The network for 'positive regulation of immunoglobulin mediated immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of immunoglobulin mediated immune response

Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.

NameDescriptionProbabilityFunc Analog Organism
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 41.000
IL4Rinterleukin 4 receptor1.000
SYKspleen tyrosine kinase0.996
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.991
PVRL4poliovirus receptor-related 40.989
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.975
PTPN6protein tyrosine phosphatase, non-receptor type 60.958
PVRL3poliovirus receptor-related 30.949
GRAP2GRB2-related adaptor protein 20.914
TRAF3TNF receptor-associated factor 30.878
ENGendoglin0.855
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.810
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.766
MDC1mediator of DNA-damage checkpoint 10.755
H2AFXH2A histone family, member X0.749
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.570
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.491
IL2RGinterleukin 2 receptor, gamma0.459
TP53BP1tumor protein p53 binding protein 10.425
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.397
NCOA6nuclear receptor coactivator 60.349
TJP1tight junction protein 1 (zona occludens 1)0.348
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.338
FSTL1follistatin-like 10.315
CFHcomplement factor H0.314
TGFBR1transforming growth factor, beta receptor 10.308
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.246
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.246
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.231
EPHB3EPH receptor B30.192
SMC1Astructural maintenance of chromosomes 1A0.192
CD80CD80 molecule0.183
TNFRSF17tumor necrosis factor receptor superfamily, member 170.180
IL4interleukin 40.174
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.156
C16orf53chromosome 16 open reading frame 530.155
THBS1thrombospondin 10.151
TGFB3transforming growth factor, beta 30.141
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D0.140
SHC1SHC (Src homology 2 domain containing) transforming protein 10.128
LMO2LIM domain only 2 (rhombotin-like 1)0.118
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.115
NCAPD3non-SMC condensin II complex, subunit D30.112
NOM1nucleolar protein with MIF4G domain 10.106
MRASmuscle RAS oncogene homolog0.106
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.106
TYROBPTYRO protein tyrosine kinase binding protein0.104
UBASH3Bubiquitin associated and SH3 domain containing B0.102
PLEKpleckstrin0.094
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.093
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.092
FCGR3BFc fragment of IgG, low affinity IIIb, receptor (CD16b)0.085
CFIcomplement factor I0.084
PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)0.081
CD163CD163 molecule0.080
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.075
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.070
TRAF5TNF receptor-associated factor 50.070
RBBP5retinoblastoma binding protein 50.068
MS4A1membrane-spanning 4-domains, subfamily A, member 10.066
CFBcomplement factor B0.061
CD22CD22 molecule0.060
CTLA4cytotoxic T-lymphocyte-associated protein 40.059
EPHB2EPH receptor B20.056
SLAMF1signaling lymphocytic activation molecule family member 10.051
CD53CD53 molecule0.051
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.050
TMEM173transmembrane protein 1730.049
ARandrogen receptor0.049
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.048
C3AR1complement component 3a receptor 10.046
ATMataxia telangiectasia mutated0.046
IRF4interferon regulatory factor 40.046
LST1leukocyte specific transcript 10.043
NCAPG2non-SMC condensin II complex, subunit G20.043
LMNB1lamin B10.042
ILF3interleukin enhancer binding factor 3, 90kDa0.041
EPHA7EPH receptor A70.040
KNTC1kinetochore associated 10.040
NRP1neuropilin 10.039
BLNKB-cell linker0.038
IGSF6immunoglobulin superfamily, member 60.038
TMEM194Atransmembrane protein 194A0.038
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.037
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.036
FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)0.036
VSIG4V-set and immunoglobulin domain containing 40.035
TLR1toll-like receptor 10.034
CD14CD14 molecule0.033
EPHB6EPH receptor B60.032
SART3squamous cell carcinoma antigen recognized by T cells 30.032
FGL2fibrinogen-like 20.032
GPR65G protein-coupled receptor 650.032
CD40CD40 molecule, TNF receptor superfamily member 50.032
CD48CD48 molecule0.031
C1Scomplement component 1, s subcomponent0.031
MPHOSPH9M-phase phosphoprotein 90.031
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.030
MLL2myeloid/lymphoid or mixed-lineage leukemia 20.030
PILRApaired immunoglobin-like type 2 receptor alpha0.030
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cd40CD40 antigen0.956
Ighimmunoglobulin heavy chain complex0.938
Tnftumor necrosis factor0.935
Il10interleukin 100.935
Lyz2lysozyme 20.863
Ltalymphotoxin A0.850
Il4interleukin 40.811
Map3k14mitogen-activated protein kinase kinase kinase 140.757
Ifnginterferon gamma0.734
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.732
Ccr1chemokine (C-C motif) receptor 10.631
Il6interleukin 60.615
Foxp3forkhead box P30.563
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.485
Cd28CD28 antigen0.466
Ptprcprotein tyrosine phosphatase, receptor type, C0.403
Il2interleukin 20.367
Icosinducible T-cell co-stimulator0.363
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.349
Cd19CD19 antigen0.308
Clec4nC-type lectin domain family 4, member n0.295
TcraT-cell receptor alpha chain0.248
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.245
Clec4dC-type lectin domain family 4, member d0.226
Ccl2chemokine (C-C motif) ligand 20.223
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.218
Cxcl13chemokine (C-X-C motif) ligand 130.212
Ikzf1IKAROS family zinc finger 10.204
Il2rginterleukin 2 receptor, gamma chain0.202
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.194
Cxcr5chemokine (C-X-C motif) receptor 50.179
Socs1suppressor of cytokine signaling 10.158
FynFyn proto-oncogene0.158
Stat5bsignal transducer and activator of transcription 5B0.156
Ccl12chemokine (C-C motif) ligand 120.141
Ltblymphotoxin B0.138
Ccr7chemokine (C-C motif) receptor 70.136
Pdcd1programmed cell death 10.128
Il1binterleukin 1 beta0.127
Il1r1interleukin 1 receptor, type I0.124
Prf1perforin 1 (pore forming protein)0.123
Batfbasic leucine zipper transcription factor, ATF-like0.116
Il4rainterleukin 4 receptor, alpha0.115
Stat5asignal transducer and activator of transcription 5A0.111
Pitx1paired-like homeodomain transcription factor 10.105
C3complement component 30.098
Lcklymphocyte protein tyrosine kinase0.097
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.096
Il2rbinterleukin 2 receptor, beta chain0.092
Folr2folate receptor 2 (fetal)0.092
TyrobpTYRO protein tyrosine kinase binding protein0.088
Ccl9chemokine (C-C motif) ligand 90.083
Ccr6chemokine (C-C motif) receptor 60.075
Cd6CD6 antigen0.069
Ccr5chemokine (C-C motif) receptor 50.068
Il7interleukin 70.067
Casp4caspase 4, apoptosis-related cysteine peptidase0.067
Inpp5dinositol polyphosphate-5-phosphatase D0.065
Msr1macrophage scavenger receptor 10.064
Pitx2paired-like homeodomain transcription factor 20.063
Irf9interferon regulatory factor 90.061
Latlinker for activation of T cells0.059
Ccl7chemokine (C-C motif) ligand 70.059
Cd96CD96 antigen0.058
Apoeapolipoprotein E0.056
MefvMediterranean fever0.055
Rag2recombination activating gene 20.053
Casp1caspase 10.053
Ccl8chemokine (C-C motif) ligand 80.052
Cd209bCD209b antigen0.052
H2-Ab1histocompatibility 2, class II antigen A, beta 10.051
Cd44CD44 antigen0.050
Mmp12matrix metallopeptidase 120.050
Lyz1lysozyme 10.048
Klrk1killer cell lectin-like receptor subfamily K, member 10.048
C3ar1complement component 3a receptor 10.045
Tlr2toll-like receptor 20.042
FaslFas ligand (TNF superfamily, member 6)0.042
Ccl22chemokine (C-C motif) ligand 220.042
Ccl3chemokine (C-C motif) ligand 30.041
Selpselectin, platelet0.040
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.040
Il6stinterleukin 6 signal transducer0.039
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.038
Gpr132G protein-coupled receptor 1320.037
FasFas (TNF receptor superfamily member 6)0.037
C1qbcomplement component 1, q subcomponent, beta polypeptide0.036
Cd8aCD8 antigen, alpha chain0.035
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.035
Cr2complement receptor 20.034
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.034
Saa3serum amyloid A 30.032
Xcl1chemokine (C motif) ligand 10.032
Ccl6chemokine (C-C motif) ligand 60.031
Ubdubiquitin D0.030
BtkBruton agammaglobulinemia tyrosine kinase0.030
Vpreb3pre-B lymphocyte gene 30.029
Sh2d2aSH2 domain protein 2A0.029
ItkIL2-inducible T-cell kinase0.029
Zap70zeta-chain (TCR) associated protein kinase0.028
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd37CD37 molecule0.179
Trim47tripartite motif-containing 470.173
Il1binterleukin 1 beta0.145
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.126
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.121
Cxcr4chemokine (C-X-C motif) receptor 40.112
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.108
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.097
Cd247Cd247 molecule0.091
Fgafibrinogen alpha chain0.090
Apol3apolipoprotein L, 30.074
Casp1caspase 10.070
Spnsialophorin0.068
Psgb1pregnancy-specific beta 1-glycoprotein0.067
Ncf1neutrophil cytosolic factor 10.060
Ptafrplatelet-activating factor receptor0.058
Myh9myosin, heavy chain 9, non-muscle0.057
Ctsecathepsin E0.055
Nr5a1nuclear receptor subfamily 5, group A, member 10.055
Klrd1killer cell lectin-like receptor, subfamily D, member 10.054
RT1-Db1RT1 class II, locus Db10.052
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.052
Gja4gap junction protein, alpha 40.050
Hckhemopoietic cell kinase0.050
Bin2bridging integrator 20.049
Psd4pleckstrin and Sec7 domain containing 40.043
LOC305103cell surface glycoprotein gp420.041
Scamp2secretory carrier membrane protein 20.040
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.039
Ccl3chemokine (C-C motif) ligand 30.038
Clec9aC-type lectin domain family 9, member a0.038
Cd53Cd53 molecule0.037
Slfn2schlafen 20.036
Ly6cLy6-C antigen0.034
Mmp8matrix metallopeptidase 80.034
Socs3suppressor of cytokine signaling 30.034
Plcg2phospholipase C, gamma 20.032
Bcl2l1Bcl2-like 10.030
Ripk3receptor-interacting serine-threonine kinase 30.030
Vom1r93vomeronasal 1 receptor 930.028
Arl5cADP-ribosylation factor-like 5C0.028
Psg29pregnancy-specific glycoprotein 290.028
Neurl3neuralized homolog 3 (Drosophila)0.028
Il2rbinterleukin 2 receptor, beta0.028
Mca32mast cell antigen 320.028
Ctla2acytotoxic T lymphocyte-associated protein 2 alpha0.027
Srgnserglycin0.027
Nos3nitric oxide synthase 3, endothelial cell0.027
Csn1s1casein alpha s10.026
Pou2af1POU class 2 associating factor 10.026
Ppardperoxisome proliferator-activated receptor delta0.026
Ccl5chemokine (C-C motif) ligand 50.026
Prss2protease, serine, 20.026
S100a8S100 calcium binding protein A80.025
Leprleptin receptor0.025
Tnfrsf26tumor necrosis factor receptor superfamily, member 260.025
Tshbthyroid stimulating hormone, beta0.024
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.024
Itih4inter alpha-trypsin inhibitor, heavy chain 40.024
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.024
Il1ainterleukin 1 alpha0.024
Gzmbgranzyme B0.023
Fam26ffamily with sequence similarity 26, member F0.023
Itgalintegrin, alpha L0.023
Havcr1hepatitis A virus cellular receptor 10.023
Engendoglin0.023
Ptprcprotein tyrosine phosphatase, receptor type, C0.023
Il2rginterleukin 2 receptor, gamma0.023
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.023
Slc15a3solute carrier family 15, member 30.023
Il7rinterleukin 7 receptor0.023
ND4NADH dehydrogenase subunit 40.023
TekTEK tyrosine kinase, endothelial0.023
Il4rainterleukin 4 receptor, alpha0.022
Hbg1hemoglobin, gamma A0.022
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.022
Cybbcytochrome b-245, beta polypeptide0.022
Igsf6immunoglobulin superfamily, member 60.022
Hes2hairy and enhancer of split 2 (Drosophila)0.021
Sdc1syndecan 10.021
RT1-N3RT1 class Ib, locus N30.021
Ccl4chemokine (C-C motif) ligand 40.020
Prkchprotein kinase C, eta0.020
Epha2Eph receptor A20.020
Tbc1d10cTBC1 domain family, member 10C0.020
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.020
Ltblymphotoxin beta (TNF superfamily, member 3)0.020
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.019
Fgfr1Fibroblast growth factor receptor 10.019
Accn5amiloride-sensitive cation channel 5, intestinal0.019
Hgfhepatocyte growth factor0.019
Actg2actin, gamma 2, smooth muscle, enteric0.019
Wt1Wilms tumor 10.019
Abi3ABI family, member 30.019
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.019
Sellselectin L0.018
Ly6blymphocyte antigen 6 complex, locus B0.018
Ucp2uncoupling protein 2 (mitochondrial, proton carrier)0.018
Rps6ka1ribosomal protein S6 kinase polypeptide 10.018
Emcnendomucin0.018
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism