The network for 'apoptotic mitochondrial changes' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

apoptotic mitochondrial changes

The morphological and physiological alterations undergone by mitochondria during apoptosis.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 21.000
BCL2L1BCL2-like 11.000
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.999
JUNjun proto-oncogene0.999
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.998
BADBCL2-associated agonist of cell death0.998
BAXBCL2-associated X protein0.997
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.997
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.994
BCL2L11BCL2-like 11 (apoptosis facilitator)0.994
BIDBH3 interacting domain death agonist0.971
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.968
CFLARCASP8 and FADD-like apoptosis regulator0.965
FOSFBJ murine osteosarcoma viral oncogene homolog0.955
VDAC1voltage-dependent anion channel 10.921
MDM2Mdm2 p53 binding protein homolog (mouse)0.921
XIAPX-linked inhibitor of apoptosis0.895
MDM4Mdm4 p53 binding protein homolog (mouse)0.881
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.880
BAK1BCL2-antagonist/killer 10.872
MAP2K4mitogen-activated protein kinase kinase 40.862
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.845
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.836
FADDFas (TNFRSF6)-associated via death domain0.835
FASFas (TNF receptor superfamily, member 6)0.834
VDAC2voltage-dependent anion channel 20.825
CASP10caspase 10, apoptosis-related cysteine peptidase0.814
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.812
BECN1beclin 1, autophagy related0.809
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.807
MAPK8mitogen-activated protein kinase 80.746
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.744
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.726
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.724
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.646
DLG4discs, large homolog 4 (Drosophila)0.637
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.601
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.601
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.597
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.553
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.537
CASP3caspase 3, apoptosis-related cysteine peptidase0.530
MAPK9mitogen-activated protein kinase 90.498
TP53BP2tumor protein p53 binding protein, 20.494
SQSTM1sequestosome 10.432
HMOX2heme oxygenase (decycling) 20.429
IER2immediate early response 20.416
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.414
BCAP31B-cell receptor-associated protein 310.412
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.399
CASP9caspase 9, apoptosis-related cysteine peptidase0.386
PDZD11PDZ domain containing 110.367
BBC3BCL2 binding component 30.352
FKBP8FK506 binding protein 8, 38kDa0.344
BIKBCL2-interacting killer (apoptosis-inducing)0.339
AKT1v-akt murine thymoma viral oncogene homolog 10.321
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.321
GRPEL1GrpE-like 1, mitochondrial (E. coli)0.307
MAPK1mitogen-activated protein kinase 10.297
SMCR7LSmith-Magenis syndrome chromosome region, candidate 7-like0.291
HIPK2homeodomain interacting protein kinase 20.290
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.275
DAXXdeath-domain associated protein0.258
EGR1early growth response 10.255
C4orf14chromosome 4 open reading frame 140.246
FOSL1FOS-like antigen 10.245
ENO2enolase 2 (gamma, neuronal)0.242
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.239
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.226
ATF3activating transcription factor 30.224
BIRC2baculoviral IAP repeat containing 20.215
WWOXWW domain containing oxidoreductase0.208
ATF2activating transcription factor 20.207
FHfumarate hydratase0.204
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.204
IL8interleukin 80.198
MAPK14mitogen-activated protein kinase 140.194
MUTEDmuted homolog (mouse)0.193
USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)0.190
ZHX1zinc fingers and homeoboxes 10.188
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.188
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.187
JUNBjun B proto-oncogene0.185
HSPA8heat shock 70kDa protein 80.182
MAP3K1mitogen-activated protein kinase kinase kinase 10.177
NLRC4NLR family, CARD domain containing 40.172
SMCR7Smith-Magenis syndrome chromosome region, candidate 70.168
LRRK2leucine-rich repeat kinase 20.168
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.166
IGF1Rinsulin-like growth factor 1 receptor0.165
PDHXpyruvate dehydrogenase complex, component X0.162
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.162
DLDdihydrolipoamide dehydrogenase0.155
FBXO7F-box protein 70.151
PSEN2presenilin 2 (Alzheimer disease 4)0.149
UBQLN1ubiquilin 10.148
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.143
HDAC4histone deacetylase 40.141
HUWE1HECT, UBA and WWE domain containing 10.140
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
ced-3Protein CED-30.040
ced-9Protein CED-90.035
F01G4.6Protein F01G4.60.034
ant-1.3Protein ANT-1.30.029
eat-3Protein EAT-30.028
dld-1Protein DLD-10.025
ttm-4Protein TTM-40.025
ttr-18Protein TTR-180.024
ant-1.4Protein ANT-1.40.022
tag-343Protein TAG-3430.021
gdh-1Protein GDH-10.020
zyx-1Protein ZYX-10.018
abts-1Protein ABTS-10.018
sut-2Protein SUT-20.018
cec-4Protein CEC-40.018
cts-1Protein CTS-10.018
ifd-2Protein IFD-20.018
F45E4.6Protein F45E4.60.017
hpd-1Protein HPD-10.017
hgrs-1Protein HGRS-10.017
plc-3Protein PLC-30.017
ifa-1Protein IFA-10.017
syd-2Protein SYD-20.016
B0511.7Protein B0511.70.016
cacn-1Protein CACN-10.016
sel-1Protein SEL-10.016
amx-2Protein AMX-20.016
sem-5Protein SEM-50.016
dlst-1Protein DLST-10.016
F33G12.5Protein F33G12.50.016
ifb-2Protein IFB-20.015
pmk-1Protein PMK-10.015
lev-11Protein LEV-110.015
lec-3Protein LEC-30.015
nhr-55Protein NHR-550.015
CELE_F39H2.3Protein F39H2.30.015
mdh-1Protein MDH-10.014
nucb-1Protein NUCB-10.014
mup-2Protein MUP-20.014
mdt-18Protein MDT-180.014
hsp-6Protein HSP-60.014
T05H10.1Protein T05H10.10.014
F46G10.2Protein F46G10.20.014
mdt-28Protein MDT-280.014
scp-1Protein SCP-10.014
letm-1Protein LETM-10.014
CELE_Y47G6A.18Protein Y47G6A.180.014
K11H12.7Protein K11H12.70.014
pry-1Protein PRY-10.014
prx-19Protein PRX-190.013
deb-1Protein DEB-10.013
pdhb-1Protein PDHB-10.013
C33F10.14Protein C33F10.140.013
rsbp-1Protein RSBP-10.013
dpf-3Protein DPF-30.013
cls-1Protein CLS-10.013
T25F10.6Protein T25F10.60.013
T14D7.1Protein T14D7.10.013
atfs-1Protein ATFS-10.013
F14B8.6Protein F14B8.60.013
pat-12Protein PAT-120.013
dnj-25Protein DNJ-250.013
haf-3Protein HAF-30.013
CELE_F46F2.3Protein F46F2.30.013
CELE_F35E12.9Protein F35E12.90.013
C06A8.3Protein C06A8.30.013
Y71H10A.1Protein Y71H10A.10.013
haly-1Protein HALY-10.012
kat-1Protein KAT-10.012
C41D11.4Protein C41D11.40.012
atp-3Protein ATP-30.012
C31H1.1Protein C31H1.10.012
Y38F1A.6Protein Y38F1A.60.012
act-3Protein ACT-30.012
M28.8Protein M28.80.012
T05H10.4Protein T05H10.40.012
ech-6Protein ECH-60.012
qdpr-1Protein QDPR-10.012
let-2Protein LET-20.012
R12C12.6Protein R12C12.60.012
K06A9.1Protein K06A9.10.012
klp-3Protein KLP-30.012
nhr-18Protein NHR-180.012
ric-3Protein RIC-30.012
ZK858.6Protein ZK858.60.012
clec-91Protein CLEC-910.012
mup-4Protein MUP-40.012
M02D8.1Protein M02D8.10.012
C15C7.5Protein C15C7.50.011
F44E7.4Protein F44E7.40.011
T08B2.7Protein T08B2.70.011
atp-2Protein ATP-20.011
pes-22Protein PES-220.011
tkt-1Protein TKT-10.011
aldo-2Protein ALDO-20.011
CELE_F11A3.2Protein F11A3.20.011
pes-7Protein PES-70.011
axl-1Protein AXL-10.011
Y43E12A.2Protein Y43E12A.20.011
tac-1Protein TAC-10.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.999
Trp53transformation related protein 530.997
Bcl2B-cell leukemia/lymphoma 20.997
Mapk8mitogen-activated protein kinase 80.987
Casp4caspase 4, apoptosis-related cysteine peptidase0.965
Tpi1triosephosphate isomerase 10.911
Gbp5guanylate binding protein 50.841
Bcl2l1BCL2-like 10.825
Mcl1myeloid cell leukemia sequence 10.801
Pnp2purine-nucleoside phosphorylase 20.798
Casp1caspase 10.769
Akt1thymoma viral proto-oncogene 10.748
BaxBCL2-associated X protein0.726
FosFBJ osteosarcoma oncogene0.709
Vhlvon Hippel-Lindau tumor suppressor0.699
Ighimmunoglobulin heavy chain complex0.698
Gclmglutamate-cysteine ligase, modifier subunit0.644
Kitkit oncogene0.628
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.571
Atg12autophagy-related 12 (yeast)0.532
Aim2absent in melanoma 20.528
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.492
Insrinsulin receptor0.457
Ldb3LIM domain binding 30.453
Gclcglutamate-cysteine ligase, catalytic subunit0.415
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.398
Ptenphosphatase and tensin homolog0.393
Tnfaip3tumor necrosis factor, alpha-induced protein 30.381
Dusp1dual specificity phosphatase 10.338
Park2Parkinson disease (autosomal recessive, juvenile) 2, parkin0.330
Mrpl18mitochondrial ribosomal protein L180.306
Mta1metastasis associated 10.290
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.277
Axin1axin 10.273
Lmnb1lamin B10.267
Lystlysosomal trafficking regulator0.262
Pim2proviral integration site 20.246
Dnm1dynamin 10.232
FasFas (TNF receptor superfamily member 6)0.225
Bak1BCL2-antagonist/killer 10.216
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.214
Trp63transformation related protein 630.207
Grb10growth factor receptor bound protein 100.205
Leprleptin receptor0.204
WrnWerner syndrome homolog (human)0.195
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.191
Slc31a1solute carrier family 31, member 10.187
Ctnnb1catenin (cadherin associated protein), beta 10.179
Mdm4transformed mouse 3T3 cell double minute 40.174
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.169
Mdm2transformed mouse 3T3 cell double minute 20.166
Igf1rinsulin-like growth factor I receptor0.165
Lrrk2leucine-rich repeat kinase 20.163
Hsd17b10hydroxysteroid (17-beta) dehydrogenase 100.161
Lmnb2lamin B20.160
SkilSKI-like0.157
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.157
Casp3caspase 30.153
Rararetinoic acid receptor, alpha0.151
Vdac2voltage-dependent anion channel 20.145
Atf3activating transcription factor 30.141
Rbl1retinoblastoma-like 1 (p107)0.141
Stim2stromal interaction molecule 20.138
Emx1empty spiracles homolog 1 (Drosophila)0.137
Camk2bcalcium/calmodulin-dependent protein kinase II, beta0.135
Pdcd6ipprogrammed cell death 6 interacting protein0.132
Tlr4toll-like receptor 40.132
Pim1proviral integration site 10.128
PycardPYD and CARD domain containing0.126
Mfn2mitofusin 20.124
Ppargperoxisome proliferator activated receptor gamma0.121
SharpinSHANK-associated RH domain interacting protein0.120
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.119
Nfe2l2nuclear factor, erythroid derived 2, like 20.118
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.118
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.116
Becn1beclin 1, autophagy related0.115
Mapk14mitogen-activated protein kinase 140.113
Actn2actinin alpha 20.113
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.111
JunbJun-B oncogene0.110
Egln1EGL nine homolog 1 (C. elegans)0.109
Dlg4discs, large homolog 4 (Drosophila)0.107
Rxraretinoid X receptor alpha0.107
Mtap2microtubule-associated protein 20.106
Nos3nitric oxide synthase 3, endothelial cell0.105
Atxn2ataxin 20.105
Rb1retinoblastoma 10.104
Smn1survival motor neuron 10.101
Zfp36zinc finger protein 360.100
Bbc3BCL2 binding component 30.098
Irf6interferon regulatory factor 60.095
Timm17atranslocase of inner mitochondrial membrane 17a0.095
Ep300E1A binding protein p3000.095
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.091
Apcadenomatosis polyposis coli0.091
Smad3MAD homolog 3 (Drosophila)0.090
Tab1TGF-beta activated kinase 1/MAP3K7 binding protein 10.090
Il18interleukin 180.088
C1qbpcomplement component 1, q subcomponent binding protein0.088
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc25a4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 40.418
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.356
Mdh1malate dehydrogenase 1, NAD (soluble)0.341
Uqcrc2ubiquinol cytochrome c reductase core protein 20.155
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.141
Mapk9mitogen-activated protein kinase 90.105
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.084
Ppardperoxisome proliferator-activated receptor delta0.079
Adrbk1adrenergic, beta, receptor kinase 10.078
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.073
Cishcytokine inducible SH2-containing protein0.072
FosFBJ osteosarcoma oncogene0.068
Vdac1voltage-dependent anion channel 10.067
Dlatdihydrolipoamide S-acetyltransferase0.066
Coro1bcoronin, actin-binding protein, 1B0.063
Fh1fumarate hydratase 10.062
Cycscytochrome c, somatic0.055
Dctn4dynactin 40.054
Trim23tripartite motif-containing 230.049
Syt4synaptotagmin IV0.049
Myo1bmyosin Ib0.047
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.044
Map2k4mitogen activated protein kinase kinase 40.036
Ucp2uncoupling protein 2 (mitochondrial, proton carrier)0.033
Plscr3phospholipid scramblase 30.032
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.032
Tgfb1transforming growth factor, beta 10.032
Eif2c2eukaryotic translation initiation factor 2C, 20.026
Hmga2high mobility group AT-hook 20.024
Ckmt1creatine kinase, mitochondrial 10.024
LOC687090hypothetical protein LOC6870900.023
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.023
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.023
Junbjun B proto-oncogene0.022
Atp5c1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 10.022
Cyb5r1cytochrome b5 reductase 10.021
Vegfavascular endothelial growth factor A0.021
Ndufc2NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 20.021
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.021
Klf6Kruppel-like factor 60.021
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.020
Pip5k1cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma0.019
Matkmegakaryocyte-associated tyrosine kinase0.018
Acadvlacyl-Coenzyme A dehydrogenase, very long chain0.018
Pomcproopiomelanocortin0.018
JunJun oncogene0.018
Hspb8heat shock protein B80.018
Mapk7mitogen-activated protein kinase 70.017
Smad1SMAD family member 10.017
Dmddystrophin0.017
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.017
Tfrctransferrin receptor0.017
Etfdhelectron-transferring-flavoprotein dehydrogenase0.016
NsfN-ethylmaleimide-sensitive factor0.016
Ptmsparathymosin0.016
Bod1biorientation of chromosomes in cell division 10.016
Ccnd3cyclin D30.016
Tagln3transgelin 30.015
Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein0.015
Rnf4ring finger protein 40.015
Taok1TAO kinase 10.015
Nrg1neuregulin 10.015
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.015
LOC684800similar to stromal membrane-associated protein 10.014
Atp6v1b2ATPase, H transporting, lysosomal V1 subunit B20.014
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.014
Dnajc5DnaJ (Hsp40) homolog, subfamily C, member 50.014
Map3k7ip1mitogen-activated protein kinase kinase kinase 7 interacting protein 10.014
Cgrrf1cell growth regulator with ring finger domain 10.014
Got1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.014
Atp6v1e1ATPase, H+ transporting, lysosomal V1 subunit E10.013
Vsnl1visinin-like 10.013
Top2btopoisomerase (DNA) II beta0.013
Tubb5tubulin, beta 50.013
Dusp1dual specificity phosphatase 10.013
Zadh2zinc binding alcohol dehydrogenase, domain containing 20.013
Vdac2voltage-dependent anion channel 20.013
Smad7SMAD family member 70.012
Lpcat4lysophosphatidylcholine acyltransferase 40.012
Homer3homer homolog 3 (Drosophila)0.012
Cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.012
Phlda1pleckstrin homology-like domain, family A, member 10.012
Eif4ebp1eukaryotic translation initiation factor 4E binding protein 10.011
Atp5hATP synthase, H+ transporting, mitochondrial F0 complex, subunit d0.011
Mecp2methyl CpG binding protein 20.011
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.011
Tatdn2TatD DNase domain containing 20.011
Pea15aphosphoprotein enriched in astrocytes 15A0.011
Acadsbacyl-Coenzyme A dehydrogenase, short/branched chain0.011
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.011
Synrgsynergin, gamma0.011
RGD1304644similar to RIKEN cDNA 2310046K010.011
Trim47tripartite motif-containing 470.011
Efhd2EF-hand domain family, member D20.011
Mapk10mitogen activated protein kinase 100.011
Anxa7annexin A70.011
Snap25synaptosomal-associated protein 250.011
Eci1enoyl-Coenzyme A delta isomerase 10.011
Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.010
Nischnischarin0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism