The network for 'positive regulation of endothelial cell migration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of endothelial cell migration

Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1.000
TEKTEK tyrosine kinase, endothelial1.000
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
LATlinker for activation of T cells1.000
PLCG1phospholipase C, gamma 11.000
PDGFRBplatelet-derived growth factor receptor, beta polypeptide1.000
FGFR2fibroblast growth factor receptor 20.999
PTPN1protein tyrosine phosphatase, non-receptor type 10.998
VEGFAvascular endothelial growth factor A0.998
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.997
GRB2growth factor receptor-bound protein 20.988
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.987
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.985
TGFB1transforming growth factor, beta 10.985
FN1fibronectin 10.984
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.979
BCAR1breast cancer anti-estrogen resistance 10.975
FYNFYN oncogene related to SRC, FGR, YES0.974
FGFR1fibroblast growth factor receptor 10.973
SHC1SHC (Src homology 2 domain containing) transforming protein 10.967
NRP1neuropilin 10.966
FGF1fibroblast growth factor 1 (acidic)0.956
YAP1Yes-associated protein 10.940
SKILSKI-like oncogene0.936
SYKspleen tyrosine kinase0.929
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.919
TAL1T-cell acute lymphocytic leukemia 10.907
ENGendoglin0.905
FKBP1AFK506 binding protein 1A, 12kDa0.901
BAG3BCL2-associated athanogene 30.898
FGAfibrinogen alpha chain0.862
CAV1caveolin 1, caveolae protein, 22kDa0.851
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.829
FSTL1follistatin-like 10.818
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.810
HSPB8heat shock 22kDa protein 80.788
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.752
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.749
PPLperiplakin0.717
SFNstratifin0.667
NOXA1NADPH oxidase activator 10.653
GRB7growth factor receptor-bound protein 70.638
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.540
PTK2PTK2 protein tyrosine kinase 20.534
SMAD3SMAD family member 30.528
PDGFCplatelet derived growth factor C0.504
ANGPT2angiopoietin 20.498
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.462
PTPRJprotein tyrosine phosphatase, receptor type, J0.436
NCF1neutrophil cytosolic factor 10.430
THBS1thrombospondin 10.420
COL5A1collagen, type V, alpha 10.417
PTPN23protein tyrosine phosphatase, non-receptor type 230.411
BMPR1Abone morphogenetic protein receptor, type IA0.409
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.409
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.406
IRS1insulin receptor substrate 10.405
TLN1talin 10.397
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.397
SMAD2SMAD family member 20.384
ITGB5integrin, beta 50.384
AMOTL1angiomotin like 10.383
RUNX1runt-related transcription factor 10.376
BCL6B-cell CLL/lymphoma 60.369
AMOTangiomotin0.339
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.333
SMAD7SMAD family member 70.319
FGF10fibroblast growth factor 100.317
HSPB1heat shock 27kDa protein 10.315
HDAC7histone deacetylase 70.315
MUC1mucin 1, cell surface associated0.314
MEF2Cmyocyte enhancer factor 2C0.311
HSPB7heat shock 27kDa protein family, member 7 (cardiovascular)0.310
VAV1vav 1 guanine nucleotide exchange factor0.305
SHC2SHC (Src homology 2 domain containing) transforming protein 20.299
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.293
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.275
CDH5cadherin 5, type 2 (vascular endothelium)0.256
BMP2bone morphogenetic protein 20.255
RFWD2ring finger and WD repeat domain 20.254
NCOR2nuclear receptor corepressor 20.253
TGFB3transforming growth factor, beta 30.241
PSEN2presenilin 2 (Alzheimer disease 4)0.239
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.235
TIMP3TIMP metallopeptidase inhibitor 30.223
AXLAXL receptor tyrosine kinase0.222
MPDZmultiple PDZ domain protein0.214
MAPK8mitogen-activated protein kinase 80.207
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.206
PDGFAplatelet-derived growth factor alpha polypeptide0.196
FZD1frizzled homolog 1 (Drosophila)0.193
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.183
COL4A1collagen, type IV, alpha 10.181
PECAM1platelet/endothelial cell adhesion molecule0.177
BRAFv-raf murine sarcoma viral oncogene homolog B10.174
SRCIN1SRC kinase signaling inhibitor 10.173
PTPN6protein tyrosine phosphatase, non-receptor type 60.173
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.964
myod1myogenic differentiation 10.240
cdh1cadherin 1, epithelial0.163
ptgs1prostaglandin-endoperoxide synthase 10.150
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.133
twist1atwist1a0.127
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.123
wtipWilms tumor 1 interacting protein0.120
kdrlkinase insert domain receptor like0.117
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.112
fgf24fibroblast growth factor 240.107
tie2endothelium-specific receptor tyrosine kinase 20.106
si:ch73-60e21.1si:ch73-60e21.10.102
mmp2matrix metalloproteinase 20.100
largelike-glycosyltransferase0.077
bmp4bone morphogenetic protein 40.077
myf5myogenic factor 50.075
col12a1collagen, type XII, alpha 10.074
cx30.3connexin 30.30.071
vegfcvascular endothelial growth factor c0.069
flhfloating head0.064
eng1aengrailed 1a0.064
etv2ets variant gene 20.061
bmperBMP binding endothelial regulator0.059
mical3flavoprotein oxidoreductase MICAL30.057
aldh1a2aldehyde dehydrogenase 1 family, member A20.056
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.051
spns2spinster homolog 2 (Drosophila)0.048
capns1acalpain, small subunit 1 a0.047
bmp2abone morphogenetic protein 2a0.043
fn1fibronectin 10.041
wt1bwilms tumor 1b0.040
cyp1acytochrome P450, family 1, subfamily A0.040
notch3notch homolog 30.039
hsp47heat shock protein 470.039
vegfaavascular endothelial growth factor Aa0.038
renrenin0.038
emilin1aelastin microfibril interfacer 1a0.038
osr1odd-skipped related 1 (Drosophila)0.037
limk2LIM domain kinase 20.037
igf2binsulin-like growth factor 2b0.037
pitx3paired-like homeodomain transcription factor 30.036
rargaretinoic acid receptor gamma a0.036
sulf1sulfatase 10.035
klf2aKruppel-like factor 2a0.035
dlx5adistal-less homeobox gene 5a0.034
aplnrbapelin receptor b0.033
cdh5cadherin 50.032
wnt11rwingless-type MMTV integration site family, member 11, related0.032
gata2aGATA-binding protein 2a0.032
hey2hairy/enhancer-of-split related with YRPW motif 20.031
hspg2heparan sulfate proteoglycan 20.031
pxnpaxillin0.029
dcndecorin0.028
mapk3mitogen-activated protein kinase 30.028
wnt2bbwingless-type MMTV integration site family, member 2Bb0.028
dab2disabled homolog 2 (Drosophila)0.027
chdchordin0.027
inhbaainhibin, beta Aa0.027
flt4fms-related tyrosine kinase 40.026
LOC100004946transient receptor potential cation channel subfamily M member 4-like0.026
tie1endothelium-specific receptor tyrosine kinase 10.025
fgf20afibroblast growth factor 20a0.025
cpn1carboxypeptidase N, polypeptide 10.025
hs3st3b1bheparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b0.024
rasl11bRAS-like, family 11, member B0.024
rbl1retinoblastoma-like 1 (p107)0.024
hand2heart and neural crest derivatives expressed transcript 20.023
plk2bpolo-like kinase 2b (Drosophila)0.023
fgf3fibroblast growth factor 30.023
ptrfbpolymerase I and transcript release factor b0.023
calm1acalmodulin 1a0.023
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.023
mbnl2muscleblind-like 2 (Drosophila)0.022
sulf2lsulfatase 2, like0.022
ccl25bchemokine (C-C motif) ligand 25b0.022
skianuclear oncoprotein skia0.022
osr2odd-skipped related 2 (Drosophila)0.022
wnt11wingless-type MMTV integration site family, member 110.022
mrc1amannose receptor, C type 1a0.022
rspo1R-spondin homolog (Xenopus laevis)0.022
spry4sprouty (Drosophila) homolog 40.022
zbtb4zinc finger and BTB domain containing 40.021
nrg1neuregulin 10.021
mespbmesoderm posterior b0.021
ntlano tail a0.021
fgf16fibroblast growth factor 160.021
nrarpanotch-regulated ankyrin repeat protein a0.021
tbx2bT-box 2b0.021
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.021
podxlpodocalyxin-like0.021
zgc:112084zgc:1120840.020
prdm16PR domain containing 160.020
s1pr1sphingosine-1-phosphate receptor 10.020
loxl2alysyl oxidase-like 2a0.020
rhagRhesus blood group-associated glycoprotein0.020
bmp3bone morphogenetic protein 30.020
nog1noggin 10.020
tll1tolloid-like 10.019
cldn5bclaudin 5b0.019
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax2paired box gene 20.996
Gli3GLI-Kruppel family member GLI30.996
Fgfr1fibroblast growth factor receptor 10.990
Fgfr2fibroblast growth factor receptor 20.988
Shhsonic hedgehog0.957
Bmp4bone morphogenetic protein 40.956
Vegfavascular endothelial growth factor A0.894
Fgf8fibroblast growth factor 80.865
Otx2orthodenticle homolog 2 (Drosophila)0.850
Pax8paired box gene 80.778
Pax3paired box gene 30.741
Foxc1forkhead box C10.715
Foxc2forkhead box C20.715
Ptk2PTK2 protein tyrosine kinase 20.701
Nognoggin0.685
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.672
Lhx1LIM homeobox protein 10.580
Kdrkinase insert domain protein receptor0.572
Fgf10fibroblast growth factor 100.555
Gli2GLI-Kruppel family member GLI20.513
Gbx2gastrulation brain homeobox 20.489
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.457
Tbx1T-box 10.400
Eya1eyes absent 1 homolog (Drosophila)0.382
Dkk1dickkopf homolog 1 (Xenopus laevis)0.373
Lmx1aLIM homeobox transcription factor 1 alpha0.369
Tgfb2transforming growth factor, beta 20.362
Rargretinoic acid receptor, gamma0.343
Hoxa1homeobox A10.282
Vangl2vang-like 2 (van gogh, Drosophila)0.254
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.252
Otx1orthodenticle homolog 1 (Drosophila)0.251
Grb2growth factor receptor bound protein 20.251
Hmx3H6 homeobox 30.245
Tcfap2atranscription factor AP-2, alpha0.237
Gab1growth factor receptor bound protein 2-associated protein 10.235
Ptenphosphatase and tensin homolog0.228
Ctnnb1catenin (cadherin associated protein), beta 10.226
Rarbretinoic acid receptor, beta0.220
Fgfr3fibroblast growth factor receptor 30.217
Pax6paired box gene 60.193
En1engrailed 10.187
Efnb2ephrin B20.185
Chrdchordin0.182
Nodalnodal0.181
Lmx1bLIM homeobox transcription factor 1 beta0.180
Ptpn11protein tyrosine phosphatase, non-receptor type 110.176
Emx2empty spiracles homolog 2 (Drosophila)0.175
Foxf2forkhead box F20.165
Prl7d1prolactin family 7, subfamily d, member 10.165
Nkx2-1NK2 homeobox 10.158
Leprleptin receptor0.155
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.151
Meox2mesenchyme homeobox 20.150
Jag1jagged 10.149
Hoxd11homeobox D110.146
Wnt4wingless-related MMTV integration site 40.139
Twist2twist homolog 2 (Drosophila)0.131
Itgb1integrin beta 1 (fibronectin receptor beta)0.128
Egfrepidermal growth factor receptor0.127
Wnt10bwingless related MMTV integration site 10b0.116
FynFyn proto-oncogene0.115
Zeb1zinc finger E-box binding homeobox 10.109
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.108
Smad3MAD homolog 3 (Drosophila)0.108
Pitx2paired-like homeodomain transcription factor 20.108
Sox7SRY-box containing gene 70.104
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.101
Msx2homeobox, msh-like 20.100
Rag2recombination activating gene 20.099
Flt4FMS-like tyrosine kinase 40.099
Acvr1activin A receptor, type 10.098
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.098
Flt1FMS-like tyrosine kinase 10.098
Dlx5distal-less homeobox 50.097
Trp53transformation related protein 530.097
Gscgoosecoid homeobox0.095
Apcadenomatosis polyposis coli0.087
Col4a2collagen, type IV, alpha 20.084
Sox9SRY-box containing gene 90.082
Shesrc homology 2 domain-containing transforming protein E0.081
Foxn1forkhead box N10.079
Prl8a2prolactin family 8, subfamily a, member 20.078
Wnt9awingless-type MMTV integration site 9A0.077
Cyr61cysteine rich protein 610.076
Ptgs2prostaglandin-endoperoxide synthase 20.074
Notch2Notch gene homolog 2 (Drosophila)0.073
Wwtr1WW domain containing transcription regulator 10.071
Zic1zinc finger protein of the cerebellum 10.070
Lmnalamin A0.070
Bcl2B-cell leukemia/lymphoma 20.070
Nr2f2nuclear receptor subfamily 2, group F, member 20.069
Prrx1paired related homeobox 10.068
Tbrachyury0.068
Smosmoothened homolog (Drosophila)0.068
Cdh5cadherin 50.068
Fgf2fibroblast growth factor 20.067
Tcf21transcription factor 210.067
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.066
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.064
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.226
Tln1talin 10.129
Fmnl1formin-like 10.117
Gpr116G protein-coupled receptor 1160.107
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.074
Plxnd1plexin D10.071
Cd38CD38 molecule0.064
Nfianuclear factor I/A0.060
Kdrkinase insert domain receptor0.056
Gna15guanine nucleotide binding protein, alpha 150.055
MGC112715hypothetical protein LOC6908990.053
Elk3ELK3, ETS-domain protein0.052
Elnelastin0.052
Bgnbiglycan0.051
Cybbcytochrome b-245, beta polypeptide0.051
Cd4Cd4 molecule0.049
Emcnendomucin0.048
Stat6signal transducer and activator of transcription 60.047
Itpr2inositol 1,4,5-triphosphate receptor, type 20.047
Cpa3carboxypeptidase A3, mast cell0.046
Hk1hexokinase 10.046
Il2rginterleukin 2 receptor, gamma0.044
Fgfr2fibroblast growth factor receptor 20.042
Lmcd1LIM and cysteine-rich domains 10.042
LOC683626similar to limb-bud and heart0.042
LOC100365152adaptor-related protein complex 1, gamma 2 subunit-like0.041
Cd200r1CD200 receptor 10.040
Npr1natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)0.040
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.039
Ednrbendothelin receptor type B0.039
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.038
Cdh5cadherin 50.036
Vom2r44vomeronasal 2 receptor 440.034
Slit3slit homolog 3 (Drosophila)0.034
Smad7SMAD family member 70.034
Ptger4prostaglandin E receptor 4 (subtype EP4)0.033
Dlc1deleted in liver cancer 10.032
Rasgrp3RAS guanyl releasing protein 3 (calcium and DAG-regulated)0.031
Cd37CD37 molecule0.031
Fbln5fibulin 50.030
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.030
Itih3inter-alpha trypsin inhibitor, heavy chain 30.030
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.029
Cd52CD52 antigen0.029
Homer3homer homolog 3 (Drosophila)0.029
Tgfbr3transforming growth factor, beta receptor III0.028
Gata2GATA binding protein 20.028
Bmp6bone morphogenetic protein 60.027
Capns1calpain, small subunit 10.027
Acvrl1activin A receptor type II-like 10.026
Sykspleen tyrosine kinase0.026
Acta2smooth muscle alpha-actin0.026
Cfpcomplement factor properdin0.025
Nrp1neuropilin 10.025
Arf5ADP-ribosylation factor 50.025
Cyyr1cysteine/tyrosine-rich 10.025
Ltbp4latent transforming growth factor beta binding protein 40.025
Adcy6adenylate cyclase 60.025
Col1a1collagen, type I, alpha 10.025
Lphn2latrophilin 20.024
Sdprserum deprivation response0.023
Tal1T-cell acute lymphocytic leukemia 10.023
Dgkzdiacylglycerol kinase zeta0.023
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.023
RT1-M4RT1 class Ib, locus M40.023
Ramp2receptor (G protein-coupled) activity modifying protein 20.023
TekTEK tyrosine kinase, endothelial0.023
Gja1gap junction protein, alpha 10.023
Nr4a3nuclear receptor subfamily 4, group A, member 30.022
Gzmkgranzyme K0.022
Ptgfrnprostaglandin F2 receptor negative regulator0.022
Matkmegakaryocyte-associated tyrosine kinase0.022
Adcy4adenylate cyclase 40.022
F13a1coagulation factor XIII, A1 polypeptide0.022
Smad3SMAD family member 30.022
Tgm1transglutaminase 1, K polypeptide0.022
Usf2upstream transcription factor 2, c-fos interacting0.021
KitlgKIT ligand0.021
Tgfb1transforming growth factor, beta 10.021
Nr2f2nuclear receptor subfamily 2, group F, member 20.021
Il1binterleukin 1 beta0.021
Ptprcprotein tyrosine phosphatase, receptor type, C0.021
FcgrtFc fragment of IgG, receptor, transporter, alpha0.021
Mmp2matrix metallopeptidase 20.021
Fgfr1Fibroblast growth factor receptor 10.021
TriobpTRIO and F-actin binding protein0.021
Gimap4GTPase, IMAP family member 40.020
Prkchprotein kinase C, eta0.020
Cabp4calcium binding protein 40.020
Sod3superoxide dismutase 3, extracellular0.020
Pde4bphosphodiesterase 4B, cAMP specific0.020
Flt1FMS-related tyrosine kinase 10.020
Eltd1EGF, latrophilin and seven transmembrane domain containing 10.020
Igfbp7insulin-like growth factor binding protein 70.020
Vdac1voltage-dependent anion channel 10.020
Col4a1collagen, type IV, alpha 10.020
Map4k4mitogen-activated protein kinase kinase kinase kinase 40.020
Crip2cysteine-rich protein 20.019
Cbscystathionine beta synthase0.019
Nek9NIMA (never in mitosis gene a)- related kinase 90.019
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism