The network for 'regulation of interleukin 8 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of interleukin 8 production

Any process that modulates the frequency, rate, or extent of interleukin-8 production.

NameDescriptionProbabilityFunc Analog Organism
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.998
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.982
BCL3B-cell CLL/lymphoma 30.877
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.809
MYD88myeloid differentiation primary response gene (88)0.752
ANXA1annexin A10.724
BIRC3baculoviral IAP repeat containing 30.671
SMN1survival of motor neuron 1, telomeric0.625
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.421
PLAUplasminogen activator, urokinase0.409
IL8interleukin 80.406
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.398
TRAF1TNF receptor-associated factor 10.384
RIPK2receptor-interacting serine-threonine kinase 20.378
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.285
CRPC-reactive protein, pentraxin-related0.260
ABI2abl-interactor 20.251
C1QAcomplement component 1, q subcomponent, A chain0.250
KLF6Kruppel-like factor 60.237
CASP8caspase 8, apoptosis-related cysteine peptidase0.227
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.221
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.203
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.191
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.174
TNFAIP3tumor necrosis factor, alpha-induced protein 30.170
KLF4Kruppel-like factor 4 (gut)0.161
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.158
S100A10S100 calcium binding protein A100.151
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.149
C1QCcomplement component 1, q subcomponent, C chain0.143
ZNF496zinc finger protein 4960.125
BIRC2baculoviral IAP repeat containing 20.107
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.107
ARRB1arrestin, beta 10.102
DLG1discs, large homolog 1 (Drosophila)0.100
ATF3activating transcription factor 30.096
TNIP1TNFAIP3 interacting protein 10.089
MAP3K2mitogen-activated protein kinase kinase kinase 20.087
MEFVMediterranean fever0.085
TNIP2TNFAIP3 interacting protein 20.085
MAP3K3mitogen-activated protein kinase kinase kinase 30.084
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.083
CARD11caspase recruitment domain family, member 110.078
DUSP1dual specificity phosphatase 10.076
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.075
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.074
CCL20chemokine (C-C motif) ligand 200.074
BMPR1Bbone morphogenetic protein receptor, type IB0.073
C9orf89chromosome 9 open reading frame 890.072
IL1R1interleukin 1 receptor, type I0.069
MT2Ametallothionein 2A0.068
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.066
NLRC4NLR family, CARD domain containing 40.063
ITGB5integrin, beta 50.062
IL1R2interleukin 1 receptor, type II0.062
IL6interleukin 6 (interferon, beta 2)0.062
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.057
JUNjun proto-oncogene0.056
SPRR2Asmall proline-rich protein 2A0.055
TLR4toll-like receptor 40.053
SOD1superoxide dismutase 1, soluble0.052
TICAM2toll-like receptor adaptor molecule 20.052
MARCOmacrophage receptor with collagenous structure0.050
TRAF3TNF receptor-associated factor 30.047
PTAFRplatelet-activating factor receptor0.046
EMP1epithelial membrane protein 10.045
CYBBcytochrome b-245, beta polypeptide0.045
HDAC7histone deacetylase 70.044
MAPK10mitogen-activated protein kinase 100.044
PYDC2pyrin domain containing 20.043
SNX33sorting nexin 330.043
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.043
S100A11S100 calcium binding protein A110.043
APOEapolipoprotein E0.042
MAP3K8mitogen-activated protein kinase kinase kinase 80.042
SH3D19SH3 domain containing 190.042
FASFas (TNF receptor superfamily, member 6)0.041
ANXA2annexin A20.040
CAMPcathelicidin antimicrobial peptide0.040
ANXA4annexin A40.039
ANXA5annexin A50.039
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.037
NLRP3NLR family, pyrin domain containing 30.037
CXCL2chemokine (C-X-C motif) ligand 20.037
CD48CD48 molecule0.036
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.036
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.036
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.035
CCR1chemokine (C-C motif) receptor 10.035
PLAURplasminogen activator, urokinase receptor0.035
IGSF6immunoglobulin superfamily, member 60.035
USP15ubiquitin specific peptidase 150.035
DBPD site of albumin promoter (albumin D-box) binding protein0.034
TLR2toll-like receptor 20.034
PRKCQprotein kinase C, theta0.034
APOA1apolipoprotein A-I0.033
PDCD6IPprogrammed cell death 6 interacting protein0.033
GNMTglycine N-methyltransferase0.032
S100A12S100 calcium binding protein A120.032
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Casp1caspase 10.991
Map3k8mitogen-activated protein kinase kinase kinase 80.788
Myd88myeloid differentiation primary response gene 880.787
Aim2absent in melanoma 20.721
Tnftumor necrosis factor0.707
Lhx1LIM homeobox protein 10.656
Tlr4toll-like receptor 40.649
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.582
Il6stinterleukin 6 signal transducer0.493
Casp4caspase 4, apoptosis-related cysteine peptidase0.461
Dkk1dickkopf homolog 1 (Xenopus laevis)0.380
Cd44CD44 antigen0.376
Traf3TNF receptor-associated factor 30.373
Cyldcylindromatosis (turban tumor syndrome)0.343
Ccl2chemokine (C-C motif) ligand 20.288
Ticam1toll-like receptor adaptor molecule 10.263
Il1ainterleukin 1 alpha0.252
Klf6Kruppel-like factor 60.245
Elaneelastase, neutrophil expressed0.244
FasFas (TNF receptor superfamily member 6)0.233
Casp8caspase 80.214
LitafLPS-induced TN factor0.209
Socs1suppressor of cytokine signaling 10.202
Arrb2arrestin, beta 20.193
Il1r1interleukin 1 receptor, type I0.191
Il12ainterleukin 12a0.174
Card11caspase recruitment domain family, member 110.171
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.171
Gdf3growth differentiation factor 30.169
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.169
Socs3suppressor of cytokine signaling 30.160
Sftpbsurfactant associated protein B0.154
Fut7fucosyltransferase 70.151
Nlrp3NLR family, pyrin domain containing 30.147
Wnt10awingless related MMTV integration site 10a0.143
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.142
Klf3Kruppel-like factor 3 (basic)0.141
Lgals3lectin, galactose binding, soluble 30.140
Vax1ventral anterior homeobox containing gene 10.136
Wnt4wingless-related MMTV integration site 40.136
Tnfaip3tumor necrosis factor, alpha-induced protein 30.135
Ror2receptor tyrosine kinase-like orphan receptor 20.128
Plaurplasminogen activator, urokinase receptor0.126
Pax2paired box gene 20.124
Wnt10bwingless related MMTV integration site 10b0.123
Tmod3tropomodulin 30.122
Pax8paired box gene 80.120
Selpselectin, platelet0.116
Treml1triggering receptor expressed on myeloid cells-like 10.116
Fgf21fibroblast growth factor 210.115
Porcnporcupine homolog (Drosophila)0.115
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.113
FaslFas ligand (TNF superfamily, member 6)0.113
Ms4a15membrane-spanning 4-domains, subfamily A, member 150.111
Anxa2annexin A20.109
Atf3activating transcription factor 30.106
Otx1orthodenticle homolog 1 (Drosophila)0.105
Fzd10frizzled homolog 10 (Drosophila)0.104
Map3k3mitogen-activated protein kinase kinase kinase 30.104
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.102
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.101
Lef1lymphoid enhancer binding factor 10.099
Ms4a3membrane-spanning 4-domains, subfamily A, member 30.099
Ccr2chemokine (C-C motif) receptor 20.096
Birc3baculoviral IAP repeat-containing 30.096
Tbxa2rthromboxane A2 receptor0.095
Cdx1caudal type homeobox 10.090
Il17ainterleukin 17A0.090
Zap70zeta-chain (TCR) associated protein kinase0.089
Cd9CD9 antigen0.089
Padi1peptidyl arginine deiminase, type I0.089
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.089
Ikbkginhibitor of kappaB kinase gamma0.089
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.087
Mmp9matrix metallopeptidase 90.087
NoboxNOBOX oogenesis homeobox0.085
5830411N06RikRIKEN cDNA 5830411N06 gene0.085
Slfn1schlafen 10.084
Zfp36zinc finger protein 360.084
Emx2empty spiracles homolog 2 (Drosophila)0.084
Itchitchy, E3 ubiquitin protein ligase0.083
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.083
Rhohras homolog gene family, member H0.083
Ageradvanced glycosylation end product-specific receptor0.083
Stat3signal transducer and activator of transcription 30.082
FosFBJ osteosarcoma oncogene0.082
Plscr1phospholipid scramblase 10.082
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.081
Mmp8matrix metallopeptidase 80.080
MgmtO-6-methylguanine-DNA methyltransferase0.080
Cd14CD14 antigen0.080
MdficMyoD family inhibitor domain containing0.079
Ctnna1catenin (cadherin associated protein), alpha 10.079
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.079
Hif1ahypoxia inducible factor 1, alpha subunit0.079
Fgf18fibroblast growth factor 180.078
Arsiarylsulfatase i0.078
Rarbretinoic acid receptor, beta0.078
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.140
Ccl2chemokine (C-C motif) ligand 20.092
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.039
Ccl3chemokine (C-C motif) ligand 30.037
Pla1aphospholipase A1 member A0.035
Il1ainterleukin 1 alpha0.033
Il6interleukin 60.025
Hckhemopoietic cell kinase0.024
Ccl4chemokine (C-C motif) ligand 40.024
Cxcl2chemokine (C-X-C motif) ligand 20.024
Plod2procollagen lysine, 2-oxoglutarate 5-dioxygenase 20.023
Casp12caspase 120.023
Il1r2interleukin 1 receptor, type II0.023
Fosl1fos-like antigen 10.022
Atf3activating transcription factor 30.021
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.021
Plaurplasminogen activator, urokinase receptor0.021
Igsf6immunoglobulin superfamily, member 60.018
Myd88myeloid differentiation primary response gene 880.018
Gja5gap junction protein, alpha 50.017
Map3k8mitogen-activated protein kinase kinase kinase 80.017
Tlr4toll-like receptor 40.016
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.015
Casp1caspase 10.014
Nraddneurotrophin receptor associated death domain0.014
Cxcl10chemokine (C-X-C motif) ligand 100.014
Arl11ADP-ribosylation factor-like 110.014
S100a9S100 calcium binding protein A90.014
Vcam1vascular cell adhesion molecule 10.014
Sh2b3SH2B adaptor protein 30.014
Iqgap1IQ motif containing GTPase activating protein 10.014
Dusp1dual specificity phosphatase 10.014
Ltbp3latent transforming growth factor beta binding protein 30.014
C5ar1complement component 5a receptor 10.013
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.013
Gpx2glutathione peroxidase 20.013
Xdhxanthine dehydrogenase0.013
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.012
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.012
Rhojras homolog gene family, member J0.012
Ctsscathepsin S0.012
PVRpoliovirus receptor0.012
F2rl2coagulation factor II (thrombin) receptor-like 20.012
Ccr1chemokine (C-C motif) receptor 10.012
Fblim1filamin binding LIM protein 10.011
Rgs1regulator of G-protein signaling 10.011
Klf3Kruppel-like factor 3 (basic)0.011
Zfp36l1zinc finger protein 36, C3H type-like 10.011
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.011
Clec10aC-type lectin domain family 10, member A0.011
Tnftumor necrosis factor (TNF superfamily, member 2)0.011
Col12a1collagen, type XII, alpha 10.011
Mmp12matrix metallopeptidase 120.011
Runx1runt-related transcription factor 10.011
Cxcr4chemokine (C-X-C motif) receptor 40.011
Hspa1aheat shock 70kD protein 1A0.010
Cr1lcomplement component (3b/4b) receptor 1-like0.010
Ccl17chemokine (C-C motif) ligand 170.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism