The network for 'cellular response to insulin stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to insulin stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
CREBBPCREB binding protein0.999
PTPN1protein tyrosine phosphatase, non-receptor type 10.998
INSRinsulin receptor0.995
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.994
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.930
NCOA1nuclear receptor coactivator 10.917
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.884
GSK3Bglycogen synthase kinase 3 beta0.870
GRB10growth factor receptor-bound protein 100.826
NCK1NCK adaptor protein 10.821
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.809
RASA1RAS p21 protein activator (GTPase activating protein) 10.782
SIRT1sirtuin 10.769
EP300E1A binding protein p3000.752
IRS1insulin receptor substrate 10.752
SKP1S-phase kinase-associated protein 10.730
IRS2insulin receptor substrate 20.727
KAT2BK(lysine) acetyltransferase 2B0.630
PTPN11protein tyrosine phosphatase, non-receptor type 110.625
MAP3K11mitogen-activated protein kinase kinase kinase 110.620
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.612
NCF1neutrophil cytosolic factor 10.585
BCAR1breast cancer anti-estrogen resistance 10.540
CSNK2A1casein kinase 2, alpha 1 polypeptide0.534
SHC1SHC (Src homology 2 domain containing) transforming protein 10.523
ESR1estrogen receptor 10.496
ARandrogen receptor0.494
FYNFYN oncogene related to SRC, FGR, YES0.464
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.463
CUL1cullin 10.433
MTORmechanistic target of rapamycin (serine/threonine kinase)0.418
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.383
RICTORRPTOR independent companion of MTOR, complex 20.363
GRB2growth factor receptor-bound protein 20.340
TOB1transducer of ERBB2, 10.336
NCOR2nuclear receptor corepressor 20.335
VAV1vav 1 guanine nucleotide exchange factor0.328
TRRAPtransformation/transcription domain-associated protein0.325
JAK2Janus kinase 20.323
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.318
SHC2SHC (Src homology 2 domain containing) transforming protein 20.313
PLCG1phospholipase C, gamma 10.281
PTPRBprotein tyrosine phosphatase, receptor type, B0.279
WRNWerner syndrome, RecQ helicase-like0.278
HNF4Ahepatocyte nuclear factor 4, alpha0.275
PLAURplasminogen activator, urokinase receptor0.271
NCOR1nuclear receptor corepressor 10.252
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.251
CAV1caveolin 1, caveolae protein, 22kDa0.242
BTRCbeta-transducin repeat containing0.239
SLC2A14solute carrier family 2 (facilitated glucose transporter), member 140.234
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.226
SLC2A3solute carrier family 2 (facilitated glucose transporter), member 30.225
SH2B1SH2B adaptor protein 10.216
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.213
SOS1son of sevenless homolog 1 (Drosophila)0.210
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.209
SMAD3SMAD family member 30.207
SKP2S-phase kinase-associated protein 2 (p45)0.193
RXRAretinoid X receptor, alpha0.192
RHOUras homolog gene family, member U0.183
FBXW11F-box and WD repeat domain containing 110.179
SIN3ASIN3 homolog A, transcription regulator (yeast)0.178
PPARAperoxisome proliferator-activated receptor alpha0.178
CREB1cAMP responsive element binding protein 10.170
IGF1Rinsulin-like growth factor 1 receptor0.170
ABI1abl-interactor 10.161
PTK2PTK2 protein tyrosine kinase 20.155
CDH5cadherin 5, type 2 (vascular endothelium)0.154
CAPNS1calpain, small subunit 10.154
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.153
PDPK13-phosphoinositide dependent protein kinase-10.152
PRKD2protein kinase D20.142
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.138
HTThuntingtin0.135
PTPN6protein tyrosine phosphatase, non-receptor type 60.132
ATXN1ataxin 10.129
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.125
RPTORregulatory associated protein of MTOR, complex 10.117
MAPTmicrotubule-associated protein tau0.109
HDAC2histone deacetylase 20.108
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.105
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.104
HDAC5histone deacetylase 50.104
IL1R1interleukin 1 receptor, type I0.102
SKILSKI-like oncogene0.100
POU5F1POU class 5 homeobox 10.098
EPORerythropoietin receptor0.097
CD28CD28 molecule0.095
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.093
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.092
SNAP25synaptosomal-associated protein, 25kDa0.090
MEF2Cmyocyte enhancer factor 2C0.088
RAB5ARAB5A, member RAS oncogene family0.087
PRKCZprotein kinase C, zeta0.084
WDYHV1WDYHV motif containing 10.083
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.080
PSIP1PC4 and SFRS1 interacting protein 10.080
VEGFAvascular endothelial growth factor A0.079
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
acs-20Protein ACS-200.019
ifg-1Protein IFG-10.014
oac-46Protein OAC-460.012
ptr-1Protein PTR-10.011
ptr-11Protein PTR-110.011
osm-6Protein OSM-60.011
CELE_C28D4.8Protein C28D4.80.010
hlh-14Protein HLH-140.010
wrn-1Protein WRN-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.913
Ilp6Insulin-like peptide 60.765
MadMothers against dpp0.753
S6kRPS6-p70-protein kinase0.671
Ilp5Insulin-like peptide 50.551
sNPF-Rshort neuropeptide F receptor0.452
Ilp2Insulin-like peptide 20.352
LnkCG17367 gene product from transcript CG17367-RC0.329
jebjelly belly0.326
sxcsuper sex combs0.299
dmdiminutive0.244
InRInsulin-like receptor0.242
Sir2CG5216 gene product from transcript CG5216-RA0.238
RhebCG1081 gene product from transcript CG1081-RA0.234
Nf1Neurofibromin 10.225
CG13253CG13253 gene product from transcript CG13253-RB0.224
IdeInsulin degrading metalloproteinase0.212
Pk61CProtein kinase 61C0.204
chicoCG5686 gene product from transcript CG5686-RB0.188
ns3nucleostemin 30.180
picoCG11940 gene product from transcript CG11940-RA0.159
spispitz0.153
skpACG16983 gene product from transcript CG16983-RD0.151
ThorCG8846 gene product from transcript CG8846-RA0.133
eglegalitarian0.129
dcodiscs overgrown0.127
Ilp3Insulin-like peptide 30.122
didumdilute class unconventional myosin0.121
ifinflated0.121
klarklarsicht0.116
ppkpickpocket0.110
B4CG9239 gene product from transcript CG9239-RA0.110
scylscylla0.108
Rac1CG2248 gene product from transcript CG2248-RA0.105
Lsd-1Lipid storage droplet-10.104
Ras85DRas oncogene at 85D0.098
mttmangetout0.097
ash2absent, small, or homeotic discs 20.087
retnretained0.084
meltmelted0.080
sNPFshort neuropeptide F precursor0.074
RanBPMRan-binding protein M0.074
TbhTyramine beta hydroxylase0.070
CG13890CG13890 gene product from transcript CG13890-RA0.067
HemHEM-protein0.065
TspThrombospondin0.063
Akt1CG4006 gene product from transcript CG4006-RA0.061
pathpathetic0.060
Octbeta2RCG33976 gene product from transcript CG33976-RA0.056
FatpFatty acid (long chain) transport protein0.056
CG11284CG11284 gene product from transcript CG11284-RA0.055
CG11486CG11486 gene product from transcript CG11486-RG0.055
BHDBirt-Hogg-Dube homolog0.054
dibdisembodied0.050
ImpL2Ecdysone-inducible gene L20.050
CycGCyclin G0.050
dockdreadlocks0.049
ClkClock0.049
Ork1Open rectifier K[+] channel 10.048
Bre1CG10542 gene product from transcript CG10542-RA0.047
CG42629CG42629 gene product from transcript CG42629-RB0.046
stepsteppke0.046
p53CG33336 gene product from transcript CG33336-RB0.044
Pdp1PAR-domain protein 10.043
MED24Mediator complex subunit 240.043
putpunt0.043
Sin3ACG8815 gene product from transcript CG8815-RC0.043
Cdc42CG12530 gene product from transcript CG12530-RA0.042
neuroliginCG13772 gene product from transcript CG13772-RA0.042
Atg1Autophagy-specific gene 10.041
CG14937CG14937 gene product from transcript CG14937-RA0.040
Stat92ESignal-transducer and activator of transcription protein at 92E0.039
NFATNFAT homolog0.038
Trxr-1Thioredoxin reductase-10.037
bossbride of sevenless0.037
HLH106Helix loop helix protein 1060.036
frafrazzled0.035
CG33138CG33138 gene product from transcript CG33138-RA0.035
CdsACDP diglyceride synthetase0.035
MTF-1Metal response element-binding Transcription Factor-10.034
Rack1Receptor of activated protein kinase C 10.034
TorTarget of rapamycin0.033
RdlResistant to dieldrin0.033
trioCG18214 gene product from transcript CG18214-RA0.032
GscGoosecoid0.031
rictorrapamycin-insensitive companion of Tor0.031
PtthProthoracicotropic hormone0.031
IndyI'm not dead yet0.030
unkunkempt0.030
klgklingon0.030
Cyp6t3CG8457 gene product from transcript CG8457-RA0.029
OambOctopamine receptor in mushroom bodies0.029
Gyc76CGuanylyl cyclase at 76C0.029
SpargelCG9809 gene product from transcript CG9809-RB0.029
MntCG13316 gene product from transcript CG13316-RD0.028
kiskismet0.028
Vha68-1CG12403 gene product from transcript CG12403-RA0.028
shgshotgun0.028
Gycalpha99BGuanylyl cyclase alpha-subunit at 99B0.028
cutletCG33122 gene product from transcript CG33122-RA0.027
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor1.000
Lepleptin0.998
Insrinsulin receptor0.996
Grb2growth factor receptor bound protein 20.984
Ctnnb1catenin (cadherin associated protein), beta 10.977
FynFyn proto-oncogene0.977
Vegfavascular endothelial growth factor A0.964
Nos3nitric oxide synthase 3, endothelial cell0.961
Ptpn11protein tyrosine phosphatase, non-receptor type 110.945
CblCasitas B-lineage lymphoma0.900
Bglapbone gamma carboxyglutamate protein0.881
Irs2insulin receptor substrate 20.874
Ghrgrowth hormone receptor0.860
Kiss1rKISS1 receptor0.848
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.846
Vhlvon Hippel-Lindau tumor suppressor0.836
Cav1caveolin 1, caveolae protein0.824
Plcg1phospholipase C, gamma 10.823
Kiss1KiSS-1 metastasis-suppressor0.823
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.808
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.805
Akt1thymoma viral proto-oncogene 10.800
C1qccomplement component 1, q subcomponent, C chain0.789
Egfrepidermal growth factor receptor0.773
Nr5a1nuclear receptor subfamily 5, group A, member 10.768
Per2period homolog 2 (Drosophila)0.757
TyrobpTYRO protein tyrosine kinase binding protein0.750
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.747
Htthuntingtin0.745
Jak2Janus kinase 20.732
Apcadenomatosis polyposis coli0.729
Clockcircadian locomotor output cycles kaput0.728
Tsc1tuberous sclerosis 10.698
C1qbcomplement component 1, q subcomponent, beta polypeptide0.688
Lhcgrluteinizing hormone/choriogonadotropin receptor0.684
Ptk2PTK2 protein tyrosine kinase 20.678
Trp53transformation related protein 530.674
Irs1insulin receptor substrate 10.667
Nos1nitric oxide synthase 1, neuronal0.660
Grb10growth factor receptor bound protein 100.648
C1qacomplement component 1, q subcomponent, alpha polypeptide0.643
Itgb1integrin beta 1 (fibronectin receptor beta)0.632
Hif1ahypoxia inducible factor 1, alpha subunit0.631
Efnb2ephrin B20.606
Ldb3LIM domain binding 30.598
Albalbumin0.597
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.581
Lipelipase, hormone sensitive0.570
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.540
Mark4MAP/microtubule affinity-regulating kinase 40.503
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.501
Ppargperoxisome proliferator activated receptor gamma0.498
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.489
Uoxurate oxidase0.479
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.466
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.462
Fshrfollicle stimulating hormone receptor0.458
Lhx3LIM homeobox protein 30.445
LOC100048884novel member of the major urinary protein (Mup) gene family0.442
Mup5major urinary protein 50.431
Csf1colony stimulating factor 1 (macrophage)0.426
Tekendothelial-specific receptor tyrosine kinase0.421
Otporthopedia homolog (Drosophila)0.389
Fstfollistatin0.386
Gnao1guanine nucleotide binding protein, alpha O0.384
Inpp5dinositol polyphosphate-5-phosphatase D0.375
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.372
Ntf3neurotrophin 30.368
Arandrogen receptor0.367
Prlrprolactin receptor0.358
Ahraryl-hydrocarbon receptor0.358
Flt4FMS-like tyrosine kinase 40.353
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.347
Nf1neurofibromatosis 10.345
Bcl2B-cell leukemia/lymphoma 20.345
Nr3c1nuclear receptor subfamily 3, group C, member 10.331
Amhr2anti-Mullerian hormone type 2 receptor0.327
Umoduromodulin0.326
Klklotho0.321
Mup19major urinary protein 190.311
Atf4activating transcription factor 40.304
Akr1c6aldo-keto reductase family 1, member C60.304
Ins2insulin II0.299
Agtr1aangiotensin II receptor, type 1a0.296
Inhbcinhibin beta-C0.295
Foxo1forkhead box O10.278
Stat3signal transducer and activator of transcription 30.273
Usp9xubiquitin specific peptidase 9, X chromosome0.272
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.271
Gnrh1gonadotropin releasing hormone 10.270
SrcRous sarcoma oncogene0.270
Nr1h4nuclear receptor subfamily 1, group H, member 40.267
Epas1endothelial PAS domain protein 10.261
Igbp1immunoglobulin (CD79A) binding protein 10.252
Rxraretinoid X receptor alpha0.251
Tgfb1transforming growth factor, beta 10.249
Ldlrlow density lipoprotein receptor0.245
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.243
Gdnfglial cell line derived neurotrophic factor0.241
Lyz2lysozyme 20.237
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rararetinoic acid receptor, alpha0.827
Akt2v-akt murine thymoma viral oncogene homolog 20.649
Gstm1glutathione S-transferase mu 10.588
Sirpasignal-regulatory protein alpha0.584
Egr1early growth response 10.567
Egfrepidermal growth factor receptor0.526
Sc4molsterol-C4-methyl oxidase-like0.519
Nr4a3nuclear receptor subfamily 4, group A, member 30.476
Tgfbr2transforming growth factor, beta receptor II0.411
Hpd4-hydroxyphenylpyruvate dioxygenase0.411
FosFBJ osteosarcoma oncogene0.388
Gna12guanine nucleotide binding protein (G protein) alpha 120.357
Nr4a1nuclear receptor subfamily 4, group A, member 10.346
Cdc42cell division cycle 42 (GTP binding protein)0.341
Metmet proto-oncogene0.333
Ptpn6protein tyrosine phosphatase, non-receptor type 60.330
Junbjun B proto-oncogene0.315
Dusp6dual specificity phosphatase 60.310
Egr2early growth response 20.305
Ptgs2prostaglandin-endoperoxide synthase 20.295
Albalbumin0.269
Myh9myosin, heavy chain 9, non-muscle0.269
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.259
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.249
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.245
Ppardperoxisome proliferator-activated receptor delta0.235
Nptnneuroplastin0.232
Ptpn12protein tyrosine phosphatase, non-receptor type 120.228
Runx1runt-related transcription factor 10.225
Plauplasminogen activator, urokinase0.218
Cugbp2CUG triplet repeat, RNA binding protein 20.217
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.216
Pkm2pyruvate kinase, muscle0.215
Calm1calmodulin 10.213
Fabp1fatty acid binding protein 1, liver0.213
Stat5bsignal transducer and activator of transcription 5B0.211
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.204
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.202
Fgafibrinogen alpha chain0.197
F2rl1coagulation factor II (thrombin) receptor-like 10.195
Hmox1heme oxygenase (decycling) 10.193
Mgst1microsomal glutathione S-transferase 10.190
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.189
Gnrhrgonadotropin releasing hormone receptor0.182
Acsl1acyl-CoA synthetase long-chain family member 10.181
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.180
Cyctcytochrome c, testis0.175
Syngr2synaptogyrin 20.175
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.169
Cd14CD14 molecule0.165
Pcnaproliferating cell nuclear antigen0.165
Stc1stanniocalcin 10.165
Socs3suppressor of cytokine signaling 30.164
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.160
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.157
Hrghistidine-rich glycoprotein0.157
Grb2growth factor receptor bound protein 20.152
Hist1h1ahistone cluster 1, H1a0.151
Slc4a1solute carrier family 4 (anion exchanger), member 10.150
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.147
Gckglucokinase0.146
Il8rbinterleukin 8 receptor, beta0.146
Gse1genetic suppressor element 10.145
Ap2m1adaptor-related protein complex 2, mu 1 subunit0.143
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.143
Morf4l2mortality factor 4 like 20.143
Fgfr4fibroblast growth factor receptor 40.143
Sod3superoxide dismutase 3, extracellular0.142
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.142
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.140
Irs1insulin receptor substrate 10.140
Mef2dmyocyte enhancer factor 2D0.138
Il6interleukin 60.137
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.137
Car3carbonic anhydrase 30.136
Clic4chloride intracellular channel 40.134
Ephx1epoxide hydrolase 1, microsomal0.134
Smad7SMAD family member 70.133
Aldobaldolase B, fructose-bisphosphate0.132
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.132
Pklrpyruvate kinase, liver and RBC0.129
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.129
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.128
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.128
Rnf10ring finger protein 100.125
Nfianuclear factor I/A0.125
Calm2calmodulin 20.124
Lbrlamin B receptor0.123
Slco2a1solute carrier organic anion transporter family, member 2a10.122
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.120
Starsteroidogenic acute regulatory protein0.120
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.119
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.118
Ptger3prostaglandin E receptor 3 (subtype EP3)0.118
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.118
Cd36CD36 molecule (thrombospondin receptor)0.117
Ptgfrprostaglandin F receptor0.117
Marcksmyristoylated alanine rich protein kinase C substrate0.116
Akr1c14aldo-keto reductase family 1, member C140.116
G6pcglucose-6-phosphatase, catalytic subunit0.114
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism