The network for 'peptide hormone secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peptide hormone secretion

The regulated release of a peptide hormone from a cell.

NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.980
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.807
TEKTEK tyrosine kinase, endothelial0.805
PDX1pancreatic and duodenal homeobox 10.799
CCNYcyclin Y0.754
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.725
IL1Binterleukin 1, beta0.708
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.694
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.671
HNF4Ahepatocyte nuclear factor 4, alpha0.663
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.599
CCR5chemokine (C-C motif) receptor 50.561
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.531
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.508
ZFYVE9zinc finger, FYVE domain containing 90.502
PTPN1protein tyrosine phosphatase, non-receptor type 10.476
IL8interleukin 80.474
EP300E1A binding protein p3000.470
CRHR1corticotropin releasing hormone receptor 10.456
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.429
INSRinsulin receptor0.425
NEUROD1neurogenic differentiation 10.387
IL1R1interleukin 1 receptor, type I0.381
HCKhemopoietic cell kinase0.356
CCL2chemokine (C-C motif) ligand 20.346
KCNE1potassium voltage-gated channel, Isk-related family, member 10.344
SETD8SET domain containing (lysine methyltransferase) 80.336
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.329
IGF1Rinsulin-like growth factor 1 receptor0.290
ESRRGestrogen-related receptor gamma0.282
CXCL9chemokine (C-X-C motif) ligand 90.281
MT1Ametallothionein 1A0.272
LIN7Blin-7 homolog B (C. elegans)0.270
CRHcorticotropin releasing hormone0.269
CHD8chromodomain helicase DNA binding protein 80.264
NOSTRINnitric oxide synthase trafficker0.263
ONECUT1one cut homeobox 10.260
HNF1BHNF1 homeobox B0.256
MAP3K5mitogen-activated protein kinase kinase kinase 50.252
MPDZmultiple PDZ domain protein0.240
GABBR1gamma-aminobutyric acid (GABA) B receptor, 10.236
CXCL2chemokine (C-X-C motif) ligand 20.232
SNAP25synaptosomal-associated protein, 25kDa0.231
SHC1SHC (Src homology 2 domain containing) transforming protein 10.217
CCL4chemokine (C-C motif) ligand 40.211
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.198
NKX2-1NK2 homeobox 10.196
FGGfibrinogen gamma chain0.175
CLOCKclock homolog (mouse)0.169
TNFAIP3tumor necrosis factor, alpha-induced protein 30.166
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.163
CCL5chemokine (C-C motif) ligand 50.159
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.155
CDX2caudal type homeobox 20.155
CCL8chemokine (C-C motif) ligand 80.152
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.152
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.150
HLA-DRB5major histocompatibility complex, class II, DR beta 50.144
CHD7chromodomain helicase DNA binding protein 70.143
HNF1AHNF1 homeobox A0.139
IDEinsulin-degrading enzyme0.138
GJD2gap junction protein, delta 2, 36kDa0.133
GRB10growth factor receptor-bound protein 100.131
CRPC-reactive protein, pentraxin-related0.125
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.124
CLASP1cytoplasmic linker associated protein 10.123
CREBBPCREB binding protein0.121
BLNKB-cell linker0.120
BMPR1Bbone morphogenetic protein receptor, type IB0.118
HLA-DMBmajor histocompatibility complex, class II, DM beta0.118
CXCL3chemokine (C-X-C motif) ligand 30.118
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.112
KAT2BK(lysine) acetyltransferase 2B0.111
MEOX1mesenchyme homeobox 10.108
FEVFEV (ETS oncogene family)0.106
AHRaryl hydrocarbon receptor0.102
CCR1chemokine (C-C motif) receptor 10.101
FGAfibrinogen alpha chain0.101
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.100
HLA-DRB4major histocompatibility complex, class II, DR beta 40.100
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.098
SMAD2SMAD family member 20.094
FGF3fibroblast growth factor 30.094
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.092
TCF12transcription factor 120.092
HOXD12homeobox D120.091
POU4F2POU class 4 homeobox 20.089
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.088
TNFtumor necrosis factor0.088
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.086
SREBF2sterol regulatory element binding transcription factor 20.086
PROX1prospero homeobox 10.085
VAC14Vac14 homolog (S. cerevisiae)0.083
NFE2L2nuclear factor (erythroid-derived 2)-like 20.081
GNA13guanine nucleotide binding protein (G protein), alpha 130.077
FOXA2forkhead box A20.077
CCL7chemokine (C-C motif) ligand 70.076
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.076
MTNR1Amelatonin receptor 1A0.076
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
elt-6Protein ELT-60.029
eat-4Protein EAT-40.024
eya-1Protein EYA-10.023
rsd-3Protein RSD-30.022
daf-11Protein DAF-110.022
lin-7Protein LIN-70.021
F53F10.2Protein F53F10.20.021
hif-1Protein HIF-10.020
ref-1Protein REF-10.019
lit-1Protein LIT-10.019
ant-1.1Protein ANT-1.10.019
dhhc-2Protein DHHC-20.018
mab-9Protein MAB-90.017
kin-29Protein KIN-290.017
mth-2Protein MTH-20.017
C15C8.1Protein C15C8.10.017
nrx-1Protein NRX-10.016
lin-11Protein LIN-110.016
ptl-1Protein PTL-10.016
ncs-2Protein NCS-20.016
pry-1Protein PRY-10.016
CELE_Y41E3.3Protein Y41E3.30.016
F13H6.5Protein F13H6.50.016
fox-1Protein FOX-10.015
F28E10.1Protein F28E10.10.015
nhr-100Protein NHR-1000.015
myo-6Protein MYO-60.015
aak-2Protein AAK-20.015
cdka-1Protein CDKA-10.015
unc-86Protein UNC-860.015
tmbi-4Protein TMBI-40.015
flh-2Protein FLH-20.015
ten-1Protein TEN-10.014
F54G2.1Protein F54G2.10.014
daf-12Protein DAF-120.014
T27A3.1Protein T27A3.10.014
rgs-6Protein RGS-60.014
F10D7.5Protein F10D7.50.014
CELE_F10G7.5Protein F10G7.50.014
ist-1Protein IST-10.014
eat-6Protein EAT-60.014
tbc-16Protein TBC-160.013
aldo-2Protein ALDO-20.013
CELE_W05H12.1Protein W05H12.10.013
lin-48Protein LIN-480.013
egl-5Protein EGL-50.013
magi-1Protein MAGI-10.013
unc-9Protein UNC-90.013
ldh-1Protein LDH-10.013
nhr-35Protein NHR-350.013
qui-1Protein QUI-10.013
unc-32Protein UNC-320.012
ZC449.3Protein ZC449.30.012
lap-2Protein LAP-20.012
nhr-32Protein NHR-320.012
W07G4.5Protein W07G4.50.012
clp-1Protein CLP-10.012
nhr-67Protein NHR-670.012
F46H5.3Protein F46H5.30.012
ztf-2Protein ZTF-20.012
Y55D5A.1Protein Y55D5A.10.012
ncs-5Protein NCS-50.012
nmur-3Protein NMUR-30.012
fkh-9Protein FKH-90.012
F55H12.3Protein F55H12.30.012
unc-43Protein UNC-430.012
CELE_C33D9.3Protein C33D9.30.012
bed-2Protein BED-20.012
unc-41Protein UNC-410.012
pll-1Protein PLL-10.012
F55C12.5Protein F55C12.50.012
tag-275Protein TAG-2750.012
C49A9.5Protein C49A9.50.012
egal-1Protein EGAL-10.012
CELE_Y47G6A.18Protein Y47G6A.180.012
CELE_F47G4.4Protein F47G4.40.011
egl-18Protein EGL-180.011
attf-4Protein ATTF-40.011
moe-3Protein MOE-30.011
unc-62Protein UNC-620.011
unc-77Protein UNC-770.011
trp-1Protein TRP-10.011
C16B8.4Protein C16B8.40.011
egl-8Protein EGL-80.011
daf-4Protein DAF-40.011
rpy-1Protein RPY-10.011
ptr-9Protein PTR-90.011
unc-94Protein UNC-940.011
K02G10.1Protein K02G10.10.011
C45G7.4Protein C45G7.40.011
ztf-16Protein ZTF-160.011
unc-54Protein UNC-540.011
cdc-42Protein CDC-420.011
glb-3Protein GLB-30.011
syd-1Protein SYD-10.011
unc-10Protein UNC-100.011
T15B12.1Protein T15B12.10.011
F09F9.4Protein F09F9.40.011
sel-7Protein SEL-70.011
nlp-16Protein NLP-160.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Plc21CPhospholipase C at 21C0.033
ShawShaker cognate w0.032
unc-13CG2999 gene product from transcript CG2999-RA0.025
DatDopamine N acetyltransferase0.023
witwishful thinking0.018
Eip63F-1Ecdysone-induced protein 63F 10.018
Irk3Inwardly rectifying potassium channel 30.016
Unc-76CG3981 gene product from transcript CG3981-RB0.015
Pka-C1cAMP-dependent protein kinase 10.013
Atg9Autophagy-specific gene 90.012
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.012
CG6490CG6490 gene product from transcript CG6490-RB0.011
Mmp2Matrix metalloproteinase 20.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gata4GATA binding protein 40.972
Drd2dopamine receptor D20.923
Nos3nitric oxide synthase 3, endothelial cell0.914
Ptpn11protein tyrosine phosphatase, non-receptor type 110.902
Pax2paired box gene 20.881
Per2period homolog 2 (Drosophila)0.823
Arntlaryl hydrocarbon receptor nuclear translocator-like0.791
Tgfb2transforming growth factor, beta 20.782
Foxc1forkhead box C10.782
Ctnnb1catenin (cadherin associated protein), beta 10.766
Lhx3LIM homeobox protein 30.719
Foxa2forkhead box A20.706
Rargretinoic acid receptor, gamma0.702
Pdx1pancreatic and duodenal homeobox 10.699
Efnb2ephrin B20.688
Gli3GLI-Kruppel family member GLI30.676
Ptenphosphatase and tensin homolog0.670
Axin1axin 10.668
Nr3c1nuclear receptor subfamily 3, group C, member 10.643
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.632
Insm1insulinoma-associated 10.630
Bmp4bone morphogenetic protein 40.624
Otporthopedia homolog (Drosophila)0.616
Jag1jagged 10.614
Insrinsulin receptor0.607
Eya1eyes absent 1 homolog (Drosophila)0.593
Npy1rneuropeptide Y receptor Y10.586
Vegfavascular endothelial growth factor A0.577
Prox1prospero-related homeobox 10.573
Thrbthyroid hormone receptor beta0.566
Nf1neurofibromatosis 10.564
Pax8paired box gene 80.557
Oprd1opioid receptor, delta 10.557
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.553
Ppargperoxisome proliferator activated receptor gamma0.552
Rxraretinoid X receptor alpha0.539
Ephb2Eph receptor B20.538
Sfrp2secreted frizzled-related protein 20.534
Clockcircadian locomotor output cycles kaput0.522
Cry2cryptochrome 2 (photolyase-like)0.489
Adra2cadrenergic receptor, alpha 2c0.465
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.456
Smad3MAD homolog 3 (Drosophila)0.455
Fgfr2fibroblast growth factor receptor 20.455
Leprleptin receptor0.451
Smad4MAD homolog 4 (Drosophila)0.449
Sstr4somatostatin receptor 40.441
Pbx1pre B-cell leukemia transcription factor 10.427
Fgf8fibroblast growth factor 80.419
Cckbrcholecystokinin B receptor0.410
Fshrfollicle stimulating hormone receptor0.406
Epas1endothelial PAS domain protein 10.393
Nrxn3neurexin III0.388
Shhsonic hedgehog0.388
Syn2synapsin II0.374
Acvr1activin A receptor, type 10.360
Aldoaaldolase A, fructose-bisphosphate0.358
ND6NADH dehydrogenase subunit 60.354
Ern2endoplasmic reticulum (ER) to nucleus signalling 20.354
Gata6GATA binding protein 60.350
Prop1paired like homeodomain factor 10.347
Onecut1one cut domain, family member 10.345
Rims2regulating synaptic membrane exocytosis 20.343
Hoxd13homeobox D130.343
Pim3proviral integration site 30.341
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.340
Isl1ISL1 transcription factor, LIM/homeodomain0.339
Sox4SRY-box containing gene 40.335
Pitx2paired-like homeodomain transcription factor 20.335
Acvr2aactivin receptor IIA0.332
Pax6paired box gene 60.327
Gcgrglucagon receptor0.325
Smad6MAD homolog 6 (Drosophila)0.323
Hand1heart and neural crest derivatives expressed transcript 10.314
Gata5GATA binding protein 50.302
Nrxn1neurexin I0.298
Egfrepidermal growth factor receptor0.297
Apcadenomatosis polyposis coli0.294
Nos2nitric oxide synthase 2, inducible0.293
Tgfbr3transforming growth factor, beta receptor III0.291
Pou3f2POU domain, class 3, transcription factor 20.291
Ppypancreatic polypeptide0.290
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.287
Htr45 hydroxytryptamine (serotonin) receptor 40.286
Chd7chromodomain helicase DNA binding protein 70.283
Sox9SRY-box containing gene 90.283
Tgfbr2transforming growth factor, beta receptor II0.279
Hoxa3homeobox A30.279
Efnb1ephrin B10.278
Hand2heart and neural crest derivatives expressed transcript 20.276
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.273
Wnt4wingless-related MMTV integration site 40.272
Slc22a12solute carrier family 22 (organic anion/cation transporter), member 120.256
Ednraendothelin receptor type A0.254
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Apoa4apolipoprotein A-IV0.368
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.276
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.263
Phkg1phosphorylase kinase, gamma 10.237
Gjd2gap junction protein, delta 20.206
Neurod2neurogenic differentiation 20.174
Glp1rglucagon-like peptide 1 receptor0.170
Abp1amiloride binding protein 1 (amine oxidase, copper-containing)0.149
Chrna7cholinergic receptor, nicotinic, alpha 70.145
Acaa1bacetyl-Coenzyme A acyltransferase 1B0.144
Inhbeinhibin beta E0.143
Unc13cunc-13 homolog C (C. elegans)0.139
Olr1078olfactory receptor 10780.131
Ush1cUsher syndrome 1C homolog (human)0.116
Pcsk1proprotein convertase subtilisin/kexin type 10.116
FevFEV (ETS oncogene family)0.112
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.111
Ptgfrprostaglandin F receptor0.109
G6pcglucose-6-phosphatase, catalytic subunit0.105
Aqp2aquaporin 2 (collecting duct)0.104
Gp2glycoprotein 2 (zymogen granule membrane)0.102
Reg3gregenerating islet-derived 3 gamma0.101
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.099
Mef2dmyocyte enhancer factor 2D0.097
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.097
S100a10S100 calcium binding protein A100.096
Syt4synaptotagmin IV0.091
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.090
Slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.089
Cxcr5chemokine (C-X-C motif) receptor 50.088
Slc28a1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.088
Slc23a3solute carrier family 23 (nucleobase transporters), member 30.087
Arpc1bactin related protein 2/3 complex, subunit 1B0.086
Myl7myosin, light chain 7, regulatory0.086
Pde4dphosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)0.086
Rims1regulating synaptic membrane exocytosis 10.085
Lifrleukemia inhibitory factor receptor alpha0.085
Sox17SRY (sex determining region Y)-box 170.084
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.084
Atp2c2ATPase, Ca++ transporting, type 2C, member 20.083
Esr2estrogen receptor 2 (ER beta)0.082
Ppyr1pancreatic polypeptide receptor 10.081
Pparaperoxisome proliferator activated receptor alpha0.081
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.081
Gucy2fguanylate cyclase 2F0.081
Notch4Notch homolog 4 (Drosophila)0.080
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.079
Pde3aphosphodiesterase 3A, cGMP inhibited0.079
Casp3caspase 30.078
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.078
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.076
Nr5a2nuclear receptor subfamily 5, group A, member 20.075
Fgf18fibroblast growth factor 180.075
Mapk10mitogen activated protein kinase 100.074
Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.074
Grm5glutamate receptor, metabotropic 50.074
Iappislet amyloid polypeptide0.073
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.073
Crhr1corticotropin releasing hormone receptor 10.072
Cgaglycoprotein hormones, alpha polypeptide0.072
Grm6glutamate receptor, metabotropic 60.072
Nrg2neuregulin 20.072
SeboxSEBOX homeobox0.072
Syt1synaptotagmin I0.071
Acsl4acyl-CoA synthetase long-chain family member 40.070
GperG protein-coupled estrogen receptor 10.070
Capza1capping protein (actin filament) muscle Z-line, alpha 10.070
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.070
Tmod2tropomodulin 20.069
Trhr2thyrotropin releasing hormone receptor 20.069
Thrbthyroid hormone receptor beta0.069
Sftpdsurfactant protein D0.068
Neurod1neurogenic differentiation 10.068
Ccr1chemokine (C-C motif) receptor 10.068
Map6microtubule-associated protein 60.068
Grifingalectin-related inter-fiber protein0.068
Galr1galanin receptor 10.067
Il23aInterleukin 23, alpha subunit p190.066
Acrv1acrosomal vesicle protein 10.066
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.065
Cntn5contactin 50.064
Nr1d2nuclear receptor subfamily 1, group D, member 20.064
Hrh3histamine receptor H30.064
Olr1701olfactory receptor 17010.063
Mospd4motile sperm domain containing 40.063
Camk2gcalcium/calmodulin-dependent protein kinase II gamma0.063
RT1-BaRT1 class II, locus Ba0.062
Il1ainterleukin 1 alpha0.062
Dbhdopamine beta-hydroxylase (dopamine beta-monooxygenase)0.062
Epm2aip1EPM2A (laforin) interacting protein 10.061
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.061
Ins2insulin 20.061
Znf483zinc finger protein 4830.061
DbpD site of albumin promoter (albumin D-box) binding protein0.061
Vamp1vesicle-associated membrane protein 10.060
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism