The network for 'base excision repair' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

base excision repair

In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

NameDescriptionProbabilityFunc Analog Organism
RPA1replication protein A1, 70kDa1.000
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.999
PARP1poly (ADP-ribose) polymerase 10.995
RPA2replication protein A2, 32kDa0.992
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.986
PCNAproliferating cell nuclear antigen0.935
MDC1mediator of DNA-damage checkpoint 10.928
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.887
BLMBloom syndrome, RecQ helicase-like0.869
CHAF1Achromatin assembly factor 1, subunit A (p150)0.865
WRNWerner syndrome, RecQ helicase-like0.847
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.797
H2AFXH2A histone family, member X0.795
APTXaprataxin0.516
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.514
RPA3replication protein A3, 14kDa0.470
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.463
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.461
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.459
MSH6mutS homolog 6 (E. coli)0.346
APEX1APEX nuclease (multifunctional DNA repair enzyme) 10.342
UNGuracil-DNA glycosylase0.327
CDT1chromatin licensing and DNA replication factor 10.319
ARID1BAT rich interactive domain 1B (SWI1-like)0.221
FANCD2Fanconi anemia, complementation group D20.218
PNKPpolynucleotide kinase 3'-phosphatase0.202
XAB2XPA binding protein 20.177
SMC1Astructural maintenance of chromosomes 1A0.163
LIG1ligase I, DNA, ATP-dependent0.150
RCC1regulator of chromosome condensation 10.148
BRCA1breast cancer 1, early onset0.145
CBX1chromobox homolog 10.144
FANCEFanconi anemia, complementation group E0.141
CDCA7cell division cycle associated 70.130
LIG3ligase III, DNA, ATP-dependent0.117
BRCA2breast cancer 2, early onset0.114
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.103
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.101
PIAS4protein inhibitor of activated STAT, 40.099
ARID1AAT rich interactive domain 1A (SWI-like)0.098
HMGN2high mobility group nucleosomal binding domain 20.095
TIMELESStimeless homolog (Drosophila)0.089
OPTNoptineurin0.088
TDP1tyrosyl-DNA phosphodiesterase 10.083
ING2inhibitor of growth family, member 20.080
APLFaprataxin and PNKP like factor0.078
HMGB1high mobility group box 10.064
RAD52RAD52 homolog (S. cerevisiae)0.062
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.061
RFC2replication factor C (activator 1) 2, 40kDa0.057
MECP2methyl CpG binding protein 2 (Rett syndrome)0.053
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.052
HMGB2high mobility group box 20.051
KIF22kinesin family member 220.046
BRIP1BRCA1 interacting protein C-terminal helicase 10.043
POLE2polymerase (DNA directed), epsilon 2 (p59 subunit)0.041
CDK2cyclin-dependent kinase 20.040
ERCC8excision repair cross-complementing rodent repair deficiency, complementation group 80.039
FKBP3FK506 binding protein 3, 25kDa0.038
PRMT6protein arginine methyltransferase 60.038
MUS81MUS81 endonuclease homolog (S. cerevisiae)0.038
FANCGFanconi anemia, complementation group G0.038
CBX5chromobox homolog 50.038
XPAxeroderma pigmentosum, complementation group A0.037
HMGA1high mobility group AT-hook 10.034
HMGN1high mobility group nucleosome binding domain 10.033
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.033
MUTYHmutY homolog (E. coli)0.032
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.030
PTMAprothymosin, alpha0.030
PGAM1phosphoglycerate mutase 1 (brain)0.030
CHEK2CHK2 checkpoint homolog (S. pombe)0.030
DNMT1DNA (cytosine-5-)-methyltransferase 10.030
EXO1exonuclease 10.029
POLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDa0.028
CHEK1CHK1 checkpoint homolog (S. pombe)0.028
NUDT1nudix (nucleoside diphosphate linked moiety X)-type motif 10.027
TOP1topoisomerase (DNA) I0.027
TOP2Atopoisomerase (DNA) II alpha 170kDa0.027
HMGB3high mobility group box 30.027
DUTdeoxyuridine triphosphatase0.026
USP4ubiquitin specific peptidase 4 (proto-oncogene)0.026
RAD18RAD18 homolog (S. cerevisiae)0.026
FEN1flap structure-specific endonuclease 10.026
KIAA0101KIAA01010.025
H2AFVH2A histone family, member V0.025
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.024
HNRNPABheterogeneous nuclear ribonucleoprotein A/B0.023
SP1Sp1 transcription factor0.022
DTLdenticleless homolog (Drosophila)0.022
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.022
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.021
MMS19MMS19 nucleotide excision repair homolog (S. cerevisiae)0.021
PRDX6peroxiredoxin 60.021
STMN1stathmin 10.020
PPP1R14Aprotein phosphatase 1, regulatory (inhibitor) subunit 14A0.020
IKIK cytokine, down-regulator of HLA II0.020
RFWD3ring finger and WD repeat domain 30.019
RAD50RAD50 homolog (S. cerevisiae)0.019
CLSPNclaspin0.019
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
rpa-2Protein RPA-20.067
F52C12.1Protein F52C12.10.049
CELE_K08F4.1Protein K08F4.10.039
lig-1Protein LIG-10.031
C24F3.2Protein C24F3.20.029
dog-1Protein DOG-10.029
zyg-9Protein ZYG-90.026
isw-1Protein ISW-10.026
C01H6.9Protein C01H6.90.025
C48B6.3Protein C48B6.30.019
ndc-80Protein NDC-800.019
CELE_F10C5.2Protein F10C5.20.019
rod-1Protein ROD-10.019
Y48G1C.1Protein Y48G1C.10.018
polh-1Protein POLH-10.018
R10H10.7Protein R10H10.70.018
F56D2.2Protein F56D2.20.017
smc-5Protein SMC-50.017
crn-1Protein CRN-10.017
lin-9Protein LIN-90.015
CELE_C49F5.6Protein C49F5.60.015
F33H2.3Protein F33H2.30.015
coh-3Protein COH-30.014
klp-19Protein KLP-190.014
dsh-2Protein DSH-20.014
dnj-23Protein DNJ-230.014
dna-2Protein DNA-20.014
mfap-1Protein MFAP-10.014
cin-4Protein CIN-40.014
Y110A7A.9Protein Y110A7A.90.014
mcm-4Protein MCM-40.013
him-18Protein HIM-180.013
wee-1.3Protein WEE-1.30.013
pme-1Protein PME-10.013
aka-1Protein AKA-10.013
T24D1.2Protein T24D1.20.012
wago-9Protein WAGO-90.012
M01E11.2Protein M01E11.20.012
nra-1Protein NRA-10.012
nasp-1Protein NASP-10.012
H06I04.1Protein H06I04.10.012
nipi-3Protein NIPI-30.012
ima-2Protein IMA-20.012
F22G12.5Protein F22G12.50.012
npp-15Protein NPP-150.012
emb-27Protein EMB-270.012
ZK1098.1Protein ZK1098.10.012
kin-4Protein KIN-40.012
H21P03.2Protein H21P03.20.012
F54E12.2Protein F54E12.20.011
evl-14Protein EVL-140.011
CELE_C50F4.16Protein C50F4.160.011
Y59E9AL.4Protein Y59E9AL.40.011
cku-80Protein CKU-800.011
rde-4Protein RDE-40.011
rbg-2Protein RBG-20.011
inx-8Protein INX-80.011
D2096.11Protein D2096.110.011
cdt-2Protein CDT-20.011
cdc-7Protein CDC-70.011
CELE_R02D3.4Protein R02D3.40.011
szy-20Protein SZY-200.011
F10C2.4Protein F10C2.40.010
C27F2.7Protein C27F2.70.010
capg-2Protein CAPG-20.010
sgo-1Protein SGO-10.010
usp-48Protein USP-480.010
rad-50Protein RAD-500.010
R11A8.2Protein R11A8.20.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
armarmadillo0.052
modmodulo0.039
bskbasket0.034
Rho1CG8416 gene product from transcript CG8416-RB0.025
DlDelta0.021
CoVaCytochrome c oxidase subunit Va0.019
Rpb10CG13628 gene product from transcript CG13628-RA0.018
brmbrahma0.017
CG11980CG11980 gene product from transcript CG11980-RB0.017
EgfrEpidermal growth factor receptor0.016
dppdecapentaplegic0.016
FibFibrillarin0.016
nosnanos0.016
CG8928CG8928 gene product from transcript CG8928-RA0.015
CG3192CG3192 gene product from transcript CG3192-RA0.015
Rac1CG2248 gene product from transcript CG2248-RA0.015
wgwingless0.014
CG2862CG2862 gene product from transcript CG2862-RA0.014
mysmyospheroid0.014
RpL14Ribosomal protein L140.014
Rpb5CG11979 gene product from transcript CG11979-RA0.014
fufused0.013
rhorhomboid0.012
OscpOligomycin sensitivity-conferring protein0.012
CG11583CG11583 gene product from transcript CG11583-RA0.012
tkvthickveins0.012
TfIIA-STranscription-factor-IIA-S0.012
eIF-3p40Eukaryotic initiation factor 3 p40 subunit0.012
CG9172CG9172 gene product from transcript CG9172-RA0.011
Ras85DRas oncogene at 85D0.011
CG1707CG1707 gene product from transcript CG1707-RA0.011
diadiaphanous0.010
Spase12Spase 12-subunit0.010
CG8386CG8386 gene product from transcript CG8386-RA0.010
NHP2CG5258 gene product from transcript CG5258-RA0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Timelesstimeless homolog (Drosophila)0.883
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.818
Arid1bAT rich interactive domain 1B (SWI-like)0.621
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.611
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.589
Gmnngeminin0.576
Cdt1chromatin licensing and DNA replication factor 10.483
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.405
Dnajc9DnaJ (Hsp40) homolog, subfamily C, member 90.367
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.296
Dnmt1DNA methyltransferase (cytosine-5) 10.195
Trp53transformation related protein 530.156
Ezh2enhancer of zeste homolog 2 (Drosophila)0.143
Nup85nucleoporin 850.137
E2f1E2F transcription factor 10.131
Eftud2elongation factor Tu GTP binding domain containing 20.122
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.109
Nbnnibrin0.102
Tipintimeless interacting protein0.099
Mlh1mutL homolog 1 (E. coli)0.094
Rb1retinoblastoma 10.089
Rfc1replication factor C (activator 1) 10.087
Ube2tubiquitin-conjugating enzyme E2T (putative)0.087
Prim1DNA primase, p49 subunit0.085
Topbp1topoisomerase (DNA) II binding protein 10.084
Cdk4cyclin-dependent kinase 40.075
Mdm4transformed mouse 3T3 cell double minute 40.075
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.073
Rpa1replication protein A10.071
Slbpstem-loop binding protein0.070
Rfc2replication factor C (activator 1) 20.070
Gm5806predicted gene 58060.067
Hdac1histone deacetylase 10.067
Brca1breast cancer 10.066
Rbl1retinoblastoma-like 1 (p107)0.065
Ncapd2non-SMC condensin I complex, subunit D20.065
Rfc3replication factor C (activator 1) 30.064
Orc6origin recognition complex, subunit 60.062
H2afzH2A histone family, member Z0.057
Lig1ligase I, DNA, ATP-dependent0.057
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.057
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.056
Nup107nucleoporin 1070.053
Parp1poly (ADP-ribose) polymerase family, member 10.052
Fen1flap structure specific endonuclease 10.050
Lrwd1leucine-rich repeats and WD repeat domain containing 10.049
Pcnaproliferating cell nuclear antigen0.049
Msh2mutS homolog 2 (E. coli)0.049
Lbrlamin B receptor0.046
Smarcd3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 30.046
Atmataxia telangiectasia mutated homolog (human)0.045
Actl6aactin-like 6A0.043
Brca2breast cancer 20.043
Hmgb1high mobility group box 10.042
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.040
Haus5HAUS augmin-like complex, subunit 50.040
Dtymkdeoxythymidylate kinase0.038
Mybl2myeloblastosis oncogene-like 20.037
Rfc4replication factor C (activator 1) 40.037
Mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.036
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.036
Parp2poly (ADP-ribose) polymerase family, member 20.035
Cks1bCDC28 protein kinase 1b0.035
Cdca7cell division cycle associated 70.034
Ssrp1structure specific recognition protein 10.032
Srrtserrate RNA effector molecule homolog (Arabidopsis)0.032
Cpsf3cleavage and polyadenylation specificity factor 30.032
Uba2ubiquitin-like modifier activating enzyme 20.031
Anapc5anaphase-promoting complex subunit 50.031
H2afxH2A histone family, member X0.030
Smc2structural maintenance of chromosomes 20.028
Ighimmunoglobulin heavy chain complex0.027
Smarcc2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.027
Siva1SIVA1, apoptosis-inducing factor0.027
Hspa14heat shock protein 140.027
Rfwd3ring finger and WD repeat domain 30.025
Impdh2inosine 5'-phosphate dehydrogenase 20.025
Smc4structural maintenance of chromosomes 40.024
Smarcb1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.022
Xrcc6X-ray repair complementing defective repair in Chinese hamster cells 60.022
Trim28tripartite motif-containing 280.022
Cdca5cell division cycle associated 50.021
Hmgb3high mobility group box 30.021
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.019
Psmg2proteasome (prosome, macropain) assembly chaperone 20.019
Acdadrenocortical dysplasia0.019
Nde1nuclear distribution gene E homolog 1 (A nidulans)0.018
2700029M09RikRIKEN cDNA 2700029M09 gene0.018
Unguracil DNA glycosylase0.018
Noc4lnucleolar complex associated 4 homolog (S. cerevisiae)0.017
Cpsf1cleavage and polyadenylation specific factor 10.016
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.016
Mms22lMMS22-like, DNA repair protein0.016
Rpa2replication protein A20.016
Hmgn1high mobility group nucleosomal binding domain 10.016
Racgap1Rac GTPase-activating protein 10.016
Hat1histone aminotransferase 10.016
Rad50RAD50 homolog (S. cerevisiae)0.015
Pold2polymerase (DNA directed), delta 2, regulatory subunit0.015
Chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.015
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Mcm6minichromosome maintenance complex component 60.067
Mcm2minichromosome maintenance complex component 20.013
Ssrp1structure specific recognition protein 10.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RAD52Rad52p0.206
RAD5Rad5p0.144
PIF1Pif1p0.139
MSH6Msh6p0.115
RAD50Rad50p0.111
RAD59Rad59p0.098
RFA1Rfa1p0.098
POL2Pol2p0.075
POL32Pol32p0.068
SWI1Swi1p0.065
DNA2Dna2p0.056
REV3Rev3p0.048
CDC21Cdc21p0.048
MRC1Mrc1p0.042
DOT1Dot1p0.040
POL30Pol30p0.038
RSC8Rsc8p0.036
ARP7Arp7p0.035
MEC1Mec1p0.035
POL1Pol1p0.032
RFA2Rfa2p0.031
NTG1Ntg1p0.029
TOF1Tof1p0.028
SAE2Sae2p0.027
EST2Est2p0.026
RFA3Rfa3p0.024
TEL1Tel1p0.023
RAD9Rad9p0.021
RAD53Rad53p0.020
SPT16Spt16p0.020
RAD27Rad27p0.019
SWI3Swi3p0.018
EXO1Exo1p0.018
POL12Pol12p0.018
XRS2Xrs2p0.018
SKG6Skg6p0.018
SRD1Srd1p0.017
MMS1Mms1p0.017
RAD26Rad26p0.017
SMC6Smc6p0.017
HOHop0.017
PDS5Pds5p0.016
YLR162Whypothetical protein0.016
MSH3Msh3p0.016
POL3Pol3p0.015
LEU2Leu2p0.015
POL31Pol31p0.015
YOL038C-Ahypothetical protein0.015
HXT3Hxt3p0.015
YLR264C-Ahypothetical protein0.015
MER1Mer1p0.015
ARP10Arp10p0.014
SPL2Spl2p0.014
URA3Ura3p0.014
MSH2Msh2p0.014
YIL151Chypothetical protein0.014
HDA2Hda2p0.014
RAD24Rad24p0.014
SNF11Snf11p0.014
YBL044Whypothetical protein0.013
MRE11Mre11p0.013
YDL156Whypothetical protein0.013
PHM6Phm6p0.013
ZPS1Zps1p0.013
DOP1Dop1p0.013
BLM10Blm10p0.013
YAR068Whypothetical protein0.013
YBR013Chypothetical protein0.013
ATP6Atp6p0.013
RAD1Rad1p0.012
YLR042Chypothetical protein0.012
ARG8Arg8p0.012
YPR157Whypothetical protein0.012
YPL168Whypothetical protein0.012
CUP1-1Cup1-1p0.012
CPD1Cpd1p0.012
YOR378Whypothetical protein0.012
AUA1Aua1p0.012
HHT1Hht1p0.012
YKR075Chypothetical protein0.012
NMA2Nma2p0.012
UPS3Ups3p0.012
HPF1Hpf1p0.012
YOL013W-Ahypothetical protein0.011
FMT1Fmt1p0.011
ADH2Adh2p0.011
PRS2Prs2p0.011
MPH1Mph1p0.011
RTT105Rtt105p0.011
YML053Chypothetical protein0.011
SLN1Sln1p0.011
PCL9Pcl9p0.011
DUN1Dun1p0.011
MGS1Mgs1p0.011
MF(ALPHA)2Mf(alpha)2p0.011
YEH2Yeh2p0.011
REV1Rev1p0.011
SWM2Swm2p0.011
EST1Est1p0.011
PTR2Ptr2p0.011