The network for 'regulation of blood coagulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.999
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.999
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.999
PLCG1phospholipase C, gamma 10.996
SYKspleen tyrosine kinase0.995
LCKlymphocyte-specific protein tyrosine kinase0.993
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.993
LATlinker for activation of T cells0.988
C1QAcomplement component 1, q subcomponent, A chain0.982
VEGFAvascular endothelial growth factor A0.980
CAV1caveolin 1, caveolae protein, 22kDa0.977
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.975
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.968
SH3BP2SH3-domain binding protein 20.965
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.964
SNAP23synaptosomal-associated protein, 23kDa0.963
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.948
NCF1neutrophil cytosolic factor 10.941
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.936
METmet proto-oncogene (hepatocyte growth factor receptor)0.925
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.922
NRP1neuropilin 10.889
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.825
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.790
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.746
PLAUplasminogen activator, urokinase0.745
C1QCcomplement component 1, q subcomponent, C chain0.731
ANXA1annexin A10.718
PTPN6protein tyrosine phosphatase, non-receptor type 60.713
GRB7growth factor receptor-bound protein 70.602
VAV1vav 1 guanine nucleotide exchange factor0.584
PRKCAprotein kinase C, alpha0.578
FGAfibrinogen alpha chain0.569
SHC1SHC (Src homology 2 domain containing) transforming protein 10.557
ALBalbumin0.530
BLNKB-cell linker0.517
C1Rcomplement component 1, r subcomponent0.495
GRB2growth factor receptor-bound protein 20.481
HPhaptoglobin0.474
PTK2BPTK2B protein tyrosine kinase 2 beta0.469
CAV2caveolin 20.469
KNG1kininogen 10.451
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.451
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.446
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.437
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.435
POU5F1POU class 5 homeobox 10.433
PLGplasminogen0.432
PTPN1protein tyrosine phosphatase, non-receptor type 10.409
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.406
PLAURplasminogen activator, urokinase receptor0.399
AXLAXL receptor tyrosine kinase0.394
FYNFYN oncogene related to SRC, FGR, YES0.374
APOHapolipoprotein H (beta-2-glycoprotein I)0.374
SPINT1serine peptidase inhibitor, Kunitz type 10.374
C1QBcomplement component 1, q subcomponent, B chain0.373
GAB1GRB2-associated binding protein 10.369
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.353
PTENphosphatase and tensin homolog0.350
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.332
APOC1apolipoprotein C-I0.331
TICAM2toll-like receptor adaptor molecule 20.316
PLATplasminogen activator, tissue0.315
PDGFCplatelet derived growth factor C0.315
S100A10S100 calcium binding protein A100.310
FGBfibrinogen beta chain0.295
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.295
NCF4neutrophil cytosolic factor 4, 40kDa0.288
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.273
F13A1coagulation factor XIII, A1 polypeptide0.259
THBS1thrombospondin 10.253
INSRinsulin receptor0.249
SHC2SHC (Src homology 2 domain containing) transforming protein 20.247
PTPRBprotein tyrosine phosphatase, receptor type, B0.246
SNAP25synaptosomal-associated protein, 25kDa0.246
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.233
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.220
TRIM9tripartite motif containing 90.207
A2Malpha-2-macroglobulin0.203
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.198
MPEG1macrophage expressed 10.195
KEAP1kelch-like ECH-associated protein 10.188
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.187
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.178
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.166
COL4A2collagen, type IV, alpha 20.159
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.157
VAV2vav 2 guanine nucleotide exchange factor0.155
CYBAcytochrome b-245, alpha polypeptide0.153
LGALS1lectin, galactoside-binding, soluble, 10.143
MSNmoesin0.142
FN1fibronectin 10.140
C8Acomplement component 8, alpha polypeptide0.138
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.132
STAB1stabilin 10.132
C3complement component 30.131
BTKBruton agammaglobulinemia tyrosine kinase0.126
IGSF6immunoglobulin superfamily, member 60.125
F11coagulation factor XI0.124
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nkx2.3NK2 transcription factor related 30.332
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.200
foxa1forkhead box A10.176
pdgfaaplatelet-derived growth factor alpha a0.140
vtnbvitronectin b0.114
gipgastric inhibitory polypeptide0.109
serpind1serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 10.103
nkx2.1aNK2 homeobox 1a0.077
col11a1acollagen, type XI, alpha 1a0.076
zgc:193613zgc:1936130.072
ambplalpha-1-microglobulin/bikunin precursor, like0.069
si:dkey-8l13.4si:dkey-8l13.40.058
pklrpyruvate kinase, liver and RBC0.056
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.054
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.053
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.053
tp63tumor protein p630.051
rock2brho-associated, coiled-coil containing protein kinase 2b0.050
col5a3bcollagen type V alpha-3b0.049
serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.046
uoxurate oxidase0.043
appl1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.043
dlx5adistal-less homeobox gene 5a0.042
si:dkey-204a24.2si:dkey-204a24.20.041
LOC100003514protein kinase C alpha type-like0.039
tm4sf4transmembrane 4 L six family member 40.039
hbaa1hemoglobin alpha adult-10.039
prkcbbprotein kinase C, beta b0.038
cldn15laclaudin 15-like a0.038
fibplfibroblast growth factor (acidic) intracellular binding protein, like0.038
pxnpaxillin0.037
tfatransferrin-a0.037
zgc:63721zgc:637210.037
c9complement component 90.037
pdgfrb2platelet derived growth factor receptor beta 20.037
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.034
grhl1grainyhead-like 1 (Drosophila)0.033
itih2inter-alpha (globulin) inhibitor H20.033
uroduroporphyrinogen decarboxylase0.032
capns1acalpain, small subunit 1 a0.032
fn1bfibronectin 1b0.031
rnf128aring finger protein 128a0.030
si:dkeyp-50f5.1si:dkeyp-50f5.10.030
f5coagulation factor V0.030
fggfibrinogen, gamma polypeptide0.029
npntnephronectin0.029
serpina1lserine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like0.029
zgc:101614zgc:1016140.029
fras1Fraser syndrome 10.029
si:dkey-12o15.1si:dkey-12o15.10.028
slc20a1asolute carrier family 20, member 1a0.028
hpcahippocalcin0.028
grhl3grainyhead-like 30.027
agxtaalanine-glyoxylate aminotransferase a0.027
sulf1sulfatase 10.027
foxaforkhead box A sequence0.026
slc10a4solute carrier family 10 (sodium/bile acid cotransporter family), member 40.025
sppl2signal peptide peptidase-like 20.025
tlr8btoll-like receptor 8b0.025
plgplasminogen0.025
trdmt1tRNA aspartic acid methyltransferase 10.024
bfbcomplement component bfb0.024
utrnutrophin0.024
smoc2secreted modular calcium binding protein 20.024
zgc:153148zgc:1531480.024
si:dkeyp-117b8.3si:dkeyp-117b8.30.023
mpllmyeloproliferative leukemia virus oncogene, like0.023
apomapolipoprotein M0.023
aco1aconitase 1, soluble0.023
zgc:92360zgc:923600.023
elovl1belongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b0.022
b4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.022
sid4secreted immunoglobulin domain 40.022
agtangiotensinogen0.022
cyyr1cysteine and tyrosine-rich protein 10.022
ptpreaprotein tyrosine phosphatase, receptor type, E, a0.022
crfb5cytokine receptor family member b50.022
a1cfapobec1 complementation factor0.021
k31k31 gene0.021
shbgsex hormone binding globulin0.021
lamb2llaminin, beta 2-like0.021
nr1h5nuclear receptor subfamily 1, group H, member 50.021
c8acomplement component 8, alpha polypeptide0.021
fxyd1FXYD domain containing ion transport regulator 1 (phospholemman)0.021
si:dkeyp-110g5.2si:dkeyp-110g5.20.020
rbm22RNA binding motif protein 220.020
bmp3bone morphogenetic protein 30.020
tagln2transgelin 20.020
camk2acalcium/calmodulin-dependent protein kinase (CaM kinase) II alpha0.020
hs6st2heparan sulfate 6-O-sulfotransferase 20.020
tlr18toll-like receptor 180.019
nr2f1anuclear receptor subfamily 2, group F, member 1a0.019
rhdRh blood group, D antigen0.019
fth1aferritin, heavy polypeptide 1a0.019
fam43bfamily with sequence similarity 43, member B0.019
elovl6lELOVL family member 6, elongation of long chain fatty acids like0.019
mybl1v-myb myeloblastosis viral oncogene homolog (avian)-like 10.018
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.018
aldh8a1aldehyde dehydrogenase 8 family, member A10.018
mgpmatrix Gla protein0.018
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ppargperoxisome proliferator activated receptor gamma0.956
Selpselectin, platelet0.919
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.906
Csf1colony stimulating factor 1 (macrophage)0.866
Cav1caveolin 1, caveolae protein0.804
Cficomplement component factor i0.683
Dysfdysferlin0.614
Ldb3LIM domain binding 30.584
Fggfibrinogen gamma chain0.580
Itgb3integrin beta 30.561
Kng1kininogen 10.534
Ccr2chemokine (C-C motif) receptor 20.533
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.511
Prkceprotein kinase C, epsilon0.511
Ptprcprotein tyrosine phosphatase, receptor type, C0.502
Apoa1apolipoprotein A-I0.496
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.479
Vhlvon Hippel-Lindau tumor suppressor0.468
Plgplasminogen0.442
Smad1MAD homolog 1 (Drosophila)0.424
Ceacam2carcinoembryonic antigen-related cell adhesion molecule 20.383
Apoeapolipoprotein E0.374
Procprotein C0.353
Mmp9matrix metallopeptidase 90.342
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.341
Lyz2lysozyme 20.338
Lipclipase, hepatic0.314
Lrp1low density lipoprotein receptor-related protein 10.314
Gcgroup specific component0.311
BlnkB-cell linker0.305
Alox5aparachidonate 5-lipoxygenase activating protein0.294
Ambpalpha 1 microglobulin/bikunin0.287
FynFyn proto-oncogene0.286
Sykbspleen tyrosine kinase0.277
Saa4serum amyloid A 40.267
Ptgs2prostaglandin-endoperoxide synthase 20.258
Ush1cUsher syndrome 1C homolog (human)0.258
1300017J02RikRIKEN cDNA 1300017J02 gene0.257
Hgfachepatocyte growth factor activator0.257
FasFas (TNF receptor superfamily member 6)0.239
F2coagulation factor II0.236
Csf1rcolony stimulating factor 1 receptor0.231
Tnfrsf11btumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)0.231
Notch2Notch gene homolog 2 (Drosophila)0.230
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.216
Fgbfibrinogen beta chain0.214
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.212
Nos3nitric oxide synthase 3, endothelial cell0.210
Ptk2PTK2 protein tyrosine kinase 20.210
C3complement component 30.202
Pzppregnancy zone protein0.201
Itih1inter-alpha trypsin inhibitor, heavy chain 10.199
Slc26a1solute carrier family 26 (sulfate transporter), member 10.199
Zap70zeta-chain (TCR) associated protein kinase0.192
F11coagulation factor XI0.190
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.187
Itih4inter alpha-trypsin inhibitor, heavy chain 40.177
Rgs14regulator of G-protein signaling 140.177
Cd44CD44 antigen0.169
Leprleptin receptor0.168
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.161
C9complement component 90.158
Pou2af1POU domain, class 2, associating factor 10.156
Actn2actinin alpha 20.153
Klklotho0.150
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.149
Hchemolytic complement0.147
Asgr2asialoglycoprotein receptor 20.144
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.141
Cd209bCD209b antigen0.139
F7coagulation factor VII0.137
Esr1estrogen receptor 1 (alpha)0.135
Cfhcomplement component factor h0.130
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.128
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.126
Hgdhomogentisate 1, 2-dioxygenase0.124
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.123
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.119
FcrlaFc receptor-like A0.117
Nfe2l2nuclear factor, erythroid derived 2, like 20.116
Cmahcytidine monophospho-N-acetylneuraminic acid hydroxylase0.113
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.112
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.111
ND6NADH dehydrogenase subunit 60.111
Ccr6chemokine (C-C motif) receptor 60.110
Fesfeline sarcoma oncogene0.109
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.108
Cd28CD28 antigen0.107
Ush1gUsher syndrome 1G homolog (human)0.107
Lepleptin0.105
Nos1nitric oxide synthase 1, neuronal0.105
Stx4asyntaxin 4A (placental)0.105
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.102
Egfrepidermal growth factor receptor0.101
Tspan10tetraspanin 100.100
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.098
Cpn1carboxypeptidase N, polypeptide 10.098
Vdrvitamin D receptor0.095
Apoa5apolipoprotein A-V0.095
Ncoa3nuclear receptor coactivator 30.095
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa5annexin A50.861
Anxa1annexin A10.761
S100a6S100 calcium binding protein A60.578
Vimvimentin0.417
Anxa2annexin A20.394
Lgals3lectin, galactoside-binding, soluble, 30.386
Anxa4annexin A40.367
Itgb1integrin, beta 10.333
AhnakAHNAK nucleoprotein0.329
C1scomplement component 1, s subcomponent0.313
Ifitm3interferon induced transmembrane protein 30.308
Pzppregnancy-zone protein0.299
Ctsbcathepsin B0.221
S100a10S100 calcium binding protein A100.209
Capn2calpain 20.168
Ccl2chemokine (C-C motif) ligand 20.166
AxlAxl receptor tyrosine kinase0.164
B2mbeta-2 microglobulin0.135
Cd151CD151 molecule (Raph blood group)0.134
Pgcpplasma glutamate carboxypeptidase0.114
Ahsgalpha-2-HS-glycoprotein0.113
Cma1chymase 1, mast cell0.095
Icam1intercellular adhesion molecule 10.093
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.076
Lpllipoprotein lipase0.075
S100a11S100 calcium binding protein A11 (calizzarin)0.067
Zfp36l1zinc finger protein 36, C3H type-like 10.058
Platplasminogen activator, tissue0.057
Cpb2carboxypeptidase B2 (plasma)0.055
Cpceruloplasmin0.054
Clec4fC-type lectin domain family 4, member f0.052
Timp1TIMP metallopeptidase inhibitor 10.050
Serpinb6aserine (or cysteine) peptidase inhibitor, clade B, member 6a0.046
Gja1gap junction protein, alpha 10.045
Agtr1aangiotensin II receptor, type 1a0.045
Myadmmyeloid-associated differentiation marker0.045
Qprtquinolinate phosphoribosyltransferase0.041
Gcgroup specific component0.041
S100a4S100 calcium-binding protein A40.041
Ghrgrowth hormone receptor0.040
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.040
Ramp1receptor (G protein-coupled) activity modifying protein 10.039
Prdx4peroxiredoxin 40.037
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.037
Synposynaptopodin0.035
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.034
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.034
Tmem59transmembrane protein 590.033
Fabp1fatty acid binding protein 1, liver0.032
Cd9CD9 molecule0.031
Pmp22peripheral myelin protein 220.031
Procprotein C0.029
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.027
MdficMyoD family inhibitor domain containing0.027
Map3k8mitogen-activated protein kinase kinase kinase 80.027
Mbl2mannose-binding lectin (protein C) 20.026
Serpinf2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.026
Adam7ADAM metallopeptidase domain 70.025
Tmbim1transmembrane BAX inhibitor motif containing 10.025
Mcpt1mast cell protease 10.023
Hpxhemopexin0.022
Ncf4neutrophil cytosolic factor 40.022
Ctsl1cathepsin L10.022
Ccl4chemokine (C-C motif) ligand 40.022
Fn1fibronectin 10.021
Pla1aphospholipase A1 member A0.021
Pnliprp2pancreatic lipase-related protein 20.021
Fads1fatty acid desaturase 10.020
Krtcap2keratinocyte associated protein 20.019
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.019
Mbl1mannose-binding lectin (protein A) 10.018
Apohapolipoprotein H (beta-2-glycoprotein I)0.018
Tm4sf1transmembrane 4 L six family member 10.018
Tal1T-cell acute lymphocytic leukemia 10.018
Tnni1troponin I type 1 (skeletal, slow)0.018
Gsngelsolin0.017
Fgfr2fibroblast growth factor receptor 20.017
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.017
Cd44Cd44 molecule0.017
Fosl1fos-like antigen 10.016
Cnn3calponin 3, acidic0.016
Vsnl1visinin-like 10.016
Myogmyogenin0.015
Ctrcchymotrypsin C (caldecrin)0.015
Olr416olfactory receptor 4160.015
Clpscolipase, pancreatic0.015
Plaurplasminogen activator, urokinase receptor0.015
Arl11ADP-ribosylation factor-like 110.014
Itpr2inositol 1,4,5-triphosphate receptor, type 20.014
Hpnhepsin0.014
Myh11myosin, heavy chain 11, smooth muscle0.014
Aqp9aquaporin 90.014
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.014
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.014
Ccl3chemokine (C-C motif) ligand 30.014
C1rcomplement component 1, r subcomponent0.014
Agaaspartylglucosaminidase0.013
Ctshcathepsin H0.013
Plauplasminogen activator, urokinase0.013
Pck1phosphoenolpyruvate carboxykinase 1 (soluble)0.013
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism