The network for 'cellular response to antibiotic' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to antibiotic

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

NameDescriptionProbabilityFunc Analog Organism
CASP9caspase 9, apoptosis-related cysteine peptidase0.477
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.292
XIAPX-linked inhibitor of apoptosis0.192
APAF1apoptotic peptidase activating factor 10.183
IL1R1interleukin 1 receptor, type I0.173
IL1RAPinterleukin 1 receptor accessory protein0.051
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.051
SNAI1snail homolog 1 (Drosophila)0.048
CASP7caspase 7, apoptosis-related cysteine peptidase0.044
HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.042
EGR2early growth response 20.041
HDAC9histone deacetylase 90.032
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.025
KAT2BK(lysine) acetyltransferase 2B0.024
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.020
EGR3early growth response 30.020
IL1RNinterleukin 1 receptor antagonist0.019
DYNLT1dynein, light chain, Tctex-type 10.016
MDM2Mdm2 p53 binding protein homolog (mouse)0.015
MAP3K5mitogen-activated protein kinase kinase kinase 50.014
IER2immediate early response 20.014
CCNDBP1cyclin D-type binding-protein 10.013
CDK6cyclin-dependent kinase 60.013
CHP2calcineurin B homologous protein 20.013
TCF4transcription factor 40.012
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.012
ACTN2actinin, alpha 20.012
SPRY2sprouty homolog 2 (Drosophila)0.011
ATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptide0.011
PRKCZprotein kinase C, zeta0.010
ABCB4ATP-binding cassette, sub-family B (MDR/TAP), member 40.010
CCND3cyclin D30.010
PSMA6proteasome (prosome, macropain) subunit, alpha type, 60.010
MYOD1myogenic differentiation 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.297
mef2camyocyte enhancer factor 2ca0.272
igf3insulin-like growth factor 30.270
cldn2claudin 20.252
paqr7bprogestin and adipoQ receptor family member VII, b0.205
mef2cbmyocyte enhancer factor 2cb0.198
lhcgrluteinizing hormone/choriogonadotropin receptor0.194
fshrfollicle stimulating hormone receptor0.188
bmp15bone morphogenetic protein 150.157
hsp90b1heat shock protein 90, beta (grp94), member 10.138
tbx5aT-box 5a0.132
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.130
nanos3nanos homolog 30.128
smyd1bSET and MYND domain containing 1b0.126
gdf9growth differentiation factor 90.126
manfmesencephalic astrocyte-derived neurotrophic factor0.100
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.099
cldn8claudin 80.092
starsteroidogenic acute regulatory protein0.091
inhainhibin, alpha0.080
hsp90a.1heat shock protein 90-alpha 10.072
paqr8progestin and adipoQ receptor family member VIII0.065
plcg1phospholipase C, gamma 10.063
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.058
acvr2aactivin receptor IIa0.054
xirp1xin actin-binding repeat containing 10.053
rag1recombination activating gene 10.053
ptgeslprostaglandin E synthase 2-like0.051
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.046
inhbabinhibin, beta Ab0.043
hspd1heat shock 60kD protein 1 (chaperonin)0.043
cldndclaudin d0.043
vasavasa homolog0.041
per2period homolog 2 (Drosophila)0.039
cldn1claudin 10.038
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.038
oepone-eyed pinhead0.036
mef2amyocyte enhancer factor 2a0.032
mt2metallothionein 20.030
rspo1R-spondin homolog (Xenopus laevis)0.030
amhanti-Mullerian hormone0.028
ctsbacathepsin B, a0.028
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.027
egr2aearly growth response 2a0.026
junbjun B proto-oncogene0.025
hspb7heat shock protein family, alpha-crystallin-related, b70.025
gapdhglyceraldehyde-3-phosphate dehydrogenase0.022
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.022
rbpms2RNA binding protein with multiple splicing 20.022
nr5a2nuclear receptor subfamily 5, group A, member 20.022
desmadesmin a0.021
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.021
prox1prospero-related homeobox gene 10.020
piwil1piwi-like 1 (Drosophila)0.020
nr4a2bnuclear receptor subfamily 4, group A, member 2b0.019
glulbglutamate-ammonia ligase (glutamine synthase) b0.019
sycp3lsynaptonemal complex protein 3 like0.019
lamb2laminin, beta 2 (laminin S)0.019
cry1acryptochrome 1a0.019
nkx2.5NK2 transcription factor related 50.018
tgfb3transforming growth factor, beta 30.018
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.017
calrcalreticulin and calreticulin0.017
tbx5bT-box 5b0.017
sox9aSRY-box containing gene 9a0.017
nppanatriuretic peptide precursor A0.017
gpiaglucose phosphate isomerase a0.017
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.017
clock3clock homolog 3 (mouse)0.016
hsp90a.2heat shock protein 90-alpha 20.016
slc8a4bsolute carrier family 8 (sodium/calcium exchanger), member 4b0.016
foxh1forkhead box H10.015
smad1MAD homolog 1 (Drosophila)0.015
dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.015
elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.015
dlg1discs, large (Drosophila) homolog 10.015
vtg1vitellogenin 10.015
cyp17a1cytochrome P450, family 17, subfamily A, polypeptide 10.015
ripk2receptor-interacting serine-threonine kinase 20.015
cldngclaudin g0.015
hspb12heat shock protein, alpha-crystallin-related, b120.014
dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.014
slc16a3solute carrier family 16 (monocarboxylic acid transporters), member 30.014
plxnb2aplexin b2a0.014
atp1b3bATPase, Na+/K+ transporting, beta 3b polypeptide0.013
crip2cysteine-rich protein 20.013
ef1aelongation factor 1-alpha0.013
unc45bunc-45 homolog B (C. elegans)0.013
lmnalamin A0.013
cldnaclaudin a0.013
igfbp1ainsulin-like growth factor binding protein 1a0.013
tmem88atransmembrane protein 88 a0.013
tbx20T-box 200.012
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.012
edn1endothelin 10.011
mpp1membrane protein, palmitoylated 10.011
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rb1retinoblastoma 10.999
Hdac4histone deacetylase 40.801
FosFBJ osteosarcoma oncogene0.781
Hdac5histone deacetylase 50.570
Manfmesencephalic astrocyte-derived neurotrophic factor0.538
Arandrogen receptor0.534
Ahraryl-hydrocarbon receptor0.498
Mef2cmyocyte enhancer factor 2C0.449
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.446
Mdm4transformed mouse 3T3 cell double minute 40.418
Kiss1KiSS-1 metastasis-suppressor0.413
Apcadenomatosis polyposis coli0.382
Trp53transformation related protein 530.369
Nfe2l2nuclear factor, erythroid derived 2, like 20.345
Lhcgrluteinizing hormone/choriogonadotropin receptor0.293
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.282
Ccnd1cyclin D10.272
Notch1Notch gene homolog 1 (Drosophila)0.242
Apoeapolipoprotein E0.225
Mdm2transformed mouse 3T3 cell double minute 20.211
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.203
Ptgs2prostaglandin-endoperoxide synthase 20.179
Nab2Ngfi-A binding protein 20.166
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.138
Nr4a1nuclear receptor subfamily 4, group A, member 10.138
Trp63transformation related protein 630.136
JunJun oncogene0.130
S100a6S100 calcium binding protein A6 (calcyclin)0.129
Nr3c1nuclear receptor subfamily 3, group C, member 10.126
Crb2crumbs homolog 2 (Drosophila)0.125
Mef2dmyocyte enhancer factor 2D0.118
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.116
Stat3signal transducer and activator of transcription 30.114
Runx1runt related transcription factor 10.110
Esr1estrogen receptor 1 (alpha)0.104
Pdia6protein disulfide isomerase associated 60.101
Kitkit oncogene0.100
Hif1ahypoxia inducible factor 1, alpha subunit0.097
Prdx1peroxiredoxin 10.097
Starsteroidogenic acute regulatory protein0.096
JunbJun-B oncogene0.095
Itgb1integrin beta 1 (fibronectin receptor beta)0.094
H47histocompatibility 470.094
Ppargperoxisome proliferator activated receptor gamma0.089
Dusp1dual specificity phosphatase 10.087
Notch2Notch gene homolog 2 (Drosophila)0.087
Serp1stress-associated endoplasmic reticulum protein 10.084
Klf5Kruppel-like factor 50.083
Zeb2zinc finger E-box binding homeobox 20.081
Ctnnb1catenin (cadherin associated protein), beta 10.078
Hspa5heat shock protein 50.077
Egr2early growth response 20.071
Ostcoligosaccharyltransferase complex subunit0.071
Sdf2l1stromal cell-derived factor 2-like 10.066
Gadd45agrowth arrest and DNA-damage-inducible 45 alpha0.063
Cyp11b1cytochrome P450, family 11, subfamily b, polypeptide 10.063
S100a10S100 calcium binding protein A10 (calpactin)0.061
Morf4l2mortality factor 4 like 20.060
Thbs1thrombospondin 10.058
Thrathyroid hormone receptor alpha0.057
Brca2breast cancer 20.056
Akr1c21aldo-keto reductase family 1, member C210.056
Anxa3annexin A30.054
Pdia3protein disulfide isomerase associated 30.053
Tgfb1transforming growth factor, beta 10.053
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.052
Pdia4protein disulfide isomerase associated 40.051
Aqp8aquaporin 80.051
Lgals1lectin, galactose binding, soluble 10.050
Btg2B-cell translocation gene 2, anti-proliferative0.050
Ptch1patched homolog 10.049
Arf4ADP-ribosylation factor 40.048
Prlrprolactin receptor0.048
WwoxWW domain-containing oxidoreductase0.048
Xbp1X-box binding protein 10.048
Aadacarylacetamide deacetylase (esterase)0.047
Hao2hydroxyacid oxidase 20.045
Kctd12potassium channel tetramerisation domain containing 120.044
Mgat2mannoside acetylglucosaminyltransferase 20.041
Esr2estrogen receptor 2 (beta)0.040
Nfil3nuclear factor, interleukin 3, regulated0.038
Tcf4transcription factor 40.037
Mt2metallothionein 20.037
Hes5hairy and enhancer of split 5 (Drosophila)0.037
3110003A17RikRIKEN cDNA 3110003A17 gene0.036
Stk11serine/threonine kinase 110.036
Irs2insulin receptor substrate 20.036
C9complement component 90.035
Esx1extraembryonic, spermatogenesis, homeobox 10.035
Nfixnuclear factor I/X0.035
Jak2Janus kinase 20.034
Ncoa3nuclear receptor coactivator 30.034
Clic1chloride intracellular channel 10.034
Nf1neurofibromatosis 10.034
Mc2rmelanocortin 2 receptor0.033
Hivep2human immunodeficiency virus type I enhancer binding protein 20.033
Mt1metallothionein 10.032
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism