The network for 'cellular response to heat' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to heat

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

NameDescriptionProbabilityFunc Analog Organism
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.964
FGFR2fibroblast growth factor receptor 20.959
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.795
FGF1fibroblast growth factor 1 (acidic)0.716
HSPA1Bheat shock 70kDa protein 1B0.626
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.577
HSPA1Aheat shock 70kDa protein 1A0.498
NOSTRINnitric oxide synthase trafficker0.440
RBBP4retinoblastoma binding protein 40.404
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.378
MAPK14mitogen-activated protein kinase 140.372
FGFR1fibroblast growth factor receptor 10.344
FKBP4FK506 binding protein 4, 59kDa0.298
HDAC1histone deacetylase 10.296
HSPH1heat shock 105kDa/110kDa protein 10.279
SIN3ASIN3 homolog A, transcription regulator (yeast)0.258
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.252
MAP2K4mitogen-activated protein kinase kinase 40.238
DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 10.237
HSPA8heat shock 70kDa protein 80.226
ARRB2arrestin, beta 20.208
MAP3K1mitogen-activated protein kinase kinase kinase 10.182
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.166
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.163
IL1R1interleukin 1 receptor, type I0.157
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.157
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.151
BAG3BCL2-associated athanogene 30.132
PPP5Cprotein phosphatase 5, catalytic subunit0.129
JUNjun proto-oncogene0.107
HSPB1heat shock 27kDa protein 10.106
NR2E3nuclear receptor subfamily 2, group E, member 30.096
NUP98nucleoporin 98kDa0.095
IRAK2interleukin-1 receptor-associated kinase 20.094
FGF10fibroblast growth factor 100.091
RBBP7retinoblastoma binding protein 70.089
STIP1stress-induced-phosphoprotein 10.089
CACYBPcalcyclin binding protein0.072
VCPvalosin containing protein0.066
DAPK1death-associated protein kinase 10.064
NXF1nuclear RNA export factor 10.057
PTGES3prostaglandin E synthase 3 (cytosolic)0.053
TRAF6TNF receptor-associated factor 60.052
HDAC2histone deacetylase 20.049
NCOR1nuclear receptor corepressor 10.048
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.047
CREBBPCREB binding protein0.043
SQSTM1sequestosome 10.042
SAP30Sin3A-associated protein, 30kDa0.041
XIAPX-linked inhibitor of apoptosis0.039
SMURF1SMAD specific E3 ubiquitin protein ligase 10.039
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.037
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.037
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.033
PDCD6IPprogrammed cell death 6 interacting protein0.031
UBE2Wubiquitin-conjugating enzyme E2W (putative)0.031
CPNE6copine VI (neuronal)0.030
TOP1topoisomerase (DNA) I0.028
CDC37cell division cycle 37 homolog (S. cerevisiae)0.028
PELI3pellino homolog 3 (Drosophila)0.027
ATF2activating transcription factor 20.024
MAP3K7mitogen-activated protein kinase kinase kinase 70.023
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.023
CXCL11chemokine (C-X-C motif) ligand 110.023
IL1RAPinterleukin 1 receptor accessory protein0.022
MAPK1mitogen-activated protein kinase 10.021
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.021
TP53tumor protein p530.020
SH3RF3SH3 domain containing ring finger 30.020
UBE2E1ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)0.020
FHL2four and a half LIM domains 20.020
BAG1BCL2-associated athanogene0.019
PKN1protein kinase N10.019
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.019
MAP3K2mitogen-activated protein kinase kinase kinase 20.019
PPIDpeptidylprolyl isomerase D0.018
FGF7fibroblast growth factor 70.017
IL1RNinterleukin 1 receptor antagonist0.016
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.016
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.015
HSPB8heat shock 22kDa protein 80.015
DUSP1dual specificity phosphatase 10.014
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.014
EEDembryonic ectoderm development0.014
ARRB1arrestin, beta 10.014
MAPKAPK3mitogen-activated protein kinase-activated protein kinase 30.013
C16orf70chromosome 16 open reading frame 700.013
NQO1NAD(P)H dehydrogenase, quinone 10.013
NEDD4neural precursor cell expressed, developmentally down-regulated 40.013
MYD88myeloid differentiation primary response gene (88)0.013
TRIM39tripartite motif containing 390.012
SH3KBP1SH3-domain kinase binding protein 10.012
EP300E1A binding protein p3000.012
IRAK3interleukin-1 receptor-associated kinase 30.012
NCF2neutrophil cytosolic factor 20.011
MTA3metastasis associated 1 family, member 30.011
FLNBfilamin B, beta0.011
XPO7exportin 70.011
SART3squamous cell carcinoma antigen recognized by T cells 30.011
TOMM34translocase of outer mitochondrial membrane 340.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Hsp70AaHeat-shock-protein-70Aa0.998
Hsp70AbHeat-shock-protein-70Ab0.997
Hsp68Heat shock protein 680.993
Mekk1CG7717 gene product from transcript CG7717-RB0.992
Hsp70BaHeat-shock-protein-70Ba0.711
Hsp70BcHeat-shock-protein-70Bc0.464
stvstarvin0.384
Hsp27Heat shock protein 270.271
Trap1CG3152 gene product from transcript CG3152-RA0.243
Hsp26Heat shock protein 260.240
Hsp70BbbCG5834 gene product from transcript CG5834-RA0.206
AceAcetylcholine esterase0.166
sec8CG2095 gene product from transcript CG2095-RA0.153
kat-60L1katanin p60-like 10.142
sec6CG5341 gene product from transcript CG5341-RA0.124
rlrolled0.121
PargPoly(ADP-ribose) glycohydrolase0.114
MTF-1Metal response element-binding Transcription Factor-10.110
Hsp70BbHeat-shock-protein-70Bb0.110
RanBPMRan-binding protein M0.103
iavinactive0.102
HisCl1Histamine-gated chloride channel subunit 10.095
yuriyuri gagarin0.088
certceramide transfer protein0.086
Mpk2CG5475 gene product from transcript CG5475-RB0.085
CatCatalase0.084
DnaJ-1DnaJ-like-10.083
RicRas which interacts with Calmodulin0.083
liclicorne0.081
Top2Topoisomerase 20.078
NLazNeural Lazarillo0.077
scnyscrawny0.077
Zasp52Z band alternatively spliced PDZ-motif protein 520.077
ParpPoly-(ADP-ribose) polymerase0.073
CG17826CG17826 gene product from transcript CG17826-RA0.071
Dcp-1Death caspase-10.069
chicoCG5686 gene product from transcript CG5686-RB0.061
CG12370CG12370 gene product from transcript CG12370-RB0.060
Vrp1Verprolin 10.059
PP2A-B'CG7913 gene product from transcript CG7913-RK0.059
Hsc70-2Heat shock protein cognate 20.057
spzspatzle0.054
Gr39aGustatory receptor 39a0.053
Ilp6Insulin-like peptide 60.052
EndoGEndonuclease G0.046
marsCG17064 gene product from transcript CG17064-RB0.045
CG1129CG1129 gene product from transcript CG1129-RC0.043
CG4836CG4836 gene product from transcript CG4836-RC0.042
CG42700CG42700 gene product from transcript CG42700-RC0.040
5-HT1ASerotonin receptor 1A0.040
Cyp6g1CG8453 gene product from transcript CG8453-RA0.039
TotCTurandot C0.039
Hsp23Heat shock protein 230.037
Hsc70-1Heat shock protein cognate 10.036
yellow-gCG5717 gene product from transcript CG5717-RA0.034
CG6418CG6418 gene product from transcript CG6418-RB0.033
Vps16AVacuolar protein sorting 16A0.029
CG2469CG2469 gene product from transcript CG2469-RB0.029
AtuAnother transcription unit0.028
CG3759CG3759 gene product from transcript CG3759-RB0.028
SKIPShal K[+] channel interacting protein0.027
Atf-2Activating transcription factor-20.027
eIF-4aEukaryotic initiation factor 4a0.027
CG18094CG18094 gene product from transcript CG18094-RA0.027
alpha-Est7alpha-Esterase-70.027
CG11501CG11501 gene product from transcript CG11501-RA0.026
RopRas opposite0.026
htshu li tai shao0.026
CG10164CG10164 gene product from transcript CG10164-RB0.026
CG3011CG3011 gene product from transcript CG3011-RA0.025
CG6486CG6486 gene product from transcript CG6486-RA0.025
Hr96Hormone receptor-like in 960.025
mei-P26CG12218 gene product from transcript CG12218-RA0.024
Mt2Methyltransferase 20.024
CG12680CG12680 gene product from transcript CG12680-RB0.024
TotATurandot A0.023
JheJuvenile hormone esterase0.023
Sry-alphaSerendipity alpha0.022
bdgbedraggled0.022
CG3085CG3085 gene product from transcript CG3085-RA0.021
foxoforkhead box, sub-group O0.021
DAAMDishevelled Associated Activator of Morphogenesis0.021
dalaoCG7055 gene product from transcript CG7055-RA0.021
Cwc25CG2843 gene product from transcript CG2843-RA0.021
CG14829CG14829 gene product from transcript CG14829-RB0.021
dnr1defense repressor 10.020
Ilp2Insulin-like peptide 20.020
CG8813CG8813 gene product from transcript CG8813-RA0.020
CG3638CG3638 gene product from transcript CG3638-RE0.019
twinCG31137 gene product from transcript CG31137-RB0.019
GRHRGonadotropin-releasing hormone receptor0.019
Nup98Nucleoporin 980.019
bossbride of sevenless0.019
Spf45CG17540 gene product from transcript CG17540-RB0.019
CG11674CG11674 gene product from transcript CG11674-RA0.019
CG2118CG2118 gene product from transcript CG2118-RB0.019
CG8709CG8709 gene product from transcript CG8709-RK0.018
Hsp67BbHeat shock gene 67Bb0.018
capaRcapa receptor0.017
neroCG2245 gene product from transcript CG2245-RA0.017
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hspa8heat shock protein 80.265
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.203
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.182
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.154
Hsph1heat shock 105kDa/110kDa protein 10.123
Trp53transformation related protein 530.089
Rac1RAS-related C3 botulinum substrate 10.054
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.045
Ptenphosphatase and tensin homolog0.040
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.039
Atf2activating transcription factor 20.029
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.022
Ahi1Abelson helper integration site 10.016
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.016
Anxa1annexin A10.015
Hdac1histone deacetylase 10.015
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.015
Cacybpcalcyclin binding protein0.015
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.014
Kitkit oncogene0.014
Mknk2MAP kinase-interacting serine/threonine kinase 20.013
Lifleukemia inhibitory factor0.013
Lrpprcleucine-rich PPR-motif containing0.013
Ptges3prostaglandin E synthase 3 (cytosolic)0.013
Mbmyoglobin0.012
Hspa5heat shock protein 50.011
Cldn16claudin 160.011
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.011
Rgs12regulator of G-protein signaling 120.010
Iqcb1IQ calmodulin-binding motif containing 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.078
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.057
Hsph1heat shock 105/110 protein 10.046
Stip1stress-induced phosphoprotein 10.044
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.031
Hspd1heat shock protein 1 (chaperonin)0.029
Cxcl10chemokine (C-X-C motif) ligand 100.028
Il1binterleukin 1 beta0.026
Socs3suppressor of cytokine signaling 30.025
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.019
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.018
Igsf6immunoglobulin superfamily, member 60.018
Ccl2chemokine (C-C motif) ligand 20.016
Fosl1fos-like antigen 10.015
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.015
Ubbubiquitin B0.014
SsbSjogren syndrome antigen B0.014
Galnt10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)0.014
Mapk1mitogen activated protein kinase 10.014
Il6interleukin 60.013
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.013
Ube2d2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.013
Hspb1heat shock protein 10.012
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.012
St13suppression of tumorigenicity 130.011
Ccl4chemokine (C-C motif) ligand 40.011
Icam1intercellular adhesion molecule 10.010
Cxcl2chemokine (C-X-C motif) ligand 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PBS2Pbs2p0.716
SSK2Ssk2p0.642
STI1Sti1p0.592
AHA1Aha1p0.527
HSP42Hsp42p0.522
BTN2Btn2p0.521
SSK1Ssk1p0.476
CPR6Cpr6p0.464
MOB1Mob1p0.456
HSP104Hsp104p0.423
SSA4Ssa4p0.405
NUP100Nup100p0.396
SSE1Sse1p0.349
YDJ1Ydj1p0.338
GLN3Gln3p0.248
STE5Ste5p0.247
STE11Ste11p0.233
RPD3Rpd3p0.219
SIN3Sin3p0.219
CTI6Cti6p0.201
MSN2Msn2p0.173
TPS1Tps1p0.171
SSE2Sse2p0.149
KIC1Kic1p0.148
NUP157Nup157p0.147
NUP170Nup170p0.145
OPY2Opy2p0.145
CLA4Cla4p0.144
SSA2Ssa2p0.143
GLE1Gle1p0.140
NUP145Nup145p0.134
RPB3Rpb3p0.129
RXT3Rxt3p0.118
NUP49Nup49p0.118
HSP26Hsp26p0.116
MBR1Mbr1p0.115
MIG1Mig1p0.114
BUR6Bur6p0.108
HSP31Hsp31p0.107
NUP120Nup120p0.105
HSC82Hsc82p0.103
FES1Fes1p0.101
DOT6Dot6p0.098
NUP116Nup116p0.095
STD1Std1p0.092
EBS1Ebs1p0.091
SIS1Sis1p0.091
PST1Pst1p0.089
HSF1Hsf1p0.087
MOT1Mot1p0.087
NBP2Nbp2p0.086
KAP95Kap95p0.086
YKR075Chypothetical protein0.085
NRG1Nrg1p0.085
MSN5Msn5p0.084
HAL5Hal5p0.084
ASH1Ash1p0.083
PHM8Phm8p0.083
NUP53Nup53p0.081
RIA1Ria1p0.081
HXT3Hxt3p0.081
HSP10Hsp10p0.079
TPO2Tpo2p0.077
RXT2Rxt2p0.075
HCH1Hch1p0.074
UME1Ume1p0.074
YPL014Whypothetical protein0.068
MOT3Mot3p0.067
SIN4Sin4p0.067
NAP1Nap1p0.066
RIM101Rim101p0.065
MKK2Mkk2p0.063
PTK2Ptk2p0.063
MSC1Msc1p0.063
CUP9Cup9p0.063
MMS22Mms22p0.062
CTK3Ctk3p0.061
POM152Pom152p0.061
GIS1Gis1p0.060
NUP82Nup82p0.058
UTP20Utp20p0.056
SSA3Ssa3p0.056
SHC1Shc1p0.054
GAL11Gal11p0.054
YRO2Yro2p0.053
NTO1Nto1p0.053
RCO1Rco1p0.052
SPT8Spt8p0.052
ASM4Asm4p0.052
CTT1Ctt1p0.051
ARP8Arp8p0.051
KAP120Kap120p0.050
SIR2Sir2p0.050
ICY1Icy1p0.050
YPR157Whypothetical protein0.050
KIN3Kin3p0.050
SGF29Sgf29p0.047
VPS75Vps75p0.047
UME6Ume6p0.046
FLO9Flo9p0.046