The network for 'epithelial tube branching involved in lung morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelial tube branching involved in lung morphogenesis

The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.

NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
FGF1fibroblast growth factor 1 (acidic)1.000
FGF10fibroblast growth factor 101.000
TBX5T-box 50.999
FGFR1fibroblast growth factor receptor 10.999
BMPR1Abone morphogenetic protein receptor, type IA0.997
FGF7fibroblast growth factor 70.988
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.979
SH3KBP1SH3-domain kinase binding protein 10.956
POU5F1POU class 5 homeobox 10.938
FGF8fibroblast growth factor 8 (androgen-induced)0.889
PAX8paired box 80.832
ARandrogen receptor0.816
FGFR3fibroblast growth factor receptor 30.773
FOXD3forkhead box D30.682
PFN1profilin 10.634
DTNAdystrobrevin, alpha0.546
GATA4GATA binding protein 40.530
SORBS3sorbin and SH3 domain containing 30.526
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.491
HOXA10homeobox A100.487
DDX47DEAD (Asp-Glu-Ala-Asp) box polypeptide 470.440
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.437
FGF3fibroblast growth factor 30.434
TNIP1TNFAIP3 interacting protein 10.432
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.426
CTNND1catenin (cadherin-associated protein), delta 10.390
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.370
BTRCbeta-transducin repeat containing0.335
CTGFconnective tissue growth factor0.323
PKP4plakophilin 40.281
IGSF21immunoglobin superfamily, member 210.275
FSTL1follistatin-like 10.270
SALL2sal-like 2 (Drosophila)0.239
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.232
SPRY1sprouty homolog 1, antagonist of FGF signaling (Drosophila)0.226
CD14CD14 molecule0.225
GLIS2GLIS family zinc finger 20.219
FGF4fibroblast growth factor 40.208
FGF2fibroblast growth factor 2 (basic)0.203
ONECUT1one cut homeobox 10.202
FOXA2forkhead box A20.195
HOXB5homeobox B50.193
WNT1wingless-type MMTV integration site family, member 10.182
SPRY2sprouty homolog 2 (Drosophila)0.178
BTBD10BTB (POZ) domain containing 100.176
FOXF2forkhead box F20.159
TGFB2transforming growth factor, beta 20.152
TCF4transcription factor 40.151
JUPjunction plakoglobin0.150
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.149
APCadenomatous polyposis coli0.141
GSCgoosecoid homeobox0.116
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.114
HOXD1homeobox D10.107
FERMT2fermitin family member 20.106
PAX7paired box 70.095
HOXA1homeobox A10.094
HOXA7homeobox A70.093
UBR1ubiquitin protein ligase E3 component n-recognin 10.092
EEA1early endosome antigen 10.085
MAP2K1mitogen-activated protein kinase kinase 10.085
ERBB2IPerbb2 interacting protein0.084
DTNBdystrobrevin, beta0.081
NEDD4neural precursor cell expressed, developmentally down-regulated 40.080
SOX1SRY (sex determining region Y)-box 10.080
FOXA1forkhead box A10.078
ALX4ALX homeobox 40.078
HNF1AHNF1 homeobox A0.078
COL2A1collagen, type II, alpha 10.078
SIX2SIX homeobox 20.075
TBX1T-box 10.074
PEBP1phosphatidylethanolamine binding protein 10.073
C9orf25chromosome 9 open reading frame 250.073
GSK3Bglycogen synthase kinase 3 beta0.071
SALL1sal-like 1 (Drosophila)0.071
FOXL1forkhead box L10.071
FGF19fibroblast growth factor 190.070
UTF1undifferentiated embryonic cell transcription factor 10.070
BAG1BCL2-associated athanogene0.070
CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 10.069
HOXB13homeobox B130.069
PEBP4phosphatidylethanolamine-binding protein 40.067
MAP2microtubule-associated protein 20.067
FOXE1forkhead box E1 (thyroid transcription factor 2)0.066
PDE4DIPphosphodiesterase 4D interacting protein0.065
SIM2single-minded homolog 2 (Drosophila)0.063
MNX1motor neuron and pancreas homeobox 10.062
WNT3wingless-type MMTV integration site family, member 30.061
EGLN1egl nine homolog 1 (C. elegans)0.061
SOX9SRY (sex determining region Y)-box 90.060
PTF1Apancreas specific transcription factor, 1a0.059
NKX2-1NK2 homeobox 10.057
SIX6SIX homeobox 60.056
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Foxc1forkhead box C11.000
Fgfr2fibroblast growth factor receptor 21.000
Shhsonic hedgehog0.999
Pax2paired box gene 20.998
Gli3GLI-Kruppel family member GLI30.991
Bmp4bone morphogenetic protein 40.982
Vangl2vang-like 2 (van gogh, Drosophila)0.973
Gli2GLI-Kruppel family member GLI20.971
Fgf8fibroblast growth factor 80.956
Fgf10fibroblast growth factor 100.953
Pax8paired box gene 80.953
Pbx1pre B-cell leukemia transcription factor 10.936
Tcf21transcription factor 210.921
Meox2mesenchyme homeobox 20.916
Pax3paired box gene 30.901
Tcfap2atranscription factor AP-2, alpha0.895
Sox2SRY-box containing gene 20.871
Sox9SRY-box containing gene 90.861
Gdnfglial cell line derived neurotrophic factor0.852
Foxc2forkhead box C20.803
Msx1homeobox, msh-like 10.800
Pitx2paired-like homeodomain transcription factor 20.782
Jag1jagged 10.772
Nkx2-1NK2 homeobox 10.727
Hoxa9homeobox A90.710
Hoxb6homeobox B60.683
Hand2heart and neural crest derivatives expressed transcript 20.678
Hoxa1homeobox A10.673
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.672
Fgfr1fibroblast growth factor receptor 10.657
Eya1eyes absent 1 homolog (Drosophila)0.657
Hoxa11homeobox A110.645
Rarbretinoic acid receptor, beta0.639
Hoxa5homeobox A50.633
Lhx1LIM homeobox protein 10.629
Ror2receptor tyrosine kinase-like orphan receptor 20.627
Efnb2ephrin B20.606
Hoxd11homeobox D110.601
Lmx1aLIM homeobox transcription factor 1 alpha0.588
Zeb1zinc finger E-box binding homeobox 10.586
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.584
Tbx1T-box 10.570
Dkk1dickkopf homolog 1 (Xenopus laevis)0.569
Tbx3T-box 30.539
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.529
Retret proto-oncogene0.514
Hoxd9homeobox D90.498
Alx4aristaless-like homeobox 40.497
Ctnnb1catenin (cadherin associated protein), beta 10.496
Ptch1patched homolog 10.496
Tbx2T-box 20.479
Fgf3fibroblast growth factor 30.471
Hand1heart and neural crest derivatives expressed transcript 10.470
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.462
Hoxc6homeobox C60.462
Gbx2gastrulation brain homeobox 20.460
Lmx1bLIM homeobox transcription factor 1 beta0.442
Prrx1paired related homeobox 10.411
Bmp7bone morphogenetic protein 70.404
Emx2empty spiracles homolog 2 (Drosophila)0.391
Hoxa10homeobox A100.356
Otx2orthodenticle homolog 2 (Drosophila)0.353
Hoxd3homeobox D30.333
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.325
Hoxb5homeobox B50.317
Wnt5awingless-related MMTV integration site 5A0.312
Rargretinoic acid receptor, gamma0.311
Twist2twist homolog 2 (Drosophila)0.307
Fgfr3fibroblast growth factor receptor 30.305
Tgfb2transforming growth factor, beta 20.297
Pou3f3POU domain, class 3, transcription factor 30.293
Hoxb3homeobox B30.292
Hoxa2homeobox A20.287
Otx1orthodenticle homolog 1 (Drosophila)0.242
Ptk7PTK7 protein tyrosine kinase 70.241
Prrx2paired related homeobox 20.240
Gata4GATA binding protein 40.228
Gli1GLI-Kruppel family member GLI10.217
Hoxb9homeobox B90.208
Hoxd4homeobox D40.201
Hoxd8homeobox D80.200
Zic3zinc finger protein of the cerebellum 30.199
Lrp2low density lipoprotein receptor-related protein 20.198
Sox7SRY-box containing gene 70.198
Gata6GATA binding protein 60.198
Dlx5distal-less homeobox 50.195
Hoxb2homeobox B20.186
Pcsk5proprotein convertase subtilisin/kexin type 50.184
Wt1Wilms tumor 1 homolog0.184
Smosmoothened homolog (Drosophila)0.182
Nf1neurofibromatosis 10.180
Pax6paired box gene 60.174
Hes1hairy and enhancer of split 1 (Drosophila)0.168
Hspg2perlecan (heparan sulfate proteoglycan 2)0.166
Hoxa3homeobox A30.158
Sall4sal-like 4 (Drosophila)0.157
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism