The network for 'negative regulation of endothelial cell migration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of endothelial cell migration

Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.988
RARAretinoic acid receptor, alpha0.967
TGFB1transforming growth factor, beta 10.930
TEKTEK tyrosine kinase, endothelial0.899
JAG1jagged 10.845
BMP2bone morphogenetic protein 20.805
NOTCH1notch 10.805
NOTCH3notch 30.624
MED25mediator complex subunit 250.596
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.496
FGAfibrinogen alpha chain0.488
FGF1fibroblast growth factor 1 (acidic)0.475
TGFB3transforming growth factor, beta 30.457
RXRAretinoid X receptor, alpha0.457
FKBP1AFK506 binding protein 1A, 12kDa0.360
NCOA1nuclear receptor coactivator 10.347
FGFR1fibroblast growth factor receptor 10.342
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.277
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.250
MEF2Cmyocyte enhancer factor 2C0.216
MAP3K2mitogen-activated protein kinase kinase kinase 20.193
MAP3K5mitogen-activated protein kinase kinase kinase 50.182
NRP1neuropilin 10.180
NOTCH2notch 20.179
MAP3K3mitogen-activated protein kinase kinase kinase 30.179
FGF10fibroblast growth factor 100.177
PRKD2protein kinase D20.170
FBLN1fibulin 10.167
MEF2Amyocyte enhancer factor 2A0.164
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.164
BMPR1Bbone morphogenetic protein receptor, type IB0.153
NCOR2nuclear receptor corepressor 20.140
GDF5growth differentiation factor 50.107
SMAD7SMAD family member 70.107
FSTL1follistatin-like 10.097
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.096
DLL1delta-like 1 (Drosophila)0.093
APOC1apolipoprotein C-I0.088
ACVR1activin A receptor, type I0.088
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.075
KLF6Kruppel-like factor 60.075
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.073
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.073
PRKG1protein kinase, cGMP-dependent, type I0.072
FAM46Afamily with sequence similarity 46, member A0.071
TGFBR1transforming growth factor, beta receptor 10.067
BMP4bone morphogenetic protein 40.067
PPARGperoxisome proliferator-activated receptor gamma0.062
KLF4Kruppel-like factor 4 (gut)0.062
JAG2jagged 20.060
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.060
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.058
S100BS100 calcium binding protein B0.058
SKILSKI-like oncogene0.057
NR0B2nuclear receptor subfamily 0, group B, member 20.055
MAPK7mitogen-activated protein kinase 70.054
FOXP3forkhead box P30.052
PROX1prospero homeobox 10.051
HDAC4histone deacetylase 40.051
PTGISprostaglandin I2 (prostacyclin) synthase0.050
CARHSP1calcium regulated heat stable protein 1, 24kDa0.049
VEGFCvascular endothelial growth factor C0.045
VEGFAvascular endothelial growth factor A0.045
BCL6B-cell CLL/lymphoma 60.044
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 400.044
FGF2fibroblast growth factor 2 (basic)0.043
SAMD4Asterile alpha motif domain containing 4A0.041
CAV1caveolin 1, caveolae protein, 22kDa0.040
LAMB1laminin, beta 10.039
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.038
ZMYND11zinc finger, MYND-type containing 110.038
FGF7fibroblast growth factor 70.037
FGFR3fibroblast growth factor receptor 30.037
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.036
ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.035
JUNjun proto-oncogene0.035
APPamyloid beta (A4) precursor protein0.034
THBS1thrombospondin 10.034
FEZ1fasciculation and elongation protein zeta 1 (zygin I)0.033
GFI1Bgrowth factor independent 1B transcription repressor0.031
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.031
SREBF2sterol regulatory element binding transcription factor 20.030
CDH5cadherin 5, type 2 (vascular endothelium)0.030
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.030
FNDC3Bfibronectin type III domain containing 3B0.029
HDAC7histone deacetylase 70.027
SMURF1SMAD specific E3 ubiquitin protein ligase 10.027
PLXDC1plexin domain containing 10.027
PPARAperoxisome proliferator-activated receptor alpha0.026
ZBTB16zinc finger and BTB domain containing 160.026
SLIT2slit homolog 2 (Drosophila)0.026
DUSP1dual specificity phosphatase 10.026
IGF2insulin-like growth factor 2 (somatomedin A)0.025
SNCGsynuclein, gamma (breast cancer-specific protein 1)0.025
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.025
ASRGL1asparaginase like 10.024
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gli2aGLI-Kruppel family member GLI2a0.834
notch3notch homolog 30.784
ascl1aachaete-scute complex-like 1a (Drosophila)0.687
notch1anotch homolog 1a0.607
kdrlkinase insert domain receptor like0.571
eya1eyes absent homolog 10.536
alcamaactivated leukocyte cell adhesion molecule a0.503
prox1prospero-related homeobox gene 10.411
sox9aSRY-box containing gene 9a0.264
neurog1neurogenin 10.259
cxcr4bchemokine (C-X-C motif), receptor 4b0.195
mibmind bomb0.189
shhasonic hedgehog a0.159
tbx2bT-box 2b0.133
her6hairy-related 60.125
sox3SRY-box containing gene 30.118
myod1myogenic differentiation 10.115
foxn4forkhead box N40.113
pitx3paired-like homeodomain transcription factor 30.107
cdh2cadherin 2, neuronal0.104
dlx5adistal-less homeobox gene 5a0.103
jag2jagged 20.103
sox10SRY-box containing gene 100.099
pcnaproliferating cell nuclear antigen0.091
sall1asal-like 1a (Drosophila)0.083
spry4sprouty (Drosophila) homolog 40.081
vegfcvascular endothelial growth factor c0.081
ptf1apancreas specific transcription factor, 1a0.081
ccm2cerebral cavernous malformation 20.078
pax2apaired box gene 2a0.073
fgfr2fibroblast growth factor receptor 20.071
neurodneurogenic differentiation0.071
cyp1acytochrome P450, family 1, subfamily A0.070
pax6apaired box gene 6a0.069
nrarpanotch-regulated ankyrin repeat protein a0.068
her4.2hairy-related 4.20.068
edn1endothelin 10.065
tal1T-cell acute lymphocytic leukemia 10.064
gata3GATA-binding protein 30.062
insm1binsulinoma-associated 1b0.058
lmx1b.1LIM homeobox transcription factor 1, beta 10.057
copebcore promoter element binding protein0.054
bmp4bone morphogenetic protein 40.052
neurod4neurogenic differentiation 40.052
cdh23cadherin-like 230.051
insm1ainsulinoma-associated 1a0.049
meis1myeloid ecotropic viral integration 10.048
birc2baculoviral IAP repeat-containing 20.047
jag1bjagged 1b0.046
metmet proto-oncogene (hepatocyte growth factor receptor)0.045
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.045
robo3roundabout homolog 30.045
tp63tumor protein p630.044
gata2aGATA-binding protein 2a0.040
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.040
jag1ajagged 1a0.040
hey1hairy/enhancer-of-split related with YRPW motif 10.039
ca2carbonic anhydrase II0.037
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.036
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.036
mdkamidkine-related growth factor0.036
aldh1a2aldehyde dehydrogenase 1 family, member A20.034
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.034
irx3airoquois homeobox protein 3a0.032
neo1neogenin 10.031
ahr2aryl hydrocarbon receptor 20.031
nkx2.2aNK2 transcription factor related 2a0.030
mmp2matrix metalloproteinase 20.030
otpborthopedia homolog b0.030
tnnt2atroponin T2a, cardiac0.029
junjun proto-oncogene0.029
traf4atnf receptor-associated factor 4a0.029
rbp4retinol binding protein 4, plasma0.028
cxcr4achemokine (C-X-C motif) receptor 4a0.028
tcf12transcription factor 120.028
nrp2bneuropilin 2b0.028
sox11aSRY-box containing gene 11a0.028
hnf1bbHNF1 homeobox Bb0.027
ift88intraflagellar transport 88 homolog0.027
notch2notch homolog 20.027
vsx2visual system homeobox 20.026
ptgs2aprostaglandin-endoperoxide synthase 2a0.025
ascl1bachaete-scute complex-like 1b (Drosophila)0.024
sarsseryl-tRNA synthetase0.024
foxa1forkhead box A10.024
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.024
fgf10afibroblast growth factor 10a0.023
sulf2sulfatase 20.023
ntn1anetrin 1a0.023
supt6hsuppressor of Ty 6 homolog0.023
hey2hairy/enhancer-of-split related with YRPW motif 20.022
ptmaaprothymosin, alpha a0.022
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dll1delta-like 1 (Drosophila)0.999
Notch1Notch gene homolog 1 (Drosophila)0.999
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.995
Notch2Notch gene homolog 2 (Drosophila)0.995
Prl7d1prolactin family 7, subfamily d, member 10.977
Psen1presenilin 10.940
Fgfr1fibroblast growth factor receptor 10.920
Prl7a1prolactin family 7, subfamily a, member 10.896
Slit3slit homolog 3 (Drosophila)0.896
Prl8a2prolactin family 8, subfamily a, member 20.877
Robo1roundabout homolog 1 (Drosophila)0.865
Cdh5cadherin 50.858
Tgfbr2transforming growth factor, beta receptor II0.796
Prl3b1prolactin family 3, subfamily b, member 10.787
Map3k14mitogen-activated protein kinase kinase kinase 140.779
Cldn5claudin 50.777
Rb1retinoblastoma 10.761
Nos3nitric oxide synthase 3, endothelial cell0.756
Tcte3t-complex-associated testis expressed 30.724
Cdkn1bcyclin-dependent kinase inhibitor 1B0.650
Thbs2thrombospondin 20.623
Prl2b1prolactin family 2, subfamily b, member 10.622
Prl8a6prolactin family 8, subfamily a, member 60.614
Prl6a1prolactin family 6, subfamily a, member 10.612
Mmp1amatrix metallopeptidase 1a (interstitial collagenase)0.561
Jag2jagged 20.549
Tpbpatrophoblast specific protein alpha0.545
Ptprbprotein tyrosine phosphatase, receptor type, B0.538
Prl8a9prolactin family8, subfamily a, member 90.511
Col13a1collagen, type XIII, alpha 10.501
Nr2f1nuclear receptor subfamily 2, group F, member 10.500
Ctsrcathepsin R0.496
Ghrgrowth hormone receptor0.487
Olfr64olfactory receptor 640.482
Chd7chromodomain helicase DNA binding protein 70.477
Efnb2ephrin B20.466
Erv3endogenous retroviral sequence 30.459
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.459
Dll4delta-like 4 (Drosophila)0.444
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.442
Ceacam11carcinoembryonic antigen-related cell adhesion molecule 110.412
Efnb1ephrin B10.409
Robo2roundabout homolog 2 (Drosophila)0.399
Serpinb9cserine (or cysteine) peptidase inhibitor, clade B, member 9c0.379
Hes1hairy and enhancer of split 1 (Drosophila)0.377
Jag1jagged 10.372
Prl3a1prolactin family 3, subfamily a, member 10.368
Loxlysyl oxidase0.354
Serpinb9gserine (or cysteine) peptidase inhibitor, clade B, member 9g0.340
Prl3d1prolactin family 3, subfamily d, member 10.330
Mef2dmyocyte enhancer factor 2D0.321
Prl7a2prolactin family 7, subfamily a, member 20.321
Prl5a1prolactin family 5, subfamily a, member 10.310
Slit1slit homolog 1 (Drosophila)0.307
Svaseminal vesicle antigen0.303
Foxg1forkhead box G10.299
Klf2Kruppel-like factor 2 (lung)0.298
Vangl2vang-like 2 (van gogh, Drosophila)0.292
Dctn1dynactin 10.274
Rhox9reproductive homeobox 90.251
Prl2a1prolactin family 2, subfamily a, member 10.245
Hand2heart and neural crest derivatives expressed transcript 20.243
Psg19pregnancy specific glycoprotein 190.242
Esamendothelial cell-specific adhesion molecule0.241
Snai1snail homolog 1 (Drosophila)0.240
Osmroncostatin M receptor0.239
Prl7c1prolactin family 7, subfamily c, member 10.235
Ceacam12carcinoembryonic antigen-related cell adhesion molecule 120.233
Ctsjcathepsin J0.222
Lyz2lysozyme 20.220
Cyr61cysteine rich protein 610.220
Masp1mannan-binding lectin serine peptidase 10.219
Kng1kininogen 10.217
Prl4a1prolactin family 4, subfamily a, member 10.215
Map3k3mitogen-activated protein kinase kinase kinase 30.213
Notch3Notch gene homolog 3 (Drosophila)0.212
Mdm2transformed mouse 3T3 cell double minute 20.212
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.210
Prss58protease, serine 580.208
Dusp1dual specificity phosphatase 10.207
Prl8a8prolactin family 8, subfamily a, member 810.206
Prl3c1prolactin family 3, subfamily c, member 10.206
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.198
Adcy4adenylate cyclase 40.196
Slco6c1solute carrier organic anion transporter family, member 6c10.189
Vmn1r42vomeronasal 1 receptor 420.173
Plac1placental specific protein 10.172
Sox17SRY-box containing gene 170.168
Cyp17a1cytochrome P450, family 17, subfamily a, polypeptide 10.166
Prl3d2prolactin family 3, subfamily d, member 10.164
Csn1s2acasein alpha s2-like A0.164
Shesrc homology 2 domain-containing transforming protein E0.159
Irs3insulin receptor substrate 30.159
Fat4FAT tumor suppressor homolog 4 (Drosophila)0.158
Apoa1apolipoprotein A-I0.156
Slco1b2solute carrier organic anion transporter family, member 1b20.152
Timp3tissue inhibitor of metalloproteinase 30.152
Psen2presenilin 20.149
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
C1scomplement component 1, s subcomponent0.037
Ifitm3interferon induced transmembrane protein 30.021
C1rcomplement component 1, r subcomponent0.019
Tcf4transcription factor 40.018
Aebp1AE binding protein 10.014
Dock6dedicator of cytokinesis 60.012
Adcy4adenylate cyclase 40.011
Bbxbobby sox homolog (Drosophila)0.011
Dusp1dual specificity phosphatase 10.011
Gja4gap junction protein, alpha 40.011
C4bcomplement component 4B (Chido blood group)0.011
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.011
Nfianuclear factor I/A0.010
Klf2Kruppel-like factor 2 (lung)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism