The network for 'positive regulation of acute inflammatory response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of acute inflammatory response

Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.

NameDescriptionProbabilityFunc Analog Organism
IL8interleukin 81.000
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11.000
PLAURplasminogen activator, urokinase receptor0.999
CXCL2chemokine (C-X-C motif) ligand 20.997
IL1Binterleukin 1, beta0.991
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.988
SYKspleen tyrosine kinase0.988
CCL2chemokine (C-C motif) ligand 20.976
CCR5chemokine (C-C motif) receptor 50.970
CXCL3chemokine (C-X-C motif) ligand 30.963
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.959
IL1R1interleukin 1 receptor, type I0.959
IL6interleukin 6 (interferon, beta 2)0.959
TNFAIP6tumor necrosis factor, alpha-induced protein 60.921
CCL20chemokine (C-C motif) ligand 200.822
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.731
ICAM1intercellular adhesion molecule 10.708
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.706
CCL4chemokine (C-C motif) ligand 40.673
BCL2A1BCL2-related protein A10.635
SRGNserglycin0.610
IL1RNinterleukin 1 receptor antagonist0.585
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.576
IL1RAPinterleukin 1 receptor accessory protein0.512
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.508
CFHcomplement factor H0.448
PLEKpleckstrin0.446
IER3immediate early response 30.401
CCR1chemokine (C-C motif) receptor 10.325
METmet proto-oncogene (hepatocyte growth factor receptor)0.324
PTX3pentraxin 3, long0.315
CFIcomplement factor I0.310
IL6Rinterleukin 6 receptor0.299
VSIG4V-set and immunoglobulin domain containing 40.299
CCL8chemokine (C-C motif) ligand 80.257
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.251
IL7Rinterleukin 7 receptor0.238
APOHapolipoprotein H (beta-2-glycoprotein I)0.232
TNFAIP2tumor necrosis factor, alpha-induced protein 20.226
TLR2toll-like receptor 20.217
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.209
TNFAIP3tumor necrosis factor, alpha-induced protein 30.202
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.193
C1Scomplement component 1, s subcomponent0.180
SLASrc-like-adaptor0.177
CD163CD163 molecule0.173
FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)0.169
CXCL5chemokine (C-X-C motif) ligand 50.167
BLNKB-cell linker0.167
CFBcomplement factor B0.166
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.162
CXCL10chemokine (C-X-C motif) ligand 100.162
C3AR1complement component 3a receptor 10.162
OSMRoncostatin M receptor0.139
SLC2A3solute carrier family 2 (facilitated glucose transporter), member 30.135
SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 20.134
BBS10Bardet-Biedl syndrome 100.128
SOD2superoxide dismutase 2, mitochondrial0.120
LIFleukemia inhibitory factor (cholinergic differentiation factor)0.119
OLR1oxidized low density lipoprotein (lectin-like) receptor 10.119
INHBAinhibin, beta A0.119
F13A1coagulation factor XIII, A1 polypeptide0.117
S100A8S100 calcium binding protein A80.116
TREM1triggering receptor expressed on myeloid cells 10.115
TYROBPTYRO protein tyrosine kinase binding protein0.113
CD53CD53 molecule0.106
ZC3H12Azinc finger CCCH-type containing 12A0.106
RNASE6ribonuclease, RNase A family, k60.101
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.099
UBASH3Bubiquitin associated and SH3 domain containing B0.097
RGS1regulator of G-protein signaling 10.096
NNMTnicotinamide N-methyltransferase0.095
CSF1Rcolony stimulating factor 1 receptor0.094
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.094
S100A9S100 calcium binding protein A90.091
KNG1kininogen 10.091
LMO4LIM domain only 40.090
C1orf93chromosome 1 open reading frame 930.089
DPP4dipeptidyl-peptidase 40.088
TNFRSF9tumor necrosis factor receptor superfamily, member 90.088
CD83CD83 molecule0.088
RGS2regulator of G-protein signaling 2, 24kDa0.087
CXCR4chemokine (C-X-C motif) receptor 40.085
HCKhemopoietic cell kinase0.084
CXCL9chemokine (C-X-C motif) ligand 90.082
THBS1thrombospondin 10.081
TRAF5TNF receptor-associated factor 50.080
PHLDA1pleckstrin homology-like domain, family A, member 10.074
TNCtenascin C0.070
GEMGTP binding protein overexpressed in skeletal muscle0.070
ALOX5AParachidonate 5-lipoxygenase-activating protein0.068
ENTPD1ectonucleoside triphosphate diphosphohydrolase 10.067
FCGR3BFc fragment of IgG, low affinity IIIb, receptor (CD16b)0.066
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.066
CCL7chemokine (C-C motif) ligand 70.063
SELEselectin E0.062
AQP9aquaporin 90.062
RNASE2ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)0.061
C5AR1complement component 5a receptor 10.061
TFPI2tissue factor pathway inhibitor 20.060
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Map3k14mitogen-activated protein kinase kinase kinase 140.991
Tnftumor necrosis factor0.977
Cd44CD44 antigen0.934
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.882
Ccl2chemokine (C-C motif) ligand 20.859
Il4interleukin 40.772
Ifnginterferon gamma0.746
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.742
Ptgs2prostaglandin-endoperoxide synthase 20.662
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.627
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.626
Il1binterleukin 1 beta0.585
Ccr1chemokine (C-C motif) receptor 10.508
Apoeapolipoprotein E0.489
Ccr2chemokine (C-C motif) receptor 20.487
Cd40CD40 antigen0.426
Cxcl13chemokine (C-X-C motif) ligand 130.418
Il1r1interleukin 1 receptor, type I0.395
Cd19CD19 antigen0.382
Tlr4toll-like receptor 40.382
Icosinducible T-cell co-stimulator0.366
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.363
Ptprcprotein tyrosine phosphatase, receptor type, C0.361
Xcr1chemokine (C motif) receptor 10.343
Nos2nitric oxide synthase 2, inducible0.339
Casp4caspase 4, apoptosis-related cysteine peptidase0.333
Ltalymphotoxin A0.298
Selpselectin, platelet0.289
Mmp9matrix metallopeptidase 90.286
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.284
Ccr6chemokine (C-C motif) receptor 60.282
Il10interleukin 100.254
Gpr132G protein-coupled receptor 1320.246
Ighimmunoglobulin heavy chain complex0.245
Lyz2lysozyme 20.216
Myd88myeloid differentiation primary response gene 880.216
Spp1secreted phosphoprotein 10.175
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.174
Ifngr1interferon gamma receptor 10.149
Il6interleukin 60.145
Tlr2toll-like receptor 20.142
Il2rginterleukin 2 receptor, gamma chain0.140
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.136
C3ar1complement component 3a receptor 10.128
Il1ainterleukin 1 alpha0.126
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.126
Cxcr5chemokine (C-X-C motif) receptor 50.125
Ccl3chemokine (C-C motif) ligand 30.125
Ccl4chemokine (C-C motif) ligand 40.123
C5ar1complement component 5a receptor 10.121
Pdcd1programmed cell death 10.118
Klrg1killer cell lectin-like receptor subfamily G, member 10.116
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.115
Ccr5chemokine (C-C motif) receptor 50.115
Slpisecretory leukocyte peptidase inhibitor0.109
Stat3signal transducer and activator of transcription 30.101
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.100
Ltblymphotoxin B0.090
F2rl2coagulation factor II (thrombin) receptor-like 20.089
Il7interleukin 70.089
Ccr3chemokine (C-C motif) receptor 30.089
Plauplasminogen activator, urokinase0.087
Ch25hcholesterol 25-hydroxylase0.083
Irg1immunoresponsive gene 10.081
Cxcr2chemokine (C-X-C motif) receptor 20.081
Ubdubiquitin D0.075
Art2a-psADP-ribosyltransferase 2a, pseudogene0.074
Tgm2transglutaminase 2, C polypeptide0.074
Pik3cgphosphoinositide-3-kinase, catalytic, gamma polypeptide0.074
Cd28CD28 antigen0.073
C3complement component 30.072
Il1rninterleukin 1 receptor antagonist0.072
Casp1caspase 10.069
Icam1intercellular adhesion molecule 10.069
Klrk1killer cell lectin-like receptor subfamily K, member 10.065
FaslFas ligand (TNF superfamily, member 6)0.063
Il27rainterleukin 27 receptor, alpha0.062
MefvMediterranean fever0.061
Efna1ephrin A10.061
BlkB lymphoid kinase0.061
Cst7cystatin F (leukocystatin)0.060
FasFas (TNF receptor superfamily member 6)0.057
Gzmkgranzyme K0.056
Lcklymphocyte protein tyrosine kinase0.056
Ccl8chemokine (C-C motif) ligand 80.056
Cxcl10chemokine (C-X-C motif) ligand 100.055
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.055
Osmroncostatin M receptor0.055
Mcpt8mast cell protease 80.054
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.053
Cxcl2chemokine (C-X-C motif) ligand 20.052
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.052
Cr2complement receptor 20.051
Ccl12chemokine (C-C motif) ligand 120.050
Folr2folate receptor 2 (fetal)0.050
Klrd1killer cell lectin-like receptor, subfamily D, member 10.050
Mplmyeloproliferative leukemia virus oncogene0.049
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.049
Bcl3B-cell leukemia/lymphoma 30.048
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.048
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il1binterleukin 1 beta0.030
Ccl2chemokine (C-C motif) ligand 20.021
Cd14CD14 molecule0.019
Il6interleukin 60.013
Ccl3chemokine (C-C motif) ligand 30.012
Cxcl2chemokine (C-X-C motif) ligand 20.011
Nr4a3nuclear receptor subfamily 4, group A, member 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism