The network for 'regulation of bone mineralization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of bone mineralization

Any process that modulates the frequency, rate or extent of bone mineralization.

NameDescriptionProbabilityFunc Analog Organism
CCR5chemokine (C-C motif) receptor 51.000
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.999
CCL5chemokine (C-C motif) ligand 50.997
BMPR1Abone morphogenetic protein receptor, type IA0.994
SMAD2SMAD family member 20.980
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.967
BMP2bone morphogenetic protein 20.961
TGFB1transforming growth factor, beta 10.928
FSTL1follistatin-like 10.901
CCL22chemokine (C-C motif) ligand 220.886
CXCL9chemokine (C-X-C motif) ligand 90.826
ENGendoglin0.813
FKBP1AFK506 binding protein 1A, 12kDa0.805
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.716
CXCL10chemokine (C-X-C motif) ligand 100.689
TGFB3transforming growth factor, beta 30.666
IFNGinterferon, gamma0.651
RUNX1runt-related transcription factor 10.636
CCR4chemokine (C-C motif) receptor 40.630
BMPR1Bbone morphogenetic protein receptor, type IB0.625
CCR7chemokine (C-C motif) receptor 70.612
TJP1tight junction protein 1 (zona occludens 1)0.560
CCL3chemokine (C-C motif) ligand 30.558
IL2RBinterleukin 2 receptor, beta0.554
SETD8SET domain containing (lysine methyltransferase) 80.547
CCL4chemokine (C-C motif) ligand 40.543
GDF5growth differentiation factor 50.467
CCL2chemokine (C-C motif) ligand 20.425
SMAD7SMAD family member 70.413
VCANversican0.345
CCL8chemokine (C-C motif) ligand 80.314
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.305
KDM2Blysine (K)-specific demethylase 2B0.267
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.256
CCL13chemokine (C-C motif) ligand 130.248
CXCR6chemokine (C-X-C motif) receptor 60.236
IRF4interferon regulatory factor 40.232
CCL19chemokine (C-C motif) ligand 190.224
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.215
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.215
IL10interleukin 100.214
CXCL13chemokine (C-X-C motif) ligand 130.211
CCR2chemokine (C-C motif) receptor 20.209
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.189
BMP4bone morphogenetic protein 40.187
CCL7chemokine (C-C motif) ligand 70.185
CCL11chemokine (C-C motif) ligand 110.183
TM4SF1transmembrane 4 L six family member 10.181
GATA2GATA binding protein 20.174
SPRR2Asmall proline-rich protein 2A0.174
COL11A2collagen, type XI, alpha 20.158
SMAD1SMAD family member 10.156
CXCR3chemokine (C-X-C motif) receptor 30.138
PTPRAprotein tyrosine phosphatase, receptor type, A0.130
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.124
SRCIN1SRC kinase signaling inhibitor 10.122
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.121
DPP4dipeptidyl-peptidase 40.119
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.111
NOGnoggin0.106
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.105
PRKG1protein kinase, cGMP-dependent, type I0.105
ARRDC3arrestin domain containing 30.103
RGS1regulator of G-protein signaling 10.090
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.089
IL1Binterleukin 1, beta0.086
CCR1chemokine (C-C motif) receptor 10.086
CD40LGCD40 ligand0.083
IL6interleukin 6 (interferon, beta 2)0.082
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.081
IL8interleukin 80.080
EP300E1A binding protein p3000.076
SLAMF7SLAM family member 70.075
GABARAPL2GABA(A) receptor-associated protein-like 20.073
ACVR1activin A receptor, type I0.073
CXCR5chemokine (C-X-C motif) receptor 50.069
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.069
EPAS1endothelial PAS domain protein 10.068
MATKmegakaryocyte-associated tyrosine kinase0.067
CCR9chemokine (C-C motif) receptor 90.065
IL16interleukin 16 (lymphocyte chemoattractant factor)0.061
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.061
CXCL11chemokine (C-X-C motif) ligand 110.061
KAT2BK(lysine) acetyltransferase 2B0.060
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.060
TGFBR1transforming growth factor, beta receptor 10.059
LTAlymphotoxin alpha (TNF superfamily, member 1)0.058
WNT2wingless-type MMTV integration site family member 20.054
ACVR2Bactivin A receptor, type IIB0.053
DNM1dynamin 10.053
CCR8chemokine (C-C motif) receptor 80.053
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.050
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.048
NRP1neuropilin 10.047
KCTD1potassium channel tetramerisation domain containing 10.045
PTGISprostaglandin I2 (prostacyclin) synthase0.045
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.044
IL1F5interleukin 1 family, member 5 (delta)0.043
FOXF2forkhead box F20.042
TNFRSF9tumor necrosis factor receptor superfamily, member 90.041
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.982
bmp4bone morphogenetic protein 40.898
col10a1collagen, type X, alpha 10.716
prdm1aPR domain containing 1a, with ZNF domain0.592
tbx5aT-box 5a0.583
rargbretinoic acid receptor, gamma b0.336
gpc4glypican 40.329
bmp7bbone morphogenetic protein 7b0.201
kdrlkinase insert domain receptor like0.189
acvr2bactivin receptor IIb0.184
msxbmuscle segment homeobox B0.178
col2a1acollagen type II, alpha-1a0.175
acvr2aactivin receptor IIa0.167
fbn2bfibrillin 2b0.155
xylt1xylosyltransferase 10.150
sox9aSRY-box containing gene 9a0.150
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.143
hand2heart and neural crest derivatives expressed transcript 20.142
wnt5bwingless-type MMTV integration site family, member 5b0.132
nog3noggin 30.131
osr1odd-skipped related 1 (Drosophila)0.125
mef2cbmyocyte enhancer factor 2cb0.113
gdf6agrowth differentiation factor 6a0.113
tbx18T-box 180.110
foxd5forkhead box D50.109
tmem2transmembrane protein 20.104
prnprs3prion protein, related sequence 30.103
mef2camyocyte enhancer factor 2ca0.103
plod2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 20.103
tuba8l3tubulin, alpha 8 like 30.102
dlx2adistal-less homeobox gene 2a0.098
runx1runt-related transcription factor 10.096
pkd2polycystic kidney disease 20.096
restRE1-silencing transcription factor0.095
pax7apaired box gene 7a0.094
bmp2abone morphogenetic protein 2a0.092
gpr126G protein-coupled receptor 1260.089
tal1T-cell acute lymphocytic leukemia 10.085
myod1myogenic differentiation 10.084
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.083
cmybtranscription factor cmyb0.082
disp1dispatched homolog 1 (Drosophila)0.082
acvr1lactivin A receptor, type I like0.080
gpm6aaglycoprotein M6Aa0.080
hoxa13ahomeo box A13a0.077
mecomMDS1 and EVI1 complex locus0.076
s1pr2sphingosine-1-phosphate receptor 20.076
prdm5PR domain containing 50.075
hoxa11ahomeo box A11a0.075
ptch1patched 10.075
twist1atwist1a0.075
spns2spinster homolog 2 (Drosophila)0.073
bmpr1abbone morphogenetic protein receptor, type 1ab0.071
gyltl1bglycosyltransferase-like 1b0.070
hoxa13bhomeo box A13b0.068
twist2twist20.065
rereaarginine-glutamic acid dipeptide (RE) repeats a0.062
aldh1a2aldehyde dehydrogenase 1 family, member A20.062
hoxd13ahomeo box D13a0.062
tgfb2transforming growth factor, beta 20.060
oepone-eyed pinhead0.058
hspa12bheat shock protein 12B0.058
sufusuppressor of fused homolog (Drosophila)0.057
szlsizzled0.056
tll1tolloid-like 10.056
aplnrbapelin receptor b0.055
egr2bearly growth response 2b0.055
wnt10awingless-type MMTV integration site family, member 10a0.054
rxraaretinoid X receptor, alpha a0.054
rnd1lRho family GTPase 1 like0.052
unc5cunc-5 homolog C (C. elegans)0.052
vcanbversican b0.052
smyhc1slow myosin heavy chain 10.051
znfl2azinc finger-like gene 2a0.050
fli1afriend leukemia integration 1a0.050
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.049
bmp1abone morphogenetic protein 1a0.048
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.048
zgc:77051zgc:770510.048
itga3bintegrin, alpha 3b0.045
tbx1T-box 10.045
lect1leukocyte cell derived chemotaxin 10.045
wnt11rwingless-type MMTV integration site family, member 11, related0.044
fgf10afibroblast growth factor 10a0.044
col11a2collagen type XI alpha-20.044
hmbsbhydroxymethylbilane synthase, b0.043
apoebapolipoprotein Eb0.043
rad21RAD21 homolog (S. pombe)0.043
bmperBMP binding endothelial regulator0.043
ptch2patched 20.043
sh3gl1bSH3-domain GRB2-like 1b0.043
nav3neuron navigator 30.043
col8a1acollagen, type VIII, alpha 1a0.041
tfe3atranscription factor binding to IGHM enhancer 3a0.041
rorabRAR-related orphan receptor A, paralog b0.040
hbae1hemoglobin alpha embryonic-10.040
ugdhUDP-glucose dehydrogenase0.039
adipor1aadiponectin receptor 1a0.039
hoxc6ahomeo box C6a0.038
ptpraprotein tyrosine phosphatase, receptor type, A0.037
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgf8fibroblast growth factor 80.926
Tgfb2transforming growth factor, beta 20.740
Gli3GLI-Kruppel family member GLI30.721
Prrx2paired related homeobox 20.718
Fgfr1fibroblast growth factor receptor 10.701
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.680
Shhsonic hedgehog0.678
Klklotho0.678
Gata4GATA binding protein 40.629
Fgfr2fibroblast growth factor receptor 20.596
Ror2receptor tyrosine kinase-like orphan receptor 20.592
Nodalnodal0.592
Smosmoothened homolog (Drosophila)0.568
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.466
Fgfr3fibroblast growth factor receptor 30.465
Prrx1paired related homeobox 10.444
Pax3paired box gene 30.409
Alx4aristaless-like homeobox 40.357
Gli2GLI-Kruppel family member GLI20.332
Foxc1forkhead box C10.325
Bmp4bone morphogenetic protein 40.325
Lhx1LIM homeobox protein 10.302
Gata6GATA binding protein 60.302
Pthlhparathyroid hormone-like peptide0.292
Hand1heart and neural crest derivatives expressed transcript 10.289
Pax2paired box gene 20.285
Msx1homeobox, msh-like 10.280
Foxc2forkhead box C20.260
Wnt7awingless-related MMTV integration site 7A0.253
Smad6MAD homolog 6 (Drosophila)0.252
Adra2aadrenergic receptor, alpha 2a0.241
Bmp2bone morphogenetic protein 20.223
Pax9paired box gene 90.212
Dlx5distal-less homeobox 50.198
Shesrc homology 2 domain-containing transforming protein E0.185
Hic1hypermethylated in cancer 10.171
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.169
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.163
Rargretinoic acid receptor, gamma0.156
Emp2epithelial membrane protein 20.153
Nf1neurofibromatosis 10.152
Tbx2T-box 20.150
Ptpn14protein tyrosine phosphatase, non-receptor type 140.147
Foxd2forkhead box D20.145
Fgf4fibroblast growth factor 40.142
Nos3nitric oxide synthase 3, endothelial cell0.142
Pnpla2patatin-like phospholipase domain containing 20.140
Hoxd13homeobox D130.140
Bmp7bone morphogenetic protein 70.140
Tgfb1i1transforming growth factor beta 1 induced transcript 10.139
Fgf3fibroblast growth factor 30.137
Wt1Wilms tumor 1 homolog0.135
Smad4MAD homolog 4 (Drosophila)0.133
Scn5asodium channel, voltage-gated, type V, alpha0.130
Gbx2gastrulation brain homeobox 20.128
Sox9SRY-box containing gene 90.126
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.125
Ror1receptor tyrosine kinase-like orphan receptor 10.123
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.122
Otx2orthodenticle homolog 2 (Drosophila)0.121
Dkk1dickkopf homolog 1 (Xenopus laevis)0.120
Wnt6wingless-related MMTV integration site 60.118
Smad3MAD homolog 3 (Drosophila)0.114
Lmx1bLIM homeobox transcription factor 1 beta0.114
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.113
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.111
Nognoggin0.111
Pax1paired box gene 10.109
Alx3aristaless-like homeobox 30.108
Lhx6LIM homeobox protein 60.108
Fgf10fibroblast growth factor 100.107
Cd80CD80 antigen0.105
Elnelastin0.102
Gpc3glypican 30.100
Fzd2frizzled homolog 2 (Drosophila)0.100
Eya1eyes absent 1 homolog (Drosophila)0.099
Pou3f2POU domain, class 3, transcription factor 20.098
Hmx3H6 homeobox 30.098
Zfpm2zinc finger protein, multitype 20.096
Hand2heart and neural crest derivatives expressed transcript 20.093
Gpr50G-protein-coupled receptor 500.093
Acvr1activin A receptor, type 10.092
Tgfbr2transforming growth factor, beta receptor II0.092
Sox7SRY-box containing gene 70.092
Zic1zinc finger protein of the cerebellum 10.090
Sox17SRY-box containing gene 170.088
Ntf3neurotrophin 30.088
Fut1fucosyltransferase 10.088
Btbd17BTB (POZ) domain containing 170.086
Emx2empty spiracles homolog 2 (Drosophila)0.085
Col11a1collagen, type XI, alpha 10.084
Epas1endothelial PAS domain protein 10.083
Foxh1forkhead box H10.083
Bmp5bone morphogenetic protein 50.082
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.081
S1pr3sphingosine-1-phosphate receptor 30.081
Wnt4wingless-related MMTV integration site 40.079
Ddr2discoidin domain receptor family, member 20.079
Tgfb3transforming growth factor, beta 30.076
Mmp2matrix metallopeptidase 20.075
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism