The network for 'embryonic epithelial tube formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic epithelial tube formation

The morphogenesis of an embryonic epithelium into a tube-shaped structure.

NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.995
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.983
APCadenomatous polyposis coli0.981
LRRK2leucine-rich repeat kinase 20.971
DVL3dishevelled, dsh homolog 3 (Drosophila)0.961
TRRAPtransformation/transcription domain-associated protein0.955
PRKCZprotein kinase C, zeta0.917
GSK3Bglycogen synthase kinase 3 beta0.906
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.898
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.871
BCORBCL6 corepressor0.858
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.840
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.831
AKT1v-akt murine thymoma viral oncogene homolog 10.827
ZRANB1zinc finger, RAN-binding domain containing 10.808
AXIN1axin 10.792
CNKSR2connector enhancer of kinase suppressor of Ras 20.771
ACTBactin, beta0.761
MEOX2mesenchyme homeobox 20.760
STK3serine/threonine kinase 30.741
ACTG1actin, gamma 10.731
RXRAretinoid X receptor, alpha0.728
ESR1estrogen receptor 10.697
SEC23ASec23 homolog A (S. cerevisiae)0.681
PPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16A0.656
STK4serine/threonine kinase 40.648
SMAD2SMAD family member 20.638
SMAD3SMAD family member 30.637
CTBP1C-terminal binding protein 10.630
SAV1salvador homolog 1 (Drosophila)0.611
DVL1dishevelled, dsh homolog 1 (Drosophila)0.600
INADLInaD-like (Drosophila)0.592
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.582
CTNND1catenin (cadherin-associated protein), delta 10.571
CSNK1Ecasein kinase 1, epsilon0.553
EXOC7exocyst complex component 70.530
CASP9caspase 9, apoptosis-related cysteine peptidase0.528
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.527
SMAD4SMAD family member 40.518
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.516
SOX10SRY (sex determining region Y)-box 100.501
POU3F2POU class 3 homeobox 20.499
PCM1pericentriolar material 10.491
USP9Xubiquitin specific peptidase 9, X-linked0.480
SETD8SET domain containing (lysine methyltransferase) 80.474
TRIP6thyroid hormone receptor interactor 60.473
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.472
CREBBPCREB binding protein0.467
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.435
WNT3Awingless-type MMTV integration site family, member 3A0.427
IQGAP1IQ motif containing GTPase activating protein 10.425
SASS6spindle assembly 6 homolog (C. elegans)0.423
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.421
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.406
AKAP11A kinase (PRKA) anchor protein 110.391
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.383
RASSF3Ras association (RalGDS/AF-6) domain family member 30.383
BMP7bone morphogenetic protein 70.382
ZFXzinc finger protein, X-linked0.380
MTA1metastasis associated 10.379
NKX2-1NK2 homeobox 10.371
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.340
ZFYVE9zinc finger, FYVE domain containing 90.338
C9orf89chromosome 9 open reading frame 890.336
CDC27cell division cycle 27 homolog (S. cerevisiae)0.330
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.329
NCOR1nuclear receptor corepressor 10.329
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.326
SKIv-ski sarcoma viral oncogene homolog (avian)0.326
PKP4plakophilin 40.321
RASA1RAS p21 protein activator (GTPase activating protein) 10.304
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.299
WASF1WAS protein family, member 10.298
SEC24DSEC24 family, member D (S. cerevisiae)0.297
MBD2methyl-CpG binding domain protein 20.296
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.287
SQSTM1sequestosome 10.284
LIN28Blin-28 homolog B (C. elegans)0.281
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.281
LDB1LIM domain binding 10.276
MED25mediator complex subunit 250.275
CENPJcentromere protein J0.270
CTBP2C-terminal binding protein 20.267
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.266
TRAF6TNF receptor-associated factor 60.266
LGALS8lectin, galactoside-binding, soluble, 80.256
ANKRD28ankyrin repeat domain 280.255
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.250
DLG5discs, large homolog 5 (Drosophila)0.250
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.248
WT1Wilms tumor 10.245
SEC24ASEC24 family, member A (S. cerevisiae)0.242
ZNF746zinc finger protein 7460.235
SP1Sp1 transcription factor0.235
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.233
EP300E1A binding protein p3000.232
GLIS2GLIS family zinc finger 20.230
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.229
EXOC5exocyst complex component 50.225
HIC1hypermethylated in cancer 10.219
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdh2cadherin 2, neuronal0.515
foxd3forkhead box D30.482
gyltl1bglycosyltransferase-like 1b0.478
pou3f3bPOU class 3 homeobox 3b0.404
nkd1naked cuticle homolog 1 (Drosophila)0.400
atoh1batonal homolog 1b0.394
wnt5bwingless-type MMTV integration site family, member 5b0.331
etv5bets variant 5b0.313
raraaretinoic acid receptor, alpha a0.301
wnt4awingless-type MMTV integration site family, member 4a0.299
smad5MAD homolog 5 (Drosophila)0.282
gbx2gastrulation brain homeo box 20.272
gdf6agrowth differentiation factor 6a0.255
fgf3fibroblast growth factor 30.215
tbx1T-box 10.210
hoxb1bhomeo box B1b0.191
otx2orthodenticle homolog 20.191
kif17kinesin family member 170.184
foxg1aforkhead box G1a0.180
otpborthopedia homolog b0.173
fgf8bfibroblast growth factor 8 b0.169
six1bsine oculis homeobox homolog 1b0.161
rx3retinal homeobox gene 30.159
bmp2bbone morphogenetic protein 2b0.156
foxi1forkhead box I10.155
sox19aSRY-box containing gene 19a0.151
sox9aSRY-box containing gene 9a0.150
ift88intraflagellar transport 88 homolog0.139
crb2acrumbs homolog 2a0.135
olig3oligodendrocyte transcription factor 30.116
sema3aasemaphorin 3aa0.116
fzd10frizzled homolog 100.115
pea3ETS-domain transcription factor pea30.113
fgfr1bfibroblast growth factor receptor 1b0.113
wnt11wingless-type MMTV integration site family, member 110.110
six1asine oculis homeobox homolog 1a0.108
olig2oligodendrocyte lineage transcription factor 20.108
epb41l5erythrocyte membrane protein band 4.1 like 50.107
zic5zic family member 5 (odd-paired homolog, Drosophila)0.106
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.104
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.103
hhiphedgehog interacting protein0.102
sox3SRY-box containing gene 30.099
foxj1aforkhead box J1a0.097
fzd7bfrizzled homolog 7b0.096
pkd2polycystic kidney disease 20.096
gli1GLI-Kruppel family member 10.095
guca1cguanylate cyclase activator 1C0.095
col2a1acollagen type II, alpha-1a0.091
smosmoothened homolog (Drosophila)0.090
six3bsine oculis homeobox homolog 3b0.088
cc2d2acoiled-coil and C2 domain containing 2A0.087
bocbrother of CDO0.086
shhasonic hedgehog a0.083
six2asine oculis-related homeobox 2a0.083
spry2sprouty homolog 20.082
aldh1a2aldehyde dehydrogenase 1 family, member A20.082
neurodneurogenic differentiation0.077
notch1anotch homolog 1a0.077
spry1sprouty homolog 1 (Drosophila)0.075
hoxb3ahomeo box B3a0.074
osr2odd-skipped related 2 (Drosophila)0.074
six3asine oculis homeobox homolog 3a0.074
eng2bengrailed 2b0.074
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.070
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.070
oc90otoconin 900.070
fzd7afrizzled homolog 7a0.070
zic4zic family member 40.068
metmet proto-oncogene (hepatocyte growth factor receptor)0.066
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.065
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.063
mecomMDS1 and EVI1 complex locus0.060
egr2bearly growth response 2b0.060
meis2.1myeloid ecotropic viral integration site 2.10.060
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.060
odz4odd Oz/ten-m homolog 40.060
fgfr4fibroblast growth factor receptor 40.059
hapln1ahyaluronan and proteoglycan link protein 1a0.059
rfx2regulatory factor X, 2 (influences HLA class II expression)0.058
wnt3wingless-type MMTV integration site family, member 30.054
crabp2bcellular retinoic acid binding protein 2, b0.054
prkciprotein kinase C, iota0.053
zeb2azinc finger E-box binding homeobox 2a0.052
fstafollistatin a0.052
hoxd4ahomeo box D4a0.051
rhoubras homolog gene family, member Ub0.051
pcdh8protocadherin 80.051
tfap2atranscription factor AP-2 alpha0.049
efnb3bephrin B3b0.049
alcambactivated leukocyte cell adhesion molecule b0.048
fn1fibronectin 10.047
gdnfglial cell derived neurotrophic factor0.046
myhz2myosin, heavy polypeptide 2, fast muscle specific0.046
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.045
hoxd3ahomeo box D3a0.045
lfnglunatic fringe homolog0.044
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
HLHmdeltaE(spl) region transcript mdelta0.862
HLHm7E(spl) region transcript m70.817
HLHmgammaE(spl) region transcript mgamma0.672
HLHmbetaE(spl) region transcript mbeta0.665
cicubitus interruptus0.650
HLHm3E(spl) region transcript m30.408
opaodd paired0.340
malphaE(spl) region transcript malpha0.321
E(spl)Enhancer of split0.306
Abd-BAbdominal B0.252
TomTwin of m40.227
argosCG4531 gene product from transcript CG4531-RA0.076
oddodd skipped0.071
eyaeyes absent0.065
HLHm5E(spl) region transcript m50.060
m2E(spl) region transcript m20.046
pdm2POU domain protein 20.044
m4E(spl) region transcript m40.033
bowlbrother of odd with entrails limited0.031
Btk29ABtk family kinase at 29A0.029
taptarget of Poxn0.029
fasfaint sausage0.027
kkvkrotzkopf verkehrt0.023
aopanterior open0.023
HmgcrHMG Coenzyme A reductase0.019
wbwing blister0.017
nkdnaked cuticle0.016
slp1sloppy paired 10.014
CG9867CG9867 gene product from transcript CG9867-RA0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Pax3paired box gene 31.000
Tcfap2atranscription factor AP-2, alpha1.000
Gli3GLI-Kruppel family member GLI31.000
Six1sine oculis-related homeobox 1 homolog (Drosophila)1.000
Hand1heart and neural crest derivatives expressed transcript 11.000
Pitx2paired-like homeodomain transcription factor 21.000
Sox2SRY-box containing gene 21.000
Fgf8fibroblast growth factor 80.999
Pax6paired box gene 60.999
Vangl2vang-like 2 (van gogh, Drosophila)0.999
Foxc1forkhead box C10.998
Pbx1pre B-cell leukemia transcription factor 10.997
Tbx1T-box 10.997
Eya1eyes absent 1 homolog (Drosophila)0.996
Msx1homeobox, msh-like 10.996
Bmp7bone morphogenetic protein 70.994
Hand2heart and neural crest derivatives expressed transcript 20.994
Hoxa13homeobox A130.992
Lhx1LIM homeobox protein 10.991
Hes1hairy and enhancer of split 1 (Drosophila)0.991
Retret proto-oncogene0.990
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.989
Tbx15T-box 150.988
Chd7chromodomain helicase DNA binding protein 70.988
Hoxa11homeobox A110.986
Emx2empty spiracles homolog 2 (Drosophila)0.983
Rarbretinoic acid receptor, beta0.983
Hoxa1homeobox A10.982
Hoxd13homeobox D130.981
Gli2GLI-Kruppel family member GLI20.981
Dvl2dishevelled 2, dsh homolog (Drosophila)0.981
Ascl1achaete-scute complex homolog 1 (Drosophila)0.979
Vegfavascular endothelial growth factor A0.975
Ctnnb1catenin (cadherin associated protein), beta 10.974
Lhx3LIM homeobox protein 30.974
Gata4GATA binding protein 40.973
Sfrp2secreted frizzled-related protein 20.973
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.972
Hes5hairy and enhancer of split 5 (Drosophila)0.972
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.970
Foxg1forkhead box G10.968
Fgfr1fibroblast growth factor receptor 10.967
Zic3zinc finger protein of the cerebellum 30.967
Prrx1paired related homeobox 10.966
Foxc2forkhead box C20.963
Pitx1paired-like homeodomain transcription factor 10.958
Wnt3awingless-related MMTV integration site 3A0.958
Sall4sal-like 4 (Drosophila)0.957
Apcadenomatosis polyposis coli0.953
Hoxd11homeobox D110.949
Pax9paired box gene 90.939
Dlx5distal-less homeobox 50.937
Jag1jagged 10.936
Tcfap2ctranscription factor AP-2, gamma0.936
Arid1aAT rich interactive domain 1A (SWI-like)0.929
Tbx3T-box 30.928
Gdnfglial cell line derived neurotrophic factor0.927
Wt1Wilms tumor 1 homolog0.925
Smosmoothened homolog (Drosophila)0.924
Emx1empty spiracles homolog 1 (Drosophila)0.921
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.916
Foxh1forkhead box H10.907
Efna2ephrin A20.906
Dvl3dishevelled 3, dsh homolog (Drosophila)0.905
Hoxa9homeobox A90.902
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.896
Hoxd9homeobox D90.896
Ror2receptor tyrosine kinase-like orphan receptor 20.891
Apaf1apoptotic peptidase activating factor 10.887
Rnf2ring finger protein 20.886
Isl1ISL1 transcription factor, LIM/homeodomain0.868
Neurog2neurogenin 20.867
Smad3MAD homolog 3 (Drosophila)0.861
Sox9SRY-box containing gene 90.861
Hoxa5homeobox A50.860
Wnt6wingless-related MMTV integration site 60.859
Smad1MAD homolog 1 (Drosophila)0.855
Sox3SRY-box containing gene 30.851
Msx2homeobox, msh-like 20.849
Wnt5awingless-related MMTV integration site 5A0.842
Alx4aristaless-like homeobox 40.840
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.840
Ptenphosphatase and tensin homolog0.827
Pax2paired box gene 20.827
Acvr1activin A receptor, type 10.804
Hoxa2homeobox A20.796
Hoxa10homeobox A100.791
Foxa2forkhead box A20.789
Prrx2paired related homeobox 20.784
Onecut1one cut domain, family member 10.778
Lmx1aLIM homeobox transcription factor 1 alpha0.777
Hoxb6homeobox B60.777
Fgfr3fibroblast growth factor receptor 30.776
Rargretinoic acid receptor, gamma0.776
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ireb2iron responsive element binding protein 20.024
Ptov1prostate tumor overexpressed 10.019
Atp6v0a1ATPase, H+ transporting, lysosomal V0 subunit A10.019
Nudt3nudix (nucleoside diphosphate linked moiety X)-type motif 30.019
Foxe3forkhead box E30.016
Ascl1achaete-scute complex homolog 1 (Drosophila)0.016
Tuba1ctubulin, alpha 1C0.016
LOC100360919Immunoglobulin lambda-like polypeptide 1-like0.015
Pip5k1cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma0.015
Pfn1profilin 10.014
Csnk1g3casein kinase 1, gamma 30.013
Pgm2phosphoglucomutase 20.013
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.013
Sox17SRY (sex determining region Y)-box 170.012
RT1-DOaRT1 class II, locus DOa0.012
Crybb3crystallin, beta B30.012
Vegfavascular endothelial growth factor A0.012
Ccna1cyclin A10.012
Scaf1SR-related CTD-associated factor 10.012
Crygbcrystallin, gamma B0.011
Cxxc4CXXC finger 40.011
Bglapbone gamma-carboxyglutamate (gla) protein0.011
Atf2activating transcription factor 20.011
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.011
Mipmajor intrinsic protein of lens fiber0.011
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.011
Prdm2PR domain containing 2, with ZNF domain0.011
Gpr176G protein-coupled receptor 1760.011
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.010
Dctn1dynactin 10.010
Il11interleukin 110.010
Ptpn12protein tyrosine phosphatase, non-receptor type 120.010
Col4a5collagen, type IV, alpha 50.010
Fat1FAT tumor suppressor homolog 1 (Drosophila)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism