The network for 'hepatocyte proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hepatocyte proliferation

The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.125
HNF4Ahepatocyte nuclear factor 4, alpha0.085
NCK2NCK adaptor protein 20.061
TNIP1TNFAIP3 interacting protein 10.050
LPXNleupaxin0.046
MED13mediator complex subunit 130.037
CCDC6coiled-coil domain containing 60.034
PLAURplasminogen activator, urokinase receptor0.032
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.025
MED10mediator complex subunit 100.023
LAPTM5lysosomal protein transmembrane 50.022
ILKintegrin-linked kinase0.021
TICAM1toll-like receptor adaptor molecule 10.020
TRRAPtransformation/transcription domain-associated protein0.019
TNIP2TNFAIP3 interacting protein 20.018
CUL1cullin 10.016
PLATplasminogen activator, tissue0.016
ESR2estrogen receptor 2 (ER beta)0.015
MMS22LMMS22-like, DNA repair protein0.015
MED29mediator complex subunit 290.014
MAGEB18melanoma antigen family B, 180.014
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.013
BTRCbeta-transducin repeat containing0.013
NR0B2nuclear receptor subfamily 0, group B, member 20.013
HIPK2homeodomain interacting protein kinase 20.013
TGS1trimethylguanosine synthase 10.012
HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.012
NR5A2nuclear receptor subfamily 5, group A, member 20.011
GIT2G protein-coupled receptor kinase interacting ArfGAP 20.011
CCNE1cyclin E10.011
THRAthyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)0.011
FBXW2F-box and WD repeat domain containing 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wnt1wingless-type MMTV integration site family, member 10.999
wnt4awingless-type MMTV integration site family, member 4a0.983
wnt10awingless-type MMTV integration site family, member 10a0.961
wnt9bwingless-type MMTV integration site family, member 9B0.938
tbx1T-box 10.928
hnf1baHNF1 homeobox Ba0.916
wnt2bbwingless-type MMTV integration site family, member 2Bb0.816
wnt10bwingless-type MMTV integration site family, member 10b0.764
wnt11rwingless-type MMTV integration site family, member 11, related0.716
wnt2wingless-type MMTV integration site family member 20.710
tob1atransducer of ERBB2, 1a0.669
fgf17fibroblast growth factor 170.665
dharmadharma0.644
wnt3wingless-type MMTV integration site family, member 30.634
grem1agremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)0.594
flhfloating head0.549
wnt8bwingless-type MMTV integration site family, member 8b0.546
fgf3fibroblast growth factor 30.527
wnt7bawingless-type MMTV integration site family, member 7Ba0.526
hoxd4ahomeo box D4a0.524
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.484
sfrp1asecreted frizzled-related protein 1a0.440
wnt5bwingless-type MMTV integration site family, member 5b0.379
wnt9awingless-type MMTV integration site family, member 9A0.371
wnt16wingless-type MMTV integration site family, member 160.365
bmp2abone morphogenetic protein 2a0.353
zfyve26zinc finger, FYVE domain containing 260.340
wnt7aawingless-type MMTV integration site family, member 7Aa0.332
lef1lymphocyte enhancer binding factor 10.330
hspa5heat shock protein 50.329
wnt11wingless-type MMTV integration site family, member 110.323
pdlim7PDZ and LIM domain 70.319
dkk1bdickkopf 1b0.316
bactin1bactin10.296
wnt3awingless-type MMTV integration site family, member 3A0.289
hmx4H6 family homeobox 40.279
bmp4bone morphogenetic protein 40.231
sox2SRY-box containing gene 20.226
gli1GLI-Kruppel family member 10.219
dag1dystroglycan 10.215
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.208
frem3Fras1 related extracellular matrix 30.207
twist1atwist1a0.203
zbtb4zinc finger and BTB domain containing 40.200
sec61al1Sec61 alpha like 10.199
znf711zinc finger protein 7110.198
pth2parathyroid hormone 20.195
foxj1aforkhead box J1a0.194
cdh1cadherin 1, epithelial0.194
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.188
mapk14amitogen-activated protein kinase 14a0.185
col11a2collagen type XI alpha-20.175
map2k4amitogen-activated protein kinase kinase 4a0.173
restRE1-silencing transcription factor0.169
LOC566708FL cytokine receptor-like0.167
map2k7mitogen-activated protein kinase kinase 70.165
fbn2bfibrillin 2b0.159
comtacatechol-O-methyltransferase a0.156
map2k4bmitogen-activated protein kinase kinase 4b0.152
ndr2nodal-related 20.150
oepone-eyed pinhead0.146
bactin2bactin20.144
dusp6dual specificity phosphatase 60.140
atp1a2aATPase, Na+/K+ transporting, alpha 2a polypeptide0.138
wnt7bbwingless-type MMTV integration site family, member 7Bb0.137
frzbfrizzled-related protein0.129
lhx2bLIM homeobox 2b0.127
etv2ets variant gene 20.125
dkk3dickkopf homolog 3 (Xenopus laevis)0.125
tnfsf10l3tumor necrosis factor (ligand) superfamily, member 10 like 30.125
twist3twist30.124
lmx1b.2LIM homeobox transcription factor 1, beta 20.122
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.122
si:dkey-236e20.2si:dkey-236e20.20.112
pdlim3bPDZ and LIM domain 3b0.112
mmp2matrix metalloproteinase 20.109
tnnt2atroponin T2a, cardiac0.108
limk1LIM domain kinase 10.105
gyltl1bglycosyltransferase-like 1b0.104
sfrp1bsecreted frizzled-related protein 1b0.104
sim1asingle-minded homolog 1a (Drosophila)0.103
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.102
spry4sprouty (Drosophila) homolog 40.101
zgc:171802zgc:1718020.101
cxcr4bchemokine (C-X-C motif), receptor 4b0.100
limk2LIM domain kinase 20.099
dab1bdisabled homolog 1b (Drosophila)0.097
ndr1nodal-related 10.097
sult1st4sulfotransferase family 1, cytosolic sulfotransferase 40.096
wnt5awingless-type MMTV integration site family, member 5a0.096
lmx1b.1LIM homeobox transcription factor 1, beta 10.095
kdrlkinase insert domain receptor like0.092
kopaskopos0.091
epb4.1l4erythrocyte protein band 4.1-like 40.091
scube2signal peptide, CUB domain, EGF-like 20.087
wlswntless homolog (Drosophila)0.086
cd63Cd63 antigen0.085
si:dkey-273o13.1si:dkey-273o13.10.083
mapk12mitogen-activated protein kinase 120.083
optcopticin0.080
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cma1chymase 1, mast cell0.396
Foxa2forkhead box A20.250
Tpsab1tryptase alpha/beta 10.190
Mbl1mannose-binding lectin (protein A) 10.149
Hpnhepsin0.124
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.110
Clec4fC-type lectin domain family 4, member f0.095
Hpgdshematopoietic prostaglandin D synthase0.091
F2coagulation factor II (thrombin)0.084
NagsN-acetylglutamate synthase0.084
Ehfets homologous factor0.084
Azgp1alpha-2-glycoprotein 1, zinc-binding0.081
Mosc1MOCO sulphurase C-terminal domain containing 10.078
Gcgroup specific component0.070
Scgb1a1secretoglobin, family 1A, member 1 (uteroglobin)0.063
Itih1inter-alpha trypsin inhibitor, heavy chain 10.058
Pzppregnancy-zone protein0.056
Procprotein C0.055
Asgr2asialoglycoprotein receptor 20.052
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.051
Hdchistidine decarboxylase0.049
Ptger3prostaglandin E receptor 3 (subtype EP3)0.045
P4hbprolyl 4-hydroxylase, beta polypeptide0.045
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.044
Dnase1l3deoxyribonuclease 1-like 30.044
RGD1308742similar to Complement C5 precursor0.042
C9complement component 90.041
A1bgalpha-1-B glycoprotein0.041
Csn1s1casein alpha s10.039
Plgplasminogen0.037
Pla1aphospholipase A1 member A0.036
Cd4Cd4 molecule0.034
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.034
Lao1L-amino acid oxidase 10.034
Fggfibrinogen gamma chain0.033
C8bcomplement component 8, beta polypeptide0.033
Twist2twist homolog 2 (Drosophila)0.033
Cficomplement factor I0.032
Nr5a2nuclear receptor subfamily 5, group A, member 20.032
LOC500300similar to hypothetical protein MGC68350.031
Apcsamyloid P component, serum0.030
Krt5keratin 50.030
Apohapolipoprotein H (beta-2-glycoprotein I)0.029
Mbl2mannose-binding lectin (protein C) 20.029
Ccl11chemokine (C-C motif) ligand 110.028
Serpinf2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.028
GperG protein-coupled estrogen receptor 10.027
Ctsecathepsin E0.027
Agmatagmatine ureohydrolase (agmatinase)0.027
Cpn1carboxypeptidase N, polypeptide 10.026
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.026
Cldn3claudin 30.026
Baatbile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)0.026
C4bpacomplement component 4 binding protein, alpha0.025
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.025
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.025
Spink8serine peptidase inhibitor, Kazal type 80.024
Hnf1bHNF1 homeobox B0.024
Creb3l3cAMP responsive element binding protein 3-like 30.024
Gcgrglucagon receptor0.024
Lipclipase, hepatic0.024
Cpb2carboxypeptidase B2 (plasma)0.023
Ang1angiogenin, ribonuclease A family, member 10.023
RGD1308065hypothetical LOC2879350.023
Apoa5apolipoprotein A-V0.023
Rhobras homolog gene family, member B0.022
Klrk1killer cell lectin-like receptor subfamily K, member 10.022
LOC100365995rCG28262-like0.022
Apoa2apolipoprotein A-II0.021
Klrd1killer cell lectin-like receptor, subfamily D, member 10.020
Errfi1ERBB receptor feedback inhibitor 10.020
Itih4inter alpha-trypsin inhibitor, heavy chain 40.020
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.020
Sh2d4aSH2 domain containing 4A0.020
Dock8dedicator of cytokinesis 80.020
Isoc2bisochorismatase domain containing 2b0.019
Pcsk9proprotein convertase subtilisin/kexin type 90.019
Adipoqadiponectin, C1Q and collagen domain containing0.019
Sardhsarcosine dehydrogenase0.019
IhhIndian hedgehog0.018
Hpxhemopexin0.018
RGD1564614similar to complement factor H-related protein0.018
F12coagulation factor XII (Hageman factor)0.018
P2ry14purinergic receptor P2Y, G-protein coupled, 140.018
Cela1chymotrypsin-like elastase family, member 10.018
Slc17a1solute carrier family 17 (sodium phosphate), member 10.018
Slc45a3solute carrier family 45, member 30.018
Colec11collectin sub-family member 110.018
Xcl1chemokine (C motif) ligand 10.017
Ttrtransthyretin0.017
Slco1a1solute carrier organic anion transporter family, member 1a10.017
Tgm1transglutaminase 1, K polypeptide0.016
C6complement component 60.016
RGD1564865similar to 20-alpha-hydroxysteroid dehydrogenase0.016
Vasnvasorin0.016
Mug1murinoglobulin 10.016
Aqp8aquaporin 80.016
Lama3laminin, alpha 30.016
Litaflipopolysaccharide-induced TNF factor0.016
Vtcn1V-set domain containing T cell activation inhibitor 10.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism