-RA0.652
CG9772CG9772 gene product from transcript CG9772-RB0.627
imdimmune deficiency0.589
Tak1TGF-beta activated kinase 10.468
DreddDeath related ced-3/Nedd2-like protein0.410
CG4030CG4030 gene product from transcript CG4030-RA0.391
CG7033CG7033 gene product from transcript CG7033-RC0.391
FhosCG42610 gene product from transcript CG42610-RC0.391
Pi3K21BCG2699 gene product from transcript CG2699-RA0.285
CG2469CG2469 gene product from transcript CG2469-RB0.265
CG5146CG5146 gene product from transcript CG5146-RA0.238
grimCG4345 gene product from transcript CG4345-RA0.219
GmdGDP-mannose 4,6-dehydratase0.215
djdon juan0.208
Art4Arginine methyltransferase 40.196
Sox14Sox box protein 140.192
toytwin of eyeless0.175
CG10630CG10630 gene product from transcript CG10630-RA0.151
Cyt-c-dCytochrome c distal0.149
XNPCG4548 gene product from transcript CG4548-RA0.137
Roc1bCG16988 gene product from transcript CG16988-RA0.136
CG5741CG5741 gene product from transcript CG5741-RC0.135
CG13597CG13597 gene product from transcript CG13597-RA0.135
AGO2Argonaute 20.130
Pkd2Polycystic kidney disease gene-20.121
CG3875CG3875 gene product from transcript CG3875-RA0.118
BG4CG12297 gene product from transcript CG12297-RA0.104
RpL7ARibosomal protein L7A0.103
MntCG13316 gene product from transcript CG13316-RD0.092
CG6412CG6412 gene product from transcript CG6412-RA0.090
Dcp-1Death caspase-10.088
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.086
HtrA2CG8464 gene product from transcript CG8464-RA0.085
CG5155CG5155 gene product from transcript CG5155-RA0.083
His3.3BHistone H3.3B0.080
Eip74EFEcdysone-induced protein 74EF0.079
ird5immune response deficient 50.074
alphaTub84Balpha-Tubulin at 84B0.073
His3.3AHistone H3.3A0.070
yuriyuri gagarin0.069
eIF4E-3CG8023 gene product from transcript CG8023-RA0.067
Tim10Translocase of inner membrane 100.067
Cks85ACyclin-dependent kinase subunit 85A0.066
Df31Decondensation factor 310.066
WRNexoWRN exonuclease0.065
eastenhanced adult sensory threshold0.064
OsbpOxysterol binding protein0.062
Mst77FMale-specific transcript 77F0.060
pod1CG4532 gene product from transcript CG4532-RF0.052
CG5794CG5794 gene product from transcript CG5794-RB0.052
Mcm7Minichromosome maintenance 70.052
CG11399CG11399 gene product from transcript CG11399-RB0.051
D19ACG10269 gene product from transcript CG10269-RA0.050
betaTub85Dbeta-Tubulin at 85D0.049
CG13366CG13366 gene product from transcript CG13366-RA0.048
dre4CG1828 gene product from transcript CG1828-RB0.045
Hr46Hormone receptor-like in 460.045
cathDCG1548 gene product from transcript CG1548-RA0.043
Gs1Glutamine synthetase 10.042
CG12214CG12214 gene product from transcript CG12214-RB0.042
p53CG33336 gene product from transcript CG33336-RB0.040
Vps28Vacuolar protein sorting 280.040
klhl10CG12423 gene product from transcript CG12423-RB0.038
CchlCytochrome c heme lyase0.037
B52CG10851 gene product from transcript CG10851-RB0.036
AdhAlcohol dehydrogenase0.036
CG14614CG14614 gene product from transcript CG14614-RA0.036
CG2519CG2519 gene product from transcript CG2519-RB0.035
Sep4Septin 40.035
Past1Putative Achaete Scute Target 10.035
DhodDihydroorotate dehydrogenase0.035
Patr-1Protein associated with topo II related - 10.035
MESR6Misexpression suppressor of ras 60.035
Npc1aNiemann-Pick type C-1a0.033
RASSF8CG5053 gene product from transcript CG5053-RA0.033
RpL12Ribosomal protein L120.031
CG3530CG3530 gene product from transcript CG3530-RC0.031
fzofuzzy onions0.031
RnrLRibonucleoside diphosphate reductase large subunit0.029
schlankCG3576 gene product from transcript CG3576-RB0.029
trioCG18214 gene product from transcript CG18214-RA0.029
trustoys are us0.029
NcNedd2-like caspase0.028
Mnn1Menin 10.028
Mcm3Minichromosome maintenance 30.028
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.999
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.968
FasFas (TNF receptor superfamily member 6)0.958
Bcl2B-cell leukemia/lymphoma 20.924
Casp4caspase 4, apoptosis-related cysteine peptidase0.867
Itgb1integrin beta 1 (fibronectin receptor beta)0.862
Kitkit oncogene0.862
Leprleptin receptor0.838
Vhlvon Hippel-Lindau tumor suppressor0.833
Stat5asignal transducer and activator of transcription 5A0.827
Tnftumor necrosis factor0.823
Casp1caspase 10.772
Lyz2lysozyme 20.753
Ikzf1IKAROS family zinc finger 10.685
Rb1retinoblastoma 10.658
Stat5bsignal transducer and activator of transcription 5B0.644
Cd44CD44 antigen0.641
Ltalymphotoxin A0.605
Irf9interferon regulatory factor 90.588
Il1r1interleukin 1 receptor, type I0.579
S100a9S100 calcium binding protein A9 (calgranulin B)0.535
Mcl1myeloid cell leukemia sequence 10.519
Ptgs2prostaglandin-endoperoxide synthase 20.513
Map3k14mitogen-activated protein kinase kinase kinase 140.499
Wt1Wilms tumor 1 homolog0.404
BaxBCL2-associated X protein0.392
Spna1spectrin alpha 10.377
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.365
Tlr4toll-like receptor 40.352
Cdkn1bcyclin-dependent kinase inhibitor 1B0.345
Foxp3forkhead box P30.333
Casp8caspase 80.320
Il2rginterleukin 2 receptor, gamma chain0.306
Ngpneutrophilic granule protein0.290
Il18interleukin 180.288
Arandrogen receptor0.278
Mndalmyeloid nuclear differentiation antigen like0.258
Ncoa3nuclear receptor coactivator 30.257
Ptprcprotein tyrosine phosphatase, receptor type, C0.256
FaddFas (TNFRSF6)-associated via death domain0.256
Stat3signal transducer and activator of transcription 30.254
Smad3MAD homolog 3 (Drosophila)0.252
Hbb-b1hemoglobin, beta adult major chain0.242
Mfn2mitofusin 20.235
Gbp5guanylate binding protein 50.234
S100a8S100 calcium binding protein A8 (calgranulin A)0.232
Ptenphosphatase and tensin homolog0.227
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.219
Ilkintegrin linked kinase0.216
Il2rbinterleukin 2 receptor, beta chain0.213
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.199
Ltblymphotoxin B0.199
Nfe2l2nuclear factor, erythroid derived 2, like 20.193
Il7interleukin 70.185
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.182
Casp7caspase 70.171
Il6stinterleukin 6 signal transducer0.163
Nos3nitric oxide synthase 3, endothelial cell0.161
Trp73transformation related protein 730.147
Il22interleukin 220.142
Mdm4transformed mouse 3T3 cell double minute 40.140
Rbl1retinoblastoma-like 1 (p107)0.134
Hif1ahypoxia inducible factor 1, alpha subunit0.134
Socs1suppressor of cytokine signaling 10.131
Tgfb1transforming growth factor, beta 10.128
Cycscytochrome c, somatic0.127
PycardPYD and CARD domain containing0.127
Prf1perforin 1 (pore forming protein)0.125
Apcadenomatosis polyposis coli0.124
Ptpn2protein tyrosine phosphatase, non-receptor type 20.124
Trim21tripartite motif-containing 210.123
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.122
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.121
Casp3caspase 30.117
Jak2Janus kinase 20.115
Il10interleukin 100.115
Lystlysosomal trafficking regulator0.114
WwoxWW domain-containing oxidoreductase0.111
Rararetinoic acid receptor, alpha0.111
Esr1estrogen receptor 1 (alpha)0.108
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.103
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.102
Cscitrate synthase0.100
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.099
Cd151CD151 antigen0.096
Atmataxia telangiectasia mutated homolog (human)0.094
Ikbkbinhibitor of kappaB kinase beta0.087
Hprthypoxanthine guanine phosphoribosyl transferase0.086
Il15interleukin 150.085
Itga3integrin alpha 30.084
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.082
Tcf3transcription factor 30.081
Vegfavascular endothelial growth factor A0.081
Lama5laminin, alpha 50.081
Notch2Notch gene homolog 2 (Drosophila)0.080
Ctnnb1catenin (cadherin associated protein), beta 10.078
Prlrprolactin receptor0.077
Timm8a1translocase of inner mitochondrial membrane 8 homolog a1 (yeast)0.077
XiapX-linked inhibitor of apoptosis0.075
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
S100a8S100 calcium binding protein A80.288
S100a9S100 calcium binding protein A90.260
Impdh2IMP (inosine monophosphate) dehydrogenase 20.116
Jak1Janus kinase 10.097
Atp5bATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.054
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.044
Smad2SMAD family member 20.041
Cd247Cd247 molecule0.040
Rpl4ribosomal protein L40.040
Txnrd1thioredoxin reductase 10.037
JunJun oncogene0.037
Smad1SMAD family member 10.036
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.035
Creb1cAMP responsive element binding protein 10.035
Akt1v-akt murine thymoma viral oncogene homolog 10.034
Tlr4toll-like receptor 40.033
Hspd1heat shock protein 1 (chaperonin)0.033
Casp3caspase 30.032
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.032
Dlstdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)0.031
Klrd1killer cell lectin-like receptor, subfamily D, member 10.031
Map3k1mitogen activated protein kinase kinase kinase 10.031
Socs3suppressor of cytokine signaling 30.030
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.029
Zfp36l1zinc finger protein 36, C3H type-like 10.029
Casp4caspase 4, apoptosis-related cysteine peptidase0.029
Plscr3phospholipid scramblase 30.028
Pdgfaplatelet-derived growth factor alpha polypeptide0.028
Map4k4mitogen-activated protein kinase kinase kinase kinase 40.027
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.027
Irak3interleukin-1 receptor-associated kinase 30.026
Mmp8matrix metallopeptidase 80.026
Cd38CD38 molecule0.026
Syt4synaptotagmin IV0.026
Ppardperoxisome proliferator-activated receptor delta0.026
Map3k8mitogen-activated protein kinase kinase kinase 80.025
Ctnna1catenin (cadherin associated protein), alpha 10.025
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.025
Psmb5proteasome (prosome, macropain) subunit, beta type 50.025
Ralbv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.025
Dcaf17DDB1 and CUL4 associated factor 170.024
Tgfbr1transforming growth factor, beta receptor 10.024
Shc2SHC (Src homology 2 domain containing) transforming protein 20.024
Man2b1mannosidase, alpha, class 2B, member 10.023
Il6interleukin 60.023
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.023
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.023
Wdr62WD repeat domain 620.023
Slfn2schlafen 20.023
Pgk1phosphoglycerate kinase 10.022
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.022
Acvr1activin A receptor, type I0.022
Gfi1growth factor independent 1 transcription repressor0.022
Il15interleukin 150.022
LOC683626similar to limb-bud and heart0.022
PawrPRKC, apoptosis, WT1, regulator0.022
Tgfbr3transforming growth factor, beta receptor III0.021
Vegfavascular endothelial growth factor A0.021
B2mbeta-2 microglobulin0.021
Rpn2ribophorin II0.021
Jundjun D proto-oncogene0.021
Rps8ribosomal protein S80.020
RGD1565591similar to Ski protein0.020
Adam17ADAM metallopeptidase domain 170.020
Kcnk1potassium channel, subfamily K, member 10.019
Ccl4chemokine (C-C motif) ligand 40.019
Myo1bmyosin Ib0.019
Fosl2fos-like antigen 20.019
Nrasneuroblastoma ras oncogene0.019
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.019
Il1binterleukin 1 beta0.019
Ntn1netrin 10.019
Snd1staphylococcal nuclease and tudor domain containing 10.019
Apex1APEX nuclease (multifunctional DNA repair enzyme) 10.019
RGD1304644similar to RIKEN cDNA 2310046K010.019
Reg3bregenerating islet-derived 3 beta0.019
Arrb2arrestin, beta 20.019
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.018
Raf1v-raf-leukemia viral oncogene 10.018
Bcl2l2Bcl2-like 20.018
Mapk6mitogen-activated protein kinase 60.018
Smc1astructural maintenance of chromosomes 1A0.018
Nek9NIMA (never in mitosis gene a)- related kinase 90.018
Ubtfupstream binding transcription factor, RNA polymerase I0.018
RGD1307799similar to RIKEN cDNA 2400003C140.018
Wt1Wilms tumor 10.018
Stfa2l3stefin A2-like 30.018
Pdia4protein disulfide isomerase family A, member 40.018
Maneamannosidase, endo-alpha0.018
Mdh1malate dehydrogenase 1, NAD (soluble)0.018
Fgf5fibroblast growth factor 50.018
MaxMYC associated factor X0.018
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.018
Zbtb10zinc finger and BTB domain containing 100.017
Reg3aregenerating islet-derived 3 alpha0.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism