The network for 'response to purine containing compound' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to purine containing compound

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus.

NameDescriptionProbabilityFunc Analog Organism
BRCA1breast cancer 1, early onset0.950
GSTM1glutathione S-transferase mu 10.938
MDM2Mdm2 p53 binding protein homolog (mouse)0.895
DRD2dopamine receptor D20.888
JUNjun proto-oncogene0.878
GSTM2glutathione S-transferase mu 2 (muscle)0.848
RB1retinoblastoma 10.796
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.794
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.774
EGR1early growth response 10.730
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.719
LIN7Blin-7 homolog B (C. elegans)0.628
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.563
FOSFBJ murine osteosarcoma viral oncogene homolog0.522
ANGPT2angiopoietin 20.502
CDK2cyclin-dependent kinase 20.497
KCNE1potassium voltage-gated channel, Isk-related family, member 10.496
NR4A2nuclear receptor subfamily 4, group A, member 20.400
C1Rcomplement component 1, r subcomponent0.394
JUNBjun B proto-oncogene0.385
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.363
NR4A3nuclear receptor subfamily 4, group A, member 30.363
TRPC4transient receptor potential cation channel, subfamily C, member 40.358
FGFR1fibroblast growth factor receptor 10.348
PLAUplasminogen activator, urokinase0.315
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.297
EGR3early growth response 30.294
UHRF2ubiquitin-like with PHD and ring finger domains 20.281
IL6interleukin 6 (interferon, beta 2)0.264
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.256
UHRF1ubiquitin-like with PHD and ring finger domains 10.245
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.225
NR4A1nuclear receptor subfamily 4, group A, member 10.218
PKM2pyruvate kinase, muscle0.207
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.189
DNMT1DNA (cytosine-5-)-methyltransferase 10.186
GSTM4glutathione S-transferase mu 40.186
IGF2insulin-like growth factor 2 (somatomedin A)0.182
IGFBP3insulin-like growth factor binding protein 30.182
CHEK2CHK2 checkpoint homolog (S. pombe)0.180
ITPR2inositol 1,4,5-trisphosphate receptor, type 20.177
ACACAacetyl-CoA carboxylase alpha0.167
NLRC4NLR family, CARD domain containing 40.163
PDLIM7PDZ and LIM domain 7 (enigma)0.161
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.156
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.154
PLATplasminogen activator, tissue0.151
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.150
SOS1son of sevenless homolog 1 (Drosophila)0.150
C3orf15chromosome 3 open reading frame 150.142
PDCD6IPprogrammed cell death 6 interacting protein0.141
NOSTRINnitric oxide synthase trafficker0.141
PRSS2protease, serine, 2 (trypsin 2)0.141
ACVR1Bactivin A receptor, type IB0.137
HDAC2histone deacetylase 20.136
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.135
E2F1E2F transcription factor 10.133
INSRinsulin receptor0.127
PTPN1protein tyrosine phosphatase, non-receptor type 10.125
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.123
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.117
TRPC3transient receptor potential cation channel, subfamily C, member 30.117
ESR1estrogen receptor 10.109
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.105
PHYHIPLphytanoyl-CoA 2-hydroxylase interacting protein-like0.102
PCNAproliferating cell nuclear antigen0.102
PLAURplasminogen activator, urokinase receptor0.101
ATF3activating transcription factor 30.101
RBBP8retinoblastoma binding protein 80.099
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.096
RAP1ARAP1A, member of RAS oncogene family0.093
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.090
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.090
EGR2early growth response 20.088
UBQLN4ubiquilin 40.085
IL8interleukin 80.082
MAPK14mitogen-activated protein kinase 140.081
ESRRGestrogen-related receptor gamma0.079
CAV1caveolin 1, caveolae protein, 22kDa0.076
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.076
CCND3cyclin D30.075
CCND1cyclin D10.074
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.072
SPTBN4spectrin, beta, non-erythrocytic 40.072
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.069
CXCL3chemokine (C-X-C motif) ligand 30.069
ANGPT1angiopoietin 10.067
HBEGFheparin-binding EGF-like growth factor0.066
GRB10growth factor receptor-bound protein 100.065
S100A4S100 calcium binding protein A40.065
NR0B2nuclear receptor subfamily 0, group B, member 20.063
IL1Binterleukin 1, beta0.060
NRIP1nuclear receptor interacting protein 10.060
CHEK1CHK1 checkpoint homolog (S. pombe)0.060
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.057
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.057
CCNE1cyclin E10.057
EGFRepidermal growth factor receptor0.056
BLMBloom syndrome, RecQ helicase-like0.055
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Cyp12a4CG6042 gene product from transcript CG6042-RA0.261
Ugt35aUDP-glycosyltransferase 35a0.184
Cyp6a9Cytochrome P450-6a90.129
Mst57DbMale-specific RNA 57Db0.093
Cyp6a21CG10247 gene product from transcript CG10247-RA0.085
Cyp6a23CG10242 gene product from transcript CG10242-RA0.074
CG12672CG12672 gene product from transcript CG12672-RA0.064
Atg9Autophagy-specific gene 90.059
Cyp4ac1CG14032 gene product from transcript CG14032-RA0.057
p53CG33336 gene product from transcript CG33336-RB0.052
RecQ5homolog of RecQ0.050
Smc5CG32438 gene product from transcript CG32438-RE0.045
rad50CG6339 gene product from transcript CG6339-RD0.044
Cyp12a5CG11821 gene product from transcript CG11821-RA0.044
Gpo-1Glycerophosphate oxidase-10.044
TbhTyramine beta hydroxylase0.043
mus205mutagen-sensitive 2050.040
tipEtemperature-induced paralytic E0.040
gekgenghis khan0.040
NPFR1neuropeptide F receptor0.038
Mekk1CG7717 gene product from transcript CG7717-RB0.038
CalxNa/Ca-exchange protein0.038
Ilp2Insulin-like peptide 20.037
Chrac-14CG13399 gene product from transcript CG13399-RA0.032
LamCLamin C0.031
Cyp28d1CG10833 gene product from transcript CG10833-RA0.030
Gadd45CG11086 gene product from transcript CG11086-RA0.028
CG4239CG4239 gene product from transcript CG4239-RA0.028
mei-9meiotic 90.028
cnkconnector enhancer of ksr0.027
Gapdh1Glyceraldehyde 3 phosphate dehydrogenase 10.027
AdhAlcohol dehydrogenase0.026
CG6834CG6834 gene product from transcript CG6834-RA0.025
MarfMitochondrial assembly regulatory factor0.025
Brca2Breast cancer 2, early onset homolog0.025
mubmushroom-body expressed0.024
Irk2Inwardly rectifying potassium channel 20.023
Gr8aGustatory receptor 8a0.023
Est-QEsterase Q0.022
CG6830CG6830 gene product from transcript CG6830-RA0.022
kibrakibra ortholog0.021
EpacCG34392 gene product from transcript CG34392-RC0.021
IrInwardly rectifying potassium channel0.021
ninaBneither inactivation nor afterpotential B0.020
Adgf-DAdenosine deaminase-related growth factor D0.020
S6kRPS6-p70-protein kinase0.020
CG9772CG9772 gene product from transcript CG9772-RB0.019
ppk25pickpocket 250.019
DhDiuretic hormone0.019
CG2064CG2064 gene product from transcript CG2064-RA0.017
Gr64eGustatory receptor 64e0.017
CG10562CG10562 gene product from transcript CG10562-RA0.017
IhI[[h]] channel0.017
foxoforkhead box, sub-group O0.016
CG3759CG3759 gene product from transcript CG3759-RB0.016
Cyp4p1Cytochrome P450-4p10.016
CG14935CG14935 gene product from transcript CG14935-RA0.016
CG13568CG13568 gene product from transcript CG13568-RG0.016
PoxnPox neuro0.015
Cyp6a13CG2397 gene product from transcript CG2397-RA0.015
Cyp12d1-pCG30489 gene product from transcript CG30489-RA0.015
Gr33aGustatory receptor 33a0.014
Spn43AbSerine protease inhibitor 43Ab0.014
LvpDLarval visceral protein D0.014
BG4CG12297 gene product from transcript CG12297-RA0.014
Obp49aOdorant-binding protein 49a0.014
CG18003CG18003 gene product from transcript CG18003-RA0.013
LnkCG17367 gene product from transcript CG17367-RC0.013
CG4744CG4744 gene product from transcript CG4744-RA0.013
ThorCG8846 gene product from transcript CG8846-RA0.013
sxcsuper sex combs0.013
CG10550CG10550 gene product from transcript CG10550-RB0.013
FatpFatty acid (long chain) transport protein0.013
CG15293CG15293 gene product from transcript CG15293-RA0.012
Irk3Inwardly rectifying potassium channel 30.012
Cyp4e2Cytochrome P450-4e20.012
Ork1Open rectifier K[+] channel 10.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.990
Leprleptin receptor0.908
Scn5asodium channel, voltage-gated, type V, alpha0.782
Cav1caveolin 1, caveolae protein0.780
Ezh2enhancer of zeste homolog 2 (Drosophila)0.770
Hif1ahypoxia inducible factor 1, alpha subunit0.703
Per2period homolog 2 (Drosophila)0.642
Cry2cryptochrome 2 (photolyase-like)0.469
Brca1breast cancer 10.458
Ghrgrowth hormone receptor0.434
Clockcircadian locomotor output cycles kaput0.353
FasFas (TNF receptor superfamily member 6)0.345
Ctnnb1catenin (cadherin associated protein), beta 10.342
Arntlaryl hydrocarbon receptor nuclear translocator-like0.338
Pax8paired box gene 80.264
Ptenphosphatase and tensin homolog0.262
Casp4caspase 4, apoptosis-related cysteine peptidase0.245
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.234
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.225
Stat3signal transducer and activator of transcription 30.225
Vhlvon Hippel-Lindau tumor suppressor0.215
Ptgs2prostaglandin-endoperoxide synthase 20.212
Gdnfglial cell line derived neurotrophic factor0.210
Arandrogen receptor0.207
Per1period homolog 1 (Drosophila)0.205
Vegfavascular endothelial growth factor A0.200
Nos3nitric oxide synthase 3, endothelial cell0.199
Thrbthyroid hormone receptor beta0.198
Egfrepidermal growth factor receptor0.174
Irs2insulin receptor substrate 20.168
Cdk6cyclin-dependent kinase 60.163
Insrinsulin receptor0.161
Selpselectin, platelet0.159
Pax2paired box gene 20.150
Brca2breast cancer 20.143
Slc4a4solute carrier family 4 (anion exchanger), member 40.137
Drd2dopamine receptor D20.132
Nos1nitric oxide synthase 1, neuronal0.129
Plauplasminogen activator, urokinase0.127
Itgb1integrin beta 1 (fibronectin receptor beta)0.124
Il1ainterleukin 1 alpha0.124
Lhx1LIM homeobox protein 10.124
Bcl2B-cell leukemia/lymphoma 20.124
Tbx5T-box 50.122
Notch2Notch gene homolog 2 (Drosophila)0.120
Lhx3LIM homeobox protein 30.120
Gja1gap junction protein, alpha 10.116
Ptpn11protein tyrosine phosphatase, non-receptor type 110.115
Seleselectin, endothelial cell0.109
Cxcl2chemokine (C-X-C motif) ligand 20.109
JunbJun-B oncogene0.107
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.106
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.104
Pdx1pancreatic and duodenal homeobox 10.103
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.101
Ins2insulin II0.097
Gbp5guanylate binding protein 50.094
Apcadenomatosis polyposis coli0.092
Ush1gUsher syndrome 1G homolog (human)0.091
Hprthypoxanthine guanine phosphoribosyl transferase0.088
Cdx2caudal type homeobox 20.086
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.085
Lyz2lysozyme 20.085
Fgf2fibroblast growth factor 20.083
Wnt4wingless-related MMTV integration site 40.082
Il1r1interleukin 1 receptor, type I0.081
Atmataxia telangiectasia mutated homolog (human)0.079
Hspa5heat shock protein 50.078
Inhbainhibin beta-A0.076
Egr2early growth response 20.075
Cdh23cadherin 23 (otocadherin)0.074
Egr1early growth response 10.072
Dusp1dual specificity phosphatase 10.072
Otcornithine transcarbamylase0.069
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.069
Cry1cryptochrome 1 (photolyase-like)0.066
LOC100503041PDZ domain-containing protein 7-like0.065
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.063
Il1binterleukin 1 beta0.063
Ep300E1A binding protein p3000.063
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.062
E2f1E2F transcription factor 10.061
Fgfr2fibroblast growth factor receptor 20.061
Gfi1bgrowth factor independent 1B0.060
Cbfbcore binding factor beta0.059
Zfp36zinc finger protein 360.059
Asprv1aspartic peptidase, retroviral-like 10.057
Twsg1twisted gastrulation homolog 1 (Drosophila)0.057
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.057
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.056
FosFBJ osteosarcoma oncogene0.054
Fgfr1fibroblast growth factor receptor 10.054
Foxa2forkhead box A20.053
Cxcl1chemokine (C-X-C motif) ligand 10.051
CblCasitas B-lineage lymphoma0.051
Casp1caspase 10.051
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
FosFBJ osteosarcoma oncogene0.972
Aqp9aquaporin 90.770
Egr1early growth response 10.760
Col1a1collagen, type I, alpha 10.727
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.686
Btg2BTG family, member 20.632
Nr4a1nuclear receptor subfamily 4, group A, member 10.617
Egr2early growth response 20.603
Junbjun B proto-oncogene0.546
Aldoaaldolase A, fructose-bisphosphate0.522
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.518
Bdkrb1bradykinin receptor B10.508
Ppardperoxisome proliferator-activated receptor delta0.508
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.505
Col1a2collagen, type I, alpha 20.485
Col3a1collagen, type III, alpha 10.484
Ptgs2prostaglandin-endoperoxide synthase 20.463
C3complement component 30.459
Gabrr3gamma-aminobutyric acid (GABA) receptor, rho 30.447
Atf3activating transcription factor 30.410
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.409
Mifmacrophage migration inhibitory factor0.405
Pou2f3POU class 2 homeobox 30.399
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.393
A1i3alpha-1-inhibitor III0.391
Ctrb1chymotrypsinogen B10.375
Cd38CD38 molecule0.351
Gpihbp1glycosylphosphatidylinositol anchored high density lipoprotein binding protein 10.340
Rdh7retinol dehydrogenase 70.335
Apohapolipoprotein H (beta-2-glycoprotein I)0.333
Cxcl2chemokine (C-X-C motif) ligand 20.329
Mmp3matrix metallopeptidase 30.321
Plaurplasminogen activator, urokinase receptor0.319
G6pcglucose-6-phosphatase, catalytic subunit0.312
Pparaperoxisome proliferator activated receptor alpha0.303
Ripk3receptor-interacting serine-threonine kinase 30.299
Prss3protease, serine, 30.298
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.297
Socs3suppressor of cytokine signaling 30.297
Dhdpsldihydrodipicolinate synthase-like, mitochondrial0.297
Olr226olfactory receptor 2260.288
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.285
Insrinsulin receptor0.283
Il1ainterleukin 1 alpha0.275
Cps1carbamoyl-phosphate synthetase 10.273
Stc1stanniocalcin 10.272
Klk6kallikrein related-peptidase 60.267
Mmp12matrix metallopeptidase 120.261
Calcbcalcitonin-related polypeptide, beta0.257
Col5a2collagen, type V, alpha 20.255
Fgf1fibroblast growth factor 10.243
Atp5bATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.230
Flt1FMS-related tyrosine kinase 10.227
LOC290595hypothetical gene supported by AF1520020.223
Tbxa2rthromboxane A2 receptor0.222
Kcna6potassium voltage gated channel, shaker related subfamily, member 60.220
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.218
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.218
Pnliprp2pancreatic lipase-related protein 20.215
Ngfnerve growth factor (beta polypeptide)0.214
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.212
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.210
Pdia6protein disulfide isomerase family A, member 60.209
Tpothyroid peroxidase0.208
Pgcprogastricsin (pepsinogen C)0.207
Zfp36zinc finger protein 360.207
Pla1aphospholipase A1 member A0.205
Il18interleukin 180.205
Cyp2b12cytochrome P450, family 2, subfamily b, polypeptide 120.205
Pfkfb16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.203
Klf4Kruppel-like factor 4 (gut)0.202
Clec4fC-type lectin domain family 4, member f0.201
Hrghistidine-rich glycoprotein0.200
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.193
Krt4keratin 40.191
Impg2interphotoreceptor matrix proteoglycan 20.191
Cxcl10chemokine (C-X-C motif) ligand 100.186
Pax4paired box 40.186
Foxe1forkhead box E1 (thyroid transcription factor 2)0.185
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.184
Serpina4serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 40.183
Fosl2fos-like antigen 20.182
Cdk2cyclin dependent kinase 20.179
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.179
Cryaacrystallin, alpha A0.179
Tnftumor necrosis factor (TNF superfamily, member 2)0.178
Mmp9matrix metallopeptidase 90.176
Glycam1glycosylation dependent cell adhesion molecule 10.175
Egr3early growth response 30.173
Leprleptin receptor0.170
Lim2lens intrinsic membrane protein 20.170
Nr4a3nuclear receptor subfamily 4, group A, member 30.170
Pnlippancreatic lipase0.169
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.168
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism