The network for 'cytokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

NameDescriptionProbabilityFunc Analog Organism
IRAK1interleukin-1 receptor-associated kinase 11.000
IL1Binterleukin 1, beta0.999
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.998
TRAF6TNF receptor-associated factor 60.998
SMAD3SMAD family member 30.998
MYD88myeloid differentiation primary response gene (88)0.997
MAPK14mitogen-activated protein kinase 140.997
BIRC3baculoviral IAP repeat containing 30.996
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.995
IRAK2interleukin-1 receptor-associated kinase 20.994
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.994
CREBBPCREB binding protein0.993
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.992
TNFAIP3tumor necrosis factor, alpha-induced protein 30.990
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.979
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.979
SOCS3suppressor of cytokine signaling 30.978
RIPK2receptor-interacting serine-threonine kinase 20.977
CXCL10chemokine (C-X-C motif) ligand 100.976
IL6interleukin 6 (interferon, beta 2)0.973
C1QAcomplement component 1, q subcomponent, A chain0.972
IL1R1interleukin 1 receptor, type I0.972
CXCL9chemokine (C-X-C motif) ligand 90.969
IL8interleukin 80.968
TRIM22tripartite motif containing 220.968
IL2RBinterleukin 2 receptor, beta0.967
HCKhemopoietic cell kinase0.966
ICAM1intercellular adhesion molecule 10.965
CCL4chemokine (C-C motif) ligand 40.962
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.962
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.961
NOTCH1notch 10.960
SMAD2SMAD family member 20.960
ANXA1annexin A10.958
CD80CD80 molecule0.957
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.954
SMAD4SMAD family member 40.951
LCKlymphocyte-specific protein tyrosine kinase0.949
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.948
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.948
EGFRepidermal growth factor receptor0.946
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.944
CCL5chemokine (C-C motif) ligand 50.941
CD86CD86 molecule0.940
CCR5chemokine (C-C motif) receptor 50.940
IL10RAinterleukin 10 receptor, alpha0.940
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.934
SH2D1ASH2 domain containing 1A0.934
IFIT3interferon-induced protein with tetratricopeptide repeats 30.932
HLA-Bmajor histocompatibility complex, class I, B0.929
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.926
SYKspleen tyrosine kinase0.916
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.909
IL4Rinterleukin 4 receptor0.909
PRKD2protein kinase D20.900
TLR2toll-like receptor 20.899
CCR1chemokine (C-C motif) receptor 10.897
TRAF1TNF receptor-associated factor 10.893
CCR7chemokine (C-C motif) receptor 70.881
IRAK3interleukin-1 receptor-associated kinase 30.870
SLAMF1signaling lymphocytic activation molecule family member 10.868
S100A6S100 calcium binding protein A60.868
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.868
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.866
IL1RNinterleukin 1 receptor antagonist0.865
PMLpromyelocytic leukemia0.864
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.864
TNFtumor necrosis factor0.863
IL10interleukin 100.856
BTN3A3butyrophilin, subfamily 3, member A30.850
STAT1signal transducer and activator of transcription 1, 91kDa0.847
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.847
ARRB1arrestin, beta 10.845
CCL2chemokine (C-C motif) ligand 20.844
PLAURplasminogen activator, urokinase receptor0.843
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.843
HLA-Cmajor histocompatibility complex, class I, C0.842
HLA-DMBmajor histocompatibility complex, class II, DM beta0.838
TRAF5TNF receptor-associated factor 50.837
PYCARDPYD and CARD domain containing0.836
TLR4toll-like receptor 40.833
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.826
IRF1interferon regulatory factor 10.824
IFNGinterferon, gamma0.819
CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)0.818
CXCL2chemokine (C-X-C motif) ligand 20.806
BCL3B-cell CLL/lymphoma 30.801
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.798
RUNX1runt-related transcription factor 10.796
DUSP1dual specificity phosphatase 10.796
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.785
MAP3K7mitogen-activated protein kinase kinase kinase 70.785
SHC1SHC (Src homology 2 domain containing) transforming protein 10.784
JAG1jagged 10.777
CCL22chemokine (C-C motif) ligand 220.773
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.770
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mpxmyeloid-specific peroxidase0.135
bmp2bbone morphogenetic protein 2b0.057
plcg1phospholipase C, gamma 10.046
nod1nucleotide-binding oligomerization domain containing 10.030
fzd7bfrizzled homolog 7b0.030
pcdh18bprotocadherin 18b0.028
anxa1bannexin A1b0.027
pglyrp5peptidoglycan recognition protein 50.025
sulf2lsulfatase 2, like0.024
wasaWiskott-Aldrich syndrome (eczema-thrombocytopenia) a0.023
col10a1collagen, type X, alpha 10.021
igf1insulin-like growth factor 10.021
eporerythropoietin receptor0.020
il1binterleukin 1, beta and interleukin 1, beta0.019
gpiaglucose phosphate isomerase a0.019
nr2f2nuclear receptor subfamily 2, group F, member 20.018
stat1bsignal transducer and activator of transcription 1b0.017
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.017
c3bcomplement component c3b0.017
plagl2pleiomorphic adenoma gene-like 20.016
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.016
myf5myogenic factor 50.013
cav1caveolin 10.013
bmp4bone morphogenetic protein 40.013
alcamaactivated leukocyte cell adhesion molecule a0.013
irak4interleukin-1 receptor-associated kinase 40.012
tnfatumor necrosis factor a (TNF superfamily, member 2)0.012
tal1T-cell acute lymphocytic leukemia 10.012
LOC557072caspase recruitment domain-containing protein 11-like0.012
s100v2S100 calcium binding protein V20.012
mpllmyeloproliferative leukemia virus oncogene, like0.011
ripk2receptor-interacting serine-threonine kinase 20.011
notch1anotch homolog 1a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Stat3signal transducer and activator of transcription 31.000
Tlr4toll-like receptor 41.000
Tnftumor necrosis factor1.000
Myd88myeloid differentiation primary response gene 880.999
Lyz2lysozyme 20.999
Cd40CD40 antigen0.997
Casp4caspase 4, apoptosis-related cysteine peptidase0.996
Il1r1interleukin 1 receptor, type I0.996
Casp1caspase 10.994
Il2rginterleukin 2 receptor, gamma chain0.992
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.986
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.984
Leprleptin receptor0.984
FaslFas ligand (TNF superfamily, member 6)0.983
Il1rninterleukin 1 receptor antagonist0.980
Il10rainterleukin 10 receptor, alpha0.979
Klrk1killer cell lectin-like receptor subfamily K, member 10.976
Il1binterleukin 1 beta0.975
Il10interleukin 100.975
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.972
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.972
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.970
Apoeapolipoprotein E0.969
Tnfaip3tumor necrosis factor, alpha-induced protein 30.967
Cd28CD28 antigen0.967
Traf6TNF receptor-associated factor 60.963
Socs1suppressor of cytokine signaling 10.959
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.959
Map3k8mitogen-activated protein kinase kinase kinase 80.958
Il2rbinterleukin 2 receptor, beta chain0.955
Icosinducible T-cell co-stimulator0.954
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.953
Nlrp3NLR family, pyrin domain containing 30.948
Ccl2chemokine (C-C motif) ligand 20.947
Thrbthyroid hormone receptor beta0.947
Batfbasic leucine zipper transcription factor, ATF-like0.945
Tgfb1transforming growth factor, beta 10.943
Ptgs2prostaglandin-endoperoxide synthase 20.943
Nos2nitric oxide synthase 2, inducible0.941
AxlAXL receptor tyrosine kinase0.939
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.921
Cybbcytochrome b-245, beta polypeptide0.920
Il6interleukin 60.918
Cd86CD86 antigen0.918
Slamf1signaling lymphocytic activation molecule family member 10.916
Birc3baculoviral IAP repeat-containing 30.912
Rxraretinoid X receptor alpha0.912
Il12binterleukin 12b0.905
Il7rinterleukin 7 receptor0.904
Ccl4chemokine (C-C motif) ligand 40.902
Ncr1natural cytotoxicity triggering receptor 10.898
Foxf1aforkhead box F1a0.896
Osmroncostatin M receptor0.894
Unc93b1unc-93 homolog B1 (C. elegans)0.893
Clec4dC-type lectin domain family 4, member d0.887
Irf9interferon regulatory factor 90.887
Sh2d2aSH2 domain protein 2A0.885
BlkB lymphoid kinase0.885
Csf1colony stimulating factor 1 (macrophage)0.884
Stat1signal transducer and activator of transcription 10.884
Inhbainhibin beta-A0.883
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.871
Pitx1paired-like homeodomain transcription factor 10.870
Snai1snail homolog 1 (Drosophila)0.865
Cd14CD14 antigen0.865
Pcdh12protocadherin 120.860
Cd44CD44 antigen0.858
Ptpn11protein tyrosine phosphatase, non-receptor type 110.857
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.856
Ccr7chemokine (C-C motif) receptor 70.854
Gzmagranzyme A0.851
Sfpi1SFFV proviral integration 10.836
Acvrl1activin A receptor, type II-like 10.836
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.834
Cd6CD6 antigen0.833
Lifleukemia inhibitory factor0.832
Gbp7guanylate binding protein 70.832
Pax8paired box gene 80.831
Tlr2toll-like receptor 20.829
Grap2GRB2-related adaptor protein 20.824
FasFas (TNF receptor superfamily member 6)0.823
Notch2Notch gene homolog 2 (Drosophila)0.822
Map3k14mitogen-activated protein kinase kinase kinase 140.817
Fpr3formyl peptide receptor 30.816
MefvMediterranean fever0.814
C3ar1complement component 3a receptor 10.809
Traf1TNF receptor-associated factor 10.809
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.808
Fpr2formyl peptide receptor 20.807
Cd96CD96 antigen0.805
Klrd1killer cell lectin-like receptor, subfamily D, member 10.805
Klrg1killer cell lectin-like receptor subfamily G, member 10.803
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.800
Il4rainterleukin 4 receptor, alpha0.799
Cd7CD7 antigen0.797
Ltalymphotoxin A0.797
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.795
Gata4GATA binding protein 40.795
Gzmkgranzyme K0.793
Itgalintegrin alpha L0.792
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il2rbinterleukin 2 receptor, beta0.761
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.690
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.685
Cxcl10chemokine (C-X-C motif) ligand 100.671
Il2rginterleukin 2 receptor, gamma0.642
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.638
Ccr2chemokine (C-C motif) receptor 20.627
Cd14CD14 molecule0.587
Csf1colony stimulating factor 1 (macrophage)0.564
Ccr5chemokine (C-C motif) receptor 50.515
Il6interleukin 60.512
Arl11ADP-ribosylation factor-like 110.490
Ccl2chemokine (C-C motif) ligand 20.460
Ccl3chemokine (C-C motif) ligand 30.429
Cd80Cd80 molecule0.409
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.390
Tlr4toll-like receptor 40.321
Cdh6cadherin 60.288
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.282
Mca32mast cell antigen 320.281
Igsf6immunoglobulin superfamily, member 60.258
Jak1Janus kinase 10.258
Casp1caspase 10.246
Il1binterleukin 1 beta0.228
Fgfr2fibroblast growth factor receptor 20.227
Cxcl2chemokine (C-X-C motif) ligand 20.226
Casp3caspase 30.224
Mmp3matrix metallopeptidase 30.218
Ncr1natural cytotoxicity triggering receptor 10.218
Gzmkgranzyme K0.215
Sellselectin L0.205
Oprk1opioid receptor, kappa 10.204
S1pr2sphingosine-1-phosphate receptor 20.204
Il1rl1interleukin 1 receptor-like 10.198
Tnftumor necrosis factor (TNF superfamily, member 2)0.197
Plauplasminogen activator, urokinase0.197
Socs3suppressor of cytokine signaling 30.195
Cd44Cd44 molecule0.191
Fosl1fos-like antigen 10.184
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.176
Stat3signal transducer and activator of transcription 30.175
Ccl4chemokine (C-C motif) ligand 40.174
Nek9NIMA (never in mitosis gene a)- related kinase 90.174
Hckhemopoietic cell kinase0.150
Ccl5chemokine (C-C motif) ligand 50.149
Nrasneuroblastoma ras oncogene0.149
JunJun oncogene0.148
Mmp12matrix metallopeptidase 120.144
Cd4Cd4 molecule0.138
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.137
Sox17SRY (sex determining region Y)-box 170.135
RatNP-3bdefensin RatNP-3 precursor0.134
Trim47tripartite motif-containing 470.134
Selpselectin P0.131
Casp12caspase 120.130
F2rl2coagulation factor II (thrombin) receptor-like 20.129
Il1r2interleukin 1 receptor, type II0.128
Gimap4GTPase, IMAP family member 40.127
Nkg7natural killer cell group 7 sequence0.122
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.121
Ccl7chemokine (C-C motif) ligand 70.121
Cd200r1CD200 receptor 10.117
Icam1intercellular adhesion molecule 10.115
Plaurplasminogen activator, urokinase receptor0.114
Rassf5Ras association (RalGDS/AF-6) domain family member 50.113
RGD1559748similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)0.111
Ciitaclass II, major histocompatibility complex, transactivator0.109
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.108
Inpp5dinositol polyphosphate-5-phosphatase D0.107
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.106
Slc15a3solute carrier family 15, member 30.101
Sirpasignal-regulatory protein alpha0.101
Leprleptin receptor0.098
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.096
Cd2Cd2 molecule0.095
Abi3ABI family, member 30.095
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.095
Ctsecathepsin E0.092
Il1ainterleukin 1 alpha0.092
Apol3apolipoprotein L, 30.091
Adora2aadenosine A2a receptor0.090
Rgs1regulator of G-protein signaling 10.090
Ins1insulin 10.089
Acrv1acrosomal vesicle protein 10.089
Batf3basic leucine zipper transcription factor, ATF-like 30.089
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.088
Phkg1phosphorylase kinase, gamma 10.087
Ripk3receptor-interacting serine-threonine kinase 30.085
Iappislet amyloid polypeptide0.083
Calcrlcalcitonin receptor-like0.083
Cd38CD38 molecule0.082
Cybbcytochrome b-245, beta polypeptide0.081
Klrd1killer cell lectin-like receptor, subfamily D, member 10.081
RGD1559588similar to cell surface receptor FDFACT0.080
Neurog3neurogenin 30.080
Litaflipopolysaccharide-induced TNF factor0.079
Folr2folate receptor 2 (fetal)0.078
Cd3gCD3 molecule, gamma0.078
Parm1prostate androgen-regulated mucin-like protein 10.078
Cd36CD36 molecule (thrombospondin receptor)0.078
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism